scholarly journals Applications of Gold Nanoparticles in Non-Optical Biosensors

Nanomaterials ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. 977 ◽  
Author(s):  
Pengfei Jiang ◽  
Yulin Wang ◽  
Lan Zhao ◽  
Chenyang Ji ◽  
Dongchu Chen ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Inductively Coupled Plasma ◽  
Electrochemical Biosensor ◽  
High Surface ◽  
Volume Ratio ◽  
Optical Biosensors ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Good Biocompatibility

Due to their unique properties, such as good biocompatibility, excellent conductivity, effective catalysis, high density, and high surface-to-volume ratio, gold nanoparticles (AuNPs) are widely used in the field of bioassay. Mainly, AuNPs used in optical biosensors have been described in some reviews. In this review, we highlight recent advances in AuNP-based non-optical bioassays, including piezoelectric biosensor, electrochemical biosensor, and inductively coupled plasma mass spectrometry (ICP-MS) bio-detection. Some representative examples are presented to illustrate the effect of AuNPs in non-optical bioassay and the mechanisms of AuNPs in improving detection performances are described. Finally, the review summarizes the future prospects of AuNPs in non-optical biosensors.

Detection of HIV-1 p24 antigen using streptavidin–biotin and gold nanoparticles based immunoassay by inductively coupled plasma mass spectrometry

2014 ◽  
Vol 29 (8) ◽  
pp. 1477-1482 ◽  
Author(s):  
Qian He ◽  
Zhenli Zhu ◽  
Lanlan Jin ◽  
Lu Peng ◽  
Wei Guo ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gold Nanoparticles ◽  
Inductively Coupled Plasma ◽  
Au Nanoparticles ◽  
Sensitive Assay ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
P24 Antigen ◽  
Hiv 1

A sensitive assay for detection of HIV-1 p24 antigen by ICP-MS was developed using a streptavidin–biotin system and Au nanoparticles based immunoassay.

Biocompatibility of Near-IR Sensitive Au-Based Nanoparticles as the Potential Drug Delivery Carriers

2007 ◽  
Vol 334-335 ◽  
pp. 1177-1180 ◽  
Author(s):  
Bin Zhang ◽  
Xiao Li Huang ◽  
Lei Ren ◽  
Qi Qing Zhang ◽  
Mei Chee Tan ◽  
...  
Keyword(s):  
Inductively Coupled Plasma ◽  
Near Infrared ◽  
Nih3t3 Cells ◽  
Inductively Coupled ◽  
Near Ir ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Good Biocompatibility

We successfully synthesized near infrared (NIR) sensitive Au(shell)-Au2S(core) nanoparticles, where Au2S dielectric core was encapsulated by a thin gold shell. The cytotoxicity in vitro and biodistribution in vivo of Au-Au2S nanoparticles was studied by using NIH3T3 cells and KM mice, respectively. The quantitative analysis of Au in each tissue of mice was done by using the Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Au-Au2S nanoparticles (< 300 μg/ml) showed good biocompatibility. Au-Au2S nanoparticles were preferentially taken up by the liver and spleen, and ultimately eliminated mostly in the feces.

scholarly journals Capabilities of fast data acquisition with microsecond time resolution in inductively coupled plasma mass spectrometry and identification of signal artifacts from millisecond dwell times during detection of single gold nanoparticles

2016 ◽  
Vol 31 (1) ◽  
pp. 135-144 ◽  
Author(s):  
I. Strenge ◽  
C. Engelhard
Keyword(s):  
Mass Spectrometry ◽  
Gold Nanoparticles ◽  
Data Acquisition ◽  
Time Resolution ◽  
Single Particle ◽  
Inductively Coupled Plasma ◽  
Inductively Coupled ◽  
Fast Data Acquisition ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

In this paper, a home-built DAQ featuring microsecond time resolution is used to demonstrate advantages of fast data acquisition and to uncover potential artifacts in single-particle ICP-MS.

Single Particle Inductively Coupled Plasma Mass Spectrometry: Investigating Nonlinear Response Observed in Pulse Counting Mode and Extending the Linear Dynamic Range by Compensating for Dead Time Related Count Losses on a Microsecond Timescale

2019 ◽  
Author(s):  
Ingo Strenge ◽  
Carsten Engelhard
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Nonlinear Response ◽  
Dynamic Range ◽  
Dead Time ◽  
Inorganic Nanoparticles ◽  
Linear Dynamic Range ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

<p>The article demonstrates the importance of using a suitable approach to compensate for dead time relate count losses (a certain measurement artefact) whenever short, but potentially strong transient signals are to be analysed using inductively coupled plasma mass spectrometry (ICP-MS). Findings strongly support the theory that inadequate time resolution, and therefore insufficient compensation for these count losses, is one of the main reasons for size underestimation observed when analysing inorganic nanoparticles using ICP-MS, a topic still controversially discussed.</p>

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