scholarly journals Synthesis of Network Polymers by Means of Addition Reactions of Multifunctional-Amine and Poly(ethylene glycol) Diglycidyl Ether or Diacrylate Compounds

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2047
Author(s):  
Naofumi Naga ◽  
Mitsusuke Sato ◽  
Kensuke Mori ◽  
Hassan Nageh ◽  
Tamaki Nakano
Keyword(s):  
Ethylene Glycol ◽  
Room Temperature ◽  
Addition Reaction ◽  
Monomer Concentration ◽  
Diglycidyl Ether ◽  
Porous Polymers ◽  
Addition Reactions ◽  
Poly Ethylene Glycol ◽  
Network Polymers ◽  
Poly Ethylene

Addition reactions of multi-functional amine, polyethylene imine (PEI) or diethylenetriamine (DETA), and poly(ethylene glycol) diglycidyl ether (PEGDE) or poly(ethylene glycol) diacrylate (PEGDA), have been investigated to obtain network polymers in H2O, dimethyl sulfoxide (DMSO), and ethanol (EtOH). Ring opening addition reaction of the multi-functional amine and PEGDE in H2O at room temperature or in DMSO at 90 °C using triphenylphosphine as a catalyst yielded gels. Aza-Michael addition reaction of the multi-functional amine and PEGDA in DMSO or EtOH at room temperature also yielded corresponding gels. Compression test of the gels obtained with PEI showed higher Young’s modulus than those with DETA. The reactions of the multi-functional amine and low molecular weight PEGDA in EtOH under the specific conditions yielded porous polymers induced by phase separation during the network formation. The morphology of the porous polymers could be controlled by the reaction conditions, especially monomer concentration and feed ratio of the multi-functional amine to PEGDA of the reaction system. The porous structure was formed by connected spheres or a co-continuous monolithic structure. The porous polymers were unbreakable by compression, and their Young’s modulus increased with the increase in the monomer concentration of the reaction systems. The porous polymers absorbed various solvents derived from high affinity between the polyethylene glycol units in the network structure and the solvents.

FABRICATION OF QCM TYPE SMOTHER DETECTION SENSOR BY PLASMA POLYMERIZING SnOx ORGANIC-LIKE FILMS AND SPIN COATING WITH POLY ETHYLENE GLYCOL

2012 ◽  
Vol 24 (02) ◽  
pp. 179-183
Author(s):  
Ko-Shao Chen ◽  
Shu-Chuan Liao ◽  
Hsin-Ming Wu ◽  
Yu-Chia Tsao ◽  
Hong-Ru Lin
Keyword(s):  
Thin Films ◽  
Ethylene Glycol ◽  
Spin Coating ◽  
Room Temperature ◽  
Plasma Deposition ◽  
Post Treatment ◽  
Detection Sensitivity ◽  
Poly Ethylene Glycol ◽  
Frequency Drop ◽  
Poly Ethylene

Quartz crystal microbalances (QCM) are transducers for chemical and biochemical sensing. The oscillation frequency of QCM is affected by the adsorbed mass on the surface. In this work, a new room temperature type gas sensor device fabricated by organically hybridized plasma deposition of tetramethyltin (TMT) and oxygen. Post treatment with poly ethylene glycol (PEG) was developed to detect the ambient environmental smother, and the responses of the fabricated sensor to smother detection were investigated. SnO x C y thin films on the sensor electrodes were obtained by plasma deposition from TMT and O 2 gas mixtures at room temperature. A spin coating post treatment on the SnO x C y thin films turns into hydrophilic property. The response of the QCM sensor to the smother detection shows a frequency drop during the burning of candle and has good detection sensitivity with Δf equal to 2400 Hz. Repeated smother testing with the QCM type smother detection sensor also indicates the stability of the fabricated sensor.

