Biocompatibility of Near-IR Sensitive Au-Based Nanoparticles as the Potential Drug Delivery Carriers

2007 ◽  
Vol 334-335 ◽  
pp. 1177-1180 ◽  
Author(s):  
Bin Zhang ◽  
Xiao Li Huang ◽  
Lei Ren ◽  
Qi Qing Zhang ◽  
Mei Chee Tan ◽  
...  
Keyword(s):  
Inductively Coupled Plasma ◽  
Near Infrared ◽  
Nih3t3 Cells ◽  
Inductively Coupled ◽  
Near Ir ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Good Biocompatibility

We successfully synthesized near infrared (NIR) sensitive Au(shell)-Au2S(core) nanoparticles, where Au2S dielectric core was encapsulated by a thin gold shell. The cytotoxicity in vitro and biodistribution in vivo of Au-Au2S nanoparticles was studied by using NIH3T3 cells and KM mice, respectively. The quantitative analysis of Au in each tissue of mice was done by using the Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Au-Au2S nanoparticles (< 300 μg/ml) showed good biocompatibility. Au-Au2S nanoparticles were preferentially taken up by the liver and spleen, and ultimately eliminated mostly in the feces.

scholarly journals The Absorption, Distribution, and Excretion of 18 Elements of Tibetan Medicine Qishiwei Zhenzhu Pills in Rats with Cerebral Ischemia

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Yinglian Song ◽  
Ke Fu ◽  
Dewei Zhang ◽  
Min Xu ◽  
Ruixia Wu ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Inductively Coupled Plasma ◽  
Microwave Digestion ◽  
Venous Blood ◽  
Artery Occlusion ◽  
Tibetan Medicine ◽  
Inductively Coupled ◽  
Icp Ms

The aim of this study is to determine 18 elements in Tibetan medicine Qishiwei Zhenzhu pills (QSW) and their absorption, distribution, and excretion in rats with cerebral ischemia. Microwave digestion and inductively coupled plasma mass spectrometry (ICP-MS) were used to determine 18 elements of QSW in simulated gastrointestinal (GI) juice. Rats were given QSW (66.68 mg/kg) followed by middle cerebral artery occlusion (MCAO). Sham rats received saline and were not subjected to MCAO. ICP-MS was applied to determine the content of 18 elements in hepatic venous blood, abdominal aortic blood, brain, liver, kidney, hair, urine, and feces 24 h after MCAO. In vitro results showed that the extraction rate of Mn, Cu, Sr, Pb, Au, and Hg of QSW in gastric juice (1 h) was higher than that in water, and the contents of Cu, Au, Sr, and As were higher in intestinal juice (4 h) than in water. In vivo results showed that the contents of elements in the blood were quite low, and QSW increased Ni, Cr, Sr, Co, and V in artery blood and decreased V in venous blood. Elements in the tissues were also low, and QSW increased brain Li but decreased Cr and Cd; QSW increased kidney Ag and Cs and liver Mn but decreased liver Ni. QSW increased urinary excretion of Li, Sr, Hg, Cs, and V; QSW increased Hg content in hair but decreased Ni. Stool is the main excretion pathway of the elements in QSW, with Ba, Mn, Sr, Cd, V, Cu, Cs, Li, Pb, Ag, Hg, Cr, As, and Co the highest. In summary, this study examined the distribution of 18 elements in QSW-treated MCAO rats. The accumulation of these elements in blood and tissues was extremely low, and the majority was excreted in feces within 24 h, highlighting the importance of the gut-microbiota-brain axis in QSW-mediated brain protection.

scholarly journals A preliminary report on bioavailability of Ayurvedic Gold Bhasma with four different accompanying media [anupana]

2021 ◽  
Vol 12 (3) ◽  
pp. 033-044
Author(s):  
Trupti Patil ◽  
Asmita Wele ◽  
Sangram Patil
Keyword(s):  
Inductively Coupled Plasma ◽  
Black Pepper ◽  
Healthy Human ◽  
Blood Samples ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Comparative Bioavailability ◽  
Human Participants

