scholarly journals Anti-Obesity and Gut Microbiota Modulation Effect of Secoiridoid-Enriched Extract from Fraxinus mandshurica Seeds on High-Fat Diet-Fed Mice

Molecules ◽  
2020 ◽  
Vol 25 (17) ◽  
pp. 4001
Author(s):  
Sen Guo ◽  
Haoan Zhao ◽  
Zhongxiao Ma ◽  
Shanshan Zhang ◽  
Mingrou Li ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Pancreatic Lipase ◽  
Inhibitory Activity ◽  
High Fat Diet ◽  
Obese Mice ◽  
Modulation Effect ◽  
Fraxinus Mandshurica ◽  
High Fat ◽  
Stress Injury ◽  
Phytochemical Study

Previously we conducted a phytochemical study on the seeds of Fraxinus excelsior and isolated nine secoiridoid compounds with adipocyte differentiation inhibitory activity and peroxisome proliferator activated receptor alpha (PPARα) activation effects. However, the bioactive constituents and functions of Fraxinus mandshurica seeds have not been studied. In the present study, we investigated the secoiridoid compounds in F. mandshurica seed extract (FM) using column chromatography, 1H-NMR, 13C-NMR and HPLC-DAD methods. The pancreatic lipase inhibitory activities of isolated compounds were evaluated in vitro. Additionally, the anti-obesity and gut microbiota modulation effect of FM on high-fat diet-induced obesity in C57BL/6 mice were also studied in vivo. The results showed that 19 secoiridoids were isolated from FM and identified. The total content of secoiridoids in FM reached 181.35 mg/g and the highest content was nuzhenide (88.21 mg/g). All these secoiridoid compounds exhibited good pancreatic lipase inhibitory activity with inhibition rate ranged from 33.77% to 70.25% at the concentration of 100 μM. After obese mice were administrated with FM at 400 mg/kg.bw for 8 weeks, body weight was decreased by 15.81%. Moreover, FM could attenuate the lipid accumulation in serum and liver, relieve the damage in liver and kidney, and extenuate oxidative stress injury and inflammation caused by obesity in mice. FM could also modulate the structural alteration of gut microbiota in obese mice, increasing the proportion of anti-obesity gut microbiota (Bacteroidetes, Bacteroidia, S24-7 and Allobaculum), and reducing the proportion of obesogenic gut microbiota (Firmicutes and Dorea). This study suggests that F. mandshurica seeds or their secoiridoids may have potential for use as a dietary supplement for obesity management.

Modulation effect of chenpi extract on gut microbiota in high‐fat diet‐induced obese C57BL/6 mice

2021 ◽  
Author(s):  
Aili Li ◽  
Nana Wang ◽  
Na Li ◽  
Bailiang Li ◽  
Fenfen Yan ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Modulation Effect ◽  
High Fat

Black rice anthocyanins alleviate hyperlipidemia, liver steatosis and insulin resistance by regulating lipid metabolism and gut microbiota in obese mice

2021 ◽  
Author(s):  
Haizhao Song ◽  
Xinchun Shen ◽  
Yang Zhou ◽  
Xiaodong Zheng
Keyword(s):  
Insulin Resistance ◽  
Lipid Metabolism ◽  
Gut Microbiota ◽  
Hepatic Steatosis ◽  
High Fat Diet ◽  
Liver Steatosis ◽  
Obese Mice ◽  
Black Rice ◽  
High Fat ◽  
Diet Induced Obesity

Supplementation of black rice anthocyanins (BRAN) alleviated high fat diet-induced obesity, insulin resistance and hepatic steatosis by improvement of lipid metabolism and modification of the gut microbiota.

scholarly journals Absence of the Caspases 1/11 Modulates Liver Global Lipid Profile and Gut Microbiota in High-Fat-Diet-Induced Obese Mice

2020 ◽  
Vol 10 ◽  
Author(s):  
Lívia Pimentel de Sant'Ana ◽  
Dalila Juliana S. Ribeiro ◽  
Aline Maria Araújo Martins ◽  
Fábio Neves dos Santos ◽  
Rafael Corrêa ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Obese Mice ◽  
High Fat