Deprotective activity of nanosized globular partially quaternized poly(tertiary amine)s in peptide synthesis

e-Polymers ◽  
2002 ◽  
Vol 2 (1) ◽  
Author(s):  
Pascal Chapon ◽  
Jean Coudane ◽  
Henri Garreau ◽  
Michel Vert ◽  
Jean Alain Ferhentz ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Aqueous Medium ◽  
Room Temperature ◽  
Heterogeneous Systems ◽  
Protecting Groups ◽  
Hydrophobic Core ◽  
Poly Ethylene Glycol ◽  
Solid Supports ◽  
Spacer Arm ◽  
Poly Ethylene

AbstractBifunctional polybases of the partially quaternized poly[thio-1-(N,Ndiethylaminomethyl) ethylene] type (Q(PTDAE),X, with X = percentage of N-quaternization) are able to catalyze various reactions including lipophilic reagents temporarily entrapped in the hydrophobic core of the globules. In this contribution it is shown that benzyloxycarbonyl (Z) and fluoromethyloxycarbonyl (Fmoc) protecting groups of peptides are cleaved at room temperature in a few minutes in an aqueous medium at pH 7,4. Deprotection was also effective when peptides were attached to solid supports of the Merrifield type provided a hydrophilic spacer arm of the poly(ethylene glycol)-type was inserted between beads and the built up peptide moieties. However, unhooking was observed when the hydrophilic spacerpeptide bond was an ester but not when it was of the amide type. The work shows that Q(PTDAE),X globules exhibit enzyme-like activity in a homogeneous aqueous medium and in heterogeneous systems as well.

Room temperature aqueous self-assembly of poly(ethylene glycol)-poly(4-vinyl pyridine) block copolymers: From spherical to worm-like micelles

2016 ◽  
Vol 145 ◽  
pp. 447-453 ◽  
Author(s):  
Daniela P. Rodrigues ◽  
João R.C. Costa ◽  
Nuno Rocha ◽  
Joana R. Góis ◽  
Arménio C. Serra ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Room Temperature ◽  
Poly Ethylene Glycol ◽  
Vinyl Pyridine ◽  
Poly Ethylene

scholarly journals Toxicity Assessment of a Single Dose of Poly(ethylene glycol) Diglycidyl Ether (PEGDE) Administered Subcutaneously in Mice

Toxics ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 354
Author(s):  
Do-Hyun Kim ◽  
Jong-Hyeon Han ◽  
Hyuk-Cheol Kwon ◽  
Su-Jin Lim ◽  
Seo-Gu Han ◽  
...  
Keyword(s):  
Body Weight ◽  
Ethylene Glycol ◽  
Feed Intake ◽  
Diglycidyl Ether ◽  
Organ Weight ◽  
The Body ◽  
The Other ◽  
Poly Ethylene Glycol ◽  
Weight Variation ◽  
Poly Ethylene

Poly(ethylene glycol) diglycidyl ether (PEGDE) is widely used to cross-link polymers, particularly in the pharmaceutical and biomaterial sectors. However, the subcutaneous toxicity of PEGDE has not yet been assessed. PEGDE samples (500–40,000 μg/mouse) were subcutaneously injected into the paraspinal dorsum of BALB/c male mice. Cage-side observations were carried out with measurement of organ weight, body weight variation, and feed intake, as well as histopathological characterization on day 28 post-exposure. Mice that received 40,000 μg of PEGDE showed severe toxic response and had to be euthanized. Subcutaneous injection of PEGDE did not alter feed intake and organ weight; however, the body weight variation of mice injected with 20,000 μg of PEGDE was significantly lower than that of the other groups. Exposure to 10,000 and 20,000 μg of PEGDE induced epidermal ulcer formation and hair loss. The histology of skin tissue in mice administered with 20,000 μg of PEGDE showed re-epithelialized or unhealed wounds. However, the liver, spleen, and kidneys were histologically normal. Collectively, PEGDE, particularly above 10,000 μg/mouse, caused subcutaneous toxicity with ulceration, but no toxicity in the other organs. These results may indicate the optimal concentration of subcutaneously injected PEGDE.

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