Background: Gold bhasma [Swarnabhasma] is a ancient Ayurvedic medicine used for rejuvenation and longevity. This is a preliminary attempt to study the bioavailability of this medicine. Objectives: It was aimed to estimate comparative bioavailability of gold bhasma up to five hours after oral dose with four different anupana. Materials and methods: In this in vivo study, 30 healthy human participants were allocated randomly into five groups having six individuals each. Gold bhasma in 30 mg dose was administered orally with four different anupana viz honey [2.5 gm], black pepper-ghee combination [250 mg and 2.5 gm respectively], lactose [250 mg], glucose [250 mg], and plain to participants in each group. Blood samples were collected at 0, 1, 3 and 5 hours after dose. Gold levels in blood were assessed by inductively coupled plasma mass spectrometry [ICP-MS]. Results: Gold levels in all blood samples were in traces. Average Cmax was 0.002333 microgram of gold per liter and Tmax was at 3 hours for honey anupana, showing maximum Cmax among all groups. Conclusions: Preliminary results indicate that bioavailability of gold from gold bhasma may be less than 0.01 % upto first five hours. Gold bhasma mixed with honey resulted in attainment of maximum Cmax. It is evident that accompanying media [anupana] play an important role in absorption of gold bhasma.

scholarly journals Applications of Gold Nanoparticles in Non-Optical Biosensors

Nanomaterials ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. 977 ◽  
Author(s):  
Pengfei Jiang ◽  
Yulin Wang ◽  
Lan Zhao ◽  
Chenyang Ji ◽  
Dongchu Chen ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Inductively Coupled Plasma ◽  
Electrochemical Biosensor ◽  
High Surface ◽  
Volume Ratio ◽  
Optical Biosensors ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Good Biocompatibility

Due to their unique properties, such as good biocompatibility, excellent conductivity, effective catalysis, high density, and high surface-to-volume ratio, gold nanoparticles (AuNPs) are widely used in the field of bioassay. Mainly, AuNPs used in optical biosensors have been described in some reviews. In this review, we highlight recent advances in AuNP-based non-optical bioassays, including piezoelectric biosensor, electrochemical biosensor, and inductively coupled plasma mass spectrometry (ICP-MS) bio-detection. Some representative examples are presented to illustrate the effect of AuNPs in non-optical bioassay and the mechanisms of AuNPs in improving detection performances are described. Finally, the review summarizes the future prospects of AuNPs in non-optical biosensors.

scholarly journals A Study on Beryl in the Cuonadong Be-W-Sn Polymetallic Deposit, Longzi County, Tibet, China

Crystals ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 777
Author(s):  
Jia-Qi Shen ◽  
Zhi-Kang Hu ◽  
Shi-Yuan Cui ◽  
Yu-Fei Zhang ◽  
En-Qi Li ◽  
...  
Keyword(s):  
Inductively Coupled Plasma ◽  
Metal Content ◽  
Near Infrared ◽  
Type I ◽  
Type Ii ◽  
Chemical Analyses ◽  
Inductively Coupled ◽  
Polymetallic Deposit ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

Recently, aquamarine was discovered in the Cuonadong Be-W-Sn Polymetallic Deposit, Longzi County, Tibet. Longzi aquamarine is being extracted and is expected to be available over the next decade. This study provides a full set of data through standard gemmological properties, including scenes, color characteristics and advanced spectroscopic and chemical analyses, including micro ultraviolet–visible–near-infrared (UV–Vis–NIR), Raman and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The main inclusions in Longzi aquamarine are gas–liquid inclusions and a great number of quartz inclusions. The content of type I H2O is greater than that of type II H2O because of the low-alkali metal content, and “tetrahedral” substitutions and “octahedral” substitutions exist at the same time.

