scholarly journals Total Synthesis of Pagoamide A

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4224
Author(s):  
Fusong Wu ◽  
Jie Yu ◽  
Jiawei Meng ◽  
Yian Guo ◽  
Tao Ye
Keyword(s):  
Liquid Phase ◽  
Total Synthesis ◽  
Phase Synthesis ◽  
Linear Sequence ◽  
Cyclic Depsipeptide

The first total synthesis of the thiazole-containing cyclic depsipeptide pagoamide A, is detailed. The longest linear sequence of the liquid-phase synthesis comprises 9 long linear steps from simple known starting materials, which led to the unambiguous structural confirmation of pagoamide A.

scholarly journals First total synthesis of hoshinoamide A

2021 ◽  
Vol 17 ◽  
pp. 2924-2931
Author(s):  
Haipin Zhou ◽  
Zihan Rui ◽  
Yiming Yang ◽  
Shengtao Xu ◽  
Yutian Shao ◽  
...  
Keyword(s):  
Amino Acids ◽  
Liquid Phase ◽  
Total Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
High Yield ◽  
Marine Cyanobacterium ◽  
Phase Synthesis ◽  
Synthetic Strategy ◽  
Coupling Yield

Hoshinoamides A, B and C, linear lipopeptides, were isolated from the marine cyanobacterium Caldora penicillata, with potent antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum. Herein, we describe the first total synthesis of hoshinoamide A by the combination of liquid-phase and solid-phase peptide synthesis. Liquid-phase synthesis is to improve the coupling yield of ʟ-Val3 and N-Me-ᴅ-Phe2. Connecting other amino acids efficiency and convergence is achieved by solid-state synthesis. Our synthetic strategy could synthesize the target peptide in high yield with good purity

Total Synthesis of Elastin Peptide Using High Pressure–Liquid Phase Synthesis Assisted by a Soluble Tag Strategy

2014 ◽  
Vol 16 (24) ◽  
pp. 6448-6451 ◽  
Author(s):  
Yohei Okada ◽  
Shoichi Hosoya ◽  
Hidenobu Suzuki ◽  
Kazuhiro Chiba
Keyword(s):  
High Pressure ◽  
Liquid Phase ◽  
Total Synthesis ◽  
Phase Synthesis

The Total Synthesis of Rhabdastrellic Acid A

2018 ◽  
Author(s):  
Yaroslav Boyko ◽  
Christopher Huck ◽  
David Sarlah
Keyword(s):  
Total Synthesis ◽  
Late Stage ◽  
Cross Coupling ◽  
Side Chains ◽  
General Strategy ◽  
Modular Approach ◽  
Linear Sequence ◽  
Generating Sequence ◽  
First Time

<div>The first total synthesis of rhabdastrellic acid A, a highly cytotoxic isomalabaricane triterpenoid, has been accomplished in a linear sequence of 14 steps from commercial geranylacetone. The prominently strained <i>trans-syn-trans</i>-perhydrobenz[<i>e</i>]indene core characteristic of the isomalabaricanes is efficiently accessed in a selective manner for the first time through a rapid, complexity-generating sequence incorporating a reductive radical polyene cyclization, an unprecedented oxidative Rautenstrauch cycloisomerization, and umpolung 𝛼-substitution of a <i>p</i>-toluenesulfonylhydrazone with in situ reductive transposition. A late-stage cross-coupling in concert with a modular approach to polyunsaturated side chains renders this a general strategy for the synthesis of numerous family members of these synthetically challenging and hitherto inaccessible marine triterpenoids.</div>

scholarly journals Morphology control of copper hydroxide based nanostructures in liquid phase synthesis

2021 ◽  
pp. 126225
Author(s):  
Rutuja Bhusari ◽  
Jean-Sébastien Thomann ◽  
Jérôme Guillot ◽  
Renaud Leturcq
Keyword(s):  
Liquid Phase ◽  
Morphology Control ◽  
Copper Hydroxide ◽  
Phase Synthesis

scholarly journals Liquid‐Phase Synthesis of Hydrophilic Luminescent Carbon Dots Using Porous Silica as a Nanotemplate

2021 ◽  
Vol 218 (15) ◽  
pp. 2170045
Author(s):  
Andrii Vasin ◽  
Dmytro Kysil ◽  
Stanislav Sevostianov ◽  
Oksana Isaieva ◽  
Galyna Rudko ◽  
...  
Keyword(s):  
Liquid Phase ◽  
Carbon Dots ◽  
Porous Silica ◽  
Phase Synthesis

scholarly journals Liquid-Phase Synthesis, Sintering, and Transport Properties of Nanoparticle-Based Boron-Rich Composites

2021 ◽  
Author(s):  
Guillaume Gouget ◽  
Damien Bregiroux ◽  
Rémi Grosjean ◽  
David Montero ◽  
Stefan Maier ◽  
...  
Keyword(s):  
Liquid Phase ◽  
Transport Properties ◽  
Phase Synthesis

scholarly journals Liquid-phase Synthesis of Highly Oxophilic Zerovalent Niobium and Tantalum Nanoparticles

2021 ◽  
Author(s):  
Alexander Egeberg ◽  
Lara-P. Faden ◽  
Anna Zimina ◽  
Jan-Dierk Grunwaldt ◽  
Dagmar Gerthsen ◽  
...  
Keyword(s):  
Liquid Phase ◽  
One Pot ◽  
Phase Synthesis

Zerovalent niobium, Nb(0), and tantalum, Ta(0), nanoparticles are prepared via a one-pot, liquid-phase synthesis. Thus, NbCl5/TaCl5 are dissolved in pyridine and reduced by lithium pyridinyl. Deep black suspensions of very...

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