Cuprous Oxide Films with Hollow Cubic Cage Structure for Nonenzymatic Glucose Detection

In this study, CuO films with hollow cubic cages were prepared by a facile two-step procedure consisting of electrodeposition synthesis and subsequent direct calcination. First, Cu2O nanocubes were fabricated on ITO substrate through a simple electrodeposition procedure. Then, Cu2O nanocubes were converted to CuO hollow cubic cages without obvious morphological change through direct calcination. The obtained CuO cubic cages serving as active materials illustrated a favorable performance for nonenzymatic glucose sensing with high sensitivity of [Formula: see text]A[Formula: see text]mM[Formula: see text][Formula: see text]cm[Formula: see text] at a low applied potential of 0.50[Formula: see text]V, fast-response time (less than 3[Formula: see text]s), low detection limit of 1.0[Formula: see text][Formula: see text]M and wide linear range up from 2.0[Formula: see text][Formula: see text]M to 1.0[Formula: see text]mM ([Formula: see text]). Moreover, the good selectivity of the CuO cubic cages-based nonenzymatic glucose sensor against electroactive compounds such as ascorbic acid, uric acid and dopamine were also demonstrated. These good features indicate that the as-prepared CuO cubic cages can be used as promising electrode materials, which have a great potential in the development of sensitive and selective nonenzymatic glucose sensors.

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Direct Growth of Copper Oxide Films on Ti Substrate for Nonenzymatic Glucose Sensors

Journal of Nanomaterials ◽

10.1155/2014/287303 ◽

2014 ◽

Vol 2014 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Xiaoxu Ji ◽

Aihua Wang ◽

Qinghuai Zhao

Keyword(s):

Copper Oxide ◽

Glucose Sensor ◽

Low Cost ◽

High Sensitivity ◽

Fast Response ◽

Glucose Sensors ◽

Electrochemical Performances ◽

Nonenzymatic Glucose Sensor ◽

Long Term Stability ◽

Direct Growth

Copper oxide (CuO) films directly grown on Ti substrate have been successfully prepared via a hydrothermal method and used to construct an amperometric nonenzymatic glucose sensor. XRD and SEM were used to characterize the samples. The electrochemical performances of the electrode for detection of glucose were investigated by cyclic voltammetry and chronoamperometry. The CuO films based glucose sensors exhibit enhanced electrocatalytic properties which show very high sensitivity (726.9 μA mM−1 cm−2), low detection limit (2 μM), and fast response (2 s). In addition, reproducibility and long-term stability have been observed. Low cost, convenience, and biocompatibility make the CuO films directly grown on Ti substrate electrodes a promising platform for amperometric nonenzymatic glucose sensor.

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Ni Hierarchical Structures Supported on Titania Nanowire Arrays as Efficient Nonenzymatic Glucose Sensor

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2020.17144 ◽

2020 ◽

Vol 20 (5) ◽

pp. 3246-3251 ◽

Cited By ~ 1

Author(s):

Hai-Long Hu ◽

Chuan He ◽

Bao-Gang Guo ◽

He-Yan Huang ◽

Xing-Quan Zhang ◽

...

Keyword(s):

Glucose Sensor ◽

Low Cost ◽

Hierarchical Structures ◽

High Sensitivity ◽

Fast Response ◽

Nanowire Arrays ◽

Nonenzymatic Glucose Sensor ◽

Conductive Substrate ◽

Nano Sensors ◽

Oxidation Of Glucose

Developing new advanced nonenzymatic electrochemical nano-sensors for glucose detection has attracted intensive attraction. In this work, we designed a novel nanocomposite nonenzymatic glucose sensor by fabricating hierarchically nanostructured metal nickel on titania nanowire arrays, which was loaded on a transparent conductive substrate (i.e., fluorine-doped tin oxide, FTO) surface by mild hydrothermal method. Due to the large surface area of the hierarchically nanostructured Ni and fast electron transfer of the TiO2 nanowire arrays electrode, the nanocomposite electrode shows excellent electrochemical activity toward the oxidation of glucose. The electrode exhibits high sensitivity in detecting glucose concentration (1472 μA mM−1 cm−2) with a wide linear range from 2×10−4 M to 2×10−3 M, fast response time (within 5 s), and small detection limit (10 μM) (S/N = 3). The good analytical performance, low cost and simple preparation method make this novel electrode material promising for the development of effective glucose nonenzymatic glucose sensor.

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Graphene Nanostructures as Nonenzymatic Glucose Sensor

Materials Research Foundations - Toxic Gas Sensors and Biosensors ◽

10.21741/9781644901175-6 ◽

2021 ◽

pp. 157-196

Keyword(s):

Quantitative Analysis ◽

Detection Limit ◽

Glucose Sensor ◽

Electrochemical Sensors ◽

High Sensitivity ◽

Glucose Sensors ◽

Nonenzymatic Glucose Sensor ◽

Industrial Sectors ◽

Electrochemically Active ◽

Increasing Demand

The increasing demand for the development of highly selective and sensitive nonenzymatic electrochemical sensors for the qualitative and quantitative analysis of glucose in pharmaceutical, clinical and industrial sectors has gained enormous attention towards the use of graphene and its derivatives. This chapter describes the efficient development of electrochemically active nonenzymatic glucose sensors using graphene and its composites, achieving high sensitivity, stability, low detection limit, wide linear range and reproducibility.

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Templating synthesis of hollow CuO polyhedron and its application for nonenzymatic glucose detection

Journal of Materials Chemistry A ◽

10.1039/c4ta00703d ◽

2014 ◽

Vol 2 (20) ◽

pp. 7306-7312 ◽

Cited By ~ 69

Author(s):

Chuncai Kong ◽

Linli Tang ◽

Xiaozhe Zhang ◽

Shaodong Sun ◽

Shengchun Yang ◽

...

