scholarly journals Structural and Functional Aspects of Ebola Virus Proteins

Pathogens ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 1330
Author(s):  
Sahil Jain ◽  
Ekaterina Martynova ◽  
Albert Rizvanov ◽  
Svetlana Khaiboullina ◽  
Manoj Baranwal
Keyword(s):  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Ebola Virus ◽  
Vaccine Development ◽  
Peptide Vaccine ◽  
Protein Residues ◽  
Functional Aspects ◽  
Infected Cells ◽  
Factor Α ◽  
Necrosis Factor

Ebola virus (EBOV), member of genus Ebolavirus, family Filoviridae, have a non-segmented, single-stranded RNA that contains seven genes: (a) nucleoprotein (NP), (b) viral protein 35 (VP35), (c) VP40, (d) glycoprotein (GP), (e) VP30, (f) VP24, and (g) RNA polymerase (L). All genes encode for one protein each except GP, producing three pre-proteins due to the transcriptional editing. These pre-proteins are translated into four products, namely: (a) soluble secreted glycoprotein (sGP), (b) Δ-peptide, (c) full-length transmembrane spike glycoprotein (GP), and (d) soluble small secreted glycoprotein (ssGP). Further, shed GP is released from infected cells due to cleavage of GP by tumor necrosis factor α-converting enzyme (TACE). This review presents a detailed discussion on various functional aspects of all EBOV proteins and their residues. An introduction to ebolaviruses and their life cycle is also provided for clarity of the available analysis. We believe that this review will help understand the roles played by different EBOV proteins in the pathogenesis of the disease. It will help in targeting significant protein residues for therapeutic and multi-protein/peptide vaccine development.

scholarly journals Infection and Activation of Monocytes by Marburg and Ebola Viruses

2001 ◽  
Vol 75 (22) ◽  
pp. 11025-11033 ◽  
Author(s):  
Ute Ströher ◽  
Elmar West ◽  
Harald Bugany ◽  
Hans-Dieter Klenk ◽  
Hans-Joachim Schnittler ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Ebola Virus ◽  
Culture Conditions ◽  
Marburg Virus ◽  
Hemorrhagic Disease ◽  
Virus Species ◽  
Factor Α ◽  
Necrosis Factor

ABSTRACT In this study we investigated the effects of Marburg virus and Ebola virus (species Zaire and Reston) infections on freshly isolated suspended monocytes in comparison to adherent macrophages under culture conditions. Our data showed that monocytes are permissive for both filoviruses. As is the case in macrophages, infection resulted in the activation of monocytes which was largely independent of virus replication. The activation was triggered similarly by Marburg and Ebola viruses, species Zaire and Reston, as indicated by the release of the proinflammatory cytokines interleukin-1β (IL-1β), tumor necrosis factor α, and IL-6 as well as the chemokines IL-8 and gro-α. Our data suggest that infected monocytes may play an important role in the spread of filoviruses and in the pathogenesis of filoviral hemorrhagic disease.

scholarly journals Markedly Elevated Levels of Interferon (IFN)‐σ, IFN‐α, Interleukin (IL)‐2, IL‐10, and Tumor Necrosis Factor‐α Associated with Fatal Ebola Virus Infection

1999 ◽  
Vol 179 (s1) ◽  
pp. S188-S191 ◽  
Author(s):  
Francois Villinger ◽  
Pierre E. Rollin ◽  
Sukhdev S. Brar ◽  
Nathaniel F. Chikkala ◽  
Jorn Winter ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Virus Infection ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Ebola Virus ◽  
Factor Α ◽  
Necrosis Factor ◽  
Ebola Virus Infection
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