Bacterial meningitis in the practice of a primary care physician. Clinical and immunological efficacy of recombinant interleukin-2 in the complex therapy of bacterial meningitis

2022 ◽  
pp. 28-33
Author(s):  
Oksana Anatolievna Gizinger ◽  
◽  
Irina Yurievna Lepina ◽  
Marina Nikolaevna Bagdasaryan ◽  
◽  
...  
Keyword(s):  
Primary Care ◽  
Bacterial Meningitis ◽  
B Lymphocytes ◽  
Interleukin 2 ◽  
Care Physician ◽  
Clonal Proliferation ◽  
Recombinant Cytokine ◽  
Proliferation And Differentiation ◽  
Complex Therapy ◽  
Recombinant Interleukin 2

The article analyzes the pathogenetic features of bacterial meningitis and substantiates the scheme of complex therapy of the disease using the recombinant cytokine interleukin-2 (IL2). The clinical, immunological and microbiological efficacy of the complex therapy scheme has been revealed. It has been shown that the pleiotropic effects of recombinant IL-2, its effect on the activity of metabolic processes at the cellular and subcellular levels, the ability to stabilize the system of lipid peroxidation of cell membranes, the ability to influence the processes of clonal proliferation and differentiation of T- and B-lymphocytes, make its use justified in complex therapy of meningitis.

Clinical and immunological and microbiological effectiveness of the use of recombinant interleukin 2 in the complex therapy of bacterial meningitis

2021 ◽  
pp. 11-18
Author(s):  
O.A. Gizinger
Keyword(s):  
Bacterial Meningitis ◽  
B Lymphocytes ◽  
Biological Effects ◽  
Interleukin 2 ◽  
Clonal Proliferation ◽  
Recombinant Cytokine ◽  
Proliferation And Differentiation ◽  
Complex Therapy ◽  
Recombinant Interleukin 2

The article shows the scheme of complex therapy of bacterial meningitis using the recombinant cytokine interleukin 2. The clinical, immunological and microbiological efficacy of the use of recombinant interleukin 2 in the complex therapy of bacterial meningitis is shown. The biological effects of recombinant IL-2 justify its use in the complex therapy of meningitis due to its influence on the activity of metabolic processes at the cellular and subcellular levels, the ability to stabilize the system of lipid peroxidation of cell membranes, to influence the processes of clonal proliferation and differentiation of T- and B-lymphocytes improving the quality of the therapy.

Lymphokines and monokines as regulators of human lymphoproliferation.

1984 ◽  
Vol 30 (9) ◽  
pp. 1539-1545 ◽  
Author(s):  
N M Kouttab ◽  
S Mehta ◽  
J Morgan ◽  
N Tannir ◽  
C Sahasrabuddhe ◽  
...  
Keyword(s):  
B Lymphocytes ◽  
Biological Fluids ◽  
Interleukin 1 ◽  
Interleukin 2 ◽  
Proliferation And Differentiation ◽  
The Face ◽  
B Cell Growth Factor ◽  
Immunoregulatory Cells ◽  
Immunodeficiency Syndromes

Abstract The development of a competent immunoregulatory response in the face of an antigenic challenge is modulated by soluble proteins of relatively low molecular mass. Lymphokines and monokines, secreted by cells of T lineage and cells of the monocyte/microphage series, respectively, function in a bimodal amplification network that results in the proliferation and differentiation of the immunoregulatory cells. Interleukin 1 is typically assayed by its effect on thymocytes or by its ability to promote the T cell-dependent release of interleukin 2. Interleukin 2 is routinely measured by its ability to support the long-term growth of cultured T cells, whereas B cell growth factor is measured by its ability to support the long-term growth of cultured B lymphocytes. The availability of homogeneous purified factors and the subsequent availability of monoclonal antibodies against these reagents should allow for the development of rapid quantitative assays for these analytes in diverse biological fluids. In addition, large quantities of purified reagents will promote studies to determine therapeutic efficacy in several immunodeficiency syndromes.

scholarly journals A primary care physician’s approach to a child with meningitis

2018 ◽  
Vol 33 (2) ◽  
pp. 31-37
Author(s):  
I Govender ◽  
C Steyn ◽  
G Maricowitz ◽  
C C Clark ◽  
M C Tjale
Keyword(s):  
Primary Care ◽  
Bacterial Meningitis ◽  
Primary Healthcare ◽  
Care Physician ◽  
Acute Bacterial Meningitis ◽  
Older Children ◽  
Neck Stiffness ◽  
Childhood Morbidity ◽  
Threatening Condition ◽  
Meningitis In Children

