scholarly journals In Vitro Evaluation of Calcium Phosphate Bone Cement Composite Hydrogel Beads of Cross-Linked Gelatin-Alginate with Gentamicin-Impregnated Porous Scaffold

2021 ◽  
Vol 14 (10) ◽  
pp. 1000
Author(s):  
Shih-Ming Liu ◽  
Wen-Cheng Chen ◽  
Chia-Ling Ko ◽  
Hsu-Ting Chang ◽  
Ya-Shun Chen ◽  
...  
Keyword(s):  
Compressive Strength ◽  
Antibacterial Activity ◽  
Calcium Phosphate ◽  
Bone Cement ◽  
Bone Defects ◽  
Composite Hydrogel ◽  
Hydrogel Beads ◽  
Hydrogel Composite ◽  
Calcium Phosphate Bone Cement ◽  
Hydrogel Composites

Calcium phosphate bone cement (CPC) is in the form of a paste, and its special advantage is that it can repair small and complex bone defects. In the case of open wounds, tissue debridement is necessary before tissue repair and the subsequent control of wound infection; therefore, CPC composite hydrogel beads containing antibiotics provide an excellent option to fill bone defects and deliver antibiotics locally for a long period. In this study, CPC was composited with the millimeter-sized spherical beads of cross-linked gelatin–alginate hydrogels at the different ratios of 0 (control), 12.5, 25, and 50 vol.%. The hydrogel was impregnated with gentamicin and characterized before compositing with CPC. The physicochemical properties, gentamicin release, antibacterial activity, biocompatibility, and mineralization of the CPC/hydrogel composites were characterized. The compressive strength of the CPC/hydrogel composites gradually decreased as the hydrogel content increased, and the compressive strength of composites containing gentamicin had the largest decrease. The working time and setting time of each group can be adjusted to 8 and 16 min, respectively, using a hardening solution to make the composite suitable for clinical use. The release of gentamicin before the hydrogel beads was composited with CPC varied greatly with immersion time. However, a stable controlled release effect was obtained in the CPC/gentamicin-impregnated hydrogel composite. The 50 vol.% hydrogel/CPC composite had the best antibacterial effect and no cytotoxicity but had reduced cell mineralization. Therefore, the optimal hydrogel beads content can be 25 vol.% to obtain a CPC/gentamicin-impregnated hydrogel composite with adequate strength, antibacterial activity, and bio-reactivity. This CPC/hydrogel containing gentamicin is expected to be used in clinical surgery in the future to accelerate bone regeneration and prevent prosthesis infection after surgery.

scholarly journals Preliminary in Vivo Evaluation of Bone Healing in Critical Size Bone Defects Implanted with an Injectable Calcium Phosphate Bone Cement (Osteopaste)

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Che Nor Zarida Che Seman ◽  
Zamzuri Zakaria ◽  
Zunariah Buyong ◽  
Mohd Shukrimi Awang ◽  
Ahmad Razali Md Ralib @ Md Raghib
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Bone Tissue ◽  
Bone Repair ◽  
Critical Size ◽  
Healing Process ◽  
Bone Defects ◽  
Calcium Phosphate Bone Cement ◽  
Rabbit Tibia

Introduction: A novel injectable calcium phosphate bone cement (osteopaste) has been developed. Its potential application in orthopaedics as a filler of bone defects has been studied. The biomaterial was composed of tetra-calcium phosphate (TTCP) and tricalcium phosphate (TCP) powder. The aim of the present study was to evaluate the healing process of osteopaste in rabbit tibia. Materials and method: The implantation procedure was carried out on thirty-nine of New Zealand white rabbits. The in vivo bone formation was investigated by either implanting the Osteopaste, Jectos or MIIG – X3 into a critical size defect (CSD) model in the proximal tibial metaphysis. CSD without treatment served as negative control. After 1 day, 6 and 12 weeks, the rabbits were euthanized, the bone were harvested and subjected for analysis. Results: Radiological images and histological sections revealed integration of implants with bone tissue with no signs of graft rejection. There was direct contact between osteopaste material and host bone. The new bone was seen bridging the defect. Conclusion: The result showed that Osteopaste could be a new promising biomaterial for bone repair and has a potential in bone tissue engineering.

Physicochemical and Mechanical Properties of Composite of Chitosan Microspheres/Calcium Phosphate Cement

2007 ◽  
Vol 336-338 ◽  
pp. 1654-1657
Author(s):  
Rui Liu ◽  
Li Min Dong ◽  
Qing Feng Zan ◽  
Chen Wang ◽  
Jie Mo Tian
Keyword(s):  
Mechanical Properties ◽  
Compressive Strength ◽  
Calcium Phosphate ◽  
Bone Cement ◽  
Setting Time ◽  
Chemical Properties ◽  
Phase Evolution ◽  
Chitosan Microspheres ◽  
Setting Times ◽  
Calcium Phosphate Bone Cement

The aim of this work is to improve the mechanical properties of calcium phosphate bone cement (CPC) by appending chitosan microspheres to CPC base. That chitosan degrades rapidly than bone cement has been proved by previous investigations. Porous CPC has low compressive strength because of the pores in it weakening the structure. Additive chitosan microspheres can improve the mechanical properties by bearing the compress with the CPC base and produce pores after degradation. This study investigates the effect of chitosan microspheres on the setting time, mechanical properties, phase evolution and morphology of CPC. The additive proportion of chitosan microspheres ranges from 0 wt% to 30 wt%. Compared with original CPC, the modified CPC has higher compressive strength, without significantly affecting the chemical properties. The phase composition of the CPC is tested by XRD. The microstructures of CPC are observed using SEM. The final setting times range from 5~15 minutes and can be modulated by using different liquid and powder (L/P) ratio.

