scholarly journals Choline Metabolites, Hydroxybutyrate and HDL after Dietary Fiber Supplementation in Overweight/Obese Hypertensive Women: A Metabolomic Study

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1437
Author(s):  
Carla Patricia Novaes dos Santos Fechine ◽  
Mussara Gomes Cavalcanti Alves Monteiro ◽  
Josean Fechine Tavares ◽  
Augusto Lopes Souto ◽  
Rafaella Cristhine Pordeus Luna ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Amino Acids ◽  
Dietary Fiber ◽  
Intervention Study ◽  
Principal Component ◽  
Fiber Intake ◽  
Peak Intensity ◽  
Before And After ◽  
Insoluble Fiber ◽  
Metabolomic Study

Metabolomics has been increasingly used to evaluate metabolic changes associated with morbidities. The objective of this study is to assess the metabolic profile before and after intervention with mixed dietary fiber in overweight and obese hypertensive women. This is an intervention study, and the sample consists of 14 women aged 28 to 58 years. An intervention with 12 g of mixed soluble and insoluble fiber is performed for a period of eight weeks. Serum metabolites are identified using a Bruker 1H NMR spectrometer at 400 MHz. Multivariate data analysis, including principal component analysis (PCA), is used to differentiate the two groups. After supplementation with dietary fiber, there is a significant increase in the peak intensity values of the metabolites HDL-C (0.0010*), choline (0.0012*) and hydroxybutyrate (0.0010*) as well as a decrease in systolic (0.0013*) and diastolic (0.0026*) blood pressure. The analysis of the metabolomic profile allows the identification of metabolites that have been associated in the literature with hypertension and excess weight (choline, hydroxybutyrate and amino acids) and with fiber intake (choline, hydroxybutyrate and amino acids) in addition to an increase in HDL-C. The increase in the detection of the described metabolites possibly occurs due to the presence of pathologies and the use of fiber in the intervention, which also contributes to elevated HDL-c and reduced blood pressure.

scholarly journals Asupan lemak jenuh dan serat pada remaja obesitas kaitannya dengan sindrom metabolik

2016 ◽  
Vol 12 (4) ◽  
pp. 131
Author(s):  
Nurmasari Widyastuti ◽  
Fillah Fithra Dieny ◽  
Deny Yudi Fitranti
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Dietary Fiber ◽  
Fasting Blood Glucose ◽  
Saturated Fat ◽  
Fat Intake ◽  
Fiber Intake ◽  
Dietary Fiber Intake ◽  
Saturated Fat Intake

Background: There is an emerging global increase of metabolic syndrome prevalence due to increasing of obesity. Obesity and metabolic syndrome beginning in childhood progressing into adulthood.  Dietary saturated fat and fiber intake play a role in etiology in obesity.Objective: This study was to examine the associations between dietary saturated fat intake, fiber intake and components of metabolic syndrome among obese adolescents.Method: A cross-sectional study was conducted to 57 obese students aged 13-15 years old of SMP Nasima and SMP Kesatrian 2 Semarang, based on body mass index for ages. Subjects of this study were collected consecutively. Data were collected through waist circumference and blood pressure measurements, fasting biochemical serum analysis and dietary intake assessment.  Rank Spearman and Pearson correlation test was used to examine the associations between of dietary saturated fat and fiber intake to components of metabolic syndrome.Results: There were 46 subjects (80,7 %) had metabolic syndrome and 11 subjects (19,3 %) had the pre-metabolic syndrome. There was no association between dietary saturated fat intake and waist circumference, HDL cholesterol, triglyceride, fasting blood glucose levels and blood pressure. Fiber intake was negatively associated with blood triglyceride levels (r = -0.340; p = 0.01).Conclusion: There was no association between dietary saturated fat intake and components of metabolic syndrome. There was an association between dietary fiber intake with blood triglyceride levels. Dietary fiber intake has an important role in lipid metabolism.

scholarly journals Dietary fiber intake and the risk of bladder cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) cohort

2019 ◽  
Vol 41 (4) ◽  
pp. 478-482
Author(s):  
Jindan Luo ◽  
Xin Xu
Keyword(s):  
Bladder Cancer ◽  
Cancer Risk ◽  
Dietary Fiber ◽  
Fiber Intake ◽  
Soluble Fiber ◽  
Bladder Cancer Risk ◽  
Dietary Fiber Intake ◽  
Diet History Questionnaire ◽  
Diet History ◽  
Insoluble Fiber

