scholarly journals New Prospects in Neutering Male Animals Using Magnetic Nanoparticle Hyperthermia

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1465
Author(s):  
José Luiz P. R. Jivago ◽  
Juliana Lis Mendes Brito ◽  
Gustavo Capistrano ◽  
Marcus Vinícius-Araújo ◽  
Ediron Lima Verde ◽  
...  

Controlling populations of free-roaming dogs and cats poses a huge challenge worldwide. Non-surgical neutering strategies for male animals have been long pursued, but the implementation of the procedures developed has remained limited to date. As submitting the testes to high temperatures impairs spermatogenesis, the present study investigated localized application of magnetic nanoparticle hyperthermia (MNH) to the testicles as a potential non-surgical sterilization method for animals. An intratesticular injection of a magnetic fluid composed of manganese-ferrite nanoparticles functionalized with citrate was administered followed by testicle exposure to an alternate magnetic field to generate localized heat. Testicular MNH was highly effective, causing progressive seminiferous tubule degeneration followed by substitution of the parenchyma with stromal tissue and gonadal atrophy, suggesting an irreversible process with few side effects to general animal health.

2021 ◽  
pp. 2101019
Author(s):  
Sandra Díez‐Villares ◽  
Miguel A. Ramos‐Docampo ◽  
Andrés da Silva‐Candal ◽  
Pablo Hervella ◽  
Abi J. Vázquez‐Ríos ◽  
...  

2018 ◽  
Vol 1154 ◽  
pp. 524-534 ◽  
Author(s):  
Sergio Martinez–Vargas ◽  
Arturo I. Martínez ◽  
Elias E. Hernández–Beteta ◽  
Oscar F. Mijangos–Ricardez ◽  
Virgilio Vázquez–Hipólito ◽  
...  

Sensors ◽  
2021 ◽  
Vol 21 (16) ◽  
pp. 5545 ◽  
Author(s):  
Izaz Raouf ◽  
Piotr Gas ◽  
Heung Soo Kim

Recently, in-vitro studies of magnetic nanoparticle (MNP) hyperthermia have attracted significant attention because of the severity of this cancer therapy for in-vivo culture. Accurate temperature evaluation is one of the key challenges of MNP hyperthermia. Hence, numerical studies play a crucial role in evaluating the thermal behavior of ferrofluids. As a result, the optimum therapeutic conditions can be achieved. The presented research work aims to develop a comprehensive numerical model that directly correlates the MNP hyperthermia parameters to the thermal response of the in-vitro model using optimization through linear response theory (LRT). For that purpose, the ferrofluid solution is evaluated based on various parameters, and the temperature distribution of the system is estimated in space and time. Consequently, the optimum conditions for the ferrofluid preparation are estimated based on experimental and mathematical findings. The reliability of the presented model is evaluated via the correlation analysis between magnetic and calorimetric methods for the specific loss power (SLP) and intrinsic loss power (ILP) calculations. Besides, the presented numerical model is verified with our experimental setup. In summary, the proposed model offers a novel approach to investigate the thermal diffusion of a non-adiabatic ferrofluid sample intended for MNP hyperthermia in cancer treatment.


2020 ◽  
Vol 11 ◽  
pp. 1891-1904
Author(s):  
Saja Al-Khabouri ◽  
Salim Al-Harthi ◽  
Toru Maekawa ◽  
Mohamed E Elzain ◽  
Ashraf Al-Hinai ◽  
...  

Free and partially encapsulated manganese ferrite (MnFe2O4) nanoparticles are synthesized and characterized regarding structure, surface, and electronic and magnetic properties. The preparation method of partially encapsulated manganese ferrite enables the formation of a hybrid nanoparticle/tube system, which exhibits properties of manganese ferrite nanoparticles inside and attached to the external surface of the tubes. The effect of having manganese ferrite nanoparticles inside the tubes is observed as a shift in the X-ray diffraction peaks and as an increase in stress, hyperfine field, and coercivity when compared to free manganese ferrite nanoparticles. On the other hand, a strong charge transfer from the multiwall carbon nanotubes is attributed to the attachment of manganese ferrite nanoparticles outside the tubes, which is detected by a significant decrease in the σ band emission of the ultraviolet photoemission spectroscopy signal. This is followed by an increase in the density of states at the Fermi level of the attached manganese ferrite nanoparticles in comparison to free manganese ferrite nanoparticles, which leads to an enhancement of the metallic properties.


Sign in / Sign up

Export Citation Format

Share Document