scholarly journals Very-Low-Calorie Ketogenic Diet as a Safe and Valuable Tool for Long-Term Glycemic Management in Patients with Obesity and Type 2 Diabetes

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 758
Author(s):  
Eleonora Moriconi ◽  
Elisabetta Camajani ◽  
Andrea Fabbri ◽  
Andrea Lenzi ◽  
Massimiliano Caprio
Keyword(s):  
Quality Of Life ◽  
Type 2 Diabetes ◽  
Ketogenic Diet ◽  
Eating Behavior ◽  
Low Calorie ◽  
T1 And T2 ◽  
Glycemic Management

Obesity-related type 2 diabetes represents one of the most difficult challenges for the healthcare system. This retrospective study aims to determine the efficacy, safety and durability of a very-low-calorie ketogenic diet (VLCKD), compared to a standard low-calorie diet (LCD) on weight-loss, glycemic management, eating behavior and quality of life in patients with type 2 diabetes (T2DM) and obesity. Thirty patients with obesity and T2DM, aged between 35 and 75 years, who met the inclusion criteria and accepted to adhere to a VLCKD or a LCD nutritional program, were consecutively selected from our electronic database. Fifteen patients followed a structured VLCKD protocol, fifteen followed a classical LCD. At the beginning of the nutritional protocol, all patients were asked to stop any antidiabetic medications, with the exception of metformin. Data were collected at baseline and after 3 (T1) and 12 (T2) months. At T1 and T2, BMI was significantly reduced in the VLCKD group (p < 0.001), whereas it remained substantially unchanged in the LCD group. HbA1c was significantly reduced in the VLCKD group (p = 0.002), whereas a slight, although not significant, decrease was observed in the LCD group. Quality of life and eating behavior scores were improved in the VLCKD group, whereas no significant changes were reported in the LCD group, both at T1 and T2. At the end of the study, in the VLCKD group 26.6% of patients had stopped all antidiabetic medications, and 73.3% were taking only metformin, whereas 46.6% of LCD patients had to increase antidiabetic medications. The study confirms a valuable therapeutic effect of VLCKD in the long-term management of obesity and T2DM and its potential contribution to remission of the disease.

scholarly journals Comment on Moriconi et al. Very-Low-Calorie Ketogenic Diet as a Safe and Valuable Tool for Long-Term Glycemic Management in Patients with Obesity and Type 2 Diabetes. Nutrients 2021, 13, 758

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3613
Author(s):  
Kirsten A. Berk ◽  
Elles J. T. M. van der Louw ◽  
Joanne F. Olieman ◽  
Aart J. van der Lely
Keyword(s):  
Type 2 Diabetes ◽  
Ketogenic Diet ◽  
Low Calorie ◽  
Glycemic Management

With interest, we have read the article of Moriconi et al. [...]

scholarly journals Reply to Berk et al. Comment on “Moriconi et al. Very-Low-Calorie Ketogenic Diet as a Safe and Valuable Tool for Long-Term Glycemic Management in Patients with Obesity and Type 2 Diabetes. Nutrients 2021, 13, 758”

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3639
Author(s):  
Eleonora Moriconi ◽  
Elisabetta Camajani ◽  
Andrea Fabbri ◽  
Andrea Lenzi ◽  
Massimiliano Caprio
Keyword(s):  
Type 2 Diabetes ◽  
Ketogenic Diet ◽  
Low Calorie ◽  
Glycemic Management

We thank the authors of the comment [...]

Effects of long-term multicomponent exercise on health-related quality of life in older adults with type 2 diabetes: evidence from a cohort study

2017 ◽  
Vol 26 (8) ◽  
pp. 2117-2127 ◽  
Author(s):  
Liliana C. Baptista ◽  
Gonçalo Dias ◽  
Nelba R. Souza ◽  
Manuel T. Veríssimo ◽  
Raul A. Martins
Keyword(s):  
Quality Of Life ◽  
Type 2 Diabetes ◽  
Older Adults ◽  
Cohort Study ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals Quality of life in people with Type 2 diabetes; a study in a multi-ethnic clinical trial population

2021 ◽  
Author(s):  
Shaifali Kulkarni ◽  
Paul Welsh ◽  
Myzoon Ali ◽  
John Petrie
Keyword(s):  
Quality Of Life ◽  
Type 2 Diabetes ◽  
Health Perception ◽  
Lower Health ◽  
Vas Scores ◽  
Perception Of Health ◽  
Anxiety Depression

