scholarly journals Silicon-Quartz Microcapillary Opto-Fluidic Platform Obtained by CMOS-Compatible Die to Wafer 200 mm Dual Bonding Process

Proceedings ◽  
2018 ◽  
Vol 2 (13) ◽  
pp. 1018
Author(s):  
Giuseppe Fiorentino ◽  
Ben Jones ◽  
Sophie Roth ◽  
Edith Grac ◽  
Murali Jayapala ◽  
...  
Keyword(s):  
Adhesive Bonding ◽  
System Analysis ◽  
Quartz Substrate ◽  
Microfluidic System ◽  
Bonding Process ◽  
Microfluidic Channels ◽  
Fully Integrated ◽  
Lab On Chip ◽  
Human Blood Cells ◽  
On Chip

A composite, capillary-driven microfluidic system suitable for transmitted light microscopy of cells (e.g., red and white human blood cells) is fabricated and demonstrated. The microfluidic system consists of a microchannels network fabricated in a photo-patternable adhesive polymer on a quartz substrate, which, by means of adhesive bonding, is then connected to a silicon microfluidic die (for processing of the biological sample) and quartz die (to form the imaging chamber). The entire bonding process makes use of a very low temperature budget (200 °C). In this demonstrator, the silicon die consists of microfluidic channels with transition structures to allow conveyance of fluid utilizing capillary forces from the polymer channels to the silicon channels and back to the polymer channels. Compared to existing devices, this fully integrated platform combines on the same substrate silicon microfluidic capabilities with optical system analysis, representing a portable and versatile lab-on-chip device.

scholarly journals Design Methodology of Passive In-Line Relays for Molecular Communication in Flow-Induced Microfluidic Channel

Biosensors ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 65
Author(s):  
Puneet Manocha ◽  
Gitanjali Chandwani
Keyword(s):  
Communication System ◽  
Communication Systems ◽  
Microfluidic Channel ◽  
Microfluidic Channels ◽  
Molecular Communication ◽  
External Energy ◽  
Lab On Chip ◽  
Molecular Communication Systems ◽  
Macro Scale ◽  
On Chip

Molecular communication is a bioinspired communication that enables macro-scale, micro-scale and nano-scale devices to communicate with each other. The molecular communication system is prone to severe signal attenuation, dispersion and delay, which leads to performance degradation as the distance between two communicating devices increases. To mitigate these challenges, relays are used to establish reliable communication in microfluidic channels. Relay assisted molecular communication systems can also enable interconnection among various entities of the lab-on-chip for sharing information. Various relaying schemes have been proposed for reliable molecular communication systems, most of which lack practical feasibility. Thus, it is essential to design and develop relays that can be practically incorporated into the microfluidic channel. This paper presents a novel design of passive in-line relay for molecular communication system that can be easily embedded in the microfluidic channel and operate without external energy. Results show that geometric modification in the microfluidic channel can act as a relay and restore the degraded signal up-to 28%.

Fabrication of Centimeter Long, Ultra-Low Aspect Ratio Nanochannel Networks in Borosilicate Glass Substrates

2013 ◽  
Vol 4 (2) ◽  
Author(s):  
Marie Pinti ◽  
Tanuja Kambham ◽  
Bowen Wang ◽  
Shaurya Prakash
Keyword(s):  
Aspect Ratio ◽  
Adhesive Bonding ◽  
Surface Defects ◽  
Device Fabrication ◽  
Lower Sensitivity ◽  
Channel Network ◽  
Lab On Chip ◽  
Low Aspect Ratio ◽  
Paper Fabrication ◽  
On Chip

Nanofluidic devices have a broad range of applications resulting from the dominance of surface-fluid interactions. Examples include molecular gating, sample preconcentration, and sample injection. Manipulation of small fluid samples is ideal for micro total analysis systems or lab on chip devices which perform multiple unit operations on a single chip. In this paper, fabrication procedures for two different ultra-low aspect ratio (ULAR) channel network designs are presented. The ULAR provides increased throughput compared to higher aspect ratio features with the same critical dimensions. Channel network designs allow for integration between microscale and nanoscale fluidic networks. A modified calcium assisted glass–glass bonding procedure was developed to fabricate chemically uniform, all glass nanochannels. A polydimethylsiloxane (PDMS)-glass adhesive bonding procedure was also developed as adhesive bonding allows for more robust fabrication with lower sensitivity to surface defects. The fabrication schemes presented allow for a broad array of available parameters for facile selection of device fabrication techniques depending on desired applications for lab on chip devices.

Thermally actuated microfluidic system for lab on chip applications

2015 ◽  
Author(s):  
Andleeb Zahra ◽  
Domenico Caputo ◽  
Augusto Nascetti ◽  
Giulia Petrucci ◽  
Nicola Lovecchio ◽  
...  
Keyword(s):  
Microfluidic System ◽  
Lab On Chip ◽  
Thermally Actuated ◽  
On Chip

Fully integrated CMOS capacitive sensor for Lab-on-Chip applications

2014 ◽  
Author(s):  
Ghazal Nabovati ◽  
Ebrahim Ghafar-Zadeh ◽  
Maryam Mirzaei ◽  
Giancarlo Ayala-Charca ◽  
Falah Awwad ◽  
...  
Keyword(s):  
Capacitive Sensor ◽  
Fully Integrated ◽  
Lab On Chip ◽  
On Chip

