INSULIN RESISTANCE IN PATIENTS WITH CONGESTIVE HEART FAILURE

Objects: To identify insulin resistance in patients with congestive heart failure and evaluated the association between insulin resistance with NYHA functional classification, EF and serum NTprpBNP level. Patients and Methods: 30 patients with congestive heart failure were assessed the NYHA functional classification and measured the concentration of NTproBNP, fasting plasma of insulin and glucose. The HOMA index; QUICKI index and I0/G0 were evaluated for insulin resistance. Results: The plasma concentration of I0 was 5,4±1,24 µU/ml. The values of I0/G0 index was 1,15±1,03, HOMA index was 1,53±1,3 and QUICKI index was 0,39±0,07. The prevalence of insulin resistance in congestive heart failure patients presented respectively from 43% to 100% basing on HOMA index and QUICKI index.There were significantly correlation between HOMA index and NYHA functional classification (r=0,502, p<0,001), NT-proBNP concentration (r=0,69, p<0,001), and EF index (r= -0,75, p<0,001). There were significantly correlation between QUICKI index with NYHA functional classification (r= - 0,407, p<0,05), NT-proBNP levels (r= - 0,7, p<0,001) and EF index (r= 0,58, p<0,001). Conclusions: Insulin-resistance was present high prevalence in patients with congestive heart failure in which there were correlation between insulin resistance with EF and NTproBNP. Key Words: Insulin resistance, heart failure