scholarly journals Internal and External Validity of Social Media and Mobile Technology-Driven HPV Vaccination Interventions: Systematic Review Using the Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) Framework

Vaccines ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 197
Author(s):  
Matthew Asare ◽  
Braden Popelsky ◽  
Emmanuel Akowuah ◽  
Beth A. Lanning ◽  
Jane R. Montealegre
Keyword(s):  
Social Media ◽  
Real World ◽  
External Validity ◽  
Hpv Vaccination ◽  
Internal Validity ◽  
Population Based ◽  
Sufficient Information ◽  
Population Based Study ◽  
Vaccination Rates ◽  
Effective Interventions

Social media human papillomavirus (HPV) vaccination interventions show promise for increasing HPV vaccination rates. An important consideration for the implementation of effective interventions into real-world practice is the translation potential, or external validity, of the intervention. To this end, we conducted a systematic literature review to describe the current body of evidence regarding the external validity of social media HPV vaccination-related interventions. Constructs related to external validity were based on the reach, effectiveness, adoption, implementation, maintenance (RE-AIM) framework. Seventeen articles published between 2006 and 2020 met the inclusion criteria. Three researchers independently coded each article using a validated RE-AIM framework. Discrepant codes were discussed with a fourth reviewer to gain consensus. Of these 17 studies, 3 were pilot efficacy studies, 10 were randomized controlled trials (RCTs) to evaluate effectiveness, 1 was a population-based study, and 3 did not explicitly state which type of study was conducted. Reflecting this distribution of study types, across all studies the mean level of reporting RE-AIM dimensions varied with reach recording 90.8%, effectiveness (72.1%), adoption (40.3%), implementation (45.6%), and maintenance (26.5%). This review suggests that while the current HPV vaccination social media-driven interventions provide sufficient information on internal validity (reach and effectiveness), few have aimed to gather data on external validity needed to translate the interventions into real world implementation. Our data suggest that implementation research is needed to move HPV vaccination-related interventions into practice. Included in this review are recommendations for enhancing the design and reporting of these HPV vaccination social media-related interventions.

scholarly journals Evaluation of the Internal and External Validity of Social Media and Mobile Technology Driven HPV Vaccination Interventions: Systematic Review Using Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) Framework

2021 ◽  
Author(s):  
Matthew Asare ◽  
Braden Popelsky ◽  
Emmanuel Akowuah ◽  
Beth A. Lanning ◽  
Jane R. Montealegre
Keyword(s):  
Social Media ◽  
Real World ◽  
External Validity ◽  
Hpv Vaccination ◽  
Internal Validity ◽  
Population Based ◽  
Sufficient Information ◽  
Population Based Study ◽  
Vaccination Rates ◽  
Effective Interventions

Social media HPV vaccination interventions show promise for increasing HPV vaccination rates. An important consideration for the implementation of effective interventions into real-world practice in the translation potential, or external validity, of the intervention. To this end, we conducted a systematic literature review to describe the current body of evidence regarding the external validity of social media HPV vaccination-related interventions. Constructs related to external validity were based on the RE-AIM (reach, effectiveness, adoption, implementation, maintenance) framework. Seventeen articles published between 2006 and 2020 met inclusion criteria. Three researchers independently coded each article using a validated RE-AIM (reach, effectiveness/efficacy, adoption, implementation, maintenance) framework. Discrepant codes were discussed with a fourth reviewer to gain consensus. Of these 17 studies, three were pilot efficacy studies, 10 were RCTs to evaluate effectiveness, one was a population-based study, and three did not explicitly state which type of study was conducted. Reflecting this distribution of study types, across all studies the mean level of reporting RE-AIM dimensions varied with reach recording 90.8%, effectiveness (72.1%), adoption (40.3%), implementation (45.6%), and maintenance (26.5%). This review suggests that while the current HPV vaccination social media-driven interventions provide sufficient information on internal validity (reach and effectiveness), few have aimed to gather data on external validity needed to translate the interventions into real world implementation. Our data suggest that implementation research is needed to move HPV vaccination-related interventions into practice. Included in this review are recommendations for enhancing the design and reporting of these HPV vaccination social media-related interventions.

