Recent Advances in Magnetite Nanoparticle Functionalization for Nanomedicine

Functionalization of nanomaterials can enhance and modulate their properties and behaviour, enabling characteristics suitable for medical applications. Magnetite (Fe3O4) nanoparticles are one of the most popular types of nanomaterials used in this field, and many technologies being already translated in clinical practice. This article makes a summary of the surface modification and functionalization approaches presented lately in the scientific literature for improving or modulating magnetite nanoparticles for their applications in nanomedicine.

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Synthesis and Characterization of Super Paramagnetic Magnetite Nanoparticles for Drug Delivery Application

International Journal of Engineering & Technology ◽

10.14419/ijet.v7i2.19.15055 ◽

2018 ◽

Vol 7 (2.19) ◽

pp. 87

Author(s):

D BALAJ ◽

C SARALA RUBI ◽

N G. RENGANATHAN

Keyword(s):

Drug Delivery ◽

Magnetite Nanoparticles ◽

Fe3o4 Nanoparticles ◽

Biomedical Application ◽

Synthesis And Characterization ◽

Xrd Pattern ◽

Magnetite Fe3o4 ◽

Tumor Hyperthermia ◽

Potential Applications

Attractive nanoparticles have been broadly considered on account of their potential applications as complexity operators in attractive reverberation imaging (MRI) of tumors, cell and DNA partition, attractively guided medication conveyance, tumor hyperthermia. Among the attractive oxides, magnetite nanoparticles are most appropriate because of their low danger and great attractive properties which may be used in drug delivery. Magnetite nanoparticles were synthesized using FeCl3 and FeSO4 as precursors and characterized for size and shape using non-contact AFM. The formation of magnetite was confirmed by XRD pattern. The elemental composition of the obtained phase was determined using EDAX. In this work, we are aiming to develop drug loaded biopolymer Magnetite nanoparticles for biomedical application. Our main objective is to synthesize and characterize Magnetite (Fe3O4) nanoparticles.

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The Oriented Attachment Crystal Growth Model in Hydrothermal Synthesis of Magnetite (Fe3O4) Nanoparticles

Journal of Applied Materials and Technology ◽

10.31258/jamt.1.1.15-19 ◽

2019 ◽

Vol 1 (1) ◽

pp. 15-19

Author(s):

Ahmad Fadli ◽

Amun Amri ◽

Esty Octiana Sari ◽

Sukoco Sukoco ◽

Deden Saprudin

Keyword(s):

Crystal Growth ◽

Growth Model ◽

Magnetite Nanoparticles ◽

Oriented Attachment ◽

X Ray Diffraction ◽

Magnetite Nanoparticle ◽

Transmission Electron ◽

Particle Size Analyzer ◽

Magnetite Fe3o4 ◽

Crystal Growth Kinetics

The magnetite nanoparticles (Fe3O4) are very promising nanomaterials to be applied as drug delivery due to their excellent superparamagnetic, biocompatibility and easily modified surface properties. Those properties are influenced by the structure and size of the material which can be controlled by studying the evolution of crystal growth. The purpose of this research is to study the evolution of crystal growth of magnetite nanoparticles in the hydrothermal system and determine the crystal growth kinetics using the Oriented Attachment Growth model. Magnetite nanoparticles were synthesized using a hydrothermal method from FeCl3, citrate, urea and polyethylene glycol at 210˚C for 1 - 12 hours at a various concentration of FeCl3 (0.05 M, 0.10 M, and 0.15 M). The characterizations were conducted by X-ray Diffraction (XRD), Transmission Electron Microscope (TEM), Particle size analyzer (PSA), and Vibrating Sample Magnetometer (VSM). The XRD difractogram indicated that the magnetite was begun to form at 3.5 hours synthesis. The crystallinity and the crystal size of magnetite rose with reaction time. The diameter of magnetite crystals was in the range of 9.4-30 nm. Characterization by TEM showed that the particles were formed from a smaller particles which were then agglomerated. The PSA characterization showed that the distribution of diameter size enlarged with the enhancement of concentrations. VSM result showed that the magnetite nanoparticle has superparamagnetic properties. The magnetite crystal growth can be fitted by the Oriented Attachment Growth model with an error of 29%.

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Preparation of Aniline Dimer-COOH Modified Magnetite (Fe3O4) Nanoparticles by Ultrasonic Dispersion Method

International Journal of Engineering & Technology ◽

10.14419/ijet.v7i4.30.22108 ◽

2018 ◽

Vol 7 (4.30) ◽

pp. 185 ◽

Cited By ~ 1

Author(s):

Zakiyyu Ibrahim Taka ◽

Mohd Kamarulzaki Mustafa ◽

Saliza Asman ◽

Khairunnadim Ahmad Sekak ◽

Jibrin Muhammada

Keyword(s):

Electron Microscope ◽

Scanning Electron Microscope ◽

Field Emission ◽

Magnetite Nanoparticles ◽

Fe3o4 Nanoparticles ◽

Spherical Shape ◽

Dispersion Method ◽

Ultrasonic Dispersion ◽

Magnetite Fe3o4 ◽

Scanning Electron

The magnetite (Fe3O4) nanoparticles capped with certain level of aniline dimer-COOH were prepared via assisted ultrasonic dispersion method and characterized by X-ray Diffraction spectra (XRD), Field Emission Scanning Electron Microscope (FESEM), Ultraviolent UV-visible (UV-vis) and Fourier Transformation Infrared spectroscopy (FTIR). The XRD result shows that both the sample of Fe3O4 nanoparticles synthesized without aniline dimer-COOH have similar peaks with the one that were capped with aniline dimer-COOH, this indicated the higher purity crystalline peaks of Fe3O4 nanoparticles was successfully synthesized. The Field Emission Scanning Electron Microscope (FESEM) result shows that, the aniline dimer-COOH modified magnetite nanoparticles are less agglomerated with spherical shape and continues size distribution, and the obtained image from EDS indicates the present of Fe3O4 nanoparticles by showing Fe-O group of element. The magnetic properties of the magnetite nanoparticles prepared by ultrasonic irradiation method was observed by vibrating sample magnetometer (VSM), the hysteresis loop of Fe3O4 nanoparticles observed by VSM has a saturation magnetization at 89.46 emug-1 indicating super paramagnetic behavior of the Fe3O4 nanoparticles.

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