Analytical Separation of Carcinogenic and Genotoxic Alkenylbenzenes in Foods and Related Products (2010–2020)

Alkenylbenzenes are potentially toxic (genotoxic and carcinogenic) compounds present in plants such as basil, tarragon, anise star and lemongrass. These plants are found in various edible consumer products, e.g., popularly used to flavour food. Thus, there are concerns about the possible health consequences upon increased exposure to alkenylbenzenes especially due to food intake. It is therefore important to constantly monitor the amounts of alkenylbenzenes in our food chain. A major challenge in the determination of alkenylbenzenes in foods is the complexity of the sample matrices and the typically low amounts of alkenylbenzenes present. This review will therefore discuss the background and importance of analytical separation methods from papers reported from 2010 to 2020 for the determination of alkenylbenzenes in foods and related products. The separation techniques commonly used were gas and liquid chromatography (LC). The sample preparation techniques used in conjunction with the separation techniques were various variants of extraction (solvent extraction, liquid-liquid extraction, liquid-phase microextraction, solid phase extraction) and distillation (steam and hydro-). Detection was by flame ionisation and mass spectrometry (MS) in gas chromatography (GC) while in liquid chromatography was mainly by spectrophotometry.

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Determination of characteristic compound in manuka honey by automatic on-line solid phase extraction-liquid chromatography-high resolution mass spectrometry

Chinese Journal of Chromatography ◽

10.3724/sp.j.1123.2017.07009 ◽

2017 ◽

Vol 35 (10) ◽

pp. 1068

Author(s):

Chongyu Shen ◽

Siyan Guo ◽

Tao Ding ◽

Yun Liu ◽

Lei Chen ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

High Resolution Mass Spectrometry ◽

Solid Phase ◽

Phase Extraction ◽

Manuka Honey ◽

On Line ◽

Extraction Liquid ◽

Resolution Mass

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Solid-phase extraction liquid chromatography–tandem mass spectrometry analytical method for the determination of 2-hydroxy-4-methoxybenzophenone and its metabolites in both human urine and semen

Analytical and Bioanalytical Chemistry ◽

10.1007/s00216-010-3947-6 ◽

2010 ◽

Vol 398 (2) ◽

pp. 831-843 ◽

Cited By ~ 52

Author(s):

Zacarías León ◽

Alberto Chisvert ◽

Isuha Tarazona ◽

Amparo Salvador

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Solid Phase ◽

Tandem Mass ◽

Phase Extraction ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass ◽

Extraction Liquid

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A green liquid chromatography method for rapid determination of ergosterol in edible fungi based on matrix solid-phase dispersion extraction and a core–shell column

Analytical Methods ◽

10.1039/d0ay00714e ◽

2020 ◽

Vol 12 (26) ◽

pp. 3337-3343 ◽

Cited By ~ 1

Author(s):

Zhengming Qian ◽

Zi Wu ◽

Chunhong Li ◽

Guoying Tan ◽

Hankun Hu ◽

...

Keyword(s):

Liquid Chromatography ◽

Solid Phase ◽

Rapid Determination ◽

Edible Fungi ◽

Chromatography Method ◽

Matrix Solid Phase Dispersion ◽

Phase Dispersion ◽

Liquid Chromatography Method ◽

Extraction Liquid

A green and rapid matrix solid-phase dispersion extraction-liquid chromatography analytical method for the determination of ergosterol in edible fungi was established.

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Determination of Niacin in Infant Formula by Solid-Phase Extraction/Liquid Chromatography: Peer-Verified Method Performance–Interlaboratory Validation

Journal of AOAC International ◽

10.1093/jaoac/85.3.654 ◽

2002 ◽

Vol 85 (3) ◽

pp. 654-664 ◽

Cited By ~ 9

Author(s):

Denis E LaCroix ◽

Wayne R Wolf ◽

G William Chase

Keyword(s):

Liquid Chromatography ◽

Standard Deviation ◽

Reference Material ◽

Infant Formula ◽

Solid Phase ◽

Phase Extraction ◽

Relative Standard ◽

Interlaboratory Validation ◽

Extraction Liquid

Abstract This paper reports the results of the interlaboratory peer validation study of AOAC Peer-Verified Method (PVM) 1:2000 for the determination of niacin in infant formula by solid-phase extraction/liquid chromatography. We have used a Data Quality Objectives (DQO) approach to address not only method variability and robustness but also accuracy of data through the use of an appropriate reference material in conjunction with the interlaboratory validation study. Our DQO included the following: (1) statistical agreement of analytical results and quantitative recovery between 2 collaborating laboratories; (2) the repeatability relative standard deviation (RSDr) values and the HORRAT (Horwitz ratio) obtained (1.07), which satisfied the criteria of the Horwitz “limits of acceptability” at the analyte level present; (3) validation of lack of interference; and (4) accuracy agreement within assigned values for a certified reference material. National Institute of Standards and Technology Standard Reference Material (NIST SRM) 1846 Infant Formula, with a certified value of 63.3 ± 7.6 μg/g for niacin content, was used as a test material for collaborative study and accuracy assessment. Niacin values obtained by the originating laboratory were 59.7 ± 4.0 μg/g (95% confidence interval [CI] = 1.4 μg/g with a relative standard deviation [RSD] of 6.7%) and by the peer laboratory were 56.6 ± 6.6 μg/g (95% CI = 4.1 μg/g, with an RSD of 11.7%). Statistical evaluation using the means equivalence test showed that nicotinic acid values obtained by the peer laboratory were equivalent to those values obtained by the originating laboratory. Linear calibration curves and quantitative recovery were obtained. Integration of the PVM process with a readily available certified reference material gives the user confidence in the accuracy of the data generated by the method through traceability to the reference material used.

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