LUNGRADS AND UPDATE OF LUNG NODULES SCREENING BY LOW DOSE COMPUTED TOMOGRAPHY

Background: A pulmonary nodule is defined as a rounded or irregular opacity, well or poorly defined, measuring up to 3 cm in diameter. Early detection the malignancy of nodules has a significant role in decreasing the mortality, increasing the survival time and consider as early diagnosis lung cancer. The main risk factors are those of current or former smokers, aged 55 to 74 years with a smoking history of at least 1 pack-day. Low dose CT: screening individuals with high risk of lung cancer by low dose CT scans could reduce lung cancer mortality by 20 percent compared to chest X-ray. Radiation dose has to maximum reduced but respect the rule of ALARA (As Low as Resonably Archivable). LungRADS 2014: Classification of American College of Radiology, LungRADS, is a newly application but showed many advantages in comparison with others classification such as increasing positive predict value (PPV), no result of false negative and cost effectiveness. Key words: LungRADS, screening lung nodule, low dose CT, lung cancer

Application “Lung Nodule" Software With Lungrads On Early Detection And Follow Up The Pulmonary Nodules By Lung Low Dose CT Findings

Journal of Clinical Medicine- Hue Central Hospital ◽

10.38103/jcmhch.2020.64.14 ◽

2020 ◽

Author(s):

Ha Hoang Thi Ngoc

Keyword(s):

Lung Cancer ◽

Early Detection ◽

Pulmonary Nodule ◽

Low Dose ◽

False Negative ◽

Lung Nodule ◽

Pulmonary Nodules ◽

Lung Cancer Mortality ◽

Smoking History ◽

Low Dose Ct

Background: A pulmonary nodule is defined as a rounded or irregular opacity, well or poorly defined, measuring up to 3 cm in diameter. Early detection the malignancy of nodules has a significant role in decreasing the mortality, increasing the survival time and consider as early diagnosis lung cancer. Content: The main risk factors are those of current or former smokers, aged 55 to 74 years with a smoking history of at least 1 pack-day. Low dose CT: Screening individuals with high risk of lung cancer by low dose CT scans could reduce lung cancer mortality by 20 percent compared to chest X-ray. Radiation dose has to maximum reduced but respect the rule of ALARA (As Low as Resonably Archivable). ACR-LungRADS 2014: Classification of American College of Radiology, LungRADS, is a newly application but showed many advantages in comparison with others classification such as increasing positive predict value (PPV), no result of false negative and cost effectiveness. “Lung nodule” was applied as a smart phone application in order to have a quickly evaluation, especially the malignancy and management face on a pulmonary nodule.

Low-Dose CT Screening for Lung Cancer

10.1093/med/9780190223700.003.0044 ◽

2016 ◽

Cited By ~ 1

Author(s):

Christoph I. Lee

Keyword(s):

Lung Cancer ◽

Low Dose ◽

Lung Cancer Mortality ◽

Clinical Implications ◽

Clinical Context ◽

Ct Screening ◽

Low Dose Ct ◽

Additional Information ◽

Study Methodology ◽

This chapter, found in the cancer screening and management section of the book, provides a succinct synopsis of a key study examining the efficacy of low-dose computed tomography screening for lung cancer. This summary outlines the study methodology and design, major results, limitations and criticisms, related studies and additional information, and clinical implications. The study showed that annual low-dose CT screening among high-risk individuals decreases lung cancer mortality. While the rate of false positives was nearly 3 times higher for those screened by low-dose CT compared to chest radiography, complications from invasive diagnostic evaluation after positive screens were rare. In addition to outlining the most salient features of the study, a clinical vignette and imaging example are included in order to provide relevant clinical context.

Screening for Lung Cancer: Who Should Be Screened?

Archives of Pathology & Laboratory Medicine ◽

10.5858/arpa.2012-0259-ra ◽

2012 ◽

Vol 136 (12) ◽

pp. 1511-1514 ◽

Author(s):

James Jett

Keyword(s):

Computed Tomography ◽

Lung Cancer ◽

Cancer Mortality ◽

Low Dose ◽

Lung Cancer Mortality ◽

The United States ◽

Computed Tomography Scans ◽

Chest X Ray ◽

Low Dose Computed Tomography ◽

First Time

Lung cancer is the most common cause of death from cancer in the United States. Previous studies of screening with chest radiographs and sputum cytology have not been shown to decrease lung cancer mortality. For the first time, a randomized screening trial with low-dose computed tomography scans has demonstrated a 20% lung cancer mortality reduction compared with screenings with a chest x-ray. Investigation is underway on many breath, sputum, and blood biomarkers to determine markers of high risk. The hope is that some (or one) of them will add to the early detection of lung cancer observed with low-dose computed tomography.

