Plasma Vitamin D Deficiency Is Associated With Poor Sleep Quality and Night-Time Eating at Mid-Pregnancy in Singapore

Background: Untreated sleep disorders have been linked with type 2 diabetes in previous evidence. This study was to investigate the correlation between serum 25(OH) vitamin D level and sleep quality in elderly patients with type 2 diabetes and reveal the therapeutic potential of 25(OH) vitamin D-based treatments to improve sleeping quality and its effect on diabetes management. Methods: The sleep quality of 186 elderly patients with type 2 diabetes were assessed by questionaires of Pittsburgh sleep index (PSQI), with a cutoff point of PSQI ≥ 7 defined as poor sleep. The measurement of serum 25(OH) vitamin D , fasting blood glucose, glycosylated hemoglobin, serum creatinine, total cholesterol, triglyceride, low-density lipoprotein cholesterol, and urinary albumin/creatinine ratio were collected. History of diabetic nephropathy, diabetic retinopathy, peripheral neuropathy, blood pressure, height, weight, hypoglycemic drug use, and the duration of diabetes also were recorded. Both univariate and multivariate logistic regression analysis was used to investigate the relationship of serum 25(OH) vitamin D and sleep quality in elderly patients with type 2 diabetes. Results: The age of elderly patients with type 2 diabetes was 73.6(4.3) years., and duration of diabetes was 8.8(3.0) years. In the study, inadequate quality of sleep was reported in 63% elderly patients with type 2 diabetes. This study revealed that lower level of 25(OH) vitamin D was significantly associated with poor sleep quality in type 2 diabetes patients(P < 0.05). Multivariate logistic regression analysis showed that 25(OH) vitamin D deficiency and the use of insulin were risk factors for of inadequate sleep quality in elderly patients with type 2 diabetes. Conclusions: Elderly type 2 diabetic patients with 25(OH) vitamin D deficiency showed a high incidence of poor sleep quality, low-level of 25(OH) vitamin D was a risk factor for inadequate quality of sleep in elderly patients with type 2 diabetes.

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Determinants of sleep quality in adults during the COVID-19 pandemic: COVID-Inconfidentes, a population-based study

10.1101/2021.09.29.21264305 ◽

2021 ◽

Author(s):

Luiz Antonio Alves Menezes-Junior ◽

Luciano Garcia Lourencao ◽

Amanda Cristina de Souza Andrade ◽

Julia Cristina Cardoso Carraro ◽

George Luiz Lins Machado-Coelho ◽

...

Keyword(s):

Vitamin D ◽

Weight Gain ◽

Sleep Quality ◽

Population Based ◽

Poor Sleep ◽

World Population ◽

Poor Sleep Quality ◽

Factors Associated ◽

Negative Effect ◽

Gain Loss

Background: The coronavirus disease 2019 (COVID-19) pandemic has had a negative effect on the health and behavior of the world population. Objectives: To evaluate sleep quality and its associated factors in adults during the COVID-19 pandemic in Brazil. Methods: This is a population-based serological survey of 1762 adults collected from October to December 2020 in the Iron Quadrangle region, Brazil. To measure sleep quality, we used the Pittsburgh Sleep Quality Index questionnaire and socio-demographic, health, health related behaviors, anxiety, vitamin D, weight gain/loss, and pandemic characteristics were assessed using a structured questionnaire. Univariate and multivariate analyses were performed to identify the factors associated with sleep quality. Results: More than half of the individuals evaluated had poor sleep quality (52.5%). In multivariate analysis, factors related to sleep quality included living alone (OR=2.36; 95%CI: 1.11-5.00), anxiety disorder (OR=2.22; 95%CI: 1.20-4.14), 5.0% weight loss during the pandemic (OR=1.66; 95%CI: 1.01-2.76), weight gain of 5.0% (OR=1.90; 95%CI: 1.08-3.34), insufficient vitamin D scenario (OR=1.47; 95%CI: 1.01-2.12), and symptoms of COVID-19 (OR=1.94; 95%CI: 1.25-3.01). Conclusions: Our study revealed that more than half of the participants had poor sleep quality during the COVID-19 outbreak, and the factors associated with poor sleep quality were related to the pandemic, such as insufficient vitamin D scenario and weight change.

