scholarly journals Pediatric COVID-19: Immunopathogenesis, Transmission and Prevention

Vaccines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1002 ◽  
Author(s):  
Geraldine Blanchard-Rohner ◽  
Arnaud Didierlaurent ◽  
Anne Tilmanne ◽  
Pierre Smeesters ◽  
Arnaud Marchant
Keyword(s):  
Respiratory Tract Infections ◽  
Rapid Development ◽  
Severe Disease ◽  
Innate Immune ◽  
The Other ◽  
High Susceptibility ◽  
Relative Resistance ◽  
Tract Infections ◽  
Inflammatory Syndrome ◽  
The Impact

Children are unique in the context of the COVID-19 pandemic. Overall, SARS-CoV-2 has a lower medical impact in children as compared to adults. A higher proportion of children than adults remain asymptomatic following SARS-CoV-2 infection and severe disease and death are also less common. This relative resistance contrasts with the high susceptibility of children to other respiratory tract infections. The mechanisms involved remain incompletely understood but could include the rapid development of a robust innate immune response. On the other hand, children develop a unique and severe complication, named multisystem inflammatory syndrome in children, several weeks after the onset of symptoms. Although children play an important role in the transmission of many pathogens, their contribution to the transmission of SARS-CoV-2 appears lower than that of adults. These unique aspects of COVID-19 in children must be considered in the benefit–risk analysis of vaccination. Several COVID-19 vaccines have been authorized for emergency use in adolescents and clinical studies are ongoing in children. As the vaccination of adolescents is rolled out in several countries, we shall learn about the impact of this strategy on the health of children and on transmission within communities.

scholarly journals Burden of disease in children with respiratory tract infections in primary care: diary-based cohort study

2019 ◽  
Vol 36 (6) ◽  
pp. 723-729
Author(s):  
M J C Schot ◽  
A R J Dekker ◽  
C H van Werkhoven ◽  
A W van der Velden ◽  
J W L Cals ◽  
...  
Keyword(s):  
Primary Care ◽  
Respiratory Tract ◽  
Family Life ◽  
Burden Of Disease ◽  
Respiratory Tract Infections ◽  
Health Care Facilities ◽  
Duration Of Symptoms ◽  
Disturbed Sleep ◽  
Tract Infections ◽  
The Impact

Abstract Background Respiratory tract infections (RTIs) are a common reason for children to consult in general practice. Antibiotics are often prescribed, in part due to miscommunication between parents and GPs. The duration of specific respiratory symptoms has been widely studied. Less is known about illness-related symptoms and the impact of these symptoms on family life, including parental production loss. Better understanding of the natural course of illness-related symptoms in RTI in children and impact on family life may improve GP–parent communication during RTI consultations. Objective To describe the general impact of RTI on children and parents regarding illness-related symptoms, absenteeism from childcare, school and work, use of health care facilities, and the use of over-the-counter (OTC) medication. Methods Prospectively collected diary data from two randomized clinical trials in children with RTI in primary care (n = 149). Duration of symptoms was analysed using survival analysis. Results Disturbed sleep, decreased intake of food and/or fluid, feeling ill and/or disturbance at play or other daily activities are very common during RTI episodes, with disturbed sleep lasting longest. Fifty-two percent of the children were absent for one or more days from childcare or school, and 28% of mothers and 20% of fathers reported absence from work the first week after GP consultation. Re-consultation occurred in 48% of the children. OTC medication was given frequently, particularly paracetamol and nasal sprays. Conclusion Appreciation of, and communication about the general burden of disease on children and their parents, may improve understanding between GPs and parents consulting with their child.

scholarly journals Non-specific protection from respiratory tract infections in cattle generated by intranasal administration of an innate immune stimulant

PLoS ONE ◽  
2020 ◽  
Vol 15 (6) ◽  
pp. e0235422
Author(s):  
William Wheat ◽  
Lyndah Chow ◽  
Vanessa Rozo ◽  
Julia Herman ◽  
Kelly Still Brooks ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Intranasal Administration ◽  
Respiratory Tract Infections ◽  
Innate Immune ◽  
Tract Infections

scholarly journals Molecular Mechanisms of Macrolide Resistance in Clinical Isolates of Mycoplasma pneumoniae from China

2009 ◽  
Vol 53 (5) ◽  
pp. 2158-2159 ◽  
Author(s):  
Deli Xin ◽  
Zuhuang Mi ◽  
Xu Han ◽  
Ling Qin ◽  
Jing Li ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Molecular Mechanism ◽  
Mycoplasma Pneumoniae ◽  
Respiratory Tract Infections ◽  
Molecular Mechanisms ◽  
Point Mutations ◽  
Macrolide Resistance ◽  
The Other ◽  
23S Rrna ◽  
Tract Infections

ABSTRACT Fifty clinical Mycoplasma pneumoniae strains were isolated from 370 children with respiratory tract infections. Four strains were susceptible to macrolides, while the other 46 (92%) were macrolide resistant. The molecular mechanism of resistance was shown to be associated with point mutations in 23S rRNA at positions 2063 and 2064.

scholarly journals Smoke-free legislation and childhood hospitalisations for respiratory tract infections

2015 ◽  
Vol 46 (3) ◽  
pp. 697-706 ◽  
Author(s):  
Jasper V. Been ◽  
Christopher Millett ◽  
John Tayu Lee ◽  
Constant P. van Schayck ◽  
Aziz Sheikh
Keyword(s):  
Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Negative Binomial ◽  
Hospital Admissions ◽  
Negative Binomial Regression ◽  
Second Hand Smoke ◽  
Incidence Trends ◽  
Group Sex ◽  
Tract Infections ◽  
The Impact

Second-hand smoke exposure is a major risk factor for respiratory tract infections (RTIs). Although evidence suggests important early-life health benefits of smoke-free public environments, the impact on childhood RTIs is unclear. We investigated the association between England's smoke-free legislation and childhood RTI hospitalisations.We used the Hospital Episode Statistics database to obtain nationwide data on hospital admissions for acute RTIs among children (<15 years of age) from 2001 to 2012. Hospitalisation counts were disaggregated by month, age group, sex and small-area level, and linked to urbanisation, region, deprivation index and corresponding population estimates. Negative binomial regression analyses were adjusted for confounders, seasonal variation, temporal autocorrelation, population-size changes and underlying incidence trends. Models allowed for sudden and gradual changes following the smoke-free legislation. We performed sensitivity and subgroup analyses, and estimated number of events prevented.We analysed 1 651 675 hospital admissions. Introduction of smoke-free legislation was followed by an immediate reduction in RTI admissions (−3.5%, 95% CI −4.7– −2.3%), this mainly being attributable to a decrease in lower RTI admissions (−13.8%, 95% CI −15.6– −12.0%). The reductions in admissions for upper RTI were more incremental.The introduction of national smoke-free legislation in England was associated with ∼11 000 fewer hospital admissions per year for RTIs in children.

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