THE APPLICATION OF ACR LUNG-RADS AND LUNG LOW DOSE COMPUTED TOMOGRAPHY IN DIAGNOSIS AND FOLLOW UP LUNG NODULES: EARLY REPORT IN 6 CASES

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2017.5.39 ◽

2017 ◽

pp. 271-280

Author(s):

Thi Ngoc Ha Hoang ◽

Trong khoan Le

Keyword(s):

Computed Tomography ◽

Lung Cancer ◽

Low Dose ◽

Early Report ◽

False Negative ◽

Lung Nodule ◽

University Hospital ◽

Lung Nodules ◽

Background: The lung low dose computed tomography and ACR LungRADS was routinely apply in diagnosis and follow up lung nodules in Hue University Hospital. A pulmonary nodule is defined as a rounded or irregular opacity, well or poorly defined, measuring up to 3 cm in diameter. Early detection the malignancy of nodules has a significant role in decreasing the mortality, increasing the survival time and consider as early diagnosis lung cancer. Classification of American College of Radiology, LungRADS, is a newly application but showed many advantages in comparison with others classification such as increasing positive predict value (PPV), no result of false negative and cost effectiveness. These 6 case report in order to show an early evaluation of the application of ACR LungRADS in diagnosis and follow up lung nodules at Hue University Hospital. Key words: LungRADS, screening lung nodule, low dose CT, lung cancer

Incidental renal tumours on low-dose CT lung cancer screening exams

Journal of Medical Screening ◽

10.1177/0969141316657115 ◽

2016 ◽

Vol 24 (2) ◽

pp. 104-109 ◽

Author(s):

Paul F Pinsky ◽

Barbara Dunn ◽

David Gierada ◽

P Hrudaya Nath ◽

Reginald Munden ◽

...

Keyword(s):

Computed Tomography ◽

Lung Cancer ◽

Renal Cancer ◽

Low Dose ◽

Lung Cancer Screening ◽

National Lung Screening Trial ◽

Renal Tumours ◽

Chest X Ray ◽

Low Dose Computed Tomography ◽

Lung Screening

Introduction Renal cancer incidence has increased markedly in the United States in recent decades, largely due to incidentally detected tumours from computed tomography imaging. Here, we analyze the potential for low-dose computed tomography lung cancer screening to detect renal cancer. Methods The National Lung Screening Trial randomized subjects to three annual screens with either low-dose computed tomography or chest X-ray. Eligibility criteria included 30 + pack-years, current smoking or quit within 15 years, and age 55–74. Subjects were followed for seven years. Low-dose computed tomography screening forms collected information on lung cancer and non-lung cancer abnormalities, including abnormalities below the diaphragm. A reader study was performed on a sample of National Lung Screening Trial low-dose computed tomography images assessing presence of abnormalities below the diaphragms and abnormalities suspicious for renal cancer. Results There were 26,722 and 26,732 subjects enrolled in the low-dose computed tomography and chest X-ray arms, respectively, and there were 104 and 85 renal cancer cases diagnosed, respectively (relative risk = 1.22, 95% CI: 0.9–1.5). From 75,126 low-dose computed tomography screens, there were 46 renal cancer diagnoses within one year. Abnormalities below the diaphragm rates were 39.1% in screens with renal cancer versus 4.1% in screens without (P < 0.001). Cases with abnormalities below the diaphragms had shorter median time to diagnosis than those without (71 vs. 160 days, P = 0.004). In the reader study, 64% of renal cancer cases versus 13% of non-cases had abnormalities below the diaphragms; 55% of cases and 0.8% of non-cases had a finding suspicious for renal cancer (P < 0.001). Conclusion Low-dose computed tomography screens can potentially detect renal cancers. The benefits to harms tradeoff of incidental detection of renal tumours on low-dose computed tomography is unknown.

Impact of low-dose computed tomography screening on lung cancer mortality among asbestos-exposed workers

International Journal of Epidemiology ◽

10.1093/ije/dyy212 ◽

2018 ◽

Vol 47 (6) ◽

pp. 1981-1991 ◽

Author(s):

Fabio Barbone ◽

Fabiano Barbiero ◽

Ornella Belvedere ◽

Valentina Rosolen ◽

Manuela Giangreco ◽

...