scholarly journals In Vivo Study of Tricomponent Resorbable Calcium Phosphate Bone Cement Based on Tricalcium Phosphate

2014 ◽  
pp. 72-77
Author(s):  
National Research Mamonov ◽  
National Research Chemis ◽  
National Research Drize ◽  
National Research Proskurina ◽  
I. I. Kryazhkov ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Tricalcium Phosphate ◽  
Bone Defects ◽  
Morphologic Study ◽  
Hemostatic Effect ◽  
Calcium Phosphate Bone Cement ◽  
Intertrabecular Space ◽  
Peripheral Bone

Results of experimental morphologic study of tricomponent resorbable calcium phosphate bone cement (CPhC), based on tricalcium phosphate for the filling of defect as a temporary bearing resorbable matrix are presented. Study was performed on soviet chinchilla rabbits weighting 3200-3500 g. The model of critical spongy bone defect was used. At different observation terms (6, 9 and 12 months) gradual substitution of biomaterial with newly formed bone tissue from periphery to the center was observed with complete cement resorption 12 months after surgery. By mechanic characteristics newly formed bone in the defect was stronger than the surrounding trabecular one. It was stated that material possessed hemostatic effect and moderate toxicity. Peripheral bone marrow maintained its cellularity at all terms, gradually filling intertrabecular space of newly formed bone. Achieved data enable to recommend wide used of CPhC for bone defects substitution.

scholarly journals In Vivo Study of Tricomponent Resorbable Calcium Phosphate Bone Cement Based on Tricalcium Phosphate

2014 ◽  
Vol 21 (1) ◽  
pp. 72-77
Author(s):  
National Research Center for Hematology, Moscow, RF Mamonov ◽  
National Research Center for Hematology, Moscow, RF Chemis ◽  
National Research Center for Hematology, Moscow, RF Drize ◽  
National Research Center for Hematology, Moscow, RF Proskurina ◽  
I. I Kryazhkov ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Tricalcium Phosphate ◽  
Bone Defects ◽  
Morphologic Study ◽  
Hemostatic Effect ◽  
Calcium Phosphate Bone Cement ◽  
Intertrabecular Space ◽  
Peripheral Bone

Results of experimental morphologic study of tricomponent resorbable calcium phosphate bone cement (CPhC), based on tricalcium phosphate for the filling of defect as a temporary bearing resorbable matrix are presented. Study was performed on soviet chinchilla rabbits weighting 3200-3500 g. The model of critical spongy bone defect was used. At different observation terms (6, 9 and 12 months) gradual substitution of biomaterial with newly formed bone tissue from periphery to the center was observed with complete cement resorption 12 months after surgery. By mechanic characteristics newly formed bone in the defect was stronger than the surrounding trabecular one. It was stated that material possessed hemostatic effect and moderate toxicity. Peripheral bone marrow maintained its cellularity at all terms, gradually filling intertrabecular space of newly formed bone. Achieved data enable to recommend wide used of CPhC for bone defects substitution.

Calcium phosphate bone cement with enhanced physicochemical properties via in situ forming an interpenetrating network

2021 ◽  
Author(s):  
Luguang Ding ◽  
Huan Wang ◽  
Weidong Zhang ◽  
Jiaying Li ◽  
Dachuan Liu ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Physicochemical Properties ◽  
Bone Cement ◽  
Calcium Phosphate Cement ◽  
Bone Defects ◽  
Interpenetrating Network ◽  
In Situ Forming ◽  
Calcium Phosphate Bone Cement

Calcium phosphate cement (CPC), which exhibits excellent biocompatibility and bioactivity, is a well-established material for the repair of bone defects. However, its weakness such as poor washout resistance and low...

Preliminary Studies in Composite Scaffolds of Calcium Phosphate Bone Cement with Polylactide

2012 ◽  
Vol 184-185 ◽  
pp. 1098-1101 ◽  
Author(s):  
Ching Wen Lou ◽  
Cheng Chun Huang ◽  
Wen Cheng Chen ◽  
Jin Jia Hu ◽  
Chao Tsang Lu ◽  
...  
Keyword(s):  
Compressive Strength ◽  
Calcium Phosphate ◽  
Bone Cement ◽  
Ceramic Material ◽  
Experimental Result ◽  
Fiber Distribution ◽  
Composite Scaffolds ◽  
Calcium Phosphate Bone Cement

Calcium phosphate bone cement (CPC), a ceramic material, is commonly used as a biomaterial for the restoration of bone injuries. This study creates the composite scaffolds by mixing CPC with various amounts of polylactide fibers. Then, the resulting scaffolds are observed and tested in terms of the morphology, compressive strength, and fiber distribution, respectively, to explore the influence of the addition of polylactide fibers on the scaffolds. According to the experimental result, the compressive strength of the scaffolds increases as a result of an increase in the addition of fibers.

Phosphoserine – a convenient compound for modification of calcium phosphate bone cement collagen composites

2004 ◽  
Vol 15 (4) ◽  
pp. 451-455 ◽  
Author(s):  
A. Reinstorf ◽  
M. Ruhnow ◽  
M. Gelinsky ◽  
W. Pompe ◽  
U. Hempel ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Calcium Phosphate Bone Cement
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