scholarly journals Quality of life in people with Type 2 diabetes; a study in a multi-ethnic clinical trial population

Author(s):  
Shaifali Kulkarni ◽  
Paul Welsh ◽  
Myzoon Ali ◽  
John Petrie

Background: The long-term burden of self-management in type 2 diabetes can impact quality of life. Aims: To examine associations between demographic and clinical factors, anxiety/depression and perception of health in people with type 2 diabetes. Methods: Retrospective analyses of anonymised data from completed clinical trials provided by the diabetes subsection of Virtual International Cardiovascular and Cognitive Trials Archive (VICCTA). Data on demographics, polypharmacy, HbA1c, anxiety/depression (EQ-5D-3L) and perception of health (EQ-5D-3L VAS) were extracted. Regression analyses explored associations amongst polypharmacy, HbA1c and quality of life (anxiety/depression and health perception) at baseline. Results: In 2783 participants with type 2 diabetes (median age 66 years (IQR 61–70), n=1,595 (57%) male), female sex and Caucasian/European ethnicity were each associated with increased anxiety/depression and lower EQ-5D-3L VAS scores. Following adjustment for covariates, each additional prescribed medication was associated with increased anxiety/depression: OR 1.09 (95% CI 1.04 to 1.14; p<0.001) and lower VAS scores: B= −1.06 (95% CI −1.37 to −0.75, p<0.001)). Conclusion: Demographic factors and polypharmacy are associated with anxiety/depression and lower health perception.

Medicina ◽  
2009 ◽  
Vol 45 (2) ◽  
pp. 85 ◽  
Author(s):  
Lina Lašaitė ◽  
Jūratė Lašienė ◽  
Gintautas Kazanavičius ◽  
Antanas Goštautas

The aim of the study was to evaluate associations of emotional state and quality of life with lipid concentration, duration of the disease, and the way of treating the disease in males and females with type 2 diabetes mellitus. A total of 53 persons with type 2 diabetes mellitus (27 males and 26 females; mean age, 58.7±8.9 years) and 56 healthy persons (26 males and 30 females; mean age, 54.7±8.3 years) participated in the study. Emotional state was evaluated by means of Profile of Mood State and quality of life by means of WHO Brief Quality of Life Questionnaire. Emotional state and quality of life were significantly worse, tension-anxiety and fatigue-inertia were significantly higher, vigor-activity was significantly lower in male patients with type 2 diabetes mellitus than in healthy males. In females, no significant differences in emotional state and quality of life comparing type 2 diabetes mellitus group and controls were detected. In females with type 2 diabetes mellitus, emotional state and quality of life were significantly better, scores of tension-anxiety, depression dejection, anger-hostility, and fatigue-inertia were significantly lower, and score of vigor-activity was significantly higher than in males with type 2 diabetes mellitus. Some significant correlations were found. In males, vigor-activity correlated with total cholesterol level and negatively correlated with triglyceride level. In females, significant correlations were found between scores of emotional state (tension-anxiety, depression-dejection, confusion-bewilderment, and total score of emotional state) and lipid levels (total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels). There were no significant associations of emotional state and quality of life with duration of the disease in males and females with type 2 diabetes mellitus. No significant differences in emotional state and quality of life were found between males and females with type 2 diabetes mellitus, who were treated with oral antidiabetic preparations and insulin preparations.


2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Luis A. Anillo Arrieta ◽  
Tania Acosta Vergara ◽  
Rafael Tuesca ◽  
Sandra Rodríguez Acosta ◽  
Karen C. Flórez Lozano ◽  
...  

