scholarly journals Screening for Hepatocellular Carcinoma in Patients with Hepatitis B

Viruses ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1318
Author(s):  
Yashasavi Sachar ◽  
Mayur Brahmania ◽  
Renumathy Dhanasekaran ◽  
Stephen E. Congly
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Risk Factor ◽  
High Risk ◽  
Hepatitis B ◽  
Risk Stratification ◽  
Significant Risk ◽  
Health Resources ◽  
Significant Risk Factor ◽  
Significant Morbidity

Chronic hepatitis B (CHB) infection is a significant risk factor for developing hepatocellular carcinoma (HCC). As HCC is associated with significant morbidity and mortality, screening patients with CHB at a high risk for HCC is recommended in an attempt to improve these outcomes. However, the screening recommendations on who to screen and how often are not uniform. Identifying patients at the highest risk of HCC would allow for the best use of health resources. In this review, we evaluate the literature on screening patients with CHB for HCC, strategies for optimizing adherence to screening, and potential risk stratification tools to identify patients with CHB at a high risk of developing HCC.

scholarly journals Vaccination in the Yugoslav National Army: A Significant Risk Factor for Acquiring Chronic Hepatitis B Virus Infection During Army Service in the Former Yugoslavia

2021 ◽  
Vol 8 (4) ◽  
Author(s):  
Nina Grasselli Kmet ◽  
Mario Poljak ◽  
Mojca Rajter ◽  
Tanja Selič ◽  
Zvonko Baklan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Hepatitis ◽  
Risk Factor ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Hbv Infection ◽  
B Virus

Background: To prevent the spread of infectious diseases, several state armies implemented obligatory vaccination programs also practiced in the former Yugoslav National Army (YNA). Iatrogenic hepatitis B virus (HBV) transmissions during vaccinations in the armies were well documented, but to the best of our knowledge, no such study has been performed in the former Yugoslavia. Objectives: In the present study, we determined risk factors for acquiring chronic hepatitis B (CHB) infection in patients in Slovenia. This study focused on the detection of a statistically significant risk factor in males, namely “vaccination in the YNA”. Methods: One thousand seven hundred and twenty-nine patients from all Slovenian regions who tested positive for HBV surface antigen (HBsAg) at the national referential laboratory for viral hepatitis diagnostics between January 1997 and December 2010 were included retrospectively. Accordingly, demographic, epidemiological, virological, and clinical data were extracted from the medical documentation and were statistically analyzed. Results: For 1,122 (64.9%) out of 1,729 patients, data regarding risk factors for acquiring HBV infection were available. The risk factor for infection of almost 60% of HBV chronically infected individuals with available data, followed by “HBV infection in the family” (19.8%) and “blood/blood products transfusion before the nineties” (8%) was unknown. Seven males (0.6%) (mean age ± SD, 53.7 ± 4.50 years) reported “vaccination in the YNA” as a risk factor for acquiring chronic HBV infection. “Vaccination in the YNA” was a significant risk factor for CHB infection in men over 46 years of age (P = 0.006). Conclusions: A significant risk factor for infection in Slovenian men over 46 years of age was identified as “vaccination in the YNA”, which is specific to this geographic region and, to the best of our knowledge, has not been previously described in the peer-reviewed literature.

Post-challenge hyperglycemia is a significant risk factor for the development of hepatocellular carcinoma in patients with chronic hepatitis C

2011 ◽  
Vol 46 (6) ◽  
pp. 790-798 ◽  
Author(s):  
Hirokazu Takahashi ◽  
Toshihiko Mizuta ◽  
Yuichiro Eguchi ◽  
Yasunori Kawaguchi ◽  
Takuya Kuwashiro ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Risk Factor ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Post Challenge

Targeted Screening For Prostate Cancer In High Risk Families: Early Onset Is A Significant Risk Factor For Disease In First Degree Relatives

2002 ◽  
Vol 168 (2) ◽  
pp. 483-487 ◽  
Author(s):  
Antoine Valeri ◽  
Luc Cormier ◽  
Marie-Pierre Moineau ◽  
Geraldine Cancel-Tassin ◽  
Rahmene Azzouzi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Risk Factor ◽  
High Risk ◽  
Early Onset ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
First Degree Relatives ◽  
Targeted Screening ◽  
High Risk Families

Abstract 3969: Hepatic microRNA as biomarker for detection of hepatocellular carcinoma in high-risk chronic Hepatitis B patients

2015 ◽  
Author(s):  
Amit Ghosh ◽  
Alip Ghosh ◽  
Somenath Datta ◽  
Debanjali Dasgupta ◽  
Soumyajit Das ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
High Risk ◽  
Hepatitis B ◽  
Chronic Hepatitis B

Pre-S Mutation Is a Significant Risk Factor for Hepatocellular Carcinoma Development: A Long-Term Retrospective Cohort Study

2012 ◽  
Vol 58 (3) ◽  
pp. 751-758 ◽  
Author(s):  
Dong Hyun Sinn ◽  
Moon Seok Choi ◽  
Geum-Youn Gwak ◽  
Yong-Han Paik ◽  
Joon Hyeok Lee ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Factor ◽  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Significant Risk ◽  
Significant Risk Factor
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