The effect of medicinal electroapplication of the biologically active agent "Pelamine" from the ELAV-8 device on microcirculation in the rabbit ear

2021 ◽  
Author(s):  
E.M. Inyushkina ◽  
D.V. Vorobiev ◽  
A.N. Inyushkin
Keyword(s):  
Key Words ◽  
Active Substance ◽  
Active Agent ◽  
Biologically Active ◽  
Transdermal Administration ◽  
Vascular Bed ◽  
Vasodilatory Effect ◽  
Rabbit Ear ◽  
Prolonged Effect ◽  
Paravertebral Region

The study was the first to study the effect of pulsed electric currents from the ELAV–8 device and the biologically active substance "Pelamine" on microcirculation in the rabbit ear. It was found that pulsed currents from the ELAV-8 device with a frequency of 100 Hz, as well as the biologically active agent "Pelamine" injected into the rabbit's paravertebral region by means of pulsed currents, have a vasodilatory effect on the vascular bed of the rabbit's ear. At the same time, transdermal administration of the biologically active agent "Pelamine" with the help of currents from the ELAV-8 device has a more prolonged effect on vasodilation. Key words: Microcirculation, rabbit ear, paravertebral region, vascular diameter, "Pelamine", ELAV-8 device.

Novel Anti-Cancer, Anti-Bacterial Coatings for Biomaterial Applications: Selenium Nanoclusters

2009 ◽  
Vol 1209 ◽  
Author(s):  
Phong Anh Tran ◽  
Erik Taylor ◽  
Love Sarin ◽  
Robert H. Hurt ◽  
Thomas J Webster
Keyword(s):  
Bone Cells ◽  
Tumor Resection ◽  
Active Agent ◽  
In Vitro Study ◽  
Biologically Active ◽  
Elemental Selenium ◽  
Orthopedic Implant ◽  
Functional Coating ◽  
Anti Cancer

AbstractTwo common problems with implantation after cancerous tumor resection are cancer recurrence and bacteria infection at the implant site. Tumor resection surgery sometimes can not remove all the cancerous cells, thus, cancer can return after implantation. In addition, bacteria infection is one of the leading causes of implant failure. Therefore, it is desirable to have anti-cancer and anti-bacterial molecules which both rapidly (for anti-infection purposes) and continuously (for anti-cancer purposes) are available at the implant site following implantation. Therefore, the objective of the present in vitro study was to create a multi-functional coating for anti-cancer and anti-bacterial orthopedic implant applications. Elemental selenium was chosen as the biologically active agent in this effort because of its known chemopreventive and anti-bacterial properties. To achieve that objective, titanium (Ti), a conventional orthopedic implant material was coated with selenium (Se) nanoclusters. Different coating densities were achieved by varying Se concentration in the reaction mixture. Titanium substrates coated with Se nanoclusters were shown to enhance healthy osteoblast (bone-forming cell) and inhibit cancerous osteoblast proliferation in co-culture experiments. Functions of S. epidermidis (one of the leading bacteria that infect implants) were inhibited on Ti coated with Se-nanoclusters compared to uncoated materials. Thus, this study provided for the first time a coating material (selenium nanoclusters) to the biomaterials’ community to promote healthy bone cells’ functions, inhibit cancer growth and prevent bacteria infection.

scholarly journals Research and development of 2-ethyl-6-methyl-3-oxypyridine succinate nano-form for the treatment of epilepsy

2019 ◽  
Vol 10 (4) ◽  
pp. 26-38
Author(s):  
G. G. Avakyan ◽  
T. A. Voronina ◽  
L. N. Nerobkova ◽  
G. N. Avakyan
Keyword(s):  
Status Epilepticus ◽  
Research And Development ◽  
Active Ingredient ◽  
Active Substance ◽  
Drug Transport ◽  
Experimental Models ◽  
Polymer Nanoparticles ◽  
Biologically Active ◽  
Epileptic Focus ◽  
Models Of Epilepsy

The aimis to develop an antiepileptic drug based on polymer nanoparticles with 2-ethyl-6-methyl-3-oxypyridine succinate to facilitate the drug transport through the blood-brain barrier.Materials and methods.The nano-drug was created using the biologically active substance 2-ethyl-6-methyl-3-hydroxypyridine succinate and polybutyl cyanoacrylate (PBCA) nanoparticles. The advantages of this nano-form over the active ingredient of the same drug were studied using experimental models: the maximum electroshock test (MES), the antagonism test with corazol, models with a cobaltinduced epileptic focus and secondary generalized convulsions, and models of status epilepticus.Results.The antiseizure effects of the nanoform on the experimental models of epilepsy are identified.Conclusion.The nano-drug reduces the number of secondary generalized clonic-tonic seizures by 7.8 times; it also reduces 10-fold the animal mortality and diminishes the seizure manifestations that occur in the interictal period of the epileptic status.

