Study of the toxicity of nanoparticles of various nature

2021 ◽  
pp. 18-20
Author(s):  
Evgeny Anatolevich Dukhnovsky
Keyword(s):  
Review Article ◽  
Toxicity Data

Nanoparticles of various nature are increasingly being subjected to extensive research in recent years, in particular, studies of toxicity. This review article briefly systematizes and summarizes the available toxicity data of nanoparticles of various nature.

Cyclosporine A: Chemistry and Toxicity – A Review

2020 ◽  
Vol 27 ◽  
Author(s):  
Jiri Patocka ◽  
Eugenie Nepovimova ◽  
Kamil Kuca ◽  
Wenda Wu
Keyword(s):  
Side Effects ◽  
Cyclosporine A ◽  
Survival Rates ◽  
Review Article ◽  
Clinical Use ◽  
Toxicity Data ◽  
High Toxicity ◽  
Administration Routes ◽  
Toxic Damage ◽  
Immunosuppressive Potency

: Cyclosporine A (CsA) is a cyclic undecapeptide with strong immunosuppressive potency. Firstly marketed in the mid-1980s, CsA was widely used in transplantation and greatly improved the survival rates of patients and grafts after solidorgan transplantation. Unfortunately, CsA administration can be associated with a number of side effects due to its high toxicity. These side effects seriously limited the clinical use of CsA. Therefore, it is important to understand the serious side effects of CsA in patients, especially in transplantation. In this review article, we are summarizing the chemistry and most known toxic effects of CsA including the nephrotoxic, hepatotoxic, neurotoxic and cardiotoxic effects. Its available toxicity data (different species, different administration routes) published formerly are also summarized. In addition, the molecular pathways of toxic damage induced by CsA are also detailly discussed. We hope that this review will help to further understand the source, chemistry and clinical application of CsA in patients as well as the potential mechanisms of CsA-induced toxicity.

scholarly journals Ecological Thresholds of Toxicological Concern: A Review

2021 ◽  
Vol 3 ◽  
Author(s):  
Mace G. Barron ◽  
Ryan R. Otter ◽  
Kristin A. Connors ◽  
Aude Kienzler ◽  
Michelle R. Embry
Keyword(s):  
Review Article ◽  
Risk Assessments ◽  
Toxicity Data ◽  
Ongoing Research ◽  
New Approach ◽  
Ecological Thresholds ◽  
Ecological Threshold ◽  
Recent Developments ◽  
Potential Applications ◽  
Computational Platform

The ecological threshold of toxicological concern (ecoTTC) is analogous to traditional human health-based TTCs but with derivation and application to ecological species. An ecoTTC is computed from the probability distribution of predicted no effect concentrations (PNECs) derived from either chronic or extrapolated acute toxicity data for toxicologically or chemically similar groups of chemicals. There has been increasing interest in using ecoTTCs in screening level environmental risk assessments and a computational platform has been developed for derivation with aquatic species toxicity data (https://envirotoxdatabase.org/). Current research and development areas include assessing mode of action-based chemical groupings, conservatism in estimated PNECs and ecoTTCs compared to existing regulatory values, and the influence of taxa (e.g., algae, invertebrates, and fish) composition in the distribution of PNEC values. The ecoTTC continues to develop as a valuable alternative strategy within the toolbox of traditional and new approach methods for ecological chemical assessment. This brief review article describes the ecoTTC concept and potential applications in ecological risk assessment, provides an overview of the ecoTTC workflow and how the values can be derived, and highlights recent developments and ongoing research. Future applications of ecoTTC concept in different disciplines are discussed along with opportunities for its use.

Desiderata in connection by the calibration of the MK-system

1966 ◽  
Vol 24 ◽  
pp. 348-349
Author(s):  
Th. Schmidt-Kaler
Keyword(s):  
Absolute Magnitude ◽  
Review Article ◽  
Stellar Systems ◽  
Astronomical Data ◽  
Intrinsic Colour

This is only an informal remark about some difficulties I am worrying about.I have tried to recalibrate the MK system in terms of intrinsic colour (B–V)0and absolute magnitudeMv. The procedures used have been described in a review article by Voigt (Mitt. Astr. Ges.1963, p. 25–35), and the results for stars of the luminosity classes Ia-O,I and II have been given also in Blaauw's article on the calibration of luminosity criteria in vol. III (Basic Astronomical Data, p. 401) ofStars and Stellar Systems.

Electron-deficient boron-based catalysts for C–H bond functionalisation

2021 ◽  
Author(s):  
Yuanhong Ma ◽  
Shao-Jie Lou ◽  
Zhaomin Hou
Keyword(s):  
Review Article ◽  
Current Status ◽  
Comprehensive Overview

This review article provides a comprehensive overview to recognise the current status of electron-deficient boron-based catalysis in C–H functionalisations.

