Phytochemistry and Pharmacological Activity of Plants of Genus Curculigo: An Updated Review Since 2013

The genus Curculigo, as a folk herbal medicine, has been used for many years in China, treating impotence, limb limpness, and arthritis of the lumbar and knee joints. The last systematic review of the genus Curculigo was written in 2013, scientifically categorizing the phytochemistry and biological activities. Hitherto, the original compounds and their pharmacological activities were presented as the development of this genus, but there is not an updated review. To conclude the progression of the genus Curculigo, we collected the new literature published from 2013 to 2021 in PubMed, Web of Science, Google Scholar databases, and the Chinese National Knowledge Infrastructure. The novel chlorophenolic glucosides, curculigine, phenolic glycosides, orcinosides and polysaccharides were isolated from Curculigo. The new analyzing methods were established to control the quality of Curculigo as a herbal medicine. In addition, the pharmacological effects of Curculigo focused on anti-diabetes, antibacterial, anti-inflammatory, osteoporosis, antioxidation, etc. The antitumor and neuroprotective activities were newly explored in recent years. The application of herbal medicine was gradually developed in scientific methods. The medicinal value of the genus Curculigo needs to further investigate its pharmacological mechanisms. This new review offers more insights into the exploitation of the pharmacological value of the genus Curculigo.

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A Review of DietaryZiziphus jujubaFruit (Jujube): Developing Health Food Supplements for Brain Protection

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2017/3019568 ◽

2017 ◽

Vol 2017 ◽

pp. 1-10 ◽

Cited By ~ 11

Author(s):

Jianping Chen ◽

Xiaoyan Liu ◽

Zhonggui Li ◽

Airong Qi ◽

Ping Yao ◽

...

Keyword(s):

Herbal Medicine ◽

Biological Activities ◽

Neurological Diseases ◽

Potential Candidate ◽

Health Food ◽

Ziziphus Jujuba ◽

Bioactive Ingredients ◽

The Mind ◽

Chinese Date

The fruits ofZiziphus jujuba, known as jujube or Chinese date, are being consumed all around the world because of their health benefits, as both food and herbal medicine. Traditionally, one of the main functions of jujube, as described in herbal medicine, is to benefit our brain by calming down the mind and improving quality of sleep. Here, the activities of jujubes on nervous system are summarized and discussed. Jujube possesses neuroprotective activities, including protecting neuronal cells against neurotoxin stress, stimulating neuronal differentiation, increasing expression of neurotrophic factors, and promoting memory and learning. Flavonoid, cAMP, and jujuboside could be the potential bioactive ingredients to account for the aforesaid biological activities. These findings imply that jujube is a potential candidate for development of health supplements for prevention and/or treatment of neurological diseases.

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The Effectiveness of Laid-back Position on Lactation Related Nipple problems and comfort: A meta-analysis

10.21203/rs.3.rs-40847/v1 ◽

2020 ◽

Author(s):

Zhi WANG ◽

Qiuyue LIU ◽

Lihua MIN ◽

Xiaorong MAO

Keyword(s):

