scholarly journals Intravenous Lipid Emulsions Affect Respiratory Outcome in Preterm Newborn: A Case-Control Study

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1243
Author(s):  
Giovanni Boscarino ◽  
Maria Giulia Conti ◽  
Francesca De Luca ◽  
Maria Di Chiara ◽  
Giorgia Deli ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Birth Weight ◽  
Gestational Age ◽  
Case Control Study ◽  
Invasive Mechanical Ventilation ◽  
Case Control ◽  
Lipid Emulsions ◽  
Metabolic Complication ◽  
Respiratory Outcome ◽  
Control Study

(1) Background: Hypertriglyceridemia (HiTG) is a metabolic complication of intravenous lipid emulsions (ILEs) infusion. We aimed to evaluate the influence of HiTG on the respiratory outcome of preterm babies; (2) Methods: We enrolled, in a case–control study, newborns with gestational age <32 weeks or birth weight <1500 g, over a 3-year period. They were divided into cases and controls; cases were defined by the detection of HiTG defined as serum triglycerides (TG) value >150 mg/dL; (3) Results: We enrolled 40 cases and 105 controls. Cases had an increased incidence of bronchopulmonary dysplasia (30.0% vs. 14.3%, p < 0.05) and longer duration of invasive mechanical ventilation (7 days, 95% CI 4–10 days vs. 4 days, 95% CI 1–7 days, p < 0.01) compared to controls. Multivariate analysis confirmed that HiTG independently influenced the duration of invasive mechanical ventilation, also in the subgroups with gestational age ≤28 + 6/7 weeks or birth weight ≤1000 g; (4) Conclusion: Newborns with HiTG related to ILEs had a longer duration of invasive mechanical ventilation. Temporary suspension or reduction in ILEs in the case of HiTG is associated with an improvement of respiratory outcome.

scholarly journals Association between cardiometabolic disease and severe COVID-19: a nationwide case–control study of patients requiring invasive mechanical ventilation

BMJ Open ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. e044486 ◽  
Author(s):  
Per Svensson ◽  
Robin Hofmann ◽  
Henrike Häbel ◽  
Tomas Jernberg ◽  
Per Nordberg
Keyword(s):  
Type 2 Diabetes ◽  
Mechanical Ventilation ◽  
Case Control Study ◽  
Invasive Mechanical Ventilation ◽  
Population Based ◽  
Case Control ◽  
Population Type ◽  
Susceptible Patient ◽  
Control Study

AimsThe risks associated with diabetes, obesity and hypertension for severe COVID-19 may be confounded and differ by sociodemographic background. We assessed the risks associated with cardiometabolic factors for severe COVID-19 when accounting for socioeconomic factors and in subgroups by age, sex and region of birth.Methods and resultsIn this nationwide case–control study, 1.086 patients admitted to intensive care with COVID-19 requiring mechanical ventilation (cases), and 10.860 population-based controls matched for age, sex and district of residency were included from mandatory national registries. ORs with 95% CIs for associations between severe COVID-19 and exposures with adjustment for confounders were estimated using logistic regression. The median age was 62 years (IQR 52–70), and 3003 (24.9%) were women. Type 2 diabetes (OR, 2.3 (95% CI 1.9 to 2.7)), hypertension (OR, 1.7 (95% CI 1.5 to 2.0)), obesity (OR, 3.1 (95% CI 2.4 to 4.0)) and chronic kidney disease (OR, 2.5 (95% CI 1.7 to 3.7)) were all associated with severe COVID-19. In the younger subgroup (below 57 years), ORs were significantly higher for all cardiometabolic risk factors. The risk associated with type 2 diabetes was higher in women (p=0.001) and in patients with a region of birth outside European Union(EU) (p=0.004).ConclusionDiabetes, obesity and hypertension were all independently associated with severe COVID-19 with stronger associations in the younger population. Type 2 diabetes implied a greater risk among women and in non-EU immigrants. These findings, originating from high-quality Swedish registries, may be important to direct preventive measures such as vaccination to susceptible patient groups.Trial registration numberClinicaltrial.gov (NCT04426084).

