scholarly journals Clinical and Nutritional Impact of a Semi-Elemental Hydrolyzed Whey Protein Diet in Patients with Active Crohn’s Disease: A Prospective Observational Study

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3623
Author(s):  
Blanca Ferreiro ◽  
Silvia Llopis-Salinero ◽  
Beatriz Lardies ◽  
Carla Granados-Colomina ◽  
Raimon Milà-Villarroel
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Observational Study ◽  
Nutritional Status ◽  
Disease Activity ◽  
Prospective Observational Study ◽  
Elemental Diet ◽  
Stool Frequency ◽  
Nutritional Treatment ◽  
The Mean

Background: Malnourishment is a common complication in patients with Crohn’s disease. Methods: An observational, prospective study was conducted to assess the nutritional status, disease activity, and stool frequency at baseline and after 12 weeks of treatment with a semi-elemental diet in patients with active Crohn’s disease. Results: A total of 144 patients with Crohn’s disease were included. The nutritional status improved after treatment, resulting in 76.1% of patients at low risk of malnourishment, 20.4% moderately malnourished, and 8.5% severely malnourished after 12 weeks of treatment. Nutritional status improvement was associated with the number of nutritional supplements. Mean albumin levels and body mass index (BMI) improved after 12 weeks of nutritional treatment (from 3.0 g/dL to 3.7 g/dL and from 20.2 kg/m2 to 21.1 kg/m2, respectively). A significant decrease in HBI was found after 12 weeks of nutritional treatment (from 10.2 to 3.7). The mean number of stools per day decreased with the 12 week semi-elemental diet (from 4.6 stools/day to 1.7 stools/day). Conclusion: In this observational study, the semi-elemental diet seemed effective in improving the nutritional status, disease activity, and stool frequency in patients with active Crohn’s disease.

scholarly journals Correlation of Stool Frequency and Abdominal Pain Measures With Simple Endoscopic Score for Crohn’s Disease

2019 ◽  
Author(s):  
James D Lewis ◽  
Paul Rutgeerts ◽  
Brian G Feagan ◽  
Geert D’haens ◽  
Silvio Danese ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Abdominal Pain ◽  
Crohn's Disease ◽  
Linear Regression ◽  
Disease Activity ◽  
Activity Index ◽  
Disease Activity Index ◽  
Stool Frequency ◽  
Endoscopic Score ◽  
Disease Location

Abstract Background The Crohn’s Disease Activity Index (CDAI) has been criticized for being weakly correlated with bowel inflammation. We assessed correlation between Simple Endoscopic Score for Crohn’s Disease (SES-CD) and individual CDAI items stratified by disease location to better understand this relationship. Methods We pooled patient-level data from 3 placebo-controlled Crohn’s disease (CD) trials that tested adalimumab, upadacitinib, and risankizumab. Disease location was defined as ileum only, colon only, or ileocolonic based upon colonoscopy at study entry. Pearson correlation coefficients and linear regression assessed correlations between items of the CDAI and SES-CD. Results A total of 353 patients were included (20.7% ileal, 30.6% colonic, 48.7% ileocolonic disease). Crohn’s Disease Activity Index and SES-CD scores were moderately correlated (R = 0.33; P < 0.001). Among CDAI items, the strongest correlations with SES-CD were seen with very soft or liquid stool frequency (SF) and patient-reported outcome 2 (PRO2; which includes SF and abdominal pain score; both R = 0.36; P < 0.001); these correlations were numerically stronger in colonic disease (SF: R = 0.46; P < 0.001; PRO2: R = 0.44; P < 0.001) than in ileal disease (SF: R = 0.14; P = 0.23; PRO2: R = 0.21; P = 0.07), although a test for interaction was not significant. In adjusted linear regression models, the proportion of mucosa that was inflamed and the proportion of mucosa with ulceration were positively correlated, whereas the presence of strictures was inversely correlated with SF. Conclusions The SF item of the CDAI is moderately correlated with SES-CD and independently correlated with mucosal ulceration, inflammation, and strictures. Understanding why bowel inflammation as measured endoscopically does not correlate more strongly with patients’ symptoms could help develop scales that link CD pathology to patient experience.

scholarly journals Serum Interleukin 17 Levels in Patients with Crohn’s Disease: Real Life Data

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Abdurrahman Sahin ◽  
Turan Calhan ◽  
Mustafa Cengiz ◽  
Resul Kahraman ◽  
Kubra Aydin ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Blood Count ◽  
Real Life ◽  
White Blood Count ◽  
Interleukin 17 ◽  
Healthy Controls ◽  
Crohn’S Disease Activity ◽  
The Mean

The aim of this study was to investigate serum IL17 levels in patients with Crohn’s disease (CD) and to investigate the relationship between serum IL17 levels with disease activity.Methods. Fifty patients with CD and sex- and age-matched 40 healthy controls were included in the study. The serum IL17 levels, complete blood count, blood chemistry, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels were measured, and Crohn’s disease activity was calculated using Crohn’s disease activity index (CDAI).Results. The mean serum IL17 level of CD patients did not differ from those of healthy controls (P>0.05). There was no difference between the mean serum IL levels of active CD patients and of quiescent CD patients (P>0.05). However, the mean IL17 level of active patients was lower than of control subjects (P=0.02). Serum IL17 was not correlated with inflammatory markers (ESR, CRP, white blood count, platelet count, and albumin) and CDAI.Conclusions. Peripheral blood serum IL17 levels of CD patients were not higher than of healthy controls, and also, serum IL17 level was not correlated with clinical disease activity. Peripheral IL17 measurement is not a useful tool for detecting and monitoring Crohn’s disease which is understood to have complex etiopathogenesis.

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