PARAMETERS RELATING TO CARDIOVASCULAR RISK FACTORS IN PATIENTS WITH CKD TREATED BY HEMODIALYSIS

2014 ◽  
pp. 21-28
Author(s):  
Tam Vo ◽  
Phai Le ◽  
Huu Vu Quang Nguyen
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Cardiovascular Risk ◽  
Kidney Disease ◽  
Systolic Blood Pressure ◽  
Cardiovascular Risk Factors ◽  
Inverse Correlation ◽  
Positive Correlation ◽  
Residual Urine

Objectives: Study the relation of the cardiovascular disease risk factors hypertension, anemia, serum CRP, dyslipidemia, blood calcium-phospho disorders, hypoalbuminemia, hyperglycemia with the time of hemodialysis, residual urine, clearance of creatinin, index of Sokolov-Lyon on the ECG and index of EF on the echocardiography. Material and Method: 80 pateints with chronic kidney disease treated by hemodialysis at Phu Yen Hospital. Results: The inverse correlation of the time of hemodialysis with systolic blood pressure (r = - 0,7175). The inverse correlation of the residual urine time with systolic blood pressure (r = - 0.7076) and the positive correlation with hemoglobin (r =0,2213), The inverse correlation of the clearance of creatinin with systolic blood pressure (r = -0.5768). The positive correlation of the index of Sokolov-Lyon on the ECG with systolic blood pressure (r = 0.4032). The inverse correlation of the index of EF on the echocardiography with systolic blood pressure (r = -0.7379) and the positive correlation with hemoglobin (r = 0,2240). Key words: Chronic kidney disease, hemodialysis, cardiovascular risk factors, hypertension, anemia, CRP

Abstract P348: Incidence of Chronic Kidney Disease (CKD) and Association of Major Cardiovascular Risk Factors With CKD in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Circulation ◽  
2017 ◽  
Vol 135 (suppl_1) ◽  
Author(s):  
Ana C Ricardo ◽  
Matthew Loop ◽  
Esteban Cedillo-Couvert ◽  
Jinsong Chen ◽  
Michael Flessner ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Cardiovascular Risk ◽  
Kidney Disease ◽  
Systolic Blood Pressure ◽  
Cardiovascular Risk Factors ◽  
Incidence Rate ◽  
Glycated Hemoglobin ◽  
Incidence Of Ckd

Background: The prevalence of major cardiovascular risk factors and chronic kidney disease (CKD) is high in U.S. Hispanics/Latinos. Hypotheses: We assessed the hypotheses that the incidence of CKD will vary by Hispanic/Latino heritage, and that cardiovascular risk factors will be associated with incident CKD among Hispanic/Latino adults. Methods: We used data from HCHS/SOL, the largest community-based cohort of 16,415 self-identified Hispanic/Latino adults from diverse backgrounds in the U.S., aged 18-74 years at visit 1 (baseline, 2008-2011), and ongoing second clinic examination (2014-2017). This preliminary analysis describes results from 7,144 adults who attended visit 1 and 2 by September 2016, and did not have CKD at baseline. Incident CKD was defined as estimated glomerular filtration rate (eGFR) <60 ml/min/1.73m 2 and eGFR decline ≥1 ml/min/year, or urine albumin-to-creatinine ratio (UACR) ≥30 mg/g. Incidence rates for CKD and incidence rate ratios (RR) for the association between cardiovascular risk factors at baseline and incident CKD were estimated using Poisson regression with robust variance while accounting for the complex sampling design of HCHS/SOL. Results: In 5.7 years mean follow-up, 430 individuals developed CKD (61.2% women). The age- and gender-adjusted incidence rate of CKD ranged from 6.0% (South Americans) to 14.9% (Puerto Ricans) per 1000 person-years (Table). Higher systolic blood pressure (RR, 95% CI, 1.02, 1.01-1.02, per one mm Hg increment), glycated hemoglobin (1.17, 1.07-1.27, per one percentage point increment), and log-UACR (3.29, 2.60-4.16, per one unit increment) were significantly associated with incident CKD. LDL and HDL cholesterol were not significantly associated with incident CKD. Conclusions: The incidence of CKD varies markedly by Hispanic/Latino heritage. Systolic blood pressure, glycated hemoglobin and albuminuria are important in the development of CKD in this population. Future work will focus on further evaluation of these differences/associations.