Effects of depressive and anxiety disorders during pregnancy on gestational age and birth weight: A case-control study

Psychiatria ◽  
2021 ◽  
Vol 18 (2) ◽  
pp. 88-91
Author(s):  
Soraia Antunes Ribeiro ◽  
Daniela Agostinho David ◽  
Ilda Vieira Murta ◽  
João Mariano Marques ◽  
Vítor Daniel Vaz ◽  
...  
Keyword(s):  
Birth Weight ◽  
Anxiety Disorders ◽  
Gestational Age ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

Determinants of Low Birth Weight in Rural Areas of North West in Iran: 2013-2017 (A Case-Control Study)

2019 ◽  
Author(s):  
Hosein Rafiemanesh ◽  
Seyed Rasoul Hashemi Aghdam ◽  
Avaz Safarzadeh ◽  
Sanaz Chapar ◽  
Alireza Zemestani ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Gestational Age ◽  
Case Control Study ◽  
Case Control ◽  
Maternal Weight ◽  
Multivariate Logistic Regression ◽  
Control Study

Abstract Background Low birth weight (LBW) is one of the main causes of death in children and is an important factor related to the growth and development of children. LBW is associated with causes but some of the risk factors may be due to the country or geographical region. Aim of this study was conducted to investigate the risk factors associated with LBW in the villages of Oskou county, northwest of Iran. Methods This study is a population-based case-control study and all the cases of LBW, that have occurred during the five years 2013-2017 in all villages of Oskou county, East Azerbaijan Province, Iran. Controls were selevted based on systematic random sampling in that same village and year. Chi-square and fisher's exact test analysed and then a univariate and multivariate logistic regression model was used to investigate possible factors. Results In this study 242 cases and 242 control groups were analyzed. Base on multivariate logistic regression important risk factors were LBW history (OR=25.87), mothers who used natural methods of contraception (OR=29.54), twin's birth (OR=24.04) and gestational age less than 37 weeks (OR=3.89). Conclusion According to the result of the present study the most important risk factors of LBW are as follows: Contraception method using, having a history of previous LBW newborn, twin's birth, gestational age, fathers’ occupation, mothers’ education, maternal weight, maternal weight gain during pregnancy and number of of caring during pregnancy.

Birth Weight for Gestational Age and PCOS in Adolescents: A Case Control Study

2017 ◽  
Vol 30 (2) ◽  
pp. 278
Author(s):  
Katharina Clore ◽  
Erin H. Sieke ◽  
Sumana Narasimhan ◽  
Sarah Worley ◽  
Andrea E. Bonny ◽  
...  
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEMATIAN PERINATAL DI RUMAH SAKIT MUHAMMADDIYAH PALEMBANG TAHUN 2013

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
LENY LENY
Keyword(s):  
Birth Weight ◽  
Perinatal Mortality ◽  
Gestational Age ◽  
Maternal Age ◽  
Case Control Study ◽  
Perinatal Death ◽  
Mode Of Delivery ◽  
Case Control ◽  
P Value ◽  
Control Study