Abstract Dietary fiber intake has been implicated as a protective factor for several human cancers in multiple epidemiologic studies. However, little is known about the effect of fiber intake on bladder cancer. This study examines the association between dietary fiber intake and bladder cancer risk among participants in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. A total of 101 721 participants were included in this study as they completed both the baseline questionnaire and the diet history questionnaire (cancer free before completion of the diet history questionnaire). Hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) were estimated using the Cox proportional hazards regression model. After a median of 12.5 years of follow-up, 776 new cases of bladder cancer were identified. Higher intake of total fiber, insoluble fiber and soluble fiber were not significantly associated with a reduced risk of bladder cancer. The multi-adjusted HRs (95 CIs) of highest versus lowest tertile of intake were 0.83 (0.66–1.04) for total fiber (P for trend = 0.098), 0.83 (95% CI: 0.67–1.03) for insoluble fiber (P for trend = 0.092) and 0.86 (95% CI: 0.68–1.08) for soluble fiber (P for trend = 0.168), respectively. There was no significant interaction of potential confounders, including education, body mass index and smoking status, with total fiber intake on bladder cancer risk. In summary, the findings of this prospective study show that there is no obvious evidence for a link between dietary fiber consumption and bladder cancer risk. Further large cohort studies are warranted to confirm these findings.

scholarly journals Exploration of the Association between Dietary Fiber Intake and Hypertension among U.S. Adults Using 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines: NHANES 2007–2014

Nutrients ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 1091 ◽  
Author(s):  
Baoqi Sun ◽  
Xiaoyan Shi ◽  
Tong Wang ◽  
Dongfeng Zhang
Keyword(s):  
Blood Pressure ◽  
Dietary Fiber ◽  
American Heart Association ◽  
Family Income ◽  
American Heart ◽  
Smoking Status ◽  
Heart Association ◽  
Fiber Intake ◽  
Dietary Fiber Intake ◽  
Vegetable Fiber

This study aimed to explore the association between dietary fiber intake and hypertension risk using 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines. Data from the National Health and Nutrition Examination Survey 2007–2014 were used in this study. Dietary fiber data were obtained through two 24-h dietary recall interviews. Hypertension was defined as systolic blood pressure (SBP) ≥ 130 mmHg or diastolic blood pressure (DBP) ≥ 80 mmHg or treatment with hypertensive medications. Logistic regression models and restricted cubic spline models were applied to evaluate the associations between dietary intakes of total, cereal, vegetable, and fruit fiber and hypertension. A total of 18,433 participants aged 18 years or older were included in the analyses. After adjustment for age, gender, body mass index (BMI), race, educational level, smoking status, family income, and total daily energy intake, compared with the lowest tertile, the odds ratios (95% confidence intervals) of hypertension for the highest tertile intakes of total, cereal, vegetable, and fruit fiber were 0.62 (0.52–0.75), 0.80 (0.67–0.96), 0.82 (0.69–0.98), and 0.86 (0.71–1.04), respectively. Dose-response analyses revealed that the risk of hypertension was associated with total fiber intake in a nonlinear trend, while the relationships were linear for cereal and vegetable fiber intakes. Our results suggested that the intakes of total, cereal, and vegetable fiber, but not fruit fiber, were associated with a decreased risk of hypertension in U.S. adults.

scholarly journals Gut Permeability Might be Improved by Dietary Fiber in Individuals with Nonalcoholic Fatty Liver Disease (NAFLD) Undergoing Weight Reduction

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1793 ◽  
Author(s):  
Marcin Krawczyk ◽  
Dominika Maciejewska ◽  
Karina Ryterska ◽  
Maja Czerwińka-Rogowska ◽  
Dominika Jamioł-Milc ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Dietary Fiber ◽  
Intestinal Permeability ◽  
Fatty Liver Disease ◽  
Fiber Intake ◽  
Alcoholic Fatty Liver ◽  
Dietary Fiber Intake ◽  
Before And After ◽  
Dietetic Intervention