scholarly journals Dry Generation of CeO2 Nanoparticles and Deposition onto a Co-Culture of A549 and THP-1 Cells in Air-Liquid Interface—Dosimetry Considerations and Comparison to Submerged Exposure

Nanomaterials ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 618 ◽  
Author(s):  
Francesca Cappellini ◽  
Sebastiano Di Bucchianico ◽  
Venkatanaidu Karri ◽  
Siiri Latvala ◽  
Maria Malmlöf ◽  
...  
Keyword(s):  
Inductively Coupled Plasma ◽  
Liquid Interface ◽  
Lung Epithelial Cells ◽  
In Vitro Assays ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Air Liquid Interface ◽  
Submerged Conditions

Relevant in vitro assays that can simulate exposure to nanoparticles (NPs) via inhalation are urgently needed. Presently, the most common method employed is to expose lung cells under submerged conditions, but the cellular responses to NPs under such conditions might differ from those observed at the more physiological air-liquid interface (ALI). The aim of this study was to investigate the cytotoxic and inflammatory potential of CeO2 NPs (NM-212) in a co-culture of A549 lung epithelial cells and differentiated THP-1 cells in both ALI and submerged conditions. Cellular dose was examined quantitatively using inductively coupled plasma mass spectrometry (ICP-MS). The role of serum and LPS-priming for IL-1β release was further tested in THP-1 cells in submerged exposure. An aerosol of CeO2 NPs was generated by using the PreciseInhale® system, and NPs were deposited on the co-culture using XposeALI®. No or minor cytotoxicity and no increased release of inflammatory cytokines (IL-1β, IL-6, TNFα, MCP-1) were observed after exposure of the co-culture in ALI (max 5 µg/cm2) or submerged (max 22 µg/cm2) conditions. In contrast, CeO2 NPs cause clear IL-1β release in monocultures of macrophage-like THP-1, independent of the presence of serum and LPS-priming. This study demonstrates a useful approach for comparing effects at various in-vitro conditions.

scholarly journals Silver Nanoparticles Stable to Oxidation and Silver Ion Release Show Size-Dependent Toxicity In Vivo

Nanomaterials ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1516
Author(s):  
Brittany Cunningham ◽  
Arek E. Engstrom ◽  
Bryan J. Harper ◽  
Stacey L. Harper ◽  
Marilyn R. Mackiewicz
Keyword(s):  
Silver Nanoparticles ◽  
Inductively Coupled Plasma ◽  
Lipid Membrane ◽  
Surface Oxidation ◽  
Ion Release ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
The Stability

Silver nanoparticles (AgNPs) are widely used in commerce, however, the effect of their physicochemical properties on toxicity remains debatable because of the confounding presence of Ag+ ions. Thus, we designed a series of AgNPs that are stable to surface oxidation and Ag+ ion release. AgNPs were coated with a hybrid lipid membrane comprised of L-phosphatidylcholine (PC), sodium oleate (SOA), and a stoichiometric amount of hexanethiol (HT) to produce oxidant-resistant AgNPs, Ag–SOA–PC–HT. The stability of 7-month aged, 20–100 nm Ag–SOA–PC–HT NPs were assessed using UV–Vis, dynamic light scattering (DLS), and inductively coupled plasma mass spectrometry (ICP-MS), while the toxicity of the nanomaterials was assessed using a well-established, 5-day embryonic zebrafish assay at concentrations ranging from 0–12 mg/L. There was no change in the size of the AgNPs from freshly made samples or 7-month aged samples and minimal Ag+ ion release (<0.2%) in fishwater (FW) up to seven days. Toxicity studies revealed AgNP size- and concentration-dependent effects. Increased mortality and sublethal morphological abnormalities were observed at higher concentrations with smaller nanoparticle sizes. This study, for the first time, determined the effect of AgNP size on toxicity in the absence of Ag+ ions as a confounding variable.

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