ABSTRACT [Perinatal mortality is a major problem, especially in developing countries. Approximately 98-99% of perinatal deaths occur in developing countries, while in developed countries only about 1-2%. Contributions perinatal mortality rate in Indonesia is still quite high, and perinatal mortality of 400 per 100,000 live births, or about 200,000 people per year so that the perinatal mortality occurs every 1.2-1.5 minutes. In the Muhammaddiyah hospital Palembang obtained perinatal mortality by the year 2013 as many as 52 cases. Many things that cause perinatal death include birth weight, maternal age, gestational age, mode of delivery and parity. The purpose of this study was to determine the relationship of birth weight, maternal age, gestational age, mode of delivery and parity simultaneously with perinatal death. This type of research is a case control study conducted retrospectively. The population in this study were all women giving birth in hospital Muhammadiyah Palembang in the year 2013 that berjumlah2565. The study sample totaled 156 respondents. In this study conducted univariate, bivariate and multivariate analyzes. From the analysis we found no association between birth weight to perinatal mortality (P Value 0.000 OR 4.250), no association of maternal age with perinatal mortality (OR 0.05 P Value 2.091), no correlation gestational age with perinatal mortality (OR 0.000 P Value 7.667), no association method of childbirth with perinatal mortality (P Value 1.000 OR 1.043), no parity relationship with perinatal mortality (P Value 0.511 OR 0.744). The most dominant variable is the age of the pregnancy. It is suggested to the leadership of Muhammadiyah hospital Palembang is hoped to be able to further improve health care programs for women giving birth so as to prevent the occurrence of complications during labor which can lead to perinatal mortality and increase the awareness programs on the importance of antenatal care during pregnancy that can detect early complications of pregnancy to facilitate the birth process.   ABSTRAK Kematian perinatal merupakan masalah besar khususnya di negara sedang berkembang. Sekitar 98-99 % kasus kematian perinatal terjadi di negara sedang berkembang sedangkan di negara maju hanya sekitar 1-2 %. Kontribusi angka kematian perinatal di Indonesia masih cukup tinggi, yaitu kematian perinatal 400 per 100.000 persalinan hidup atau sekitar 200.000 orang pertahun sehingga kematian perinatal terjadi setiap 1,2-1,5 menit. Di Rumah Sakit Muhammaddiyah Palembang didapatkan kematian perinatal pada tahun 2013 sebanyak 52 kasus. Banyak hal yang menyebabkan kematian perinatal diantaranya berat badan lahir, usia ibu, usia kehamilan, cara persalinan dan paritas. Tujuan penelitian ini untuk mengetahui hubungan berat badan lahir, usia ibu, usia kehamilan, cara persalinan dan paritas secara simultan dengan kematian perinatal. Jenis penelitian ini merupakan penelitian case control study yang dilakukan secara retrospektif. Populasi dalam penelitian ini adalah semua ibu bersalin di rumah sakit Muhammadiyah Palembang pada Tahun 2013 yang berjumlah2565. Sampel penelitian ini berjumlah 156 responden. Dalam penelitian ini dilakukan analisis univariat, bivariat dan multivariat. Dari hasil analisis didapatkan ada hubungan antara berat badan lahir dengan kematian perinatal (P Value 0,000 OR 4,250), ada hubungan usia ibu dengan kematian perinatal (P Value 0,05 OR 2,091), ada hubungan usia kehamilan dengan kematian perinatal (P Value 0,000 OR 7,667), tidak ada hubungan cara persalinan dengan kematian perinatal (P Value 1,000 OR 1,043), tidak ada hubungan paritas dengan kematian perinatal (P Value 0,511 OR 0,744). Variabel paling dominan adalah usia kehamilan. Disarankan kepada pimpinan rumah sakit Muhammadiyah Palembang Diharapkan untuk dapat lebih meningkatkan program pelayanan kesehatan kepada ibu bersalin sehingga  mencegah terjadinya komplikasi selama persalinan yang dapat menyebabkan kematian perinatal serta meningkatkan program penyuluhan tentang pentingnya pemeriksaan kehamilan selama masa kehamilan yang dapat mendeteksi dini komplikasi kehamilan untuk memperlancar proses persalinan.  

scholarly journals Predictors of Low Birth Weight at Lumbini Provincial Hospital, Nepal: A Hospital-Based Unmatched Case Control Study

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Saneep Shrestha ◽  
Sandeep Shrestha ◽  
Upasana Shakya Shrestha ◽  
Kamala Gyawali
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Gestational Age ◽  
Case Control Study ◽  
Mode Of Delivery ◽  
Case Control ◽  
Bivariate Analysis ◽  
Maternal Weight ◽  
History Of ◽  
Control Study

Background. Low birth weight (LBW) is defined as the birth weight of live born infants below 2500 g, regardless of gestational age. It is a public health problem caused by factors that are potentially modifiable. The purpose of this study was to determine the socioeconomic, obstetric, and maternal factors associated with LBW in Lumbini Provincial Hospital, Nepal. Methods. The study was conducted using case control study design with 1 : 2 case control ratio. A total of 105 cases and 210 controls were taken in this study. Data were entered on Epi data software version 3.1 and exported to Statistical Package for Social Science (SPSS) software version 25 for analysis. Characteristics of the sample were described using mean and standard deviation. Bivariate analysis was done to assess the association between dependent and independent variables. The ultimate measure of association was odds ratio. Variables found to be associated with bivariate analysis were entered into a multivariable logistic regression model to identify predictors of LBW. Results. The mean age of the participants was 25.98 years with ±4.40 standard deviation. Mothers with literate educational background (AOR 0.32, 95% CI 0.13–0.81), housewife (AOR 2.63, 95% CI 1.11–6.20), vaginal mode of delivery (AOR 0.45, 95% CI 0.25–0.82), gestational age <37 weeks (AOR 2.51, 95% CI 1.15–5.48), history of LBW (AOR 5.12, 95% CI 1.93–13.60), and maternal weight <50 kilograms (AOR 2.23, 95% CI 1.23–4.02) were significantly associated with LBW. Conclusion. Educational and occupational status, mode of delivery, gestational age, maternal weight, and history of LBW were found to be independent predictors of LBW. There is need of developing coordination with education sector for increasing educational status of mothers and adolescent girls. Social determinants of health need to be considered while developing interventional programs. Similarly, interventional programs need to be developed considering identified predictors of low birth weight.

