scholarly journals Composite Materials Based on Iron Oxide Nanoparticles and Polyurethane for Improving the Quality of MRI

Polymers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 4316
Author(s):  
Luiza Madalina Gradinaru ◽  
Mihaela Barbalata Mandru ◽  
Mioara Drobota ◽  
Magdalena Aflori ◽  
Maria Butnaru ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Iron Oxide ◽  
Composite Materials ◽  
Iron Oxide Nanoparticles ◽  
Magnetic Particles ◽  
Oxide Nanoparticles ◽  
Magnetic Composite ◽  
Hematite Fe2o3

Polyether urethane (PU)-based magnetic composite materials, containing different types and concentrations of iron oxide nanostructures (Fe2O3 and Fe3O4), were prepared and investigated as a novel composite platform that could be explored in different applications, especially for the improvement of the image quality of MRI investigations. Firstly, the PU structure was synthetized by means of a polyaddition reaction and then hematite (Fe2O3) and magnetite (Fe3O4) nanoparticles were added to the PU matrices to prepare magnetic nanocomposites. The type and amount of iron oxide nanoparticles influenced its structural, morphological, mechanical, dielectric, and magnetic properties. Thus, the morphology and wettability of the PU nanocomposites surfaces presented different behaviours depending on the amount of the iron oxide nanoparticles embedded in the matrices. Mechanical, dielectric, and magnetic properties were enhanced in the composites’ samples when compared with pristine PU matrix. In addition, the investigation of in vitro cytocompatibility of prepared PU nanocomposites showed that these samples are good candidates for biomedical applications, with cell viability levels in the range of 80–90%. Considering all the investigations, we can conclude that the addition of magnetic particles introduced additional properties to the composite, which could significantly expand the functionality of the materials developed in this work.

scholarly journals In vitro toxicity evaluation of silica-coated iron oxide nanoparticles in human SHSY5Y neuronal cells

2016 ◽  
Vol 5 (1) ◽  
pp. 235-247 ◽  
Author(s):  
Gözde Kiliç ◽  
Carla Costa ◽  
Natalia Fernández-Bertólez ◽  
Eduardo Pásaro ◽  
João Paulo Teixeira ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Biomedical Applications ◽  
Neuronal Cells ◽  
In Vitro Toxicity ◽  
Oxide Nanoparticles ◽  
Toxicity Evaluation ◽  
Diagnosis And Therapy

Iron oxide nanoparticles (ION) have been widely used in biomedical applications, for both diagnosis and therapy, due to their unique magnetic properties.

In vitro biomedical applications of functionalized iron oxide nanoparticles, including those not related to magnetic properties

2010 ◽  
pp. n/a-n/a ◽  
Author(s):  
Carmen Burtea ◽  
Sophie Laurent ◽  
Isabelle Mahieu ◽  
Lionel Larbanoix ◽  
Alain Roch ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Biomedical Applications ◽  
Oxide Nanoparticles

scholarly journals The Influence of Synthesis Parameters on Structural and Magnetic Properties of Iron Oxide Nanomaterials

2019 ◽  
Author(s):  
Laura-Madalina Cursaru ◽  
Roxana Mioara Piticescu ◽  
Dumitru Valentin Dragut ◽  
Ioan Albert Tudor ◽  
Victor Kuncser ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Crystalline Phase ◽  
Oxide Nanoparticles ◽  
Zero Field ◽  
Iron Oxide Particles ◽  
Different Temperatures ◽  
Low Toxicity

Magnetic iron oxide particles are used for in vitro diagnostics for nearly 40 years. Due to their unique physical, chemical, thermal and mechanical properties, as well as biocompatibility and low toxicity in the human body, iron oxide nanoparticles have been used in many biomedical applications, such as contrast agents for magnetic resonance imaging, carriers for controlled drug delivery and immunoassays, but also in magnetic hyperthermia. Our aim is to investigate the effect of pressure and temperature on the structural, thermal and magnetic properties of iron oxide nanomaterials prepared by hydrothermal synthesis. Iron oxide nanoparticles were synthesized at temperatures of 100-200°C and pressures of 20-1000 bar. It has been found that pressure influences the type of iron oxide crystalline phase. Thus, for lower pressure values (< 100 bar), iron oxide is predominantly formed as hematite, while at pressures > 100 bar, the major crystalline phase is goethite. The complex thermal analysis revealed the polymorphic changes of iron oxides at different temperatures. The existence of specific magnetite and hematite phases in all thermally treated samples are evidenced through the specific Verwey and Morin transitions highlighted by ZFC-FC (Zero Field Cooled-Field Cooled) measurements, whereas their relative content is precisely provided by Mössbauer spectroscopy.