Keyword(s):

Detection Limit ◽

Modified Electrode ◽

Glucose Sensor ◽

High Sensitivity ◽

Fast Response ◽

Good Stability ◽

Glucose Detection ◽

Nonenzymatic Glucose Sensor ◽

Oxidation Of Glucose ◽

Templating Synthesis

In this paper, we successfully fabricated a novel type of a hollow CuO polyhedron that consists of numerous nanoplates using Cu2O as a template. The hollow CuO polyhedron-modified electrode exhibits high sensitivity, low detection limit, good stability and fast response towards the oxidation of glucose, suggesting it to be a promising nonenzymatic glucose sensor.

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One-step synthesis of novel Cu@polymer nanocomposites through a self-activated route and their application as nonenzymatic glucose sensors

Dalton Transactions ◽

10.1039/c7dt01931a ◽

2017 ◽

Vol 46 (30) ◽

pp. 9918-9924 ◽

Cited By ~ 4

Author(s):

Yinlin Tong ◽

Jiaying Xu ◽

Hong Jiang ◽

Feng Gao ◽

Qingyi Lu

Keyword(s):

Polymer Nanocomposites ◽

Glucose Sensor ◽

Glucose Sensors ◽

Core Shell ◽

Nonenzymatic Glucose Sensor ◽

One Step

Novel core–shell Cu@polymer nanocomposites were synthesized through a one-step self-activated route and developed as nonenzymatic glucose sensor.

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A comparative study of electrocatalytic oxidation of glucose on conductive Ni-MOF nanosheet arrays with different ligands

New Journal of Chemistry ◽

10.1039/d0nj04150e ◽

2020 ◽

Vol 44 (41) ◽

pp. 17849-17853

Author(s):

Yanxia Qiao ◽

Rui Zhang ◽

Fangyuan He ◽

Wenli Hu ◽

Xiaowei Cao ◽

...

Keyword(s):

Detection Limit ◽

Comparative Study ◽

Response Time ◽

Electrocatalytic Oxidation ◽

Glucose Sensor ◽

High Sensitivity ◽

Fast Response ◽

Serum Samples ◽

Nanosheet Arrays ◽

Oxidation Of Glucose

A glucose sensor based on conductive Ni-MOF nanosheet arrays/CC exhibits a fast response time, a low detection limit, a high sensitivity, and it can also be applied for the detection of glucose in human serum samples.

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Synthesis of Novel Pd Nanosponges for Non-Enzymatic Glucose Sensor

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2020.18753 ◽

2020 ◽

Vol 20 (12) ◽

pp. 7333-7341

Author(s):

Feng Chen ◽

Jing-Hao Li ◽

Yu-Chen Chi ◽

Zhen-Hua Dan ◽

Feng-Xiang Qin

Keyword(s):

Glucose Sensor ◽

High Sensitivity ◽

Cost Effective ◽

Active Surface ◽

Glucose Sensing ◽

Active Surface Area ◽

Long Term Stability ◽

High Uniformity ◽

One Step ◽

The Cost

A unique nanostructured electrocatalyst based on Palladium (Pd) nanosponge architecture is synthesized by one-step dealloying of the amorphous alloy precursor with low Pd concentration. The sponge-like nanostructure with hollow interiors enables sufficient contact between reactants andboth the interior and exterior surfaces. The results of cyclic voltammetry reveal that the as-prepared Pd nanosponge exhibits high sensitivity of 32 μA mM−1 cm−2 in a wide linear range (1–18 mM), and long-term stability toward glucose electro-oxidation. The Pd nanosponge also manifests detection limit as low as 2.0 μM (S/N = 3) and high selectivity for glucose sensing. The enhanced catalytic activity of the Pd nanosponge is attributed to the bimetallic synergistic effect and the large active surface area of the high-uniformity porous structure. The facile synthesis of the cost-effective Pd nanosponge with superior electrocatalytic performance makes it hold great potentials for biosensor and other catalysis applications.

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Synthesis of Ni-Co Hydroxide Nanosheets Constructed Hollow Cubes for Electrochemical Glucose Determination

Sensors ◽

10.3390/s19132938 ◽

2019 ◽

Vol 19 (13) ◽

pp. 2938 ◽

Cited By ~ 8

Author(s):

Fengchao Sun ◽

Shutao Wang ◽

Yuqi Wang ◽

Jingtong Zhang ◽

Xinping Yu ◽

...

Keyword(s):

Electrode Materials ◽

High Efficiency ◽

Particle Morphology ◽

Glucose Sensing ◽

Glucose Sensors ◽

Molar Ratio ◽

Glucose Determination ◽

Lamellar Morphology ◽

Transmission Electron ◽

Double Transition

Hierarchical Ni-Co double transition metal hydroxide nanosheets have been explored as an effective strategy for the design of nonenzymatic glucose sensors. Ni-Co hydroxide nanosheets constructed hollow cubes were successfully synthesized by using Cu2O cubes as templates and subsequently etched by Na2S2O3 to achieve a hollow cubic structure. The molar ratio between Ni and Co was tuned by varying the precursor ratio of NiCl2 and CoCl2. It was observed by transmission electron microscopy (TEM) that the increasing Ni precursor resulted in particle morphology, and the increasing ratio of the Co precursor resulted in more lamellar morphology. The sample with the composition of Ni0.7Co0.3(OH)2 displayed the best performance for glucose sensing with high selectivity (1541 μA mM–1 cm–2), low detection limit (3.42 µM with S/N = 3), and reasonable selectivity. Similar strategies could be applied for the design of other electrode materials with high efficiency for nonenzymatic glucose determination.

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