scholarly journals The Effect of n-3 PUFA Binding Phosphatidylglycerol on Metabolic Syndrome-Related Parameters and n-3 PUFA Accretion in Diabetic/Obese KK-Ay Mice

Nutrients ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2866 ◽  
Author(s):  
Liping Chen ◽  
Naoki Takatani ◽  
Fumiaki Beppu ◽  
Kazuo Miyashita ◽  
Masashi Hosokawa
Keyword(s):  
Phospholipase D ◽  
Health Benefits ◽  
Liver Lipids ◽  
Fatty Acid Binding ◽  
Feeding Duration ◽  
Lipid Reduction ◽  
The Brain ◽  
Tissue Accretion ◽  
Ay Mice ◽  
Hepatic Lipid Content

n-3 Polyunsaturated fatty acid binding phospholipids (n-3 PUFA-PLs) are known to be potent carriers of n-3 PUFAs and provide health benefits. We previously prepared n-3 PUFA binding phosphatidylglycerol (n-3 PUFA-PG) by phospholipase D-mediated transphosphatidylation. Because PG has excellent emulsifiability, n-3 PUFA-PG is expected to work as a functional molecule with properties of both PG and n-3 PUFAs. In the present study, the health benefits and tissue accretion of dietary n-3 PUFA-PG were examined in diabetic/obese KK-Ay mice. After a feeding duration over 30 days, n-3 PUFA-PG significantly reduced the total and non-HDL cholesterols in the serum of diabetic/obese KK-Ay mice. In the mice fed n-3 PUFA-PG, but not n-3 PUFA-TAG, hepatic lipid content was markedly alleviated depending on the neutral lipid reduction compared with the SoyPC-fed mice. Further, the n-3 PUFA-PG diet increased eicosapentaenoic acid and docosahexaenoic acid (DHA) and reduced arachidonic acid in the small intestine, liver, perirenal white adipose tissue, and brain, and the ratio of the n-6 PUFAs to n-3 PUFAs in those tissues became lower compared to the SoyPC-fed mice. Especially, the DHA level was more significantly elevated in the brains of n-3 PUFA-PG-fed mice compared to the SoyPC-fed mice, whereas n-3 PUFA-TAG did not significantly alter DHA in the brain. The present results indicate that n-3 PUFA-PG is a functional lipid for reducing serum and liver lipids and is able to supply n-3 PUFAs to KK-Ay mice.

scholarly journals Impact of Fatty Acid-Binding Proteins in α-Synuclein-Induced Mitochondrial Injury in Synucleinopathy

Biomedicines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 560
Author(s):  
An Cheng ◽  
Wenbin Jia ◽  
Ichiro Kawahata ◽  
Kohji Fukunaga
Keyword(s):  
Fatty Acid ◽  
Binding Proteins ◽  
Neuronal Loss ◽  
Krabbe Disease ◽  
Fatty Acid Binding Proteins ◽  
Mitochondrial Outer Membrane ◽  
Fatty Acid Binding ◽  
Mitochondrial Injury ◽  
Abnormal Accumulation ◽  
The Brain

Synucleinopathies are diverse diseases with motor and cognitive dysfunction due to progressive neuronal loss or demyelination, due to oligodendrocyte loss in the brain. While the etiology of neurodegenerative disorders (NDDs) is likely multifactorial, mitochondrial injury is one of the most vital factors in neuronal loss and oligodendrocyte dysfunction, especially in Parkinson’s disease, dementia with Lewy body, multiple system atrophy, and Krabbe disease. In recent years, the abnormal accumulation of highly neurotoxic α-synuclein in the mitochondrial membrane, which leads to mitochondrial dysfunction, was well studied. Furthermore, fatty acid-binding proteins (FABPs), which are members of a superfamily and are essential in fatty acid trafficking, were reported to trigger α-synuclein oligomerization in neurons and glial cells and to target the mitochondrial outer membrane, thereby causing mitochondrial loss. Here, we provide an updated overview of recent findings on FABP and α-synuclein interactions and mitochondrial injury in NDDs.

ChemInform Abstract: Role of Heart-Type Fatty Acid Binding Protein in the Brain Function

ChemInform ◽  
2009 ◽  
Vol 40 (26) ◽  
Author(s):  
Keiju Motohashi ◽  
Yui Yamamoto ◽  
Norifumi Shioda ◽  
Hisatake Kondo ◽  
Yuji Owada ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Brain Function ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
The Brain

scholarly journals Health benefits of bioactive compounds from cocoa (Theobroma cacao)

2019 ◽  
Author(s):  
Shahanas E ◽  
Seeja T Panjikkaran ◽  
Sharon C L ◽  
Remya P R
Keyword(s):  
Bioactive Compounds ◽  
Vascular Function ◽  
Health Benefits ◽  
Nutrient Content ◽  
Brain Regions ◽  
Bioactive Components ◽  
Cocoa Products ◽  
High Nutrient ◽  
Health Promoting ◽  
The Brain

