scholarly journals Recent Advances in Non-Enzymatic Glucose Sensors Based on Metal and Metal Oxide Nanostructures for Diabetes Management- A Review

2021 ◽  
Vol 9 ◽  
Author(s):  
Gowhar A. Naikoo ◽  
Hiba Salim ◽  
Israr U. Hassan ◽  
Tasbiha Awan ◽  
Fareeha Arshad ◽  
...  
Keyword(s):  
Active Sites ◽  
Glucose Oxidation ◽  
Diabetes Management ◽  
Glucose Sensing ◽  
Glucose Sensors ◽  
Glucose Detection ◽  
Hydrous Oxide ◽  
Oxide Nanostructures ◽  
Metal Oxide Nanostructures ◽  
Glucose Electrooxidation

There is an undeniable growing number of diabetes cases worldwide that have received widespread global attention by many pharmaceutical and clinical industries to develop better functioning glucose sensing devices. This has called for an unprecedented demand to develop highly efficient, stable, selective, and sensitive non-enzymatic glucose sensors (NEGS). Interestingly, many novel materials have shown the promising potential of directly detecting glucose in the blood and fluids. This review exclusively encompasses the electrochemical detection of glucose and its mechanism based on various metal-based materials such as cobalt (Co), nickel (Ni), zinc (Zn), copper (Cu), iron (Fe), manganese (Mn), titanium (Ti), iridium (Ir), and rhodium (Rh). Multiple aspects of these metals and their oxides were explored vis-à-vis their performance in glucose detection. The direct glucose oxidation via metallic redox centres is explained by the chemisorption model and the incipient hydrous oxide/adatom mediator (IHOAM) model. The glucose electrooxidation reactions on the electrode surface were elucidated by equations. Furthermore, it was explored that an effective detection of glucose depends on the aspect ratio, surface morphology, active sites, structures, and catalytic activity of nanomaterials, which plays an indispensable role in designing efficient NEGS. The challenges and possible solutions for advancing NEGS have been summarized.

Advances in Noninvasive Glucose Sensing Enabled by Photonics, Acoustics, and Microwaves

2018 ◽  
Vol 12 (1) ◽  
pp. 64-72
Author(s):  
Takuro Tajima ◽  
◽  
Masahito Nakamura ◽  
Yujiro Tanaka ◽  
Michiko Seyama
Keyword(s):  
Near Infrared ◽  
Diabetes Management ◽  
Glucose Sensing ◽  
Glucose Sensors ◽  
Optical Absorption Spectroscopy ◽  
High Quality ◽  
Broadband Dielectric Spectroscopy ◽  
Initial Clinical Trial ◽  
Infrared Photoacoustic Spectroscopy ◽  
Increasing Demand

More than two decades have passed since the initial clinical trial of noninvasive glucose sensing using optical absorption spectroscopy. Today, noninvasive sensing technologies are expected to meet the increasing demand for high-quality diabetes management. Here, we review the latest advances in noninvasive glucose sensing research, focusing on how photonics-, acoustic- and electronics-based sensing technologies have played key roles in the development of the first noninvasive glucose sensors. We also present our recent work on multiphysics-based glucose sensing using near-infrared photoacoustic spectroscopy and broadband dielectric spectroscopy and a comparison with other competitive technologies.

Probing the shape-specific electrochemical properties of cobalt oxide nanostructures for their application as selective and sensitive non-enzymatic glucose sensors

2017 ◽  
Vol 5 (26) ◽  
pp. 6497-6505 ◽  
Author(s):  
Shrabani Mondal ◽  
Rashmi Madhuri ◽  
Prashant K. Sharma
Keyword(s):  
Electrochemical Properties ◽  
Cobalt Oxide ◽  
Glucose Sensing ◽  
Glucose Sensors ◽  
Oxide Nanostructures

Shape-specific electrochemical properties of cobalt oxide nanostructures along with selective and sensitive non-enzymatic glucose sensing.