Background: The long-term burden of self-management in type 2 diabetes can impact quality of life. Aims: To examine associations between demographic and clinical factors, anxiety/depression and perception of health in people with type 2 diabetes. Methods: Retrospective analyses of anonymised data from completed clinical trials provided by the diabetes subsection of Virtual International Cardiovascular and Cognitive Trials Archive (VICCTA). Data on demographics, polypharmacy, HbA1c, anxiety/depression (EQ-5D-3L) and perception of health (EQ-5D-3L VAS) were extracted. Regression analyses explored associations amongst polypharmacy, HbA1c and quality of life (anxiety/depression and health perception) at baseline. Results: In 2783 participants with type 2 diabetes (median age 66 years (IQR 61–70), n=1,595 (57%) male), female sex and Caucasian/European ethnicity were each associated with increased anxiety/depression and lower EQ-5D-3L VAS scores. Following adjustment for covariates, each additional prescribed medication was associated with increased anxiety/depression: OR 1.09 (95% CI 1.04 to 1.14; p<0.001) and lower VAS scores: B= −1.06 (95% CI −1.37 to −0.75, p<0.001)). Conclusion: Demographic factors and polypharmacy are associated with anxiety/depression and lower health perception.

Eating behavior affects quality of life in type 2 diabetes mellitus

2005 ◽  
Vol 10 (4) ◽  
pp. 251-257 ◽  
Author(s):  
F. Cerrelli ◽  
R. Manini ◽  
G. Forlani ◽  
L. Baraldi ◽  
N. Melchionda ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Eating Behavior

scholarly journals Lifestyle medicine for type 2 diabetes: practice-based evidence for long-term efficacy of a multicomponent lifestyle intervention (Reverse Diabetes2 Now)

2020 ◽  
pp. bmjnph-2020-000081
Author(s):  
Gerda K Pot ◽  
Marieke CE Battjes-Fries ◽  
Olga N Patijn ◽  
Nynke van der Zijl ◽  
Hanno Pijl ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Type 2 Diabetes ◽  
Real Life ◽  
Density Lipoprotein ◽  
Lifestyle Interventions ◽  
Cholesterol Levels ◽  
Hba1c Levels

IntroductionA wealth of evidence supports short-term efficacy of lifestyle interventions in type 2 diabetes (T2D). However, little is known about long-term effects of lifestyle interventions in real-life settings.MethodsThis observational, single-arm study evaluated long-term impact of ‘Voeding Leeft: Reverse-Diabetes2-Now’, a 6-month multicomponent lifestyle programme, on glycaemic control and glucose-lowering medication (GLmed) use, other T2D parameters and quality of life in 438 T2D participants at 6, 12, 18 and 24 months using paired sample t-tests, χ2 and generalised linear models.ResultsAt 24 months, 234 participants provided information on GLmed and HbA1c (‘responders’). 67% of the responders used less GLmed, and 28% ceased all GLmed. Notably, 71% of insulin users at baseline (n=47 of 66 insulin users) were off insulin at 24 months. Mean HbA1c levels were similar at 24 months compared with baseline (55.6±12.8 vs. 56.3±10.5 mmol/mol, p=0.43), but more responders had HbA1c levels ≤53 mmol/mol at 24 months (53% vs 45% at baseline). Furthermore, triglyceride levels (−0.34±1.02 mmol/L, p=0.004), body weight (−7.0±6.8 kg, p<0.001), waist circumference (−7.9±8.2 cm, p<0.001), body mass index (−2.4±2.3 kg/m2, p<0.001) and total cholesterol/high-density lipoprotein (HDL) ratio (−0.22±1.24, p=0.044) were lower, while HDL (+0.17 ± 0.53 mmol/L, p<0.001) and low-density lipoprotein-cholesterol levels (+0.18 ± 1.06 mmol/L, p=0.040) were slightly higher. No differences were observed in fasting glucose or total cholesterol levels. Quality of life and self-reported health significantly improved.ConclusionThis study indicates robust, durable real-life benefits of this lifestyle group programme after up to 24 months of follow-up, particularly in terms of medication use, body weight and quality of life in T2D patients.

scholarly journals Characteristics of Patients, Self-Efficacy and Quality of Life among Patients with Type 2 Diabetes Mellitus