Long-term effects (>24 months) of multiple lifestyle intervention on major cardiovascular risk factors among high risk subjects: a meta-analysis

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
H Bergum ◽  
I Sandven ◽  
TO Klemsdal
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Systolic Blood Pressure ◽  
Total Cholesterol ◽  
Cardiovascular Risk Factors ◽  
Lifestyle Intervention ◽  
Small Study ◽  
Long Term Effects

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): The Norwegian health department Background The evidence of the long-term effects of multiple lifestyle intervention on cardiovascular risk is uncertain. We aimed to summarize the evidence from randomized clinical trials examining the efficacy of lifestyle intervention on major cardiovascular risk factors in subjects at high cardiovascular risk. Methods  Eligible trials investigated the impact of lifestyle intervention versus usual care with minimum 24 months follow-up, reporting more than one major cardiovascular risk factor. A literature search updated April 15, 2020 identified 12 eligible studies. The results from individual trials were combined using fixed and random effect models, using the standardized mean difference (SMD) to estimate effect sizes. Small-study effect was evaluated, and heterogeneity between studies examined by subgroup and meta-regression analyses considering patient- and study-level variables. Results  Small-study effect was not identified. Lifestyle intervention reduced systolic blood pressure modestly with an estimated SMD of -0.13, 95% confidence interval (CI): -0.21 to -0.04, with moderate heterogeneity (I² = 59%), corresponding to a mean difference of approximately 2 mmHg (MD = -1.86, 95% CI: -3.14 to -0.57, p = 0.0046). This effect disappeared in the subgroup of trials judged at low risk of bias (SMD = 0.02, 95% CI: -0.08 to 0.11). For the outcome total cholesterol SMD was -0.06, 95% CI: -0.13 to 0.00, with no heterogeneity (I² = 0%), indicating no effect of the intervention. Conclusion  Lifestyle intervention resulted in only a modest effect on systolic blood pressure and no effect on total cholesterol after 24 months. Further lifestyle trials should consider the challenge of maintaining larger long-term benefits to ensure impact on cardiovascular outcomes.

Abstract P011: Cardiovascular Risk Factors and Longevity

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Michelle C Odden ◽  
Andreea Rawlings ◽  
Alice Arnold ◽  
Mary Cushman ◽  
Mary Lou Biggs ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Risk Factor ◽  
Cardiovascular Risk ◽  
Systolic Blood Pressure ◽  
Cardiovascular Risk Factors ◽  
Old Age ◽  
Repeated Measures ◽  
Ldl Cholesterol ◽  
Low Cardiovascular Risk

Introduction: Cardiovascular disease is the leading cause of mortality in old age, yet there is limited research on the patterns of cardiovascular risk factors that predict survival to 90 years. Hypothesis: The patterns of cardiovascular risk factors that portend longevity will differ from those that confer low cardiovascular risk. Methods: We examined repeated measures of blood pressure, LDL-cholesterol, and BMI from age 67 and survival to 90 years in the Cardiovascular Health Study (CHS). CHS is a prospective study of 5,888 black and white adults in two waves (1989-90 and 1992-93) from Medicare eligibility lists in four counties in the U.S. We restricted to participants aged 67 to 75 years at baseline to control for birth cohort effects and examined repeated measures of cardiovascular risk factors throughout the late-life course. We fit logistic regression models to predict survival to age 90 using generalized estimating equations, and modeled the risk factors as linear, a linear spline, and clinically relevant categories. Models were adjusted for demographics and medication use, and we also examined whether the association of each risk factor with longevity varied by the age of risk factor measurement. Best fit models are presented. Results: Among 3,645 participants in the birth cohort, 1,160 (31.8%) survived to 90 by June 16 th , 2015. Higher systolic blood pressure in early old age was associated with reduced odds for longevity, but there was an interaction with age such that the association crossed the null at 80 years. (Table) Among those with LDL-cholesterol <130 mg/dL, higher LDL-cholesterol was associated with greater longevity; at levels above 130 mg/dL there was no association between LDL-cholesterol and longevity. BMI had a u-shaped association with longevity. Conclusions: In summary, the patterns of risk factors that predict longevity differ from that considered to predict low cardiovascular risk. The risk of high systolic blood pressure appears to depend on the age of blood pressure measurement.

scholarly journals Urinary Retinol-Binding Protein: Relationship to Renal Function and Cardiovascular Risk Factors in Chronic Kidney Disease

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0162782 ◽  
Author(s):  
Maria Alice Muniz Domingos ◽  
Silvia Regina Moreira ◽  
Luz Gomez ◽  
Alessandra Goulart ◽  
Paulo Andrade Lotufo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Renal Function ◽  
Cardiovascular Risk ◽  
Kidney Disease ◽  
Cardiovascular Risk Factors ◽  
Binding Protein ◽  
Retinol Binding Protein
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