Abstract Purpose The purpose of this study was to describe the health-related quality of life (HRQoL) characteristics in a population at risk of developing type 2 diabetes in Barranquilla and Bogotá, Colombia. Methods A cross-sectional study with 1135 participants older than 30 years-of-age recruited in Bogotá D.C., and Barranquilla by cluster sampling in 2018 to 2019. The Finnish Diabetes Risk Score (FINDRISC) was used to detect participants at risk of developing type 2 diabetes (T2D). HRQoL was assessed using the EQ-5D-3L questionnaire. Unadjusted and adjusted logistic regression models were used to calculate odds ratios (OR) and their corresponding 95% confidence intervals CI). Results Moderate or extreme problems appeared more frequently in the dimensions of Pain/Discomfort (60.8%) and Anxiety/Depression (30.8%). The mean score of the EQ-VAS was 74.3 (± 17.3), significantly larger in the state of complete health (11111) compared with those with problems in more than one of the quality-of-life dimensions. Being female and living in Bogota D.C., were associated with greater odds of reporting problems in the Pain (OR 1.6; 95% CI 1.2–2.2) and Discomfort dimensions (OR 1.6; 95% CI 1.2–2.0) respectively and Anxiety/Depression (OR 1.9; 95% CI 1.3–2.7), (OR 9.1; 95% CI 6.6–12.4), respectively. Conclusions As living place and sex were associated with dimensions of Pain/Discomfort and Anxiety/Depression in the HRQoL in people at risk of T2D, greater attention should be paid to these determinants of HRQoL to design and reorient strategies with a territorial and gender perspective to achieve better health outcomes. Plain English summary Diabetes is one of the four non-communicable diseases with increasing prevalence in the world, which has made it a serious public health problem. In Colombia, in 2019 diabetes affected 8.4% of the Colombian adult population and more than one million Colombian adults of this age group have hidden or undetected diabetes. This disease is not only characterized by increased premature mortality, loss of productivity, and economic impact, but it also involves a deterioration in the quality of life of people with diabetes with their respective families. However, very Little is known about health-related quality of life (HRQoL) in a population at risk or with prediabetes. This study has evaluated the quality of life in patients at risk of diabetes and their behavior with some variables as sociodemographic, lifestyle, history, and established their difference in two territories of the Colombian Caribbean. The results of this study indicate that the HRQoL of people at risk of type 2 diabetes is affected by factors such as gender, city, dysglycemia, medication for hypertension and education level. Therefore, greater attention should be paid to these determinants of HRQL to design and implement strategies that reduce this risk of developing type 2 diabetes, prevent prediabetes and improve the quality of life in prediabetic or diabetic patients.


2019 ◽  
Vol 13 (3) ◽  
pp. 1995-1999 ◽  
Author(s):  
Rashmi Shiju ◽  
Daisy Thomas ◽  
Monira Al Arouj ◽  
Prem Sharma ◽  
Jaakko Tuomilehto ◽  
...  

2017 ◽  
Vol 26 (8) ◽  
pp. 2117-2127 ◽  
Author(s):  
Liliana C. Baptista ◽  
Gonçalo Dias ◽  
Nelba R. Souza ◽  
Manuel T. Veríssimo ◽  
Raul A. Martins

2020 ◽  
pp. bmjnph-2020-000081
Author(s):  
Gerda K Pot ◽  
Marieke CE Battjes-Fries ◽  
Olga N Patijn ◽  
Nynke van der Zijl ◽  
Hanno Pijl ◽  
...  

IntroductionA wealth of evidence supports short-term efficacy of lifestyle interventions in type 2 diabetes (T2D). However, little is known about long-term effects of lifestyle interventions in real-life settings.MethodsThis observational, single-arm study evaluated long-term impact of ‘Voeding Leeft: Reverse-Diabetes2-Now’, a 6-month multicomponent lifestyle programme, on glycaemic control and glucose-lowering medication (GLmed) use, other T2D parameters and quality of life in 438 T2D participants at 6, 12, 18 and 24 months using paired sample t-tests, χ2 and generalised linear models.ResultsAt 24 months, 234 participants provided information on GLmed and HbA1c (‘responders’). 67% of the responders used less GLmed, and 28% ceased all GLmed. Notably, 71% of insulin users at baseline (n=47 of 66 insulin users) were off insulin at 24 months. Mean HbA1c levels were similar at 24 months compared with baseline (55.6±12.8 vs. 56.3±10.5 mmol/mol, p=0.43), but more responders had HbA1c levels ≤53 mmol/mol at 24 months (53% vs 45% at baseline). Furthermore, triglyceride levels (−0.34±1.02 mmol/L, p=0.004), body weight (−7.0±6.8 kg, p<0.001), waist circumference (−7.9±8.2 cm, p<0.001), body mass index (−2.4±2.3 kg/m2, p<0.001) and total cholesterol/high-density lipoprotein (HDL) ratio (−0.22±1.24, p=0.044) were lower, while HDL (+0.17 ± 0.53 mmol/L, p<0.001) and low-density lipoprotein-cholesterol levels (+0.18 ± 1.06 mmol/L, p=0.040) were slightly higher. No differences were observed in fasting glucose or total cholesterol levels. Quality of life and self-reported health significantly improved.ConclusionThis study indicates robust, durable real-life benefits of this lifestyle group programme after up to 24 months of follow-up, particularly in terms of medication use, body weight and quality of life in T2D patients.


Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 758
Author(s):  
Eleonora Moriconi ◽  
Elisabetta Camajani ◽  
Andrea Fabbri ◽  
Andrea Lenzi ◽  
Massimiliano Caprio

Obesity-related type 2 diabetes represents one of the most difficult challenges for the healthcare system. This retrospective study aims to determine the efficacy, safety and durability of a very-low-calorie ketogenic diet (VLCKD), compared to a standard low-calorie diet (LCD) on weight-loss, glycemic management, eating behavior and quality of life in patients with type 2 diabetes (T2DM) and obesity. Thirty patients with obesity and T2DM, aged between 35 and 75 years, who met the inclusion criteria and accepted to adhere to a VLCKD or a LCD nutritional program, were consecutively selected from our electronic database. Fifteen patients followed a structured VLCKD protocol, fifteen followed a classical LCD. At the beginning of the nutritional protocol, all patients were asked to stop any antidiabetic medications, with the exception of metformin. Data were collected at baseline and after 3 (T1) and 12 (T2) months. At T1 and T2, BMI was significantly reduced in the VLCKD group (p < 0.001), whereas it remained substantially unchanged in the LCD group. HbA1c was significantly reduced in the VLCKD group (p = 0.002), whereas a slight, although not significant, decrease was observed in the LCD group. Quality of life and eating behavior scores were improved in the VLCKD group, whereas no significant changes were reported in the LCD group, both at T1 and T2. At the end of the study, in the VLCKD group 26.6% of patients had stopped all antidiabetic medications, and 73.3% were taking only metformin, whereas 46.6% of LCD patients had to increase antidiabetic medications. The study confirms a valuable therapeutic effect of VLCKD in the long-term management of obesity and T2DM and its potential contribution to remission of the disease.


2019 ◽  
Vol 7 (3) ◽  
Author(s):  
Karina Megasari Winahyu ◽  
Revi Anggita ◽  
Giri Widakdo

Diabetes mellitus as a chronic disease requires a long-term care, which influence the quality of life (QOL). A mechanism perceived by the patients who engage in long-term treatment, such as self-efficacy (SE) is prerequisite for the success of disease management. The study aimed to identify the relationship between characteristics of patients, SE and domains of QOL among patients with type 2 diabetes mellitus (T2DM) living in community. The study used a correlational analytical with a cross-sectional approach and recruited 105 patients with type 2 diabetes in Sukasari Public Health Center, Tangerang. Self-administered questionnaires were used to measure sociodemographic of T2DM patients, while the Diabetes Management Self-Efficacy Scale (DMSES) UK and Asian Diabetes Quality of Life (Asian DQOL) were used to measure SF and QOL, respectively. Data were analyzed using Spearman Rank-Order Correlation. The study revealed that characteristics of patients, including age and period of illness were negatively associated with memory and cognition domains of QOL, while years of education positively associated interpersonal relationship domains of QOL. For SE, it was positively significant associated with diet habit, energy, and financial aspects domains of QOL. The SE was positively associated with the QOL (r=0.31; p-value ≤ 0.01). The SE is relationship with QOL of T2DM. Therefore,  health care provider should need to maintain the domains of QOL through improving SE, while considering the characteristics of T2DM patients, including age, period of illness, and years of education.


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