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Sleep Quality and Associated Factors in Adults with Type 2 Diabetes: A Retrospective Cohort Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18063025 ◽

2021 ◽

Vol 18 (6) ◽

pp. 3025

Author(s):

Ching-Pyng Kuo ◽

Shu-Hua Lu ◽

Chien-Ning Huang ◽

Wen-Chun Liao ◽

Meng-Chih Lee

Keyword(s):

Type 2 Diabetes ◽

Sleep Quality ◽

Excessive Daytime Sleepiness ◽

Daytime Sleepiness ◽

Diabetes Control ◽

Poor Sleep ◽

Poor Sleep Quality ◽

Night Time ◽

Patients With Diabetes

Purpose: Sleep disturbance is one of the major complaints among patients with diabetes. The status of diabetes control and associated complications may contribute to sleep disturbance. This study explored night time sleep and excessive daytime sleepiness in adults with type 2 diabetes and examined the association of diabetes control and associated complications on their sleep quality. Methods: A retrospective cohort study design was used. Type 2 diabetic patients (87 females and 79 males, aged 63.1 ± 10.5 years) were recruited from the outpatient clinics of the endocrine department. Sleep quality was assessed by the Pittsburg Sleep Quality Index and the Epworth Sleepiness Scale. Diabetes control and complications were obtained by retrospectively reviewing patients’ medical records over 1 year prior to study enrollment. Results: 72.3% of recruited patients had poor glycemic control, and 71.1% had at least one diabetic complication. 56.0% of patients experienced poor sleep quality, and 24.1% had excessive daytime sleepiness. Those who were female (OR = 3.45) and who had ophthalmological problems (OR = 3.17) were associated with poor night time sleep quality, but if they did exercise to the point of sweating (OR = 0.48) reduced the risk of poor sleep quality. Furthermore, poor sleep quality (OR = 4.35) and having nephropathy (OR = 3.78) were associated with a higher risk of excessive daytime sleepiness. Conclusions: Sex, ophthalmological problems, nephropathy, and no exercise to the point of sweating are associated with sleep problems in patients with type 2 diabetes. Both lifestyle behaviors and diabetic complications affect sleep disturbances in patients with diabetes.

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Sleep and its management in dementia

Reviews in Clinical Gerontology ◽

10.1017/s095925980600205x ◽

2006 ◽

Vol 16 (1) ◽

pp. 59-70 ◽

Cited By ~ 3

Author(s):

Eamonn Eeles

Keyword(s):

Circadian Rhythm ◽

Sleep Quality ◽

Sleep Disturbance ◽

Functional Decline ◽

Poor Sleep ◽

Poor Sleep Quality ◽

Behavioural Disturbance ◽

Night Time ◽

Clinically Significant ◽

Over Time

Sleep disturbance is a clinically significant problem in nearly one half of patients with dementia and is a predictor of cognitive and functional decline. There are multiple causes of sleep disturbance in dementia and all represent diagnostic and management challenges. Impaired circadian rhythm is a disorder characterized by an increase in daytime sleep with reduced night-time sleep, a reversal of the sleep/wake cycle. Such disrupted circadian rhythm may occur early in Alzheimer's disease, worsen over time, and is associated with behavioural disturbance, including aggression. In addition to the timing of sleep, the structure of sleep may deteriorate, giving rise to poor sleep quality.

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EVALUATION OF VITAMIN D SERUM LEVELS IN PATIENTS WITH INSOMNIA

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i11.27776 ◽

2018 ◽

Vol 11 (11) ◽

pp. 259

Author(s):

Maria Jai Joseph ◽

Karthik V P

Keyword(s):

Vitamin D ◽

Sleep Quality ◽

Vitamin D Deficiency ◽

Medical Center ◽

General Medicine ◽

Serum Levels ◽

Primary Objective ◽

Poor Sleep ◽

Eligibility Criteria ◽

Informed Consent Form

Objectives: The primary objective of the study was to evaluate the link existing between insomnia and low levels of Vitamin D and the secondary objective was to confirm a link between age and insomnia.Methods: The study assessed the Vitamin D serum levels in 50 subjects with insomnia (diagnosed using Pittsburgh Sleep Quality Index [PSQI]) from the outpatient clinic, Department of General Medicine of Sri Ramachandra Medical Center. All subjects fulfilled the eligibility criteria and also signed the informed consent form provided in patient’s native language for their convenience. With all aseptic precautions, 5 ml of blood was collected from the subjects for tyhe measurement of 25-OH Vitamin-D total levels using fully automated chemiluminescent immunoassay. Statistical analysis was performed using the Statistical Package for the Social Sciences (SPSS 1 7.1). Quantitative variables will be expressed as mean ± standard deviation (SD), and qualitative variables will be expressed as percentage values.Results: All the patients who are insomniacs were deficient of Vitamin D. Of this, 80% were in deficient state (i.e.,>20 ng/ml) and the rest 20% were in the insufficient state (i.e., 20–30 ng/ml). Most of the insomniacs were younger adults. As shown in the graph, 27 patients were in between the age group of 20 and 30 years, 13 patients of 50 patients were between 30 and 40 years of age, 4 patients between 40 and 50 years of age, 4 patients between 50 and 60 years of age, and 2 patients were of age between 60 and 70 years.Conclusion: Our results concluded that insomnia has a direct link with Vitamin D deficiency. Male insomniacs who were Vitamin D deficient were 40% more than female insomniacs with Vitamin D deficiency. It was noted that the incidence of increased body mass index and systolic blood pressure was seen among Vitamin D-deficient insomniacs. Insomnia was more prevalent among younger age groups rather than older adults. Global PSQI value evaluated among all Vitamin D-deficient patients was >5, which indicated poor sleep quality.

