Incorporation of poorly soluble drug Cefixime inside the micellar core of conventional and gemini surfactants

This work reports the physicochemical behavior of antibiotic drug, cefixime (CEF) in presence of cetyl trimethyl ammonium bromide (CTAB), dodecyl trimethyl ammonium bromide (DTAB), dodecyl ethyl dimethyl ammonium bromide, (DDAB),...

Light-Responsive Polymeric Micellar Nanoparticles with Enhanced Formulation Stability

Light-sensitive polymeric micelles have recently emerged as promising drug delivery systems for spatiotemporally controlled release of payload at target sites. Here, we developed diazonaphthoquinone (DNQ)-conjugated micellar nanoparticles that showed a change in polarity of the micellar core from hydrophobic to hydrophilic under UV light, releasing the encapsulated anti-cancer drug, doxetaxel (DTX). The micelles exhibited a low critical micelle concentration and high stability in the presence of bovine serum albumin (BSA) solution due to the hydrophobic and π–π stacking interactions in the micellar core. Cell studies showed enhanced cytotoxicity of DTX-loaded micellar nanoparticles upon irradiation. The enhanced stability would increase the circulation time of the micellar nanoparticles in blood, and enhance the therapeutic effectiveness for cancer therapy.

Encapsulation induced aggregation: a self-assembly strategy for weakly pi-stacking chromophores

Confinement of weakly pi-stacking dyes within a micellar core leads to a rapid aggregation.

Amphiphilic block copolymers from a renewable ε-decalactone monomer: prediction and characterization of micellar core effects on drug encapsulation and release

Block co-polymers with a block derived from a sustainable monomer source are used to encapsulate and release the drug indomethacin.