(1) Introduction: Zonulin (ZO) has been proposed as a marker of intestinal permeability. Only a few studies have analyzed to date how diet influences the serum concentration of ZO among patients with non-alcoholic fatty liver disease (NAFLD). We performed a six-month dietetic intervention to evaluate the association between fiber intake and ZO concentration in 32 individuals with NAFLD. (2) Methods: Fiber content in the diet was estimated by Food Frequency Questionnaire (FFQ) and by analyzing 72-h nutritional diaries. ZO concentrations in serum were measured before and after the intervention by immunoenzymatic assay (ELISA). Fatty liver was quantified using the Hamaguchi score before and after the dietetic intervention. (3) Results: During the intervention, the dietary fiber intake increased from 19 g/day to the 29 g/day concomitant with an increase in the frequency of fiber consumption. All patients experienced significant (all p < 0.05) improvements in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGTP) activities. We also detected decreased serum triglycerides (p = 0.036), homeostatic model assessment insulin resistance (HOMA-IR (p = 0.041) and insulin content (p = 0.34), and improvement of fatty liver status according to the Hamaguchi score (p = 0.009). ZO concentration in serum decreased by nearly 90% (7.335 ± 13.492 vs. 0.507 ± 0.762 ng/mL, p = 0.001) and correlated with the amount of dietary fiber intake (p = 0.043) as well as the degree of fatty liver (p = 0.037). (4) Conclusion: Increasing nutritional fiber results in reduced serum ZO levels, reduced liver enzymes and improved hepatic steatosis in patients with NAFLD, possibly by altering intestinal permeability. Increased dietary fiber intake should be recommended in patients with NAFLD.

scholarly journals Effects of dietary soluble or insoluble fiber intake in late gestation on litter performance, milk composition, immune function, and redox status of sows around parturition

2020 ◽  
Vol 98 (10) ◽  
Author(s):  
Yang Liu ◽  
Nan Chen ◽  
Dan Li ◽  
Hua Li ◽  
Zhengfeng Fang ◽  
...  
Keyword(s):  
Immune Function ◽  
Dietary Fiber ◽  
Redox Status ◽  
Milk Composition ◽  
Late Gestation ◽  
Fiber Intake ◽  
Soluble Fiber ◽  
High Fiber ◽  
Dietary Treatments ◽  
Insoluble Fiber

Abstract The objective of this study was to investigate the effects of dietary soluble fiber (SF) or insoluble fiber (ISF) intake in late gestation on litter performance, milk composition, immune function, and redox status of sows around parturition. A total of 60 Yorkshire sows were randomly assigned into three dietary treatments: normal level of dietary fiber (CON, 16.16% dietary fiber with 1.78% soluble fiber and 14.38% insoluble fiber), high insoluble fiber (ISF, 30.12% dietary fiber with 2.97% soluble fiber and 27.15% insoluble fiber), and high soluble fiber (SF, 30.15% dietary fiber with 4.57% soluble fiber and 25.58% insoluble fiber). Digestible energy and crude protein intake were comparable among treatments via adjusting feed intake from day 90 of gestation to parturition. After parturition, all sows were fed the same lactation diet. Results showed that litter performance of sows was not markedly affected by maternal fiber intake. However, sows fed ISF or SF diet had increased concentration of plasma mmunoglobulin G at day 107 (P &lt; 0.05) and parturition (P &lt; 0.01), and the SF diet had a tendency to increase fat content in both colostrum and milk relative to the CON diet. Furthermore, sows fed ISF diet had increased glutathione peroxidase activity (P &lt; 0.05) at day 107, but decreased the plasma level of malondialdehyde at parturition (P &lt; 0.05). High maternal SF intake tended to decrease the number of weaned piglets due to the increased preweaning mortality, as compared with sows fed the ISF diet. In conclusion, high fiber intake in late gestation may improve immune function and redox status, but differentially influenced the milk composition and preweaning mortality.

scholarly journals Intake of Dietary Fiber From Grains and the Risk of Hypertension in Late Midlife Women: Results From the SWAN Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Peng Du ◽  
Kaifeng Luo ◽  
Yali Wang ◽  
Qi Xiao ◽  
Jiansheng Xiao ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Regression Analysis ◽  
Dietary Fiber ◽  
Systolic Hypertension ◽  
Smooth Curve ◽  
Midlife Women ◽  
Confounding Factors ◽  
Fiber Intake ◽  
Dietary Fiber Intake ◽  
Diastolic Hypertension

