scholarly journals Raman Analysis of Tear Fluid Alteration Following Contact Lense Use

Sensors ◽  
2019 ◽  
Vol 19 (15) ◽  
pp. 3392 ◽  
Author(s):  
Angela Capaccio ◽  
Antonio Sasso ◽  
Giulia Rusciano
Keyword(s):  
Raman Spectroscopy ◽  
Contact Lens ◽  
Contact Lenses ◽  
Inflammatory Responses ◽  
Tear Fluid ◽  
Complex Composition ◽  
Contact Lens Wearer ◽  
Raman Analysis ◽  
Fluid Alteration ◽  
Contact Lense

Tear fluid is a heterogeneous solution containing mainly proteins, lipids, mucins and electrolytes, which regulates the physiology of the human eye. The complex composition of tears can be altered in the presence of eye inflammations. The use of contact lenses is one of the most frequent causes of inflammatory responses of the eye, with the related discomfort often causing the wearer to give up using them. In this paper, we exploit the potentiality of Raman Spectroscopy to analyse the biochemical changes in tear fluid in a contact lens wearer. In particular, we analysed the tear fluid collected from a volunteer as a function of the wearing time for two types of monthly contact lenses (Hydrogel and Si-Hydrogel). Our experimental results show an alteration of the relative concentrations of proteins and lipids in both of the analysed cases. More importantly, our results highlight the diagnostic sensitivity of Raman analysis to select the proper contact lens type for each wearer and optimise the lens wearing conditions.

Plasmin and Epidermal Growth Factor in the Tear Fluid of Contact-Lens Wearers: Effect of Wearing Different Types of Contact Lenses and Association with Clinical Findings

1990 ◽  
Vol 22 (4) ◽  
pp. 233-240 ◽  
Author(s):  
G.-B. van Setten ◽  
T. Tervo ◽  
R. Andersson ◽  
J. Perheentupa ◽  
A. Tarkkanen
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Contact Lens ◽  
Contact Lenses ◽  
Clinical Findings ◽  
Tear Fluid ◽  
Different Types ◽  
Epidermal Growth

scholarly journals Contact lens-based lysozyme detection in tear using a mobile sensor

Lab on a Chip ◽  
2020 ◽  
Vol 20 (8) ◽  
pp. 1493-1502 ◽  
Author(s):  
Zachary Ballard ◽  
Sarah Bazargan ◽  
Diane Jung ◽  
Shyama Sathianathan ◽  
Ashley Clemens ◽  
...  
Keyword(s):  
Mobile Health ◽  
Contact Lens ◽  
Contact Lenses ◽  
Cost Effective ◽  
Tear Fluid ◽  
Mobile Sensor ◽  
Cost Effective Method ◽  
Mobile Health Applications ◽  
Health Applications

A rapid and cost-effective method for monitoring proteins in tear-fluid is reported, which enables biomarker monitoring using contact lenses toward personalized mobile-health applications.

scholarly journals An Engineered Contact Lens for Passive and Sustained Release of Lifitegrast, an Anti-Dry Eye Syndrome Drug

2021 ◽  
Author(s):  
Changhua Mu ◽  
Victoria Lee ◽  
Yiran Liu ◽  
Ying Han ◽  
gerard marriott
Keyword(s):  
Drug Utilization ◽  
Dry Eye ◽  
Contact Lens ◽  
Ocular Surface ◽  
Contact Lenses ◽  
Inflammatory Responses ◽  
Bond Cleavage ◽  
Tear Film ◽  
Dry Eye Syndrome ◽  
Zero Order Reaction

Lifitegrast is an FDA-approved drug that inhibits T-cell mediated inflammation associated with dry eye syndrome (DES). Lifitegrast is a potent inhibitor of the interaction between LFA-1 on T-cells and ICAM-1 on endothelial cells at the ocular surface. While effective in treating DES, 5% (81.2 mM) lifitegrast has low drug utilization and elicits off-target effects. Here we engineer contact lenses to release therapeutically relevant doses of lifitegrast to every tear film for up to 10-hours. Lifitegrast is coupled to the polymer of the soft hydrogel lens via a photolabile (caged) crosslinker. Exposures of the lens to the 400-430 nm wavelengths of indoor daylight excite the caged crosslinker molecules and trigger a bond-cleavage reaction that releases authentic lifitegrast passively to the tear film. The photoproduct of the reaction remains chemically linked to the polymer of the single-use lens. Our studies show that passive exposures of the lens to indoor light would generate an average of 990 nM lifitegrast to every tear film in a zero-order reaction for up to 10-hours. This concentration exceeds the Kd for the interaction between ICAM-1 and LFA-1 by ~330-fold and would sustain inhibition of inflammatory responses at the ocular surface. The amount of lifitegrast released from the lens increases during exposures to outdoor sunlight. Over a 10-hour exposure to indoor light, a single lens would release 0.44% of the lifitegrast present in two drops of commercial 5% lifitegrast. Compared to tear-drop approaches, our engineered lenses would sustain the passive delivery of therapeutically relevant doses of lifitegrast over a longer period, and exhibit improved drug utilization at a lower cost. Our technology could easily be integrated into daily-use contact lenses in order to prevent inflammation at the ocular surface, dry-eye and contact lens-mediated discomfort.

Keeping an Eye on Contact Lenses: Safety, Options Shape Contact Lens Decisions

1998 ◽  
Author(s):  
Dixie Farley
Keyword(s):  
Contact Lens ◽  
Contact Lenses

Optimum Infinite is a new era of oxygen permeability material for contact lenses

The Eye ◽  
2020 ◽  
Vol 22 (129) ◽  
pp. 44-46
Author(s):  
Mark Eddleston
Keyword(s):  
Contact Lens ◽  
Oxygen Permeability ◽  
Contact Lenses ◽  
New Era ◽  
Lens Material ◽  
Insight Into

Optimum Infinite is a new GP contact lens material, with an oxygen permeability of 180 barrer and was launched by Contamac at the GSLS 2019. This article provides an insight into the development and characteristics of this breakthrough material.

Managing Corneal Epithelial Defects Using High Molecular Weight Fluorescein to Prevent Contact Lens Staining and Removal of Bandage Contact Lenses

2020 ◽  
Vol 3 (8) ◽  
pp. 20-22
Author(s):  
Muhammad Hamza ◽  
Chrishan Gunasekera ◽  
Samar Nahas ◽  
Z CX Lin ◽  
Hatch Mukherjee ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Contact Lens ◽  
Contact Lenses ◽  
Corneal Epithelial
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