scholarly journals Real-world Outcomes of First-line Anti-PD-1 Therapy for Advanced Melanoma: A Nationwide Population-based Study

2020 ◽  
Vol 43 (8) ◽  
pp. 256-264
Author(s):  
Michiel C.T. van Zeijl ◽  
John B.A.G. Haanen ◽  
Michel W.J.M. Wouters ◽  
Liesbeth C. de Wreede ◽  
Anouk Jochems ◽  
...  
Keyword(s):  
Real World ◽  
Population Based ◽  
Advanced Melanoma ◽  
First Line ◽  
Population Based Study

Aplastic Anemia in Thailand: Incidence and Treatment Outcome from a Prospective Nationwide Population-Based Study

Blood ◽  
2020 ◽  
Vol 136 (Supplement 1) ◽  
pp. 8-9
Author(s):  
Lalita Norasetthada ◽  
Somchai Wongkhantee ◽  
Jindaratn Chaipokam ◽  
Kanyaporn Charoenprasert ◽  
Suporn Chuncharunee ◽  
...  
Keyword(s):  
Aplastic Anemia ◽  
Anabolic Steroid ◽  
Real World ◽  
Conflicts Of Interest ◽  
Bone Marrow Failure ◽  
Population Based ◽  
Annual Incidence ◽  
Severe Aplastic Anemia ◽  
Treatment Modalities ◽  
Population Based Study

Background: Incidence of Aplastic Anemia (AA) in Asia tends to be higher than in western countries, but contemporary real-world incidence and outcomes of AA in Asia remain limited. This study aimed to explore the incidence across the country regions and to evaluate the patient outcomes according to age, the severity of disease, and treatment modalities. Method: This is a prospective multicenter nationwide population-based observational study of patients with AA aged over 15 years old, diagnosed between August 1st, 2014 to July 31st, 2016, with a longitudinal follow-up period over 2 years, from 30 medical centers. Patients with suspected hypocellular MDS and congenital bone marrow failure syndrome were excluded. Results: During the study period of 2 years, there were 348 newly diagnosed patients with aplastic anemia, giving the annual incidence of 4.6 per million inhabitants. There was a higher annual incidence of severe (SAA) and very severe aplastic anemia (VSAA) (3.8 per million) than non-severe aplastic anemia (NSAA) (0.8 per million). The incidence was greater among older patients with a peak incidence in patients aged 60-89 years old. (Figure 1) There was a high variation in the geographic incidences across country regions, ranging from 2.6 to 6.6 per million per year. (Figure 2) The 2-year overall survival (OS) for NSAA, SAA, and VSAA were 65.5%, 49.3%, and 20.1%, respectively (P < 0.001). Patients aged older than 60 years had the worst OS (42.6% as compared with 47.7% for the age 41-60 years and 64.5% for the age 15-40 years, P = 0.002). Among patients with SAA and VSAA (n = 280), the overall response rate (ORR) among patients treated with rabbit anti-thymocyte globulin and/or cyclosporin A (rATG±CsA) was significantly superior than those treated with CsA-based therapy and those treated with anabolic steroid (44.4% vs. 36.4% and 31.2%, respectively, P < 0.001). Among evaluable patients, ORR after the 1st treatment with rATG±CsA at 3, 6, 12 and 24 months were 23.9%, 43.8%, 68.4% and 89.2%, respectively. The 2-year OS among SAA/VSAA patients treated with rATG±CsA, CsA-based therapy, and anabolic steroid were 54.8%, 54.5%, and 37.6% (P = 0.037), respectively (Figure 3). From multivariate analysis, age > 60 years (HR 1.63, 95%CI, 1.14-2.33, P = 0.007), VSAA (HR 2.24, 95% CI, 1.45-3.46, P < 0.001) and not receiving immunosuppressive therapy or anabolic steroid (HR 4.96, 95%CI, 2.88-8.54, P <0.001), were independently associated with inferior OS among patients with SAA/VSAA. Conclusion: The incidence rate of AA in Thailand from this contemporary nationwide population-based study is high, especially in the elderly. Patients treated with rATG±CsA had superior survival than those receiving anabolic steroid. The real-world outcome of patients with SAA/VSAA, especially in those aged over 60 years, is substantially poor. Figure 1 Disclosures No relevant conflicts of interest to declare.