Background: The possible effects of dietary fiber intake on hypertension have not been clarified fully. The association of dietary fiber intake with hypertension risk in midlife women was analyzed in this study.Methods: Baseline data were obtained from the Study of Women's Health Across the Nation (SWAN). Smooth curve, linear regression, and logistic regression analyses were performed to investigate the associations of four indices of daily dietary estimate (DDE) of dietary fiber (dietary fiber intake, dietary fiber intake from beans, dietary fiber intake from vegetables/fruit, and dietary fiber intake from grains) with blood pressure in midlife women. For this research purpose, diastolic blood pressure (DBP) ≥90 mmHg was defined as diastolic hypertension, and systolic blood pressure (SBP) ≥140 mmHg was defined as systolic hypertension.Results: This study included 2,519 participants with an average age of 46. The smooth curve showed approximate negative correlations between three fiber indices (DDE dietary fiber, DDE fiber from vegetables/fruit, and DDE fiber from grains) and blood pressure, including DBP and SBP (all P &lt; 0.005). There were also approximate negative correlations between two fiber indices (DDE dietary fiber and DDE fiber from grains) and the risk of diastolic hypertension and systolic hypertension (all P &lt; 0.05). Furthermore, multiple linear regression analysis suggested that DDE dietary fiber (Sβ = −0.057, 95% CI −0.194 – −0.012, P = 0.027), DDE fiber from vegetables/fruit (Sβ = −0.046, 95% CI −0.263 – −0.007, P = 0.039), and DDE fiber from grains (Sβ = −0.073, 95% CI −0.600 – −0.099, P = 0.006, Model 4) were still negatively correlated with DBP after adjusting for confounding factors. Only DDE fiber from grains was independently and negatively associated with SBP (Sβ = −0.060, 95% CI −0.846 – −0.093, P = 0.015) after these same confounding factors were adjusted for. Importantly, multiple logistic regression analysis suggested that only higher DDE fiber from grains was independently associated with a reduced risk of diastolic hypertension (OR = 0.848, 95% CI 0.770–0.934, P = 0.001, Model 4) and systolic hypertension (OR = 0.906, 95% CI 0.826–0.993, P = 0.034, Model 4) after the adjustments were made for confounding factors.Conclusions: We found that dietary fiber intake, especially DDE fiber from grains, contributes to a lower risk of systolic hypertension and diastolic hypertension in midlife women.

Dietary Fiber Consumption Decreases the Risks of Overweight and Hypercholesterolemia in Japanese Children

2015 ◽  
Vol 67 (1) ◽  
pp. 58-64 ◽  
Author(s):  
Keiko Shinozaki ◽  
Masayuki Okuda ◽  
Satoshi Sasaki ◽  
Ichiro Kunitsugu ◽  
Mayumi Shigeta
Keyword(s):  
Blood Pressure ◽  
Total Cholesterol ◽  
Dietary Fiber ◽  
High Blood Pressure ◽  
Weight Status ◽  
Body Height ◽  
Water Soluble ◽  
Fiber Intake ◽  
Japanese Children ◽  
Dietary Fiber Intake

Aims: It remains inconclusive whether high dietary fiber intake decreases the risk of obesity, hypercholesterolemia or high blood pressure during childhood. Therefore, this study investigated the relationships of dietary fiber intake with weight status and related clinical parameters among Japanese children. Methods: We analyzed the data of 5,600 subjects aged 10-11 years, between 2006 and 2010. Fiber intake was assessed using the Brief-type Diet History Questionnaire. Body height and weight and blood pressure were measured. Serum levels of total cholesterol, low- and high-density lipoprotein cholesterol and triglycerides were analyzed. Fiber intake was categorized into quintiles, and multivariate models were used to adjust for lifestyle factors. Results: Total fiber intake decreased the risks of overweight and high total cholesterol (OR Quintile 5 vs. Quintile 1 overweight: 0.71 for boys, 0.40 for girls; total cholesterol: 0.60 for boys, 0.66 for girls). Water-soluble fiber intake was associated with a lower risk of high blood pressure, although the ORs were not significant. Conclusions: Increasing the dietary fiber intake in Japanese children may have favorable effects on overweight and hypercholesterolemia.

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