Construction of highly efficient non-enzymatic glucose sensors based on micro-spherical Ni-metal-organic frameworks

2020 ◽  
Vol 13 (05) ◽  
pp. 2050022 ◽  
Author(s):  
Junli Chen ◽  
Haoyong Yin ◽  
Shumin Zhao ◽  
Jianying Gong ◽  
Zhenguo Ji ◽  
...  
Keyword(s):  
High Performance ◽  
Oxidation Process ◽  
Metal Organic Frameworks ◽  
Glucose Sensing ◽  
Glucose Sensors ◽  
Serum Analysis ◽  
Glucose Detection ◽  
Highly Efficient ◽  
Efficient Charge ◽  
Metal Organic

The Ni-metal-organic frameworks microspheres (Ni-BTC) were prepared and used directly to construct non-enzymatic glucose sensors. The Ni-BTC sensors displayed much higher glucose sensing performance than that of Ni-MOFs derived NiO, which showed wide detection regions of 5–3000[Formula: see text][Formula: see text]M and 3500–6000[Formula: see text][Formula: see text]M with the sensitivity of 932.68[Formula: see text][Formula: see text]A[Formula: see text]mM[Formula: see text]cm[Formula: see text] and 273.04[Formula: see text][Formula: see text]A[Formula: see text]mM[Formula: see text]cm[Formula: see text], respectively. Moreover, it also displayed good selectivity and favorable sensing feasibility for serum analysis. The high performance of the non-enzymatic glucose detection on Ni-BTC may be due to the highly efficient charge transfers during the electrocatalytic glucose oxidation process.

scholarly journals Development of Glucose Meter Using Boric Acid-Modified Carbon Dots as Fluorescent Probe

2021 ◽  
Vol 13 (3) ◽  
pp. 49
Author(s):  
Akhiruddin Maddu ◽  
Sejahtera Ahmad ◽  
Tony Sumaryada
Keyword(s):  
Boric Acid ◽  
Glucose Concentration ◽  
Boronic Acid ◽  
Carbon Dots ◽  
Diabetes Management ◽  
Fluorescence Probe ◽  
Fluorescence Emission ◽  
Glucose Sensing ◽  
Glucose Sensors ◽  
Glucose Meter

A glucose meter has been developed utilizing boric acid-modified carbon dots as a fluorescence probe. Boric acid-modified carbon dots produces varying fluorescence emission with varying glucose concentration in water. Boric acid-modified carbon dots mixed with glucose addition was excited by a violet laser (405 nm), then the emission intensity was detected by a photodetector to be converted to an electrical signal that as an input signal for a microcontroller for glucose concentration measurement. The output voltage of the glucose meter is corresponding to the fluorescence emission measured by using a spectrofluorometer with glucose concentration in the boric acid-modified carbon dots. Full Text: PDF ReferencesH. Teymourian, A. Barfidokht, J. Wang, "Electrochemical glucose sensors in diabetes management: an updated review (2010–2020)", Chem. Soc. Rev. 49, 7671 (2020). CrossRef D.C. Klonoff, "Overview of Fluorescence Glucose Sensing: A Technology with a Bright Future", J Diabetes Sci. Technol. 6(6), 1242 (2012). CrossRef J.C. Pickup, F. Hussain, N.D. Evans, O.J. Rolinski, David J.S. Birch, "Fluorescence-based glucose sensors", Biosens. Bioelectron. 20, 2555 (2005). CrossRef H. Fang, G. Kaur, B. Wang, "Progress in Boronic Acid-Based Fluorescent Glucose Sensors", J. Fluoresc. 14(5), 481 (2004). CrossRef T. Kawanishi, M.A. Romey, P.C. Zhu, M.Z. Holody, S. Shinkai, "A Study of Boronic Acid Based Fluorescent Glucose Sensors", J. Fluoresc. 14(5), 499 (2004). CrossRef A.S. Krishna, P.A. Nair, C. Radhakumary, K. Sreenivasan, "Carbon dot based non enzymatic approach for the detection and estimation of glucose in blood serum", Mater. Res. Express 3(1), 055001 (2016). CrossRef G.P.C. Mello, E.F.C. Simões, D.M.A. Crista, J.M.M. Leitão, L. Pinto da Silva, J.C.G. Esteves da Silva, "Glucose Sensing by Fluorescent Nanomaterials", Crit. Rev. Anal. Chem. 49(6), 542 (2019). CrossRef X. Shan, L. Chai, J. Ma, Z. Qian, J. Chen, H. Feng, "B-doped carbon quantum dots as a sensitive fluorescence probe for hydrogen peroxide and glucose detection", Analyst 139, 2322 (2014). CrossRef J. Dong, S. Li, H. Wang, Q. Meng, L. Fan, H. Xie, C. Cao, W. Zhang, "Simple Boric Acid-Based Fluorescent Focusing for Sensing of Glucose and Glycoprotein via Multipath Moving Supramolecular Boundary Electrophoresis Chip", Anal. Chem. 85(12), 5884 (2013). CrossRef Y. Cui, F. Chen, X-B. Yin, "A ratiometric fluorescence platform based on boric-acid-functional Eu-MOF for sensitive detection of H2O2 and glucose", Biosens. Bioelectron. 135, 208 (2019). CrossRef

scholarly journals Performance-Enhanced Non-Enzymatic Glucose Sensor Based on Graphene-Heterostructure

