scholarly journals Electrospun Silver Nanoparticles-Embedded Feather Keratin/Poly(vinyl alcohol)/Poly(ethylene oxide) Antibacterial Composite Nanofibers

Polymers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 305 ◽  
Author(s):  
Ming He ◽  
Man Chen ◽  
Yao Dou ◽  
Jiao Ding ◽  
Hangbo Yue ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Ethylene Oxide ◽  
Vinyl Alcohol ◽  
Composite Nanofibers ◽  
Poly Vinyl Alcohol ◽  
Feather Keratin ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Feathers, which contain >90% keratin, are valuable natural protein resources. The aim of this study is to prepare antimicrobial feather keratin (FK)-based nanofibers by incorporating silver nanoparticles (AgNPs). A series of AgNPs-embedded feather keratin/poly(vinyl alcohol)/poly(ethylene oxide) (FK/PVA/PEO) composite nanofibers with varying amounts of AgNPs content were fabricated by electrospinning. Their morphology, crystallinity, thermal stability, tensile property, and antibacterial activity were systematically investigated. The average diameters of composite nanofibers gradually decreased with increases in the amount of AgNPs. The crystallinity, thermal stability, and antibacterial activity of FK/PVA/PEO nanofibers were enhanced by embedding AgNPs. When embedded with 1.2% AgNPs, both the tensile strength and elongation-at-break reached the highest level. This work has the potential to expand the application of FK-based nanofibers in the biomaterial field.

Miscible blends of poly(ethylene oxide) with brush copolymers of poly(vinyl alcohol)-graft -poly(l -lactide)

2016 ◽  
Vol 54 (13) ◽  
pp. 1217-1226 ◽  
Author(s):  
Ainhoa Lejardi ◽  
Jose-Ramon Sarasua ◽  
Agustin Etxeberria ◽  
Emilio Meaurio
Keyword(s):  
Ethylene Oxide ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
Miscible Blends ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Fabrication of electrospun poly(ethylene oxide)–poly(capro lactone) composite nanofibers for co-delivery of niclosamide and silver nanoparticles exhibits enhanced anti-cancer effects in vitro

2016 ◽  
Vol 4 (4) ◽  
pp. 726-742 ◽  
Author(s):  
Poornima Dubey ◽  
P. Gopinath
Keyword(s):  
Silver Nanoparticles ◽  
Ethylene Oxide ◽  
Anticancer Drugs ◽  
Composite Nanofibers ◽  
Water Solubility ◽  
Intrinsic Property ◽  
Anti Cancer ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

An intrinsic property of many anticancer drugs including niclosamide is poor water solubility, which hindered their translation from laboratory to clinics.

scholarly journals Enhancement in the antibacterial activity of cephalexin by its delivery through star-shaped poly(ε-caprolactone)-block-poly(ethylene oxide) coated silver nanoparticles

2020 ◽  
Vol 7 (10) ◽  
pp. 201097
Author(s):  
Sana Rahim ◽  
Samina Perveen ◽  
Shakil Ahmed ◽  
Muhammad Raza Shah ◽  
Muhammad Imran Malik
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Ethylene Oxide ◽  
Inhibitory Concentration ◽  
Bacterial Cells ◽  
Force Microscopy ◽  
Atomic Force ◽  
Biofilm Destruction ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

The antibacterial activity of silver nanoparticles (AgNPs) stabilized with a four-armed star-shaped poly(ε-caprolactone)-block-poly(ethylene oxide) copolymer [St-P(CL-b-EO)] and its application as a drug delivery vehicle for cephalexin (Cp) was evaluated against pathogenic Staphylococcus aureus . The prepared AgNPs were characterized by ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, zeta sizer and atomic force microscopy (AFM). The antibacterial efficiency of Cp is enhanced several-fold by its delivery through complexation with St-P(CL-b-EO)-AgNPs, monitored by microplate assay and biofilm destruction studies. Finally, the visual destruction of bacterial cells and its biofilms by employing Cp and its conjugates at their minimum inhibitory concentration (MIC 50 ) and minimum biofilm inhibitory concentration (MBIC 50 ), respectively, is observed by topographic imaging by AFM. Enhanced antibacterial activity of St-P(CL-b-EO)-AgNPs loaded Cp is attributed to penetrative nature of the drug cargo St-P(CL-b-EO)-AgNPs towards the bacterial cell wall.

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