Meta Analysis ◽

Current Evidence ◽

Cochrane Library ◽

Control Group ◽

International Consensus ◽

Factors Affecting ◽

Key Words Breast ◽

Knowledge Infrastructure ◽

Chinese National Knowledge Infrastructure

Abstract Background The importance of breastfeeding for maternal and child health has become an international consensus. However, it has been found that lactation-related nipple problems are common and there are some important factors affecting the effectiveness of breastfeeding. Multiple studies recommended the laid-back breastfeeding, but the researches are on various levels of quality and the results are controversial.Methods We systematically searched the following twelve databases: Cochrane Library, EMBASE, Medline, Ovid, PubMed, Web of Science, CINAHL, Scopus, SinoMed, Chinese National Knowledge Infrastructure (CNKI), WanFang, and VIP from inception to January 28,2020. All studies reporting the laid-back breastfeeding or biological nurturing were considered, regardless of they are randomized controlled trials. Two trained investigators independently evaluated the quality of the included the articles and screened the data. All the data were analyzed separately using Review Manager Version 5.3 and STATA/SE Version 15.1. Results A total of 12 studies involving 1,936 groups of postpartum women and their newborns were included. The results of meta-analysis showed that nipple trauma (RR = 0.47; 95% CI 0.29,0.75; p < 0.002), nipple pain (RR = 0.25; 95% CI 0.20,0.32; p < 0.00001), the correct posture of latching (RR = 1.22; 95% CI 1.11,1.33; p < 0.00001)and position comfort (ES = 0.01; 95%CI -0.28,0.30; p = 0.006) of experimental group were all better than control group, and the differences were statistically significant ( p < 0.05), which indicates that the laid-back position has a positive effect on maternal breastfeeding. Conclusion Laid-back position has significant advantages in decreasing the incidence of nipple trauma and nipple pain compared with traditional breastfeeding postures, and it appears that laid-back position is conducive to the correct posture of latching. However, current evidence does not show different breastfeeding outcomes in the two groups of position comfort. Laid-back position is helpful to solve lactation-related nipple problems and it can be used as a recommended position for breastfeeding. Key words: Breast-feeding, Biological Nurturing, Laid-back Breastfeeding, Meta-Analysis

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The Effectiveness of Laid-back Position on Lactation Related Nipple problems and comfort: A meta-analysis

10.21203/rs.3.rs-40847/v2 ◽

2020 ◽

Author(s):

Zhi WANG ◽

Qiuyue LIU ◽

Lihua MIN ◽

Xiaorong MAO

Keyword(s):

Meta Analysis ◽

Current Evidence ◽

Cochrane Library ◽

Correct Position ◽

International Consensus ◽

Factors Affecting ◽

Knowledge Infrastructure ◽

Chinese National Knowledge Infrastructure ◽

Positive Effect

Abstract Background The importance of breastfeeding for maternal and child health has become an international consensus. However, it has been found that lactation-related nipple problems are common and there are some important factors affecting the breastfeeding. Multiple studies recommended the laid-back breastfeeding, but they are on various levels of quality and the results are inconclusive. Methods We systematically searched the following twelve databases: Cochrane Library, EMBASE, Medline, Ovid, PubMed, Web of Science, CINAHL, Scopus, SinoMed, Chinese National Knowledge Infrastructure (CNKI), WanFang, and VIP from inception to January 28,2020. All studies regarding the laid-back breastfeeding or biological nurturing were considered, regardless of whether they are randomized controlled trials or not. Two trained investigators independently evaluated the quality of the selected articles and screened the data. All the data were analyzed separately using Review Manager Version 5.3 and STATA/SE Version 15.1.Results A total of 12 studies involving 1,936 groups of postpartum women and their newborns were included. The results of meta-analysis showed that nipple pain (RR = 0.24; 95% CI 0.14,0.40; p < 0.00001), nipple trauma (RR = 0.47; 95% CI 0.29,0.75; p = 0.002), the correct position of latching (RR = 1.22; 95% CI 1.11,1.33; p < 0.00001) and position comfort (ES = 0.09; 95% CI -0.63,0.81; p = 0.000) of experimental groups were all better than that of the control groups, and the differences were statistically significant (p < 0.05), which indicate that the laid-back position has a positive effect on maternal breastfeeding.Conclusion Laid-back position has been proved to related with decreasing the incidence of nipple trauma and nipple pain compared with traditional breastfeeding positions, and it appears that laid-back position is conducive to the correct position of latching. However, current evidence does not show different breastfeeding outcomes in the two groups of position comfort. Laid-back position is helpful to solve lactation-related nipple problems and it can be used as a recommended position for breastfeeding.