Parental acceptability of HPV vaccination for boys and girls aged 9–13 years in China – A population-based study

Vaccine ◽  
2018 ◽  
Vol 36 (19) ◽  
pp. 2657-2665 ◽  
Author(s):  
Zixin Wang ◽  
Jingjing Wang ◽  
Yuan Fang ◽  
Danielle L. Gross ◽  
Martin C.S. Wong ◽  
...  
Keyword(s):  
Hpv Vaccination ◽  
Population Based ◽  
Population Based Study ◽  
Parental Acceptability

External Validity Reconsidered

2011 ◽  
Author(s):  
Diana C. Mutz
Keyword(s):  
Political Science ◽  
Real World ◽  
External Validity ◽  
Observational Studies ◽  
Internal Validity ◽  
Conventional Wisdom ◽  
Observational Research ◽  
Convincing Case

This chapter talks about the significance of generalizability. Experimentalists often go to great lengths to argue that student or other convenience samples are not problematic in terms of external validity. Likewise, a convincing case for causality is often elusive with observational research, no matter how stridently one might argue to the contrary. The conventional wisdom is that experiments are widely valued for their internal validity, and experiments lack external validity. These assumptions are so widespread as to go without question in most disciplines, particularly those emphasizing external validity, such as political science and sociology. But observational studies, such as surveys, are still supposed to be better for purposes of maximizing external validity because this method allows studying people in real world settings.

scholarly journals Coverage and Acceptability of Mobile Phone Messages for Cancer Prevention: a Population-Based Study in a Latin American Country

2020 ◽  
Author(s):  
Raúl Murillo ◽  
Camila Ordóñez-Reyes ◽  
María Caicedo-Martínez ◽  
Sandra Paola Vargas ◽  
Elsa Ariza ◽  
...  
Keyword(s):  
Cancer Prevention ◽  
Latin American ◽  
Internal Validity ◽  
Population Based ◽  
Insurance Company ◽  
Post Intervention ◽  
Population Based Study ◽  
Middle Income ◽  
Positive Effects ◽  
Message Service

AbstractMobile health (m-health) has shown positive effects on disease prevention; however, several factors might influence its effectiveness, particularly in low- and middle-income countries. Randomized trials provide data with high internal validity but no major information on population impact. We conducted a pilot population-based study to assess the feasibility of cancer prevention through m-health in a Latin American population. A sample of affiliates to a health insurance company in Colombia was randomly selected and assigned to receive a short message service (SMS) or voice messages (VMS) during 4 weeks; weekly frequencies 2 and 7. Baseline and post-intervention surveys were conducted. Overall, 797 affiliates were contacted (SMS 393, VMS 404) but only 15.3% and 24.8% enrolled, respectively. Over 80% acceptability was observed among participants for all items evaluated (usefulness, understandability, timing, and frequency); however, 2-VMS per week was the only frequency consistent with the declared number of messages received and listened. Other frequencies resulted in high reception recall but low willingness to read/listen the messages. The willingness to be part of future programs was 20.0%. The gap between declared acceptability and practice, low participation rates, and low willingness to read/listen messages indicate m-health should be part of multicomponent interventions and should not be conceived as the sole intervention.

Sign in / Sign up

Export Citation Format

Share Document