scholarly journals Dietary Cholesterol Contained in Whole Eggs Is Not Well Absorbed and Does Not Acutely Affect Plasma Total Cholesterol Concentration in Men and Women: Results from 2 Randomized Controlled Crossover Studies

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1272 ◽  
Author(s):  
Jung Kim ◽  
Wayne Campbell
Keyword(s):  
Total Cholesterol ◽  
Plasma Cholesterol ◽  
Dietary Cholesterol ◽  
Cholesterol Absorption ◽  
Blood Cholesterol ◽  
Cholesterol Concentration ◽  
Total Cholesterol Concentration ◽  
Plasma Total Cholesterol ◽  
Crossover Studies ◽  
Whole Egg

Whole egg is a food source of dietary cholesterol and inconsistent research findings exist about the effect of dietary cholesterol from whole egg on blood cholesterol concentration. We assessed the effect of co-consuming cooked whole egg (CWE) on dietary cholesterol absorption from two randomized-crossover studies. For study 1, 16 men consumed raw vegetables with no egg, 75 g CWE, or 150 g CWE. For study 2, 17 women consumed cooked vegetables with no egg or 100 g CWE. Triacylglycerol-rich lipoprotein fractions (TRL) were isolated from collected blood. In study 1, total-cholesterol areas under the curve (AUC)0–10h in TRL were not different but triacylglycerol AUC0–10h in TRL was greater for 150 g CWE vs. 75 g CWE and no egg. Similarly, in study 2, total-cholesterol AUC0–10h in TRL was not different but triacylglycerol AUC0–10h in TRL was greater for 100 g CWE vs. no egg. In both studies, whole egg consumption did not affect plasma total-cholesterol AUC0–10h, while triacylglycerol AUC0–10h was increased. These results suggest that the dietary cholesterol in whole egg was not well absorbed, which may provide mechanistic insight for why it does not acutely influence plasma total-cholesterol concentration and is not associated with longer-term plasma cholesterol control.

scholarly journals Health benefits of a vegetarian diet

1999 ◽  
Vol 58 (2) ◽  
pp. 271-275 ◽  
Author(s):  
Timothy J. Key ◽  
Gwyneth K. Davey ◽  
Paul N. Appleby
Keyword(s):  
Adverse Effects ◽  
Total Cholesterol ◽  
Diverticular Disease ◽  
Lower Risk ◽  
Causes Of Death ◽  
Vegetarian Diet ◽  
Cholesterol Concentration ◽  
Total Cholesterol Concentration ◽  
Plasma Total Cholesterol

Compared with non-vegetarians, Western vegetarians have a lower mean BMI (by about 1 kg/m2), a lower mean plasma total cholesterol concentration (by about 0.5 mmol/l), and a lower mortality from IHD (by about 25 %). They may also have a lower risk for some other diseases such as constipation, diverticular disease, gallstones and appendicitis. No differences in mortality from common cancers have been established. There is no evidence of adverse effects on mortality. Much more information is needed, particularly on other causes of death, other morbidity including osteoporosis, and long-term health in vegans. The evidence available suggests that widespread adoption of a vegetarian diet could prevent approximately 40 000 deaths from IHD in Britain each year.

Long-term Effect of Sotalol on Plasma Lipids

1979 ◽  
Vol 57 (s5) ◽  
pp. 405s-407s ◽  
Author(s):  
A. Lehtonen ◽  
J. Viikari
Keyword(s):  
Total Cholesterol ◽  
Plasma Lipids ◽  
Plasma Cholesterol ◽  
Hdl Cholesterol ◽  
Plasma Free Fatty Acid ◽  
Cholesterol Concentration ◽  
Plasma Total Cholesterol ◽  
Long Term Effect ◽  
The Difference

1. We studied the effect on plasma lipids of sotalol given orally over a 12 month period to patients with essential hypertension. 2. Plasma free fatty acid concentration was lower than initially at 1, 3, 6 and 12 months. The difference was significant (P < 0·01) at 1 and 3 months. 3. Plasma cholesterol (VLDL + LDL-cholesterol) increased during treatment. Plasma total cholesterol increased from 5·49 ± sd 0·94 mmol/l at the beginning to 6·37 ± 1·10 mmol/l at 12 months (P < 0·01). 4. HDL-cholesterol concentration and the ratio of HDL-cholesterol to total cholesterol decreased significantly. The ratios were 0·28 and 0·18 at the beginning and at 12 months respectively (P < 0·001). 5. Plasma triglycerides increased simultaneously from 1·14 ± 0·31 to 1·89 ± 0·99 mmol/l (P < 0·01).

scholarly journals The hypocholesterolaemic effects of sitostanol in the guinea pig are in part related to changes in hepatic lipids and lipoprotein composition

2001 ◽  
Vol 85 (2) ◽  
pp. 165-172 ◽  
Author(s):  
Tripurasundari Ramjiganesh ◽  
Suheeta Roy ◽  
Jonathan C. McIntyre ◽  
Maria Luz Fernandez
Keyword(s):  
Total Cholesterol ◽  
Guinea Pigs ◽  
Corn Oil ◽  
Cholesterol Metabolism ◽  
Plasma Cholesterol ◽  
Dietary Cholesterol ◽  
Cholesterol Absorption ◽  
Negative Control ◽  
Control Group ◽  
Hepatic Cholesterol

To evaluate some of the mechanisms involved in the plasma cholesterol lowering of sitostanol (SI), male Hartley guinea pigs were fed diets containing cholesterol (0.25 g/100 g) and four doses of SI: either 0 (control), 0.75, 1.5 or 2.25 g/100 g. In addition a negative control (-C) group with dietary cholesterol (0.04 g/100 g) was included. Corn oil was used as the source of fat and the contribution of fat energy was 35 %. Plasma total cholesterol was 43, 49 and 53 % (P<0.0001) lower after SI intake compared to the control. Plasma LDL concentrations were 47, 53 and 61 % lower with increasing doses of SI. In addition, intake of SI resulted in 26–42 % lower hepatic total cholesterol. Hepatic esterified cholesterol and triacylglycerols were 32–60 % and 55–61 % lower after SI intake. SI intake resulted in favourable plasma and hepatic cholesterol concentrations similar to those in guinea pigs fed low levels of dietary cholesterol (-C). The LDL obtained from the control group had a higher number of molecules of free and esterified cholesterol than the SI groups. SI intake resulted in 69–71 % higher cholesterol excretion compared to the control. SI treatment enhanced the total faecal neutral sterol excretion by 54–58 % compared to control and by 70–76 % compared to the (-C) group. These results suggest that SI might have its hypocholesterolaemic effect by reducing cholesterol absorption, which results in lower concentration of cholesterol in liver. This reduction in hepatic cholesterol might possibly alter hepatic cholesterol metabolism and affect lipoprotein concentration and composition.

scholarly journals Effect of dietary cholesterol on plasma cholesterol concentration in subjects following reduced fat, high fibre diet.

BMJ ◽  
1987 ◽  
Vol 294 (6568) ◽  
pp. 333-336 ◽  
Author(s):  
J Edington ◽  
M Geekie ◽  
R Carter ◽  
L Benfield ◽  
K Fisher ◽  
...  
Keyword(s):  
Plasma Cholesterol ◽  
Dietary Cholesterol ◽  
Cholesterol Concentration ◽  
Plasma Cholesterol Concentration ◽  
High Fibre Diet ◽  
Reduced Fat ◽  
Fibre Diet ◽  
High Fibre
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