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The Effectiveness and Safety of Moxibustion for Peripheral Facial Paralysis：A Protocol for Systematic Review and Meta-Analysis

10.21203/rs.3.rs-549760/v1 ◽

2021 ◽

Author(s):

Shanshan Xiang ◽

Ting Fang ◽

Changan Ren ◽

Junnan Qi ◽

Zheng Guo ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Document Retrieval ◽

Effective Rate ◽

Cochrane Library ◽

Peripheral Facial Paralysis ◽

Randomized Controlled ◽

Knowledge Infrastructure ◽

Chinese National Knowledge Infrastructure

Abstract Background: Moxibustion has been used in treating patients with Peripheral Facial Paralysis(PFP), but its effectiveness and safety have not been systematically evaluated. Therefore, the objective of this review is to comprehensively assess the effectiveness and safety of moxibustion for PFP.Methods: We will conduct a systematic document retrieval of databases from inception to March 18, 2021, including Embase, Cochrane Library, Pubmed, Chinese databases SinoMed, Chinese National Knowledge Infrastructure (CNKI), Chinese Scientific Journals Database and Wanfang Data (WF). Reviewers will independently retrieve databases, identify trials, extract data, and evaluate the quality of eligible randomized controlled trials(RCTs). The outcomes will include: the effective rate, the House-Brackmann (H-B) score, Facial Disability Index (FDI), and side effects. The quality of eligible RCT will be assessed by the Cochrane risk-of-bias. Meta-analysis will be processed by the Cochrane Collaboration’s RevMan 5.3.0.Discussion: This review will provide comprehensive evidence of moxibustion for PFP.Systematic review registration: PROSPERO CRD42020207068

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Depression among left-behind children in China

Journal of Health Psychology ◽

10.1177/1359105316676333 ◽

2016 ◽

Vol 22 (14) ◽

pp. 1897-1905 ◽

Cited By ~ 17

Author(s):

Ying Liang ◽

Lei Wang ◽

Guoqiang Rui

Keyword(s):

Meta Analysis ◽

Children's Depression Inventory ◽

Left Behind ◽

Children’S Depression Inventory ◽

Knowledge Infrastructure ◽

Children’S Depression ◽

Newcastle Ottawa Scale ◽

Chinese National Knowledge Infrastructure ◽

Ottawa Scale

By retrieving literature published from 2005 to 2015 from Chinese National Knowledge Infrastructure, Wanfang, Vip, PubMed, and Web of Science, we filtered out studies using the Children’s Depression Inventory only and compared left-behind children and non-left-behind children. The methodological quality of the papers was evaluated using the Newcastle–Ottawa Scale. Finally, we included six studies to carry out a meta-analysis. The results showed that the Children’s Depression Inventory scores of left-behind children are significantly higher than those of non-left-behind children (standardized mean difference: −0.233, 95% confidence interval: −0.036 to −0.430, p < 0.05).

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Systematic Review and Meta-Analysis of Diagnostic Accuracy of miRNAs in Patients with Pancreatic Cancer

Disease Markers ◽

10.1155/2018/6292396 ◽

2018 ◽

Vol 2018 ◽

pp. 1-13 ◽

Cited By ~ 10

Author(s):

Xiao Sun ◽

Xiaobin Zhou ◽

Yuan Zhang ◽

Xiaoyan Zhu ◽

Haihua Liu

Keyword(s):

Pancreatic Cancer ◽

Diagnostic Accuracy ◽

Web Of Science ◽

Meta Analysis ◽

Diagnostic Value ◽

Biomedical Literature ◽

Knowledge Infrastructure ◽

Literature Database ◽

Chinese National Knowledge Infrastructure

Background. It is reported that miRNAs are aberrantly expressed in patients with pancreatic cancer. However, the diagnostic value of miRNAs in pancreatic cancer remains controversial. The meta-analysis was to access diagnostic accuracy of miRNAs in pancreatic cancer. Methods. PubMed, Scopus, Web of Science, Chinese National Knowledge Infrastructure (CNKI), WANFANG Data, China Biomedical Literature Database (CBM), and VIP databases were retrieved up to June 30, 2016, to collect articles concerning the diagnosis of miRNAs in pancreatic cancer. The methodological quality of each study was assessed by the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2). This meta-analysis was conducted using RevMan5.0, MetaDiSc 1.4, and Stata 12.0 software. Results. There are 40 articles including 109 studies. The pooled SEN was 0.81 (95% CI, 0.80–0.82), the pooled SPE was 0.78 (95% CI, 0.77–0.79), the pooled +LR was 3.32 (95% CI, 2.92–3.80), the pooled −LR was 0.27 (95% CI, 0.24–0.31), the pooled DOR was 14.56 (95% CI, 11.55–18.34), and pooled AUC was 0.86 (95% CI, 0.84–0.88). Discussion. This meta-analysis demonstrated that miRNA makes a significant impact in the pancreatic cancer diagnosis with a high SEN and SPE, particularly using multiple miRNAs.

