scholarly journals COVID-19 Modulates Inflammatory and Renal Markers That May Predict Hospital Outcomes among African American Males

Viruses ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2415
Author(s):  
Wendy Fonseca ◽  
Nobuhiro Asai ◽  
Kazuma Yagi ◽  
Carrie-Anne Malinczak ◽  
Gina Savickas ◽  
...  
Keyword(s):  
African American ◽  
Hospital Mortality ◽  
African American Males ◽  
Inflammatory Responses ◽  
Control Group ◽  
Icu Patients ◽  
Incremental Value ◽  
Renal Markers ◽  
Male Patients ◽  
Outcome Differences

Background and Objectives: African Americans and males have elevated risks of infection, hospitalization, and death from SARS-CoV-2 in comparison with other populations. We report immune responses and renal injury markers in African American male patients hospitalized for COVID-19. Methods: This was a single-center, retrospective study of 56 COVID-19 infected hospitalized African American males 50+ years of age selected from among non-intensive care unit (ICU) and ICU status patients. Demographics, hospitalization-related variables, and medical history were collected from electronic medical records. Plasma samples collected close to admission (≤2 days) were evaluated for cytokines and renal markers; results were compared to a control group (n = 31) and related to COVID-19 in-hospital mortality. Results: Among COVID-19 patients, eight (14.2%) suffered in-hospital mortality; seven (23.3%) in the ICU and one (3.8%) among non-ICU patients. Interleukin (IL)-18 and IL-33 were elevated at admission in COVID-19 patients in comparison with controls. IL-6, IL-18, MCP-1/CCL2, MIP-1α/CCL3, IL-33, GST, and osteopontin were upregulated at admission in ICU patients in comparison with controls. In addition to clinical factors, MCP-1 and GST may provide incremental value for risk prediction of COVID-19 in-hospital mortality. Conclusions: Qualitatively similar inflammatory responses were observed in comparison to other populations reported in the literature, suggesting non-immunologic factors may account for outcome differences. Further, we provide initial evidence for cytokine and renal toxicity markers as prognostic factors for COVID-19 in-hospital mortality among African American males.

scholarly journals The efects of whey protein and resistant starch on body weight

2015 ◽  
Vol 5 (8) ◽  
pp. 275
Author(s):  
Fatemah Malekian ◽  
Sebhatu Sebhatu Gebrelul ◽  
James F Henson ◽  
Kasundra D. Cyrus ◽  
Mfamara Goita ◽  
...  
Keyword(s):  
Body Weight ◽  
African American ◽  
Treatment Group ◽  
African Americans ◽  
Nutrition Education ◽  
Whey Protein ◽  
African American Males ◽  
Resistant Starch ◽  
Control Group ◽  
Males And Females

Background: Obesity is widely recognized as one of the most critical health threats to families and children across the country.  Obesity is a very serious health problem for people in Louisiana and especially in African Americans Children with 40.5% in the State classified as either overweight or obese as compared to 41.2% nationally. African American women have the highest rates of being overweight or obese (79.8%) compared to non-Hispanic whites (57.9%). In 2007, African Americans were 1.4 times as likely to be obese as whites. Therefore this study was designed to test the impact of dietary whey protein (WP) and resistant starch (RS) shakes/smoothies on reduction of body fat via increased satiety and increased energy expenditure in African Americans. Methods: Twenty eight African American males and females, age 21-43 years old were randomly divided into two groups.  For a period of 24-weeks, the treatment group consumed WP and RS shakes/smoothies for breakfast and received nutrition education. For the same period, the control group consumed the same shake/smoothies but with starch powder and received nutrition education. The data was analyzed using SAS version 9.3. Results: At the end of the 24 week study, the treatment group lost a mean body weight of approximately 7 kg (P ≤ 0.008) that was significantly different from the control group (P ≤ 0.209). In addition, the treatment group exhibited a significant decrease of ~6 cm in waist circumference (P ≤ 0.023).  There was no significant effect on mean blood pressure in treatment and control group.Conclusion: The findings from this study suggest that a combination of WP and RS in the form of shake/smoothie consumed for breakfast along with a nutrition education component may be an effective method in decreasing body weight, improving waist circumferences and cumulative food intake in African American males and females. Key Words:  Whey Protein, Resistant Starch, Obesity, Breakfast shakes, Nutrition education 

Evaluation of Community-Based Program for African-American Males: The Real Men, Real Heroes Project

2009 ◽  
Author(s):  
Felecia Arlene Lee ◽  
Rhonda Lewis-Moss ◽  
Jamilia Sly ◽  
Shani Roberts
Keyword(s):  
African American ◽  
African American Males ◽  
Community Based ◽  
The Real

Rheumatoid Factor in Type 2 Male Diabetes Mellitus Patients in a Tertiary Care Hospital of Bangladesh

2018 ◽  
Vol 4 (2) ◽  
pp. 58-62
Author(s):  
Roksana Yeasmin ◽  
MA Muttalib ◽  
Kazi Nazneen Sultana ◽  
Nizamul Hoque Bhuiyan ◽  
Md Jamil Hasan Karami ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Rheumatoid Factor ◽  
Serum Uric Acid ◽  
Control Group ◽  
Healthy Male ◽  
Male Patients

Background: Type 2 diabetes mellitus is a chronic disease characterized by relative or absolute deficiency of insulin, resulting in glucose intolerance.Objectives: The present study was planned to see the associations of serum uric acid with positive Rheumatoid factor in type 2 male diabetes mellitus patients. Methodology: This case control study was carried out at the department of Biochemistry at Ibrahim Medical College, Dhaka, Bangladesh. The duration of the study was from June 2015 to June 2016 for a period of one year. In this present study, male patients with type 2 diabetes mellitus were taken as case group and age and sex matched healthy male were taken as control group. Rheumatoid factor was measured from the blood of all case and control group respondents. Others blood para meters were also measured for the correlation with the diabetes mellitus patients.Results: In this present study, 110 male patients presented with type 2 diabetes mellitus were recruited as case and age and sex matched healthy male were recruited as control. More rheumatoid factor positive in type 2 DM male patients with the uric acid range between 6.5 to 9.5 mg/dL. The number of patients was 5 out of total 9 rheumatoid factor positive cases. In this study serum uric acid was significantly correlated with rheumatoid factor in type 2 male diabetic patients. Rheumatoid factor positive cases were taking insulin among 9 and it was statistically significantly associated (p<0.001). Conclusion: In this study serum uric acid is significantly associated with positive rheumatoid factor in type 2 male diabetic patients.Journal of Current and Advance Medical Research 2017;4(2):58-62

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