scholarly journals Hydrogel-Based Colloidal Photonic Crystal Devices for Glucose Sensing

Polymers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 625 ◽  
Author(s):  
Wenwei Tang ◽  
Cheng Chen

Diabetes, a common epidemic disease, is increasingly hazardous to human health. Monitoring body glucose concentrations for the prevention and therapy of diabetes has become very important. Hydrogel-based responsive photonic crystal (PC) materials are noninvasive options for glucose detection. This article reviews glucose-sensing materials/devices composed of hydrogels and colloidal photonic crystals (CPCs), including the construction of 2D/3D CPCs and 2D/3D hydrogel-based CPCs (HCPCs). The development and mechanisms of glucose-responsive hydrogels and the achieved technologies of HCPC glucose sensors were also concluded. This review concludes by showing a perspective for the future design of CPC glucose biosensors with functional hydrogels.

2021 ◽  
Vol 9 ◽  
Author(s):  
Gowhar A. Naikoo ◽  
Hiba Salim ◽  
Israr U. Hassan ◽  
Tasbiha Awan ◽  
Fareeha Arshad ◽  
...  

There is an undeniable growing number of diabetes cases worldwide that have received widespread global attention by many pharmaceutical and clinical industries to develop better functioning glucose sensing devices. This has called for an unprecedented demand to develop highly efficient, stable, selective, and sensitive non-enzymatic glucose sensors (NEGS). Interestingly, many novel materials have shown the promising potential of directly detecting glucose in the blood and fluids. This review exclusively encompasses the electrochemical detection of glucose and its mechanism based on various metal-based materials such as cobalt (Co), nickel (Ni), zinc (Zn), copper (Cu), iron (Fe), manganese (Mn), titanium (Ti), iridium (Ir), and rhodium (Rh). Multiple aspects of these metals and their oxides were explored vis-à-vis their performance in glucose detection. The direct glucose oxidation via metallic redox centres is explained by the chemisorption model and the incipient hydrous oxide/adatom mediator (IHOAM) model. The glucose electrooxidation reactions on the electrode surface were elucidated by equations. Furthermore, it was explored that an effective detection of glucose depends on the aspect ratio, surface morphology, active sites, structures, and catalytic activity of nanomaterials, which plays an indispensable role in designing efficient NEGS. The challenges and possible solutions for advancing NEGS have been summarized.


Nanoscale ◽  
2019 ◽  
Vol 11 (24) ◽  
pp. 11856-11863 ◽  
Author(s):  
Wangdong Lu ◽  
Muqiang Jian ◽  
Qi Wang ◽  
Kailun Xia ◽  
Mingchao Zhang ◽  
...  

Flexible enzymatic glucose sensors have been investigated extensively for health monitoring systems.


2020 ◽  
Vol 13 (05) ◽  
pp. 2050022 ◽  
Author(s):  
Junli Chen ◽  
Haoyong Yin ◽  
Shumin Zhao ◽  
Jianying Gong ◽  
Zhenguo Ji ◽  
...  

The Ni-metal-organic frameworks microspheres (Ni-BTC) were prepared and used directly to construct non-enzymatic glucose sensors. The Ni-BTC sensors displayed much higher glucose sensing performance than that of Ni-MOFs derived NiO, which showed wide detection regions of 5–3000[Formula: see text][Formula: see text]M and 3500–6000[Formula: see text][Formula: see text]M with the sensitivity of 932.68[Formula: see text][Formula: see text]A[Formula: see text]mM[Formula: see text]cm[Formula: see text] and 273.04[Formula: see text][Formula: see text]A[Formula: see text]mM[Formula: see text]cm[Formula: see text], respectively. Moreover, it also displayed good selectivity and favorable sensing feasibility for serum analysis. The high performance of the non-enzymatic glucose detection on Ni-BTC may be due to the highly efficient charge transfers during the electrocatalytic glucose oxidation process.