Sensors ◽  
2019 ◽  
Vol 20 (1) ◽  
pp. 145 ◽  
Author(s):  
Mahmoud A. Sakr ◽  
Karim Elgammal ◽  
Anna Delin ◽  
Mohamed Serry
Keyword(s):  
Film Thickness ◽  
Layer Thickness ◽  
Active Sites ◽  
Glucose Oxidation ◽  
Glucose Sensor ◽  
Schottky Diodes ◽  
Glucose Monitoring ◽  
Platinum Oxide ◽  
Glucose Sensing ◽  
Market Demand

Non-enzymatic glucose sensing is a crucial field of study because of the current market demand. This study proposes a novel design of glucose sensor with enhanced selectivity and sensitivity by using graphene Schottky diodes, which is composed of graphene (G)/platinum oxide (PtO)/n-silicon (Si) heterostructure. The sensor was tested with different glucose concentrations and interfering solutions to investigate its sensitivity and selectivity. Different structures of the device were studied by adjusting the platinum oxide film thickness to investigate its catalytic activity. It was found that the film thickness plays a significant role in the efficiency of glucose oxidation and hence in overall device sensitivity. 0.8–2 μA output current was obtained in the case of 4–10 mM with a sensitivity of 0.2 μA/mM.cm2. Besides, results have shown that 0.8 μA and 15 μA were obtained by testing 4 mM glucose on two different PtO thicknesses, 30 nm and 50 nm, respectively. The sensitivity of the device was enhanced by 150% (i.e., up to 30 μA/mM.cm2) by increasing the PtO layer thickness. This was attributed to both the increase of the number of active sites for glucose oxidation as well as the increase in the graphene layer thickness, which leads to enhanced charge carriers concentration and mobility. Moreover, theoretical investigations were conducted using the density function theory (DFT) to understand the detection method and the origins of selectivity better. The working principle of the sensors puts it in a competitive position with other non-enzymatic glucose sensors. DFT calculations provided a qualitative explanation of the charge distribution across the graphene sheet within a system of a platinum substrate with D-glucose molecules above. The proposed G/PtO/n-Si heterostructure has proven to satisfy these factors, which opens the door for further developments of more reliable non-enzymatic glucometers for continuous glucose monitoring systems.

scholarly journals Hydrogel-Based Colloidal Photonic Crystal Devices for Glucose Sensing

Polymers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 625 ◽  
Author(s):  
Wenwei Tang ◽  
Cheng Chen
Keyword(s):  
Photonic Crystal ◽  
Health Monitoring ◽  
Glucose Sensing ◽  
Glucose Sensors ◽  
Glucose Detection ◽  
Epidemic Disease ◽  
Future Design ◽  
Colloidal Photonic Crystals ◽  
Responsive Hydrogels ◽  
Prevention And Therapy

Diabetes, a common epidemic disease, is increasingly hazardous to human health. Monitoring body glucose concentrations for the prevention and therapy of diabetes has become very important. Hydrogel-based responsive photonic crystal (PC) materials are noninvasive options for glucose detection. This article reviews glucose-sensing materials/devices composed of hydrogels and colloidal photonic crystals (CPCs), including the construction of 2D/3D CPCs and 2D/3D hydrogel-based CPCs (HCPCs). The development and mechanisms of glucose-responsive hydrogels and the achieved technologies of HCPC glucose sensors were also concluded. This review concludes by showing a perspective for the future design of CPC glucose biosensors with functional hydrogels.