scholarly journals Investigations on Terminalia Arjuna Fruits: Part 1- Isolation of Comounds from Petroleum Ether Fractions

1970 ◽  
Vol 43 (1) ◽  
pp. 123-130 ◽  
Author(s):  
M Zahurul Haque ◽  
M Abdullah As Saki ◽  
M Umar Ali ◽  
M Yusuff Ali
Keyword(s):  
Petroleum Ether ◽  
Key Words ◽  
1H Nmr ◽  
13C Nmr ◽  
Chromatographic Separation ◽  
Spectroscopic Studies ◽  
Biologically Active ◽  
Terminalia Arjuna ◽  
Pure Compounds ◽  
Column Chromatographic

Arjun (Terminalia arjuna) is a source of many potent, biologically active compounds, planned all over Bangladesh. The chemical examinations of its fruits were taken up to isolate and identify active principles. For this purpose fresh fruits of Terminalia arjuna were extracted with rectified spirit. The extract was then triturated with petroleum ether (40-60°C), which was then subjected to column chromatographic separation followed by PTLC. Such separation led to the isolation of some new pure compounds, TA-1 to TA-5. The structures of compounds were characterized through spectroscopic studies (IR, 1H-NMR and 13C-NMR). Key words: Arjun, TA-1, TA-5, Spectroscopic studies DOI: 10.3329.bjsir.v43i1.863 Bangladesh J. Sci. Ind. Res. 43(1),123-130, 2008

scholarly journals Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology

Molecules ◽  
2020 ◽  
Vol 25 (4) ◽  
pp. 857 ◽  
Author(s):  
Hossein Yazdani ◽  
Esha Kaul ◽  
Ayoob Bazgir ◽  
Dusica Maysinger ◽  
Ashok Kakkar
Keyword(s):  
Polyethylene Glycol ◽  
Drug Design ◽  
Cell Survival ◽  
Active Agent ◽  
Water Soluble ◽  
Biologically Active ◽  
Nitrile Oxide ◽  
Dipolar Cycloaddition ◽  
U251 Cell ◽  
Macromolecular Drug

An architectural polymer containing hydrophobic isoxazole-based dendron and hydrophilic polyethylene glycol linear tail is prepared by a combination of the robust ZnCl2 catalyzed alkyne-nitrile oxide 1,3-dipolar cycloaddition and esterification chemistry. This water soluble amphiphilic telodendrimer acts as a macromolecular biologically active agent and shows concentration dependent reduction of glioblastoma (U251) cell survival.

Binding of staphylococcal cell surface polysaccharide to human fibrinogen

1990 ◽  
Vol 36 (3) ◽  
pp. 206-210
Author(s):  
Toshichika Ohtomo ◽  
Tsugiaki Kobayashi ◽  
Yukio Ohshima ◽  
Yukio Usui ◽  
Masaru Suganuma ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Cell Surface ◽  
Binding Site ◽  
Key Words ◽  
Active Substance ◽  
Soft Agar ◽  
Alkaline Ph ◽  
Human Fibrinogen ◽  
Surface Polysaccharide ◽  
Alkaline Range

The interaction between the binding site of a polysaccharide (called compact colony forming active substance (CCFAS)), obtained from the cell surface of a strain of Staphylococcus, and human fibrinogen (HF) was investigated. The CCFAS was found to bind specifically to both the Bβ and γ chains of HF at pH 7.0 and 8.0, and the Aα chain at pH 5.0. The binding of CCFAS with fibrinogen fragments obtained by digestion with plasmin were also investigated. Fragments with Mr of 55 000, 24 000, and 19 000 were the major bands precipitated by CCFAS at pH 7.0 and 8.0. Fragments with Mr of 85 000 and 75 000 bound to CCFAS at pH 5.0. Binding of CCFAS (7 μg) with fibrinogen could be inhibited by 1.2 μg of Bβ chain and 1.5 μg γ chain at alkaline pH or 6.2 μg of the Aα chain at pH 5.0. CCFAS was, therefore, assumed to be specifically bonded with HF molecules, in the alkaline range at least, resulting in compact colony forming activity in serum soft agar and paracoagulation. Key words: cell surface, polysaccharide, Staphylococcus aureus, fibrinogen.

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