Cocoa is regarded as a super food due to its high nutrient content and proven health benefits. Cocoa beans are rich in carbohydrate (31%), protein (11%), fat (54%), fibre (16%) and minerals. Cocoa is a good source of bioactive compounds too. The major bioactive components are polyphenols constituted of flavanoids and non flavanoids. The bioactive components with rich antioxidants and anti-inflammatory activities contribute to various health benefits. The flavonoid rich chocolates improve peripheral vascular function. The consumption of cocoa or chocolate are beneficial in inhibiting the complex molecular process leading to cancer. Flavanoids in cocoa increases insulin sensitivity by improving endothelial function and reducing oxidative stress. The cocoa flavonoids also penetrate and accumulate in the brain regions involved in learning and memory. The knowledge on bioactive compounds in cocoa and cocoa products suggests that they could be consumed as a part of wholesome, health promoting nutritional food.

scholarly journals Fatty Acid Binding Protein 3 Enhances the Spreading and Toxicity of α-Synuclein in Mouse Brain

2020 ◽  
Vol 21 (6) ◽  
pp. 2230 ◽  
Author(s):  
Yasushi Yabuki ◽  
Kazuya Matsuo ◽  
Ichiro Kawahata ◽  
Naoya Fukui ◽  
Tomohiro Mizobata ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Mouse Brain ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Lewy Bodies ◽  
Substantia Nigra Pars Compacta ◽  
Fatty Acid Binding ◽  
Knock Out ◽  
Acid Binding Protein ◽  
The Brain

Oligomerization and/or aggregation of α-synuclein (α-Syn) triggers α-synucleinopathies such as Parkinson’s disease and dementia with Lewy bodies. It is known that α-Syn can spread in the brain like prions; however, the mechanism remains unclear. We demonstrated that fatty acid binding protein 3 (FABP3) promotes propagation of α-Syn in mouse brain. Animals were injected with mouse or human α-Syn pre-formed fibrils (PFF) into the bilateral substantia nigra pars compacta (SNpc). Two weeks after injection of mouse α-Syn PFF, wild-type (WT) mice exhibited motor and cognitive deficits, whereas FABP3 knock-out (Fabp3−/−) mice did not. The number of phosphorylated α-Syn (Ser-129)-positive cells was significantly decreased in Fabp3−/− mouse brain compared to that in WT mice. The SNpc was unilaterally infected with AAV-GFP/FABP3 in Fabp3−/− mice to confirm the involvement of FABP3 in the development of α-Syn PFF toxicity. The number of tyrosine hydroxylase (TH)- and phosphorylated α-Syn (Ser-129)-positive cells following α-Syn PFF injection significantly decreased in Fabp3−/− mice and markedly increased by AAV-GFP/FABP3 infection. Finally, we confirmed that the novel FABP3 inhibitor MF1 significantly antagonized motor and cognitive impairments by preventing α-Syn spreading following α-Syn PFF injection. Overall, FABP3 enhances α-Syn spreading in the brain following α-Syn PFF injection, and the FABP3 ligand MF1 represents an attractive therapeutic candidate for α-synucleinopathy.

scholarly journals CMET-19. THE ROLE OF BRAIN SPECIFIC FATTY ACID BINDING PROTEIN 7 IN BREAST CANCER METASTASES TO THE BRAIN

2017 ◽  
Vol 19 (suppl_6) ◽  
pp. vi43-vi43
Author(s):  
Alex Cordero ◽  
Deepak Kanojia ◽  
Wojciech K Panek ◽  
Annie Xiao ◽  
Meijing Wu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Fatty Acid Binding ◽  
Specific Fatty Acid ◽  
Breast Cancer Metastases ◽  
Acid Binding Protein ◽  
Cancer Metastases ◽  
The Brain

scholarly journals Regulation of Dopaminergic Neuronal Activity by Heart-type Fatty Acid Binding Protein in the Brain

2011 ◽  
Vol 131 (4) ◽  
pp. 497-501 ◽  
Author(s):  
Yui YAMAMOTO ◽  
Norifumi SHIODA ◽  
Yuji OWADA ◽  
Kohji FUKUNAGA
Keyword(s):  
Fatty Acid ◽  
Neuronal Activity ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
The Brain

scholarly journals Multilingualism and Personal Health Benefits: Connecting the Dots

2021 ◽  
Author(s):  
Mohammed H. Al Aqad
Keyword(s):  
Health Benefits ◽  
Well Being ◽  
Management Plan ◽  
Stroke Recovery ◽  
Social Psychological ◽  
Cross Culture ◽  
New Research ◽  
Connecting The Dots ◽  
Multiple Languages ◽  
The Brain

Being multilingual is a valuable advantage in today’s global society, which is right at everyone’s doorstep. Language and the ability to communicate are important skills to possess. These skills are particularly useful for healthcare professionals because without effective communication, it is tricky to collect reliable information, inform patients of a diagnosis, and/or engage them in developing a management plan. This chapter discusses the connection between speaking several languages and speaker’s mind health. New research on multilingualism has impacted the author insight into the effect of learning and using two or more languages on cognition, the brain, and success and well-being across the lifetime in the last twenty years. The notion of learning various languages expose the linguistic and cognitive development in the community, the latest findings imply that people gain a swathe of health benefits, becoming more open to different languages and new learning in general. An old saying says, speaking more than one language inevitably means that one’s have access to more than one culture, the person tend to have a better understand of intercultural differences and the nuances of different subcultures within an entire culture. The finding of the study shows that knowing several languages support ones life style, boost to live longer and the speaker become a certain kind of personification of cultural dynamicity and cross-culture exchange. Consequently, multilingualism has a range of social, psychological, and lifestyle benefits. Furthermore, experts are discovering a slew of health benefits from learning multiple languages, including quicker stroke recovery and delayed dementia development.

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