scholarly journals Light-Responsive Polymeric Micellar Nanoparticles with Enhanced Formulation Stability

Polymers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 377
Author(s):  
Kyoung Nan Kim ◽  
Keun Sang Oh ◽  
Jiwook Shim ◽  
Isabel R. Schlaepfer ◽  
Sana D. Karam ◽  
...  
Keyword(s):  
High Stability ◽  
Polymeric Micelles ◽  
Uv Light ◽  
Cancer Drug ◽  
Stacking Interactions ◽  
Anti Cancer ◽  
Target Sites ◽  
Formulation Stability ◽  
Micellar Core ◽  
Micellar Nanoparticles

Light-sensitive polymeric micelles have recently emerged as promising drug delivery systems for spatiotemporally controlled release of payload at target sites. Here, we developed diazonaphthoquinone (DNQ)-conjugated micellar nanoparticles that showed a change in polarity of the micellar core from hydrophobic to hydrophilic under UV light, releasing the encapsulated anti-cancer drug, doxetaxel (DTX). The micelles exhibited a low critical micelle concentration and high stability in the presence of bovine serum albumin (BSA) solution due to the hydrophobic and π–π stacking interactions in the micellar core. Cell studies showed enhanced cytotoxicity of DTX-loaded micellar nanoparticles upon irradiation. The enhanced stability would increase the circulation time of the micellar nanoparticles in blood, and enhance the therapeutic effectiveness for cancer therapy.

scholarly journals Polymeric micelles from poly(ethylene glycol)–poly(amino acid) block copolymer for drug and gene delivery

2009 ◽  
Vol 6 (suppl_3) ◽  
Author(s):  
Kensuke Osada ◽  
R. James Christie ◽  
Kazunori Kataoka
Keyword(s):  
Gene Delivery ◽  
Polymeric Micelles ◽  
Genetic Diseases ◽  
Cancer Drug ◽  
Biological Research ◽  
Medical Treatments ◽  
Technical Problems ◽  
Anti Cancer ◽  
Poly Ethylene ◽  
Drug And Gene Delivery

Dramatic advances in biological research have revealed the mechanisms underlying many diseases at the molecular level. However, conventional techniques may be inadequate for direct application of this new knowledge to medical treatments. Nanobiotechnology, which integrates biology with the rapidly growing field of nanotechnology, has great potential to overcome many technical problems and lead to the development of effective therapies. The use of nanobiotechnology in drug delivery systems (DDS) is attractive for advanced treatment of conditions such as cancer and genetic diseases. In this review paper for a special issue on biomaterial research in Japan, we discuss the development of DDS based on polymeric micelles mainly in our group for anti-cancer drug and gene delivery, and also address our challenges associated with developing polymeric micelles as super-functionalized nanodevices with intelligent performance.

scholarly journals pH-responsive polymeric micelles with core–shell–corona architectures as intracellular anti-cancer drug carriers

2013 ◽  
Vol 14 (4) ◽  
pp. 044402 ◽  
Author(s):  
Bishnu Prasad Bastakoti ◽  
Shih-Hsiang Liao ◽  
Masamichi Inoue ◽  
Shin-Ichi Yusa ◽  
Masataka Imura ◽  
...  
Keyword(s):  
Polymeric Micelles ◽  
Drug Carriers ◽  
Cancer Drug ◽  
Core Shell ◽  
Ph Responsive ◽  
Anti Cancer

Recent advances in polymeric micelles for anti-cancer drug delivery

2016 ◽  
Vol 83 ◽  
pp. 184-202 ◽  
Author(s):  
Swati Biswas ◽  
Preeti Kumari ◽  
Prit Manish Lakhani ◽  
Balaram Ghosh
Keyword(s):  
Drug Delivery ◽  
Polymeric Micelles ◽  
Cancer Drug ◽  
Recent Advances ◽  
Anti Cancer ◽  
Cancer Drug Delivery

Reduction-responsive dithiomaleimide-based polymeric micelles for controlled anti-cancer drug delivery and bioimaging

2017 ◽  
Vol 8 (46) ◽  
pp. 7160-7168 ◽  
Author(s):  
Ting Bai ◽  
Junjie Du ◽  
Jianxin Chen ◽  
Xiao Duan ◽  
Qiang Zhuang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Tumor Cells ◽  
Disulfide Bonds ◽  
Polymeric Micelles ◽  
Amphiphilic Block Copolymers ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Model Drug ◽  
Cancer Drug Delivery

The biocompatible amphiphilic block copolymers and the CPT model drug were self-assembled into micelles with bright fluorescence and taken up by tumor cells. Then, the disulfide bonds in the micelles were cleaved to release CPT at a high GSH concentration.

DPD Simulations on Mixed Polymeric DOX-loaded Micelles Assembled from PCL-SS-PPEGMA/ PDEA-PPEGMA and Their Dual pH/Reduction-responsive Release

2021 ◽  
Author(s):  
Zexiong Yang ◽  
Haiqian Zhao ◽  
Delin Wang ◽  
Li Yin ◽  
Kenxiang Cai ◽  
...  
Keyword(s):  
Polymeric Micelles ◽  
Drug Loading ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Ph Reduction ◽  
Mixed Polymeric Micelles ◽  
Stimuli Response ◽  
Potential Strategy ◽  
Cancer Drug Delivery ◽  
Micellization Behavior

Mixed polymeric micelles by combination of two or more dissimilar polymers is a potential strategy to achieve multiple stimuli-response for anti-cancer drug delivery. However, their drug loading co-micellization behavior and...

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

Xenobiotica ◽  
2009 ◽  
Vol 00 (00) ◽  
pp. 090901052053001-8
Author(s):  
K. Murai ◽  
H. Yamazaki ◽  
K. Nakagawa ◽  
R. Kawai ◽  
T. Kamataki
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cytochrome P450 2A6

Psychogenic Mass Syndrome in Anti-Cancer Drug Exposure

2010 ◽  
Author(s):  
N. Magnavita ◽  
I. lavicoli ◽  
V. Leso ◽  
A. Bergamaschi
Keyword(s):  
Drug Exposure ◽  
Cancer Drug ◽  
Anti Cancer
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