scholarly journals The Effect of Blood Contained in the Samples on the Metabolomic Profile of Mouse Brain Tissue: A Study by NMR Spectroscopy

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3096
Author(s):  
Anastasia Glinskikh ◽  
Olga Snytnikova ◽  
Ekaterina Zelentsova ◽  
Maria Borisova ◽  
Yuri Tsentalovich ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Brain Tissue ◽  
Statistical Data ◽  
Tissue Sample ◽  
Chloroform Solution ◽  
Metabolomic Profile ◽  
Statistical Data Analysis ◽  
Native State ◽  
Metabolomic Profiling ◽  
The Brain

(1) Recently, metabolic profiling of the tissue in the native state or extracts of its metabolites has become increasingly important in the field of metabolomics. An important factor, in this case, is the presence of blood in a tissue sample, which can potentially lead to a change in the concentration of tissue metabolites and, as a result, distortion of experimental data and their interpretation. (2) In this paper, the metabolomic profiling based on NMR spectroscopy was performed to determine the effect of blood contained in the studied samples of brain tissue on their metabolomic profile. We used 13 male laboratory CD-1® IGS mice for this study. The animals were divided into two groups. The first group of animals (n = 7) was subjected to the perfusion procedure, and the second group of animals (n = 6) was not perfused. The brain tissues of the animals were homogenized, and the metabolite fraction was extracted with a water/methanol/chloroform solution. Samples were studied by high-frequency 1H-NMR spectroscopy with subsequent statistical data analysis. The group comparison was performed with the use of the Student’s test. We identified 36 metabolites in the brain tissue with the use of NMR spectroscopy. (3) For the major set of studied metabolites, no significant differences were found in the brain tissue metabolite concentrations in the native state and after the blood removal procedure. (4) Thus, it was shown that the presence of blood does not have a significant effect on the metabolomic profile of the brain in animals without pathologies.

A Region-Based Ontology of the Brain Ventricular System and Its Relation to Schizophrenia

2012 ◽  
pp. 255-272
Author(s):  
Paulo Santos ◽  
Rodolpho Freire ◽  
Danilo N. dos Santos ◽  
Carlos Thomaz ◽  
Paulo Sallet ◽  
...  
Keyword(s):  
Data Analysis ◽  
Statistical Data ◽  
Ventricular System ◽  
Statistical Data Analysis ◽  
Initial Region ◽  
Schizophrenic Patients ◽  
Formal Basis ◽  
Brain Ventricular System ◽  
The Brain

This chapter describes an initial region-based formalisation of some concepts about neuroanatomy into ontological and epistemic terms, as part of a major effort into the formalisation of the knowledge contained in neuroimages of patients with schizophrenia. The long-term goal is to build an ontology that is a formal basis for the expectations generated from statistical data analysis. To this end, the chapter presents an example of applying this ontology to interpret the results of image-based analysis of neuroimages from schizophrenic patients.

scholarly journals Complete Coding Sequence of Usutu Virus Strain Gracula religiosa/U1609393/Belgium/2016 Obtained from the Brain Tissue of an Infected Captive Common Hill Myna (Gracula religiosa)

2017 ◽  
Vol 5 (12) ◽  
Author(s):  
Steven Van Borm ◽  
Bénédicte Lambrecht ◽  
Frank Vandenbussche ◽  
Mieke Steensels
Keyword(s):  
Brain Tissue ◽  
Virus Strain ◽  
Tissue Sample ◽  
Virus Genome ◽  
Noncoding Sequence ◽  
Coding Sequence ◽  
Usutu Virus ◽  
The Brain

ABSTRACT The complete and annotated coding sequence and partial noncoding sequence of an Usutu virus genome were sequenced from RNA extracted from a clinical brain tissue sample obtained from a common hill myna (Gracula religiosa), demonstrating close homology with Usutu viruses circulating in Europe.

Knowledge-Based Decision Support for Diagnosis and Therapy: On the Multiple Usability of Patient Data

1989 ◽  
Vol 28 (02) ◽  
pp. 69-77 ◽  
Author(s):  
R. Haux
Keyword(s):  
Expert Systems ◽  
Statistical Data ◽  
Patient Data ◽  
Attribute Selection ◽  
Patient Specific ◽  
Statistical Data Analysis ◽  
Inference Mechanism ◽  
Diagnosis And Therapy ◽  
Knowledge Based ◽  
Clinical Registries

Abstract:Expert systems in medicine are frequently restricted to assisting the physician to derive a patient-specific diagnosis and therapy proposal. In many cases, however, there is a clinical need to use these patient data for other purposes as well. The intention of this paper is to show how and to what extent patient data in expert systems can additionally be used to create clinical registries and for statistical data analysis. At first, the pitfalls of goal-oriented mechanisms for the multiple usability of data are shown by means of an example. Then a data acquisition and inference mechanism is proposed, which includes a procedure for controlling selection bias, the so-called knowledge-based attribute selection. The functional view and the architectural view of expert systems suitable for the multiple usability of patient data is outlined in general and then by means of an application example. Finally, the ideas presented are discussed and compared with related approaches.