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The effectiveness of the laid-back position on lactation-related nipple problems and comfort: a meta-analysis

BMC Pregnancy and Childbirth ◽

10.1186/s12884-021-03714-8 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Zhi Wang ◽

Qiuyue Liu ◽

Lihua Min ◽

Xiaorong Mao

Keyword(s):

Meta Analysis ◽

Statistical Significance ◽

Current Evidence ◽

Cochrane Library ◽

Factors Affecting ◽

Knowledge Infrastructure ◽

Significant Difference ◽

Chinese National Knowledge Infrastructure ◽

Positive Effect

Abstract Background The importance of breastfeeding for maternal and child health is agreed upon worldwide. However, lactation-related nipple problems are common and are important factors affecting breastfeeding. Multiple studies recommended laid-back breastfeeding, but they are of various levels of quality, and the results are inconclusive. Methods We systematically searched the following twelve databases from inception to January 28,2020: Cochrane Library, EMBASE, Medline, Ovid, PubMed, Web of Science, CINAHL, Scopus, Chinese National Knowledge Infrastructure (CNKI), China Biology Medicine disc (CBM), WanFang, and VIP. All studies regarding laid-back breastfeeding or biological nurturing were considered, regardless of whether they were randomized controlled trials. Two trained investigators independently evaluated the quality of the selected articles and screened the data. All the data were analysed separately using Review Manager Version 5.3 and STATA/SE Version 15.1. Results A total of 12 studies involving 1936 groups of postpartum women and their newborns were included. The results of the meta-analysis showed that nipple pain (RR = 0.24; 95% CI 0.14, 0.40; p < 0.00001), nipple trauma (RR = 0.47; 95% CI 0.29, 0.75; p = 0.002) and correct latching position (RR = 1.22; 95% CI 1.11, 1.33; p < 0.0001) in the experimental groups were all better than those of the control groups, and the differences were statistically significant (p < 0.05), which indicates that the laid-back position has a positive effect on maternal breastfeeding. However, the results of position comfort showed that there was no statistical significance between the two groups (ES = 0.09; 95% CI -0.63, 0.81; p = 0.798). Conclusion Compared with traditional breastfeeding positions, the laid-back position has been proven to be related to a decreased incidence of nipple pain and nipple trauma and is seemingly conducive to the use of the correct latching position. It is suggested that the laid-back position is helpful in solving lactation-related nipple problems and can be recommended as a position for breastfeeding. However, no significant difference in position comfort was found between the two groups based on the current evidence, and further studies are still needed to validate these results due to the limitations of the included studies.

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Strategic threats to energy security as risks of quality of people's life

National Interests Priorities and Security ◽

10.24891/ni.16.4.730 ◽

2020 ◽

Vol 16 (4) ◽

pp. 730-744

Author(s):

V.I. Loktionov

Keyword(s):

Quality Of Life ◽

Energy Security ◽

Well Being ◽

Scientific Methods ◽

Analysis And Synthesis ◽

General Scientific ◽

And Performance ◽

Economic Well Being ◽

The Way

Subject. The article reviews the way strategic threats to energy security influence the quality of people's life. Objectives. The study unfolds the theory of analyzing strategic threats to energy security by covering the matter of quality of people's life. Methods. To analyze the way strategic threats to energy security spread across cross-sectoral commodity and production chains and influences quality of people's living, I applied the factor analysis and general scientific methods of analysis and synthesis. Results. I suggest interpreting strategic threats to energy security as risks of people's quality of life due to a reduction in the volume of energy supply. I identified mechanisms reflecting how the fuel and energy complex and its development influence the quality of people's life. The article sets out the method to assess such quality-of-life risks arising from strategic threats to energy security. Conclusions and Relevance. In the current geopolitical situation, strategic threats to energy security cause long-standing adverse consequences for the quality of people's life. If strategic threats to energy security are further construed as risk of quality of people's life, this will facilitate the preparation and performance of a more effective governmental policy on energy, which will subsequently raise the economic well-being of people.