Polymer Coated Iron Nanoparticles: Radiolabeling & In Vitro Studies

2020 ◽  
Vol 13 ◽  
Author(s):  
Selin Yılmaz ◽  
Çiğdem İçhedef ◽  
Kadriye Buşra Karatay ◽  
Serap Teksöz
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Breast Cancer Cells ◽  
Cancer Drug ◽  
Oxide Nanoparticles ◽  
Sem Images

Backgorund: Superparamagnetic iron oxide nanoparticles (SPIONs) have been extensively used for targeted drug delivery systems due to their unique magnetic properties. Objective: In this study, it’s aimed to develop a novel targeted 99mTc radiolabeled polymeric drug delivery system for Gemcitabine (GEM). Methods: Gemcitabine, an anticancer agent, was encapsulated into polymer nanoparticles (PLGA) together with iron oxide nanoparticles via double emulsion technique and then labeled with 99mTc. SPIONs were synthesized by reduction–coprecipitation method and encapsulated with oleic acid for surface modification. Size distribution and the morphology of the synthesized nanoparticles were caharacterized by dynamic light scattering(DLS)and scanning electron microscopy(SEM), respectively. Radiolabeling yield of SPION-PLGAGEM nanoparticles were determined via Thin Layer Radio Chromatography (TLRC). Cytotoxicity of GEM loaded SPION-PLGA were investigated on MDA-MB-231 and MCF7 breast cancer cells in vitro. Results: SEM images displayed that the average size of the drug-free nanoparticles was 40 nm and the size of the drug-loaded nanoparticles was 50 nm. The diameter of nanoparticles were determined as 366.6 nm by DLS, while zeta potential was found as-29 mV. SPION was successfully coated with PLGA, which was confirmed by FTIR. GEM encapsulation efficiency of SPION-PLGA was calculated as 4±0.16 % by means of HPLC. Radiolabeling yield of SPION-PLGA-GEM nanoparticles were determined as 97.8±1.75 % via TLRC. Cytotoxicity of GEM loaded SPION-PLGA were investigated on MDA-MB-231 and MCF7 breast cancer cells. SPION-PLGA-GEM showed high uptake on MCF-7, whilst incorporation rate was increased for both cell lines which external magnetic field application. Conclusion: 99mTc labeled SPION-PLGA nanoparticles loaded with GEM may overcome some of the obstacles in anti-cancer drug delivery because of their appropriate size, non-toxic, and supermagnetic characteristics.

Shaping and Cellular Uptake of Folic Acid Coated Gold and Magnetite Nanoparticles

2019 ◽  
Vol 9 (2) ◽  
pp. 166-172
Author(s):  
Ahmed A.G. El-Shahawy ◽  
Gamal Elghnam ◽  
Alsayed A.M. Alsherbini
Keyword(s):  
Folic Acid ◽  
Iron Oxide ◽  
Tumor Cells ◽  
Iron Oxide Nanoparticles ◽  
Individual Cell ◽  
Oxide Nanoparticles ◽  
Cellular Compartment ◽  
Specific Tumor ◽  
Uv Visible

Background:Gold and Iron Oxide nanoparticles NPs play as nanocarriers for a specific drug delivery and contrast agents. Intercellular uptake of these nanoparticles and targeting to individual cell and sub-cellular compartment is essential.Objective:The aim of the current study is to evaluate the intracellular uptake of these NPs to specific tumor cells in vitro conjugated with folic acid with a goal of enhancing the efficiency of specific targeting to tumor cells.Methods:We synthesized the nanoparticles by a chemical method and characterized by UV-Visible, FTIR, XRD, and TEM.Results & Conclusion:The results revealed the conjugation of Gold and Iron Oxide nanoparticles with folic acid increased the intercellular uptake with high percent compared to non- conjugated nanoparticles.

Comparative study on the magnetic properties of iron oxide nanoparticles loaded on mesoporous silica and carbon materials with different structure

2009 ◽  
Vol 121 (1-3) ◽  
pp. 178-184 ◽  
Author(s):  
Sher Alam ◽  
Chokkalingam Anand ◽  
Radhakrishnan Logudurai ◽  
Veerappan V. Balasubramanian ◽  
Katsuhiko Ariga ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Iron Oxide ◽  
Mesoporous Silica ◽  
Comparative Study ◽  
Iron Oxide Nanoparticles ◽  
Carbon Materials ◽  
Oxide Nanoparticles

Photo-fluorescent and magnetic properties of iron oxide nanoparticles for biomedical applications

Nanoscale ◽  
2015 ◽  
Vol 7 (18) ◽  
pp. 8209-8232 ◽  
Author(s):  
Donglu Shi ◽  
M. E. Sadat ◽  
Andrew W. Dunn ◽  
David B. Mast
Keyword(s):  
Magnetic Properties ◽  
Iron Oxide ◽  
Physical Properties ◽  
Iron Oxide Nanoparticles ◽  
Basic Science ◽  
Biomedical Applications ◽  
Oxide Nanoparticles ◽  
Nanometer Range

Iron oxide exhibits fascinating physical properties especially in the nanometer range, not only from the standpoint of basic science, but also for a variety of engineering, particularly biomedical applications.

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