Challenges in the realization of a fully integrated optical lab-on-chip

2014 ◽  
Author(s):  
S. Nicoletti ◽  
P. Barritault ◽  
S. Boutami ◽  
M. Brun ◽  
A. Gliere ◽  
...  
Keyword(s):  
Fully Integrated ◽  
Lab On Chip ◽  
Integrated Optical ◽  
On Chip

High-throughput acoustofluidic microchannels for single cell rotation

2021 ◽  
Author(s):  
Junwen Zhu ◽  
Qiqian Zhang ◽  
Fei Liang ◽  
Yongxiang Feng ◽  
Wenhui Wang
Keyword(s):  
High Throughput ◽  
Low Cost ◽  
Rotation Velocity ◽  
Microfluidic Channels ◽  
Lab On Chip ◽  
Dead End ◽  
Cell Rotation ◽  
Fabrication Procedure ◽  
On Chip ◽  
Highly Uniform

Abstract There is a growing desire for cell rotation in the field of biophysics, bioengineering and biomedicine. We herein present novel microfluidic channels for simultaneous high-throughput cell self-rotation using local circular streaming generated by ultrasonic wave excited bubble arrays. The bubble traps achieve high homogeneity of liquid-gas interface by setting capillary valves at the entrances of dead-end bubble trappers orthogonal to the main microchannel. In such a highly uniform bubble array, rotation at different fields of bubble-relevant vortices is considered equal and interconvertible. The device is compatible with cells of various size and retains manageable rotation velocity when actuated by signals of varying frequency and voltage. Experimental observations were confirmed consistent with theoretical estimation and numerical simulation. Comparing with the conventional approaches of cell rotation, our device has multiple merits such as high throughput, low cost and simple fabrication procedure, and high compatibility for lab-on-chip integration. Therefore, the platform holds a promise in cell observation, medicine development and biological detection.

A Fast Computational Method for Particle Dynamics in Dielectrophoretic Lab-on-Chip Systems

2007 ◽  
Author(s):  
Indranil Chowdhury ◽  
Vikram Jandhyala ◽  
John D. Rockway
Keyword(s):  
Field Distribution ◽  
Iterative Solvers ◽  
Computational Method ◽  
Microfluidic Channels ◽  
Computational Domain ◽  
Time Step ◽  
Lab On Chip ◽  
Time Stepping ◽  
Fast Solver ◽  
On Chip

An accelerated boundary element method (BEM) is proposed for predicting the motion of bio-particles under combined electromagnetic and fluidic force fields. Many Lab-on-chip (LoC) designs are based on dielectrophoretic (DEP) manipulation of polarized species inside microfluidic channels. The BEM approach presented here relies entirely on modeling the surface of the computational domain, significantly reducing the number of unknowns when compared to volume-based methods. Additionally, the need for re-meshing the whole domain at each time-step of particle movement is prevented. A coupled circuit-EM formulation is presented for accurate prediction of dielectophoretic field distribution due to on-chip electrodes. This allows the circuit control of the resulting electromagnetic fields. Next, BEM formulations for predicting DEP and fluidic traction forces on arbitrarily shaped bio-particles are presented. EM fields produced by the electrodes induce the DEP forces, while the fluid flow is driven by a pressure gradient across the channel. The resultant motion of the subjected particles is studied using a simple time-stepping algorithm. The algorithm has a time complexity of O(N3), where N is the number of unknowns), which leads to a large bottleneck during simulation of each time step. This problem is addressed by implementing oct-tree based O(N) multilevel iterative solvers. The methodology is used to study the field distribution due to distributed electrode systems and particle motion in fluidic channels. Evidence of O(N) behavior of the fast solver is presented. The resulting simulator can be used to study complicated distributed structures and explore new LoC design ideas.

scholarly journals Improved method to reduce interfacial defects in bonding polydimethylsiloxane layers of microfluidic devices for lab–on–chip applications

2017 ◽  
Vol 30 (2) ◽  
pp. 25-29
Author(s):  
Salvador Mendoza-Acevedo ◽  
Luis Alfonso Villa-Vargas ◽  
Héctor Francisco Mendoza-León ◽  
Miguel Ángel Alemán-Arce ◽  
Jacobo Esteban Munguía-Cervantes
Keyword(s):  
Oxygen Plasma ◽  
Pressure Sensors ◽  
Microfluidic Devices ◽  
Bonding Process ◽  
Improved Method ◽  
Microfluidic Systems ◽  
Lab On Chip ◽  
Interfacial Defects ◽  
On Chip ◽  
Bonding Method

This work describes a method to achieve a nearly seamless bonding between two polydimethylsiloxane (PDMS) surfaces. This material is widely used to realize microfluidic systems, and obtaining a strong union is an important step in the fabrication process. From the proposed bonding method, a minimal interface is accomplished, useful for hermetic seals in microfluidic systems. The presented method relies in the surface activation by oxygen plasma and the interaction of said treated surface with uncured PDMS. A comparison of bonding methods is presented in this paper in order to assess the performance of the bonding process and verify the interface formed between the bonded surfaces. The intended application of the presented method is the fabrication of pressure sensors, micropumps, microchannels, microfluidic pumps, valves, mixers and other structures that demand a complete seal over the bonded surfaces.

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