2019 ◽  
Vol 7 (3) ◽  
Author(s):  
Karina Megasari Winahyu ◽  
Revi Anggita ◽  
Giri Widakdo
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Self Efficacy ◽  
Term Care ◽  
Long Term Treatment

Diabetes mellitus as a chronic disease requires a long-term care, which influence the quality of life (QOL). A mechanism perceived by the patients who engage in long-term treatment, such as self-efficacy (SE) is prerequisite for the success of disease management. The study aimed to identify the relationship between characteristics of patients, SE and domains of QOL among patients with type 2 diabetes mellitus (T2DM) living in community. The study used a correlational analytical with a cross-sectional approach and recruited 105 patients with type 2 diabetes in Sukasari Public Health Center, Tangerang. Self-administered questionnaires were used to measure sociodemographic of T2DM patients, while the Diabetes Management Self-Efficacy Scale (DMSES) UK and Asian Diabetes Quality of Life (Asian DQOL) were used to measure SF and QOL, respectively. Data were analyzed using Spearman Rank-Order Correlation. The study revealed that characteristics of patients, including age and period of illness were negatively associated with memory and cognition domains of QOL, while years of education positively associated interpersonal relationship domains of QOL. For SE, it was positively significant associated with diet habit, energy, and financial aspects domains of QOL. The SE was positively associated with the QOL (r=0.31; p-value ≤ 0.01). The SE is relationship with QOL of T2DM. Therefore,  health care provider should need to maintain the domains of QOL through improving SE, while considering the characteristics of T2DM patients, including age, period of illness, and years of education.

scholarly journals Do Long-Term Complications of Type 2 Diabetes Increase Susceptibility to Geriatric Syndromes in Older Adults?

Medicina ◽  
2021 ◽  
Vol 57 (9) ◽  
pp. 968
Author(s):  
Güzin Çakmak ◽  
Sencer Ganidağlı ◽  
Eyyüp Efendioğlu ◽  
Ercüment Öztürk ◽  
Zeynel Öztürk
Keyword(s):  
Quality Of Life ◽  
Type 2 Diabetes ◽  
Short Form ◽  
Handgrip Strength ◽  
Microvascular Complications ◽  
Macrovascular Complications ◽  
Geriatric Syndromes

Background and Objectives: Type 2 diabetes is one of the common chronic diseases in the elderly. It is thought that long-term complications of type 2 diabetes will negatively affect the quality of life in elderly individuals. It is possible that geriatric syndromes, especially frailty syndrome, are associated with diabetic complications, too. In this study, we aimed to evaluate the effect of macrovascular and microvascular complications of type 2 diabetes on frailty and other geriatric syndromes. In addition, the effect of these complications on quality of life was also reviewed. Materials and Methods: We conducted a cross-sectional study for four months. Comprehensive geriatric assessment tests were done on all patients. The Fried frailty index (FFI) was used for the evaluation of frailty syndrome. We assessed malnutrition by mini nutritional assessment short-form (MNA-SF), and Global Leadership Initiative on Malnutrition criteria (GLIM). The EWGSOP 2 criteria were used for the diagnosis of sarcopenia. Quality of life (QoL) was evaluated using the short form-36 (SF-36) questionnaire. Data analysis was done by SPSS version 22. Results: 237 females and 142 males with a mean age of 71.7 ± 6.1 years were included in the study. The frequency of macrovascular and microvascular complications was 41.4% and 68.1%, respectively. Frailty was found to be associated with macrovascular complications (p = 0.003). Handgrip strength, skeletal muscle mass index, and gait speed were decreased in the presence of macrovascular complications (p = 0.043, p < 0.001, p < 0.001). QoL was also decreased in patients with macrovascular complications (p = 0.003). Nutritional status and handgrip strength were negatively affected in patients with diabetic neuropathy (p = 0.019, p = 0.014). Polypharmacy was also found to be associated with macrovascular complications (p < 0.001, p < 0.001). Macrovascular complications were 2.5 times more common in malnourished patients according to GLIM and 3.2 times more common in patients with decreased gait speed. Conclusion: In this study, we observed that both macrovascular and microvascular complications of diabetes increase susceptibility to geriatric syndromes in elderly individuals. It could be useful to conduct prospective studies in which we can compare the effectiveness of treatment methods on this subject.

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