scholarly journals Cytotoxic and Proapoptotic Activity of Sanguinarine, Berberine, and Extracts of Chelidonium majus L. and Berberis thunbergii DC. toward Hematopoietic Cancer Cell Lines

Toxins ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 485 ◽  
Author(s):  
Anna Och ◽  
Daniel Zalewski ◽  
Łukasz Komsta ◽  
Przemysław Kołodziej ◽  
Janusz Kocki ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Blue Staining ◽  
Berberis Thunbergii ◽  
Isoquinoline Alkaloids ◽  
Chelidonium Majus ◽  
High Biological Activity ◽  
Hematopoietic Cancer ◽  
Hematopoietic Cell Lines

Isoquinoline alkaloids belong to the toxic secondary metabolites occurring in plants of many families. The high biological activity makes these compounds promising agents for use in medicine, particularly as anticancer drugs. The aim of our study was to evaluate the cytotoxicity and proapoptotic activity of sanguinarine, berberine, and extracts of Chelidonium majus L. and Berberis thunbergii DC. IC10, IC50, and IC90 doses were established toward hematopoietic cancer cell lines using trypan blue staining. Alterations in the expression of 18 apoptosis-related genes in cells exposed to IC10, IC50, and IC90 were evaluated using real-time PCR. Sanguinarine and Chelidonium majus L. extract exhibit significant cytotoxicity against all studied cell lines. Lower cytotoxic activity was demonstrated for berberine. Berberis thunbergii DC. extract had no influence on cell viability. Berberine, sanguinarine, and Chelidonium majus L. extract altered the expression of apoptosis-related genes in all tested cell lines, indicating the induction of apoptosis. The presented study confirmed the substantial cytotoxicity and proapoptotic activity of sanguinarine, berberine, and Chelidonium majus L. extract toward the studied hematopoietic cell lines, which indicates the utility of these substances in anticancer therapy.

Medicinal plants show remarkable antiproliferative potential in human cancer cell lines

2022 ◽  
Author(s):  
Aisha Nawaz ◽  
Amina Arif ◽  
Adil Jamal ◽  
Muhammad Naveed Shahid ◽  
Ibtesam Nomani ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Nigella Sativa ◽  
Cancer Cell Lines ◽  
Chemotherapeutic Drugs ◽  
Human Cancer Cell ◽  
Chelidonium Majus ◽  
Silybum Marianum ◽  
Human Cancer Cell Lines

Abstract Molecules isolated and identified from plant origin are used to manufacture most chemotherapeutic drugs for cancer treatment. We assumed that these plant extracts contain prolific bioactive compounds with potent antiproliferative activities and could be effective against different human cancer cells. Ethanolic extracts were prepared from Chelidonium majus, Myrica cerifera, Fumaria indica, Nigella sativa, and Silybum marianum, and the antiproliferative assay was performed in HepG2 and HeLa human cancer cell lines. All plants extract exhibited antiproliferative potential against studied cancer cell lines in the dose and time-dependent manner. Chelidonium majus and Silybum marianum have shown promising results against HepG2 and HeLa cells, respectively, followed by Myrica cerifera, Fumaria indica, and Nigella sativa. Results indicated that utilization of whole plant extract as anticancer compounds could be of great value in generating novel chemotherapeutic drugs.

Expression of CD34 in hematopoietic cancer cell lines reflects tightly regulated stem/progenitor-like state

2011 ◽  
Vol 112 (5) ◽  
pp. 1277-1285 ◽  
Author(s):  
Klaudia Kuranda ◽  
Céline Berthon ◽  
Frédéric Leprêtre ◽  
Renata Polakowska ◽  
Nathalie Jouy ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Hematopoietic Cancer

scholarly journals Characterization of Telomerase (hTERT) in Solid and Hematopoietic Cancer Cell Lines Reveals Different Expression Patterns

2019 ◽  
Vol 39 (9) ◽  
pp. 4743-4748 ◽  
Author(s):  
LUCAS SILVA DE HOLANDA ◽  
FELIPE PANTOJA MESQUITA ◽  
MANOEL ODORICO DE MORAES-FILHO ◽  
MARIA ELISABETE AMARAL DE MORAES ◽  
RAQUEL CARVALHO MONTENEGRO ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Expression Patterns ◽  
Cancer Cell Lines ◽  
Hematopoietic Cancer

797: Noggin Blocks the Osteoinductive Properties of Human Prostate Cancer Cell Lines

2006 ◽  
Vol 175 (4S) ◽  
pp. 258-258
Author(s):  
Ruth Schwaninger ◽  
Cyrill A. Rentsch ◽  
Antoinette Wetterwald ◽  
Irena Klima ◽  
Gabri Van der Pluijm ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Human Prostate Cancer Cell ◽  
Prostate Cancer Cell Lines
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