Background: Paediatric meningitis remains a common cause of childhood morbidity and mortality in developing countries. In children the peak age for meningitis is six to 12 months old, with 90% of cases occurring in children younger than five years. It is imperative that a primary healthcare physician be aware of and is capable of managing this life-threatening condition as most caregivers first present to a primary healthcare physician with their sick child.Discussion: Common symptoms are headaches, photophobia, drowsiness, fatigue, unexplained crying, convulsions, irritability, and lethargy. Signs include fever, vomiting, neck stiffness and signs of increased intracranial pressure. Acute bacterial meningitis, especially meningococcal meningitis can present with petechiae and/or purpura. Cranial nerve palsy occurs commonly in cryptococcal meningitis, which can occur as part of immune reconstitution inflammatory syndrome (IRIS) after initiation of antiretroviral therapy. Older children may present with behavioural changes and localising signs such as hemiparesis and coma.Conclusion: This paper discusses the lumbar puncture technique and findings, drug and non-drug management, information on chemoprophylaxis for bacterial meningitis, and the possible complications of meningitis in children. This is an important area for the primary care physician as they are usually the first port of call by caregivers.

Platelet Activating Factor Inhibits Both the Proliferation and the Differentiation of Activated B Lymphocytes in Response to Interleukin-2

1992 ◽  
Vol 5 (3) ◽  
pp. 155-163 ◽  
Author(s):  
B. Dugas ◽  
J.P. Kolb ◽  
Nathalie Paul-Eugene ◽  
J.M. Mencia-Huerta ◽  
P. Braquet
Keyword(s):  
B Lymphocytes ◽  
B Lymphocyte ◽  
Interleukin 2 ◽  
Platelet Activating Factor ◽  
Interleukin 4 ◽  
Delayed Response ◽  
Suppression Effect ◽  
Paf Antagonists ◽  
Proliferation And Differentiation ◽  
Humoral Responses

The role of the platelet activating factor in human B lymphocyte responses to Interleukin-2 was examined and compared with that of Interleukin-4 by assessing the ability of this molecule to modulate proliferation and differentiation. Highly purified B lymphocytes were prestimulated for 48 h with Staphylococcus aureus Cowan Strain I and then were cultured with Interleukin-2 alone or in combination with either Interleukin-4 or the platelet activating factor and the proliferation (after 3 days) and the immunoglobulins (IgG and IgM) production (after 7 days) were evaluated. When SAC-activated B lymphocytes were preincubated overnight with PAF (0.0001 to 1 μM) or with IL-4 (1 to 100 U/ml) both the IL-2-induced proliferation and immunoglobulins secretion were inhibited. This inhibition was not a reflection of a decreased expression of the IL-2 receptor (CD25) because this expression was not modified on SAC-activated B lymphocytes after preincubation with either PAF or IL-4. Moreover, this suppression effect was not the result of a delayed response to IL-2. The PAF-induced suppression was overcome in the presence of PAF antagonists (BN 52021 and BN 50730) but was not modified in the presence of a neutralizing anti-IL-4 antiserum. On the other hand, the IL-4 mediated suppression was totally reversed in the presence of the neutralizing anti-serum and only marginally reversed in the presence of the PAF antagonists. These results indicate that both PAF and IL-4 may exert a number of immunoregulatory actions on human B lymphocyte proliferation and differentiation. They interfere with the stimulation of activated B lymphocytes by IL-2 and could play an important immunoregulatory role in the determination of isotypic regulation in the specific humoral responses.

Recombinant cytokines in the practice of the therapist

2021 ◽  
pp. 11-18
Author(s):  
Margarita Valentinovna Antonenko
Keyword(s):  
Tissue Repair ◽  
T Regulatory Cells ◽  
Interleukin 2 ◽  
Premature Death ◽  
Immunological Tolerance ◽  
Regulatory Cells ◽  
Activated T Cells ◽  
Tissue Repair And Regeneration ◽  
Proliferation And Differentiation ◽  
Recombinant Interleukin 2

The article contains information presented in the open press based on the results of studies of the clinical efficacy of recombinant interleukin 2. Roncoleukin provides immune protection against tumor cells, pathogens of viral, bacterial and fungal nature, activates the processes of tissue repair and regeneration, promotes adequate interaction of the immune, endocrine and nervous systems. Interleukin-2 is an activation, proliferation and differentiation factor for T- and B-lymphocytes, T-regulatory cells, natural killer cells, monocytes / macrophages, dendritic and oligodendroglial cells; protects activated T cells from premature death (apoptosis) and cancels immunological tolerance.

Review of The fifteen minute hour: Applied psychotherapy for the primary care physician.

1988 ◽  
Vol 6 (4) ◽  
pp. 483-487
Author(s):  
Richard P. McQuellon ◽  
Guyton J. Winker
Keyword(s):  
Primary Care ◽  
Primary Care Physician ◽  
Care Physician
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