scholarly journals The Genetics and Clinical Variables of Retinopathy of Prematurity: A Matched Case Control Study

2021 ◽  
Author(s):  
Congcong Zhao ◽  
Zhansheng Wang ◽  
Yuebing Lu ◽  
Li Li ◽  
Lei Liu ◽  
...  
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Retinopathy Of Prematurity ◽  
Genetic Factors ◽  
Case Control Study ◽  
Case Control ◽  
Exon 2 ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

Abstract Purpose: Retinopathy of prematurity (ROP) is a major cause of childhood blindness worldwide; it is a proliferative retinal vascular disease in preterm infants. Some infants progress to severe disease despite absence of these clinical risk factors such as low birth weight, gestational age and oxygen. Genetic factors seem to have etiologic roles in retinopathy of prematurity (ROP). This matched case-control study examined genetic factors for ROP.Methods: Confirmed 71 severe ROP cases and gestational age, birth weight and days of oxygen therapy matched controls (1:1) were enrolled from September 2015 to August 2020. Exome sequencing was performed and accomplished by next-generation sequencing. Gene mutations on heritable retinal vascular diseases related to Norrin signaling pathway were analyzed. Results: Seven heterozygous variants in exon 2 and the 3′ UTR were identified in the FZD4 gene in 28 patients with ROP. Variants c.*3770A > T and c.*2971T > C were found to be significantly associated with ROP (P = 0.033 and P = 0.017 respectively). Screening of LPR5 revealed five heterozygous variants. The rate of variant c.575 + 6T > C was much higher in infants with ROP (P = 0.009). One variant in exon 3 (c.67-9delT) was found in the TSPAN12 gene in one infant with ROP, whereas another variant of TSPAN12, c.*1139A > T, was identified in both groups. Two variants of ZNF408, c.581_592del AGTGGTGACAGA and c.1007C > T, were found in infants with ROP, with the rate of change of the former being much higher in infants with ROP (P < 0.001 and P = 0.033 respectively). Conclusions: This study revealed genetic factors in Norrin signaling may contributed to the development and severity of ROP, which warrants further detailed investigation worldwide.

Does Placental Weight Affects Perinatal Outcome? A Prospective Case-control Study

2020 ◽  
Vol 16 (1) ◽  
pp. 52-59
Author(s):  
Naina Kumar ◽  
Himani Agarwal
Keyword(s):  
Birth Weight ◽  
High Risk ◽  
Perinatal Outcome ◽  
Case Control Study ◽  
Neonatal Outcome ◽  
Case Control ◽  
Placental Weight ◽  
Tertiary Center ◽  
Control Study ◽  
Prospective Case Control Study

Background: Placenta plays a very important role in the growth and development of fetus. Objective: To know the correlation between placental weight and perinatal outcome in term antenatal women. Methods: Present prospective case-control study was conducted in the rural tertiary center of Northern India over one year (January-December 2018) on 1,118 term (≥37-≤42 weeks) antenatal women with singleton pregnancy fulfilling inclusion criteria with 559 women with high-risk pregnancy as cases and 559 low-risk pregnant women as controls. Placental weight, birth weight was measured immediately after delivery and compared between the two groups along with gestation, parity, fetal gender, and neonatal outcome. Statistical analysis was done using SPSS 22 version. Results: Mean placental weight [481.98±67.83 gm vs. 499.47±59.59 gm (p=.000)] and birth weight [2.68±0.53 Kg vs. 2.88±0.4 Kg (p=.000)] was significantly lower in high risk as compared to lowrisk participants, whereas placental birth weight ratio was higher in high-risk cases [18.35±2.37 vs. 17.41±1.38 (p=.000)] respectively. Placental weight was positively correlated with birth weight and placental weight and birth weight increased with increasing gestation in both cases and controls. Male neonates had higher placental weight [492.74±68.24 gm vs. 488±58.8 gm (p=0.224)] and birth weight [2.81±0.5 Kg vs. 2.74±0.45 Kg (p=0.033)] as compared to females. Neonatal Intensive Care Unit admission was significantly associated with low placental and birth weight (p=.000). Conclusion: There is a significant correlation between placental weight, birth weight and neonatal outcome, hence placental weight can be used as an indirect indicator of intrauterine fetal growth.

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