scholarly journals Hexagonal Boron Nitride Functionalized with Au Nanoparticles—Properties and Potential Biological Applications

Nanomaterials ◽  
2018 ◽  
Vol 8 (8) ◽  
pp. 605 ◽  
Author(s):  
Magdalena Jedrzejczak-Silicka ◽  
Martyna Trukawka ◽  
Mateusz Dudziak ◽  
Katarzyna Piotrowska ◽  
Ewa Mijowska
Keyword(s):  
Gold Nanoparticles ◽  
Boron Nitride ◽  
Hexagonal Boron Nitride ◽  
Drug Carrier ◽  
Cancer Drug ◽  
Mitochondrial Activity ◽  
Uptake Assay ◽  
White Graphene ◽  
Cancer Drug Delivery ◽  
Mcf 7

Hexagonal boron nitride is often referred to as white graphene. This is a 2D layered material, with a structure similar to graphene. It has gained many applications in cosmetics, dental cements, ceramics etc. Hexagonal boron nitride is also used in medicine, as a drug carrier similar as graphene or graphene oxide. Here we report that this material can be exfoliated in two steps: chemical treatment (via modified Hummers method) followed by the sonication treatment. Afterwards, the surface of the obtained material can be efficiently functionalized with gold nanoparticles. The mitochondrial activity was not affected in L929 and MCF-7 cell line cultures during 24-h incubation, whereas longer incubation (for 48, and 72 h) with this nanocomposite affected the cellular metabolism. Lysosome functionality, analyzed using the NR uptake assay, was also reduced in both cell lines. Interestingly, the rate of MCF-7 cell proliferation was reduced when exposed to h-BN loaded with gold nanoparticles. It is believed that h-BN nanocomposite with gold nanoparticles is an attractive material for cancer drug delivery and photodynamic therapy in cancer killing.

Synthesis of Polynucleotide Modified Gold Nanoparticles as a High Potent Anti-Cancer Drug Carrier

2009 ◽  
Vol 56 (4) ◽  
pp. 703-708 ◽  
Author(s):  
Ching-Ming Wu ◽  
Ping-Ching Wu ◽  
Yun-Han Wang ◽  
Tsung-Ju Li ◽  
Li-Xing Yang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Drug Carrier ◽  
Cancer Drug ◽  
Anti Cancer

scholarly journals Hydrophilic Polyhedral Oligomeric Silsesquioxane, POSS(OH)32, as a Complexing Nanocarrier for Doxorubicin and Daunorubicin

Materials ◽  
2020 ◽  
Vol 13 (23) ◽  
pp. 5512 ◽  
Author(s):  
Kinga Piorecka ◽  
Anna Janaszewska ◽  
Marta Majkowska ◽  
Monika Marcinkowska ◽  
Jan Kurjata ◽  
...  
Keyword(s):  
Drug Carrier ◽  
Correlation Spectroscopy ◽  
Hydroxyl Group ◽  
Cancer Drug ◽  
Breast Adenocarcinoma ◽  
Hydroxyl Groups ◽  
Polyhedral Oligomeric Silsesquioxanes ◽  
Molar Ratios ◽  
Anti Cancer ◽  
Mcf 7

A novel strategy, recently developed by us, to use polyhedral oligomeric silsesquioxanes (POSS) as an anti-cancer drug carrier is presented. Anthracycline:POSS complexes were prepared by simple co-addition of doxorubicin (DOX) or daunorubicin (DAU) with hydrophilic POSS(OH)32. Co-delivery of POSS and anthracyclines led to higher anti-cancer activity towards HeLa (cervical cancer endothelial) and MCF-7 (human breast adenocarcinoma) cell lines. The obtained supramolecular hybrid complexes were characterised by nuclear magnetic resonance (NMR) spectroscopy (nuclear Overhauser effect spectroscopy [NOESY] and homonuclear correlation spectroscopy [COSY]), Fourier transform infrared spectroscopy (FTIR), and dynamic light scattering (DLS). The two-dimensional (2D) NOESY spectra of the complexes showed the cross-correlation peaks for hydroxyl groups of POSS (~4.3–4.8 ppm) with OH groups of DOX and DAU. FTIR showed that hydroxyl group of POSS can interact with amine and hydroxyl groups of DOX and DAU. The viability of HeLa and MCF-7 was analysed with the MTT assay to evaluate the cytotoxicity of free DOX and DAU and the relevant complexes with POSS at different molar ratios. At a low DOX concentration (2.5 µM), for molar ratios 1:1, 1:4, and 1:8 (POSS:DOX), the complexes showed two and three times higher cytotoxicity towards HeLa and MCF-7 cells, respectively, than DOX itself after both 24- and 48-h incubation. The 1 µM concentration for a 1:4 POSS:DOX molecular ratio and the 2.5 µM concentration for all complexes were more toxic towards MCF-7 cells than free DOX after 48-h incubation. In the case of POSS:DAU complexes, there was higher toxicity than that of free drug after 48-h incubation. It can be concluded that the formation of non-covalent complexes increases toxicity of anthracycline drugs towards Hela and MCF-7 cells. The novel complexes are inexpensive to prepare and more effective than free drugs at low systemic toxicity.

Influence of BaTiO3/white graphene filler synergy on the energy harvesting performance of a piezoelectric polymer nanocomposite

2019 ◽  
Vol 3 (3) ◽  
pp. 774-785 ◽  
Author(s):  
Deepalekshmi Ponnamma ◽  
Mariam Al Ali Al-Maadeed
Keyword(s):  
Energy Harvesting ◽  
Boron Nitride ◽  
Polyvinylidene Fluoride ◽  
Hexagonal Boron Nitride ◽  
Polymer Nanocomposite ◽  
Piezoelectric Polymer ◽  
White Graphene

Designing a piezoelectric nanogenerator based on ternary polyvinylidene fluoride hexafluoropropylene (PVDF-HFP) nanocomposite containing ceramic BaTiO3 and hexagonal boron nitride nanomaterials.

scholarly journals Pulsed laser deposition of single layer, hexagonal boron nitride (white graphene, h-BN) on fiber-oriented Ag(111)/SrTiO3(001)

2016 ◽  
Vol 119 (9) ◽  
pp. 095306 ◽  
Author(s):  
Daniel Velázquez ◽  
Rachel Seibert ◽  
Hamdi Man ◽  
Linda Spentzouris ◽  
Jeff Terry
Keyword(s):  
Boron Nitride ◽  
Pulsed Laser Deposition ◽  
Hexagonal Boron Nitride ◽  
Pulsed Laser ◽  
Single Layer ◽  
Laser Deposition ◽  
White Graphene
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