Rice bran attenuated obesity via alleviating dyslipidemia, browning of white adipocytes and modulating gut microbiota in high-fat diet-induced obese mice

2020 ◽  
Vol 11 (3) ◽  
pp. 2406-2417 ◽  
Author(s):  
Yucheng Zou ◽  
Xingrong Ju ◽  
Wenye Chen ◽  
Juan Yuan ◽  
Zhigao Wang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Rice Bran ◽  
Significant Role ◽  
High Fat Diet ◽  
Prevention And Control ◽  
Obese Mice ◽  
High Fat ◽  
White Adipocytes ◽  
And Control

Rice bran supplementation played a significant role in reducing dyslipidemia and inflammation, enhancing browning of white adipocytes and modulating gut microbiota for the prevention and control of obesity.

scholarly journals Altered Gut Microbiota Is a Novel Mechanism for the Adverse Effects Induced by Foodborne Titanium Dioxide Nanoparticles in Obese and Non-obese Mice (P21-021-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Hengjun Du ◽  
Xiaoqiong Cao ◽  
Yanhui Han ◽  
Min Gu ◽  
Hang Xiao
Keyword(s):  
Titanium Dioxide ◽  
Adverse Effects ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Obese Mice ◽  
High Fat ◽  
Low Fat ◽  
Colonic Inflammation ◽  
Tio2 Nps ◽  
Low Fat Diet

Abstract Objectives Many food products contain inorganic nanoparticles (NPs), such as titanium dioxide (TiO2) NPs. There is increasing concern about the potential unintended health risks associated with foodborne TiO2 NPs in certain populations, such as the obese. The purpose of this study was to determine the adverse effects of TiO2 NPs in obese individuals, the molecular mechanism involved and the potential role of gut microbiota in mediating the adverse effects. Methods Two types of TiO2 (30 nm and E171-Food grade TiO2) were mixed with mouse diet at 0.1 wt% and fed to two populations of mice (high-fat diet-fed obese mice and non-obese mice). Meanwhile, fecal samples from the above groups of mice were collected weekly for transplanting to four groups of mice fed a low-fat diet for 10 weeks. 16 s rRNA gene amplicon sequencing, histological analysis, immunohistochemistry, ELISA and SCFAs analysis were utilized to characterize the composition of the microbiota, inflammation status, and the effects of altered gut microbiota on the inflammation status of the mouse colon. Results TiO2 NPs significantly altered the composition of gut microbiota with stronger alterations in the high-fat diet-fed obese mice than the low-fat diet-fed non-obese mice. The abundance of inflammation-related cytokines (e.g., IL-10, IL-12p70, and IL-17) and myeloperoxidase (MPO) in the mouse colonic mucosa were significantly altered by TiO2 NPs to produce an inflammatory state. TiO2 NPs decreased the cecal levels of SCFAs such as butyrate. Moreover, the magnitude of the above alteration was higher in the obese mice than in the non-obese mice. After 10 weeks of microbial transplant, microbiota from the mice consuming a high-fat diet with TiO2 NPs led to an increase of pro-inflammatory cytokines, loss of healthy colonic morphology, and infiltration of immune cells in the colon of the low-fat diet-fed recipient mice, indicating a significant colonic inflammation. Conclusions TiO2 NPs altered gut microbiota in both obese and non-obese mice, with stronger effects in the obese mice, and the alteration of gut microbiota led to colonic inflammation in the mice. Overall, these findings provided a valuable new perspective on the potential adverse effects and appropriate mechanisms of foodborne TiO2 NPs among populations with different obese status. Funding Sources USDA/NIFA competitive grants to Hang Xiao.

The metabolic regulation of Fuzhuan brick tea in the high-fat diet-induced obese mice and the potential contribution of gut microbiota

2021 ◽  
Author(s):  
Dongming Liu ◽  
Jianhui Wang ◽  
Hongliang Zeng ◽  
Fang Zhou ◽  
Bei-Bei Wen ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Metabolic Regulation ◽  
Metabolic Effects ◽  
Potential Contribution ◽  
Obese Mice ◽  
High Fat

This study investigated the metabolic effects of Fuzhuan brick tea (FBT) in high-fat diet (HFD)-induced obese mice and the potential contribution of gut microbiota. The results showed that FBT ameliorated...

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