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ДИАГНОСТИКА ХРОНИЧЕСКИХ ИНДУЦИРОВАННЫХ КРАПИВНИЦ

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/raj.2019.2.41457 ◽

2019 ◽

pp. 5-13

Author(s):

E.Yu. Borzova

Keyword(s):

Quality Of Life ◽

Biological Therapy ◽

Treatment Algorithm ◽

The Novel ◽

International Guidelines ◽

Systemic Reactions ◽

Significant Impairment ◽

Challenge Tests

Хронические индуцированные крапивницы имеют важное социальноэкономическое значение вследствие риска развития системных реакций и значительного снижения качества жизни пациентов. Диагностика хронических индуцированных крапивниц основывается на анамнестических данных и проведении провокационных тестов. Современный протокол ведения больных хронической крапивницей включает применение неседативных антигистаминных препаратов. Международные согласительные документы по лечению крапивницы рекомендуют 4кратное увеличение суточной дозы неседативных антигистаминных препаратов при их неэффективности в стандартных дозах. Данные метаанализа указывают на эффективность омализумаба при хронических индуцированных крапивницах. В перспективе ожидается расширение арсенала генноинженерной биологической терапии хронических индуцированных крапивниц.Chronic inducible urticarias are characterized by the risks of systemic reactions and a significant impairment of patients quality of life. The diagnosis of chronic inducible urticarias relies on the patients history and the challenge tests. A treatment algorithm for the management of chronic inducible urticarias includes nonsedating antihistamines as a firstline treatment. The international guidelines for the management of chronic inducible urticarias recommend updosing of nonsedating antihistamines up to four fold if standard doses are not effective. The metaanalysis suggests the efficacy of omalizumab in chronic inducible urticarias. In the prospect, the novel options of biological therapy for chronic inducible urticarias are expected.

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ДИАГНОСТИКА ХРОНИЧЕСКИХ ИНДУЦИРОВАННЫХ КРАПИВНИЦ

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/raj.2019.2.53301 ◽

2019 ◽

Author(s):

E.Yu. Borzova

Keyword(s):

Biological Therapy ◽

Meta Analysis ◽

Treatment Algorithm ◽

The Novel ◽

First Line ◽

Systemic Reactions ◽

Significant Impairment ◽

Challenge Tests ◽

First Line Treatment

Хронические индуцированные крапивницы имеют важное социально-экономическое значение вследствие риска развития системных реакций и значительного снижения качества жизни пациентов. Диагностика хронических индуцированных крапивниц основывается на анамнестических данных и проведении провокационных тестов. Современный протокол ведения больных хронической крапивницей включает применение неседативных антигистаминных препаратов. Международные согласительные документы по лечению крапивницы рекомендуют 4-кратное увеличение суточной дозы неседативных антигистаминных препаратов при их неэффективности в стандартных дозах. Данные мета-анализа указывают на эффективность омализумаба при хронических индуцированных крапивницах. В перспективе ожидается расширение арсенала генно-инженерной биологической терапии хронических индуцированных крапивниц.Chronic inducible urticarias are characterized by the risks of systemic reactions and a significant impairment of patients quality of life. The diagnosis of chronic inducible urticarias relies on the patients history and the challenge tests. A treatment algorithm for the management of chronic inducible urticarias includes nonsedating antihistamines as a first-line treatment. The international guidelines for the management of chronic inducible urticarias recommend updosing of nonsedating antihistamines up to four fold if standard doses are not effective. The meta-analysis suggests the efficacy of omalizumab in chronic inducible urticarias. In the prospect, the novel options of biological therapy for chronic inducible urticarias are expected.

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