Market of Insurance in Russia: Major Tendencies and Problems of Development

2006 ◽  
pp. 115-127
Author(s):  
T Natkhov
Keyword(s):  
Data Analysis ◽  
Statistical Data ◽  
Statistical Data Analysis ◽  
Medium Term ◽  
Insurance Sector ◽  
Different Types ◽  
Basic Characteristics

The article considers recent tendencies in the development of the market of insurance in Russia. On the basis of statistical data analysis the most urgent problems of the insurance sector are formulated. Basic characteristics of different types of insurance are revealed, and measures on perfection of the insurance institution in the medium term are proposed.

Visual Merchandising and Customers’ Impulse Buying Behavior: A Case of a Fashion Specialty Store

2020 ◽  
Vol 4 (1) ◽  
pp. 1
Author(s):  
Hadijah Iberahim ◽  
Nur Amira Zureena Zulkurnain ◽  
Raja Najwa Syamim Raja Ainal Shah ◽  
Siti Quraisyiah Rosli
Keyword(s):  
Adverse Effect ◽  
Statistical Data ◽  
Impulse Buying ◽  
Kuala Lumpur ◽  
Statistical Data Analysis ◽  
Buying Behavior ◽  
Specialty Store ◽  
Research Outcome ◽  
Five Elements ◽  
Visual Merchandising

Visual merchandising is an extremely important element as the first visual cue that affects buying behavior of customers. This study aims to identify determinants of visual merchandising that influence customers’ impulse buying behavior. This study focuses on five elements of visual merchandising which are window display, mannequin display, floor merchandising, promotional signage and lighting. Investigation was conducted at a popular fashion specialty store in Kuala Lumpur, Malaysia. A total of 150 customers' feedback was collected. Results of statistical data analysis show that three out of five visual merchandising elements are important in influencing the customers’ impulse buying behavior. Window display, mannequin display and promotional signage are positively related and identified as determinants of effective visual merchandising for impulse buying decision at the women fashion specialty store. The research outcome extends understanding on the adverse effect of visual merchandising on customers’ behavior.

BANK SPÓŁDZIELCZY (COOPERATIVE BANK) AS A GUARANTOR OF THE STABILISATION OF THE LOCAL FINANCIAL SYSTEM1

2019 ◽  
pp. 173-179
Author(s):  
Andrzej Pawlik
Keyword(s):  
Data Analysis ◽  
Banking Sector ◽  
Statistical Data ◽  
Local Development ◽  
Banking System ◽  
Analysis Method ◽  
Statistical Data Analysis ◽  
Data Analysis Method ◽  
Strong Position ◽  
Cooperative Banks

Urgency of the research. One of the most essential sources of supporting regional and local development is the banking system. Target setting. The study presented describes cooperative banking, represented by Bank Polskiej Spółdzielczości S.A. and Bank Spółdzielczy w Kielcach. The use of the statistical data analysis method allowed to demonstrate the strong position of cooperative banking in the market, fostering regional and local development. Actual scientific researches and issues analysis. The foundations for the modern cooperative banking sector were laid by cooperative financial organisations functioning more than 150 years ago [Pawlik, 2017, s. 152]. Its history is connected with difficulties faced in the period of partitions, work at the foundations after the end of World War I and Poland’s regaining its national independence. Uninvestigated parts of general matters defining. At present, cooperative banking functions as a result of the adoption by the Sejm of the Republic of Poland on 7 December 2000 of the act on the functioning of cooperative banks, their associations and associating banks, which ensured new legal conditions for the functioning of the sector2. The research objective. The article formulates the hypothesis that nowadays activities of cooperative banks will contribute to regional and local development. The statement of basic materials. One of the most essential sources of supporting regional and local development is the banking system. This system can guarantee the stabilisation of the local financial system. By supporting the development of regional and local entrepreneurship through loans, investment activities of the banks and financial and investment consulting, it will determine the identity of the region concerned. Conclusions. The use of the statistical data analysis method allowed to demonstrate the strong position of cooperative banking in the market, fostering regional and local development.

Functional Statistical Data Analysis and Modeling

1990 ◽  
Author(s):  
Emanuel Parzen ◽  
Scott D. Grimshaw ◽  
William P. Alexander
Keyword(s):  
Data Analysis ◽  
Statistical Data ◽  
Statistical Data Analysis
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