Amino-functional polyethers: versatile, stimuli-responsive polymers

2020 ◽  
Vol 11 (24) ◽  
pp. 3940-3950 ◽  
Author(s):  
Patrick Verkoyen ◽  
Holger Frey
Keyword(s):  
Ring Opening ◽  
Review Article ◽  
Stimuli Responsive ◽  
New Class ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers

Amino-functional polyethers have emerged as a new class of “smart”, i.e. pH- and thermoresponsive materials. This review article summarizes the synthesis and applications of these materials, obtained from ring-opening of suitable epoxide monomers.

Developing Evidence-Based Assessment to Prevent Over- or Underidentification of Disorders for New Language Learners

2020 ◽  
Vol 5 (4) ◽  
pp. 1026-1038
Author(s):  
Sandra Levey ◽  
Li-Rong Lilly Cheng ◽  
Diana Almodovar
Keyword(s):  
Language Learners ◽  
Grade Level ◽  
Reading Skills ◽  
Language Disorder ◽  
Academic Development ◽  
Review Article ◽  
Evidence Based ◽  
Clinical Knowledge ◽  
Language And Literacy ◽  
Support Evidence

Purpose The purpose of this review article is to present certain linguistic domains to consider in the assessment of children learning a new language. Speech-language pathologists frequently face difficulty when determining if a bilingual or multilingual child possesses a true speech or language disorder. Given the increased number of new language learners across the world, clinicians must understand differences versus disorders to prevent underidentification or overidentification of a disorder. Conclusions Early identification of a true disorder has been shown to prevent language and literacy difficulties, given that children are able to achieve grade-level reading skills when given intervention. Clinical knowledge and skills are strongly required so that children receive evidence-based assessment to support their academic development. Learning Goal Readers will gain an understanding of the factors that support evidence-based assessment of bilingual and multilingual language learners.

Treatment Considerations for Adolescents Who Exhibit Cognitive/Communication Problems: A Neuroscience Perspective

2020 ◽  
Vol 5 (6) ◽  
pp. 1767-1775
Author(s):  
Martha S. Burns
Keyword(s):  
Social Communication ◽  
Transition Period ◽  
Clinical Intervention ◽  
Review Article ◽  
Sensitive Period ◽  
Clinical Implications ◽  
Evidence Based ◽  
Communication Problems ◽  
Treatment Considerations ◽  
Behavioral Growth

Purpose Adolescence is a period of substantial neurophysiological and behavioral growth, representing a second sensitive period of brain development. It is a psychological and social transition period between childhood and adulthood with many beneficial changes occurring, especially with respect to potential responsiveness to clinical intervention. However, adolescent behavioral complexities introduce clinical challenges as well. The purpose of this review article is to review the current neuroimaging research on neurophysiological changes observed during adolescence and the cognitive and social behavioral counterparts, with specific attention to the clinical implications. The review article will then summarize currently available intervention tools that can be utilized by speech-language pathologists working with this population. It will conclude with available evidence-based social-communication approaches that may be applicable as well as available evidence-based supplemental technological cognitive interventions that may be useful in working with adolescents who exhibit language and communication issues. Conclusion As a transition period between childhood and adulthood, adolescence represents a second sensitive period during which there is opportunity for clinically derived beneficial cognitive and communication growth.

PET/CT

2005 ◽  
Vol 44 (S 01) ◽  
pp. S51-S57 ◽  
Author(s):  
T. Beyer ◽  
G. Brix
Keyword(s):  
Diagnostic Accuracy ◽  
Radiation Exposure ◽  
Dose Reduction ◽  
Pet Imaging ◽  
Clinical Studies ◽  
Review Article ◽  
Whole Body ◽  
High Radiation ◽  
Radiation Burden ◽  
Pet Ct

Summary:Clinical studies demonstrate a gain in diagnostic accuracy by employing combined PET/CT instead of separate CT and PET imaging. However, whole-body PET/CT examinations result in a comparatively high radiation burden to patients and thus require a proper justification and optimization to avoid repeated exposure or over-exposure of patients. This review article summarizes relevant data concerning radiation exposure of patients resulting from the different components of a combined PET/CT examination and presents different imaging strategies that can help to balance the diagnostic needs and the radiation protection requirements. In addition various dose reduction measures are discussed, some of which can be adopted from CT practice, while others mandate modifications to the existing hardand software of PET/CT systems.

Discriminant Analysis and its Applications in Epidemiology

1980 ◽  
Vol 19 (04) ◽  
pp. 220-226 ◽  
Author(s):  
P. A. Lachenbruch ◽  
W. R. Clarke
Keyword(s):  
Discriminant Analysis ◽  
Historical Review ◽  
Review Article ◽  
Logistic Discrimination

This review article discusses current use of discriminant analysis in epidemiology. Contents include historical review, simple extensions and generalizations, examples, evaluation of rules, logistic discrimination, and robustness.

Sign in / Sign up

Export Citation Format

Share Document