Sensors ◽  
2021 ◽  
Vol 21 (14) ◽  
pp. 4672
Author(s):  
Mohamed H. Hassan ◽  
Cian Vyas ◽  
Bruce Grieve ◽  
Paulo Bartolo

The detection of glucose is crucial in the management of diabetes and other medical conditions but also crucial in a wide range of industries such as food and beverages. The development of glucose sensors in the past century has allowed diabetic patients to effectively manage their disease and has saved lives. First-generation glucose sensors have considerable limitations in sensitivity and selectivity which has spurred the development of more advanced approaches for both the medical and industrial sectors. The wide range of application areas has resulted in a range of materials and fabrication techniques to produce novel glucose sensors that have higher sensitivity and selectivity, lower cost, and are simpler to use. A major focus has been on the development of enzymatic electrochemical sensors, typically using glucose oxidase. However, non-enzymatic approaches using direct electrochemistry of glucose on noble metals are now a viable approach in glucose biosensor design. This review discusses the mechanisms of electrochemical glucose sensing with a focus on the different generations of enzymatic-based sensors, their recent advances, and provides an overview of the next generation of non-enzymatic sensors. Advancements in manufacturing techniques and materials are key in propelling the field of glucose sensing, however, significant limitations remain which are highlighted in this review and requires addressing to obtain a more stable, sensitive, selective, cost efficient, and real-time glucose sensor.


2013 ◽  
Vol 48 ◽  
pp. 94-99 ◽  
Author(s):  
Yumei Hu ◽  
Xiaomei Jiang ◽  
Laiying Zhang ◽  
Jiao Fan ◽  
Weitai Wu

2006 ◽  
Vol 78 (14) ◽  
pp. 5149-5157 ◽  
Author(s):  
Matti Ben-Moshe ◽  
Vladimir L. Alexeev ◽  
Sanford A. Asher

2003 ◽  
Vol 75 (10) ◽  
pp. 2316-2323 ◽  
Author(s):  
Vladimir L. Alexeev ◽  
Anjal C. Sharma ◽  
Alexander V. Goponenko ◽  
Sasmita Das ◽  
Igor K. Lednev ◽  
...  

Sensors ◽  
2019 ◽  
Vol 19 (13) ◽  
pp. 2979 ◽  
Author(s):  
Naiyuan Cui ◽  
Pei Guo ◽  
Qilong Yuan ◽  
Chen Ye ◽  
Mingyang Yang ◽  
...  

The development of accurate, reliable devices for glucose detection has drawn much attention from the scientific community over the past few years. Here, we report a single-step method to fabricate Ni nanoparticle-modified graphene–diamond hybrid electrodes via a catalytic thermal treatment, by which the graphene layers are directly grown on the diamond surface using Ni thin film as a catalyst, meanwhile, Ni nanoparticles are formed in situ on the graphene surface due to dewetting behavior. The good interface between the Ni nanoparticles and the graphene guarantees efficient charge transfer during electrochemical detection. The fabricated electrodes exhibit good glucose sensing performance with a low detection limit of 2 μM and a linear detection range between 2 μM–1 mM. In addition, this sensor shows great selectivity, suggesting potential applications for sensitive and accurate monitoring of glucose in human blood.


NANO ◽  
2019 ◽  
Vol 14 (04) ◽  
pp. 1950045
Author(s):  
Fang Sun ◽  
Lehong Xing ◽  
Xihui Yang ◽  
Hailiang Huang ◽  
Lina Ning

In this study, CuO films with hollow cubic cages were prepared by a facile two-step procedure consisting of electrodeposition synthesis and subsequent direct calcination. First, Cu2O nanocubes were fabricated on ITO substrate through a simple electrodeposition procedure. Then, Cu2O nanocubes were converted to CuO hollow cubic cages without obvious morphological change through direct calcination. The obtained CuO cubic cages serving as active materials illustrated a favorable performance for nonenzymatic glucose sensing with high sensitivity of [Formula: see text]A[Formula: see text]mM[Formula: see text][Formula: see text]cm[Formula: see text] at a low applied potential of 0.50[Formula: see text]V, fast-response time (less than 3[Formula: see text]s), low detection limit of 1.0[Formula: see text][Formula: see text]M and wide linear range up from 2.0[Formula: see text][Formula: see text]M to 1.0[Formula: see text]mM ([Formula: see text]). Moreover, the good selectivity of the CuO cubic cages-based nonenzymatic glucose sensor against electroactive compounds such as ascorbic acid, uric acid and dopamine were also demonstrated. These good features indicate that the as-prepared CuO cubic cages can be used as promising electrode materials, which have a great potential in the development of sensitive and selective nonenzymatic glucose sensors.


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