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Sleep and chronobiology in cluster headache

Cephalalgia ◽

10.1177/0333102414564892 ◽

2015 ◽

Vol 35 (11) ◽

pp. 969-978 ◽

Cited By ~ 49

Author(s):

M Barloese ◽

N Lund ◽

A Petersen ◽

M Rasmussen ◽

P Jennum ◽

...

Keyword(s):

Sleep Quality ◽

Cluster Headache ◽

Pittsburgh Sleep Quality Index ◽

Headache Disorder ◽

National Institutes Of Health ◽

Poor Sleep ◽

Structured Interviews ◽

Poor Sleep Quality ◽

Night Time ◽

Impaired Sleep

Background and aim M.R. present address: PAIN, National Institutes of Health, Bethesda, MD, USA Cluster headache (CH) is the headache disorder with the strongest chronobiological traits. The severe attacks of pain occur with diurnal and annual rhythmicity but the precise rhythm and involvement of potential zeitgebers is unknown. Patients complain of poor sleep quality yet this has never been studied. We investigated triggers, rhythms, sleep quality and chronotypes in CH. Methods Patients and controls completed questionnaires and structured interviews composed of new and previously validated parts including the Pittsburgh Sleep Quality Index (PSQI) and Morningness-Eveningness Questionnaire (MEQ). Patients were characterized by a CH index, a unified measure of headache burden. Results A total of 275 CH patients and 145 matched controls were included. The most common trigger was sleep (80%) and a relationship between clusters and daylight was identified. Of the patients, 82.2% reported diurnal and 56% annual rhythmicity. Patients reported impaired sleep quality (PSQI) ( p < 0.0001) and an inverse relationship between time passed since last attack and sleep quality was identified ( p < 0.0001). The CH index was positively related to the PSQI ( p < 0.0001). Conclusion Diurnally, CH exhibits a relationship with night-time and annually with daylight hours. Patients’ sleep quality is reduced compared with controls. Results suggest a complex relationship as sleep quality improves between clusters, but remains pathological.

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Determinants of Sleep Quality in Adults During the COVID-19 Pandemic: COVID-Inconfidentes, A Population-Based Study

10.21203/rs.3.rs-978743/v1 ◽

2021 ◽

Author(s):

Luiz Antonio Alves Menezes Júnior ◽

Luciano Garcia Lourenção ◽

Amanda Cristina de Souza Andrade ◽

Júlia Cristina Cardoso Carraro ◽

George Luiz Lins Machado-Coelho ◽

...

Keyword(s):

Vitamin D ◽

Weight Gain ◽

Sleep Quality ◽

Population Based ◽

Poor Sleep ◽

Poor Sleep Quality ◽

Factors Associated ◽

Health Related ◽

Negative Effect ◽

Gain Loss

Abstract Background The coronavirus disease 2019 (COVID-19) pandemic has had a negative effect on the health and behavior of the world’s population. Objectives To evaluate sleep quality and its associated factors in adults during the COVID-19 pandemic in Brazil. Methods This is a population-based serological survey of 1762 adults collected from October to December 2020 in the Iron Quadrangle region, Brazil. To measure sleep quality, we used the Pittsburgh Sleep Quality Index questionnaire and socio-demographic, health, health related behaviors, anxiety, vitamin D, weight gain/loss, and pandemic characteristics were assessed using a structured questionnaire. Univariate and multivariate analyses were performed to identify the factors associated with sleep quality. Results More than half of the individuals evaluated had poor sleep quality (52.5%). In multivariate analysis, factors related to sleep quality included living alone (OR=2.36; 95%CI: 1.11-5.00), anxiety disorder (OR=2.22; 95%CI: 1.20-4.14), 5.0% weight loss during the pandemic (OR=1.66; 95%CI: 1.01-2.76), weight gain of 5.0% (OR=1.90; 95%CI: 1.08-3.34), insufficient vitamin D scenario (OR=1.47; 95%CI: 1.01-2.12), and symptoms of COVID-19 (OR=1.94; 95%CI: 1.25-3.01). Conclusions Our study revealed that more than half of the participants had poor sleep quality during the COVID-19 outbreak, and the factors associated with poor sleep quality were related to the pandemic, such as insufficient vitamin D scenario and weight change.

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