Metal Oxide Nanostructures Chemistry

2019 ◽  
Author(s):  
Jean-Pierre Jolivet
Keyword(s):  
Particle Growth ◽  
General View ◽  
Ceramic Powders ◽  
Metal Hydroxides ◽  
Synthesis Conditions ◽  
Zirconium Oxides ◽  
Oxide Nanostructures ◽  
Metal Oxide Nanostructures ◽  
Ordered Aggregation ◽  
Size And Morphology

This much-anticipated new edition of Jolivet's work builds on the edition published in 2000. It is entirely updated, restructured and increased in content. The book focuses on the formation by techniques of green chemistry of oxide nanoparticles having a technological interest. Jolivet introduces the most recent concepts and modelings such as dynamics of particle growth, ordered aggregation, ionic and electronic interfacial transfers. A general view of the metal hydroxides, oxy-hydroxides and oxides through the periodic table is given, highlighting the influence of the synthesis conditions on crystalline structure, size and morphology of nanoparticles. The formation of aluminum, iron, titanium, manganese and zirconium oxides are specifically studied. These nanomaterials have a special interest in many technological fields such as ceramic powders, catalysis and photocatalysis, colored pigments, polymers, cosmetics and also in some biological or environmental phenomena.

scholarly journals Recent Advances in Enzymatic and Non-Enzymatic Electrochemical Glucose Sensing

Sensors ◽  
2021 ◽  
Vol 21 (14) ◽  
pp. 4672
Author(s):  
Mohamed H. Hassan ◽  
Cian Vyas ◽  
Bruce Grieve ◽  
Paulo Bartolo
Keyword(s):  
Noble Metals ◽  
Direct Electrochemistry ◽  
Glucose Sensing ◽  
Glucose Sensors ◽  
Diabetic Patients ◽  
Past Century ◽  
Industrial Sectors ◽  
Recent Advances ◽  
Wide Range ◽  
Sensitivity And Selectivity

The detection of glucose is crucial in the management of diabetes and other medical conditions but also crucial in a wide range of industries such as food and beverages. The development of glucose sensors in the past century has allowed diabetic patients to effectively manage their disease and has saved lives. First-generation glucose sensors have considerable limitations in sensitivity and selectivity which has spurred the development of more advanced approaches for both the medical and industrial sectors. The wide range of application areas has resulted in a range of materials and fabrication techniques to produce novel glucose sensors that have higher sensitivity and selectivity, lower cost, and are simpler to use. A major focus has been on the development of enzymatic electrochemical sensors, typically using glucose oxidase. However, non-enzymatic approaches using direct electrochemistry of glucose on noble metals are now a viable approach in glucose biosensor design. This review discusses the mechanisms of electrochemical glucose sensing with a focus on the different generations of enzymatic-based sensors, their recent advances, and provides an overview of the next generation of non-enzymatic sensors. Advancements in manufacturing techniques and materials are key in propelling the field of glucose sensing, however, significant limitations remain which are highlighted in this review and requires addressing to obtain a more stable, sensitive, selective, cost efficient, and real-time glucose sensor.

scholarly journals N, S and Transition-Metal Co-Doped Graphene Nanocomposites as High-Performance Catalyst for Glucose Oxidation in a Direct Glucose Alkaline Fuel Cell

Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 202
Author(s):  
Yexin Dai ◽  
Jie Ding ◽  
Jingyu Li ◽  
Yang Li ◽  
Yanping Zong ◽  
...  
Keyword(s):  
Fuel Cell ◽  
Active Sites ◽  
High Performance ◽  
Glucose Oxidation ◽  
Alkaline Fuel Cell ◽  
Blank Group ◽  
Graphene Nanocomposites ◽  
Doped Graphene ◽  
One Step ◽  
Hydrothermal Approach

In this work, reduced graphene oxide (rGO) nanocomposites doped with nitrogen (N), sulfur (S) and transitional metal (Ni, Co, Fe) were synthesized by using a simple one-step in-situ hydrothermal approach. Electrochemical characterization showed that rGO-NS-Ni was the most prominent catalyst for glucose oxidation. The current density of the direct glucose alkaline fuel cell (DGAFC) with rGO-NS-Ni as the anode catalyst reached 148.0 mA/cm2, which was 40.82% higher than the blank group. The DGAFC exhibited a maximum power density of 48 W/m2, which was more than 2.08 folds than that of blank group. The catalyst was further characterized by SEM, XPS and Raman. It was speculated that the boosted performance was due to the synergistic effect of N, S-doped rGO and the metallic redox couples, (Ni2+/Ni3+, Co2+/Co3+ and Fe2+/Fe3+), which created more active sites and accelerated electron transfer. This research can provide insights for the development of environmental benign catalysts and promote the application of the DGAFCs.

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