scholarly journals Correction: Gobinath, P., et al. Grindstone Chemistry: Design, One-Pot Synthesis, and Promising Anticancer Activity of Spiro[acridine-9,2′-indoline]-1,3,8-trione Derivatives against the MCF-7 Cancer Cell Line. Molecules 2020, 25, 5862

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1131
Author(s):  
Perumal Gobinath ◽  
Ponnusamy Packialakshmi ◽  
Ali Daoud ◽  
Saud Alarifi ◽  
Akbar Idhayadhulla ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
One Pot ◽  
One Pot Synthesis ◽  
Mcf 7

In the original article [...]

scholarly journals Grindstone Chemistry: Design, One-Pot Synthesis, and Promising Anticancer Activity of Spiro[acridine-9,2′-indoline]-1,3,8-trione Derivatives against the MCF-7 Cancer Cell Line

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5862
Author(s):  
Perumal Gobinath ◽  
Ponnusamy Packialakshmi ◽  
Ali Daoud ◽  
Saud Alarifi ◽  
Akbar Idhayadhulla ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Cancer Cell ◽  
Anticancer Agents ◽  
Mass Spectra ◽  
Cancer Cell Line ◽  
One Pot ◽  
Solvent Free Conditions ◽  
Cyclocondensation Reaction ◽  
Ft Ir ◽  
Mcf 7

In this study, the synthesis of one-pot 10-phenyl-3,4,6,7-tetrahydro-1H-spiro [acridine-9,2′-indoline]-1,3,8-trione derivatives was achieved via a four-component cyclocondensation reaction, which was carried out in solvent-free conditions, and using p-toluenesulfonic acid (p-TSA) as a catalyst. The product was confirmed by FT-IR, 1H-NMR, 13C-NMR, mass spectra, and elemental analysis. Furthermore, the anticancer activity was screened for all compounds. Among these compounds, compound 1c was more effective (GI50 0.01 µm) against MCF-7 cancer cell lines than standard and other compounds. Therefore, the objective of this study was achieved with a few promising molecules having been demonstrated to be potential anticancer agents.

One-pot synthesis of fused benzoxazino[1,2,3]triazolyl[4,5-c]quinolinone derivatives and their anticancer activity

RSC Advances ◽  
2016 ◽  
Vol 6 (78) ◽  
pp. 74332-74339 ◽  
Author(s):  
Sirassu Narsimha ◽  
Kumara Swamy Battula ◽  
Satheesh Kumar Nukala ◽  
Ramesh Gondru ◽  
Yellu Narasimha Reddy ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Anticancer Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Human Cancer Cell ◽  
One Pot ◽  
Human Cancer Cell Lines ◽  
One Pot Synthesis ◽  
Mcf 7

Cu/Pd catalyzed one pot synthesis of fused benzoxazino[1,2,3]triazolyl[4,5-c]quinolinone hybrids and their cytotoxic activity against human cancer cell lines MCF-7, HeLa and A-549 is described.

scholarly journals Anticancer Activity from Active Fraction of Sea Cucumber

2017 ◽  
Vol 20 (1) ◽  
pp. 53 ◽  
Author(s):  
Nurul Mutia Putram ◽  
Iriani Setyaningsih ◽  
Kustiariyah Tarman
Keyword(s):  
Ethyl Acetate ◽  
Anticancer Activity ◽  
Cell Line ◽  
Cancer Cell ◽  
Hela Cells ◽  
Crude Extract ◽  
Sea Cucumber ◽  
Cancer Cell Line ◽  
Toxicity Tests ◽  
Mcf 7

Sea Cucumber Holothuria atra is one of marine organisms has been used as a new source of novel bioactive compounds. Many of them have been used as the lead compounds in discovery of new anticancer drugs. The objective of this study was to determine the active fractions of sea cucumber (H. atra) which have anticancer activity. H. atra was macerated using ethanol and the extract was freezedried using a freeze dryer. The crude extract was partitioned using n-hexane, ethyl acetate, and methanol-water (3:1:1:1). Cytotoxicity test was performed using HeLa (cervic cancer) cell line and MCF-7 (breast cancer) cell line based on the MTT assay. The crude extract of H. atra showed the best cytotoxic activity against HeLa cells (IC50 = 12.48 µg/mL) and MCF-7 cells (IC50 = 17.90 µg/mL). The toxicity tests showed the IC50 value of the n-hexane fraction, ethyl acetate fraction, and methanol-water fraction against HeLa cells HeLa (IC50 = 76.45 µg/mL; 77.95 µg/mL;  14.27 µg/mL) and MCF-7 cells (IC50 = 58.50 µg/mL; 59.59 µg/mL; 14.33 µg/mL).

Hexasaccharide resin glycosides from the jalap roots as modulators of multidrug resistance in MCF-7 cancer cell line

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
E Bautista ◽  
M Fragoso ◽  
R Pereda-Miranda
Keyword(s):  
Multidrug Resistance ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Mcf 7

Effect Of Selected Herbal Extracts On MCF-7(Breast Cancer) Cell Line

Planta Medica ◽  
2016 ◽  
Vol 82 (05) ◽  
Author(s):  
U Chandur ◽  
G Rao Battu ◽  
S Chitti
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Cancer Cell Line ◽  
Herbal Extracts ◽  
Mcf 7

Effects of Ganoderma lucidum (Higher Basidiomycetes) Extracts on the miRNA Profile and Telomerase Activity of the MCF-7 Breast Cancer Cell Line

2015 ◽  
Vol 17 (3) ◽  
pp. 231-239 ◽  
Author(s):  
Oyku Gonul ◽  
Hikmet Hakan Aydin ◽  
Erbil Kalmis ◽  
Husniye Kayalar ◽  
Ali Burak Ozkaya ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Ganoderma Lucidum ◽  
Cancer Cell Line ◽  
Telomerase Activity ◽  
Mirna Profile ◽  
Mcf 7
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