Keyword(s):

Computed Tomography ◽

Lung Cancer ◽

Cancer Mortality ◽

Low Dose ◽

Lung Cancer Mortality ◽

Exposed Workers ◽

ELIGIBILITY FOR LOW-DOSE COMPUTED TOMOGRAPHY LUNG CANCER SCREENING IN OLDER ASIAN AMERICAN SMOKERS

Innovation in Aging ◽

10.1093/geroni/igz038.679 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

pp. S189-S189

Author(s):

Chien-Ching Li ◽

Kelsey Choi ◽

Alicia Matthews ◽

Raj Shah

Keyword(s):

Computed Tomography ◽

Lung Cancer ◽

Asian American ◽

Low Dose ◽

Task Force ◽

Significant Proportion ◽

Lung Cancer Screening ◽

Lung Cancer Mortality ◽

Eligibility Criteria ◽

Abstract Lung cancer is the leading cause of cancer-related deaths in Asian Americans. Low-dose computed tomography lung cancer (LDCT) screening is an effective way to decrease lung cancer mortality. This study aimed to examine the difference in LDCT screening eligibility among Asian American subgroups. The National Health Interview Survey data (2006-2016) was analyzed. The U.S. Preventive Services Task Force guideline was used to determine the LDCT eligibility. A higher and statistically significant proportion of current Filipino smokers (35.4%) met LDCT screening eligibility criteria compared to Chinese (26.5%) and other Asian smokers (22.7%) (p=0.02). Hierarchical logistic regression results further showed that Filipino were more likely to meet LDCT screening criteria than other Asian while adjusting demographics (OR=1.87; p=0.01). The differences in LDCT screening eligibility no longer existed after additionally adjusting socioeconomic factors as well as perceived health status. Future targeted outreach and intervention research is needed for Filipinos with lower socioeconomic status.

Kezdeti tapasztalatok a HUNCHEST – alacsony dózisú CT-tüdőrákszűrési pilotprogrammal

Orvosi Hetilap ◽

10.1556/650.2018.31167 ◽

2018 ◽

Vol 159 (43) ◽

pp. 1741-1746 ◽

Cited By ~ 1

Author(s):

Anna Kerpel-Fronius ◽

Zsuzsanna Monostori ◽

Diana Solymosi ◽

Zsolt Markóczy ◽

Lívia Rojkó ◽

...

Keyword(s):

Lung Cancer ◽

Low Dose ◽

Screening Programme ◽

Lung Cancer Screening ◽

Lung Cancer Mortality ◽

Chronic Obstructive ◽

International Studies ◽

Obstructive Pulmonary Disease ◽

Low Dose Ct ◽

First Results

Abstract: Introduction: Lung cancer is the cause of death of around 8000 Hungarians each year. Aim: International studies have proved that low-dose CT (LDCT) screening lowers the lung cancer mortality of high risk patients. The HUNCHEST pilot study launched in 2014 studies the possibilities of a lung cancer screening programme in Hungary. The study is also aimed at showing whether there is an increased number of detected lung cancer in the subgroup with chronic obstructive pulmonary disease (COPD). Method: COPD and nonCOPD subjects, smokers and non-smokers are screened with low-dose CT in the 50–79 age group. Results and conclusion: The study is still undergoing recruitement, but in the light of the first results, the principles of the screening programme at the National Korányi Institute of Pulmonology are also presented. Orv Hetil. 2018; 159(43): 1741–1746.

Low-dose computed tomography screening reduces lung cancer mortality

Advances in Medical Sciences ◽

10.1016/j.advms.2017.12.002 ◽

2018 ◽

Vol 63 (2) ◽

pp. 230-236 ◽

Cited By ~ 10

Author(s):

Marcin Ostrowski ◽

Tomasz Marjański ◽

Witold Rzyman

Keyword(s):

Computed Tomography ◽

Lung Cancer ◽

Cancer Mortality ◽

Low Dose ◽

Lung Cancer Mortality ◽

Ten years of experience in lung cancer screening in Gdańsk, Poland: a comparative study of the evaluation and surgical treatment of 14 200 participants of 2 lung cancer screening programmes

Interactive CardioVascular and Thoracic Surgery ◽

10.1093/icvts/ivz079 ◽

2019 ◽

Vol 29 (2) ◽

pp. 266-274 ◽

Author(s):

Marcin Ostrowski ◽

Tomasz Marjański ◽

Robert Dziedzic ◽

Małgorzata Jelitto-Górska ◽

Katarzyna Dziadziuszko ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Screening ◽

Pilot Study ◽

Low Dose ◽

Screening Programme ◽

Lung Cancer Screening ◽

Smoking History ◽

Diagnostic Work ◽

Low Dose Computed Tomography ◽

Tomography Scan

Abstract OBJECTIVES The European Society of Thoracic Surgeons’ recommendations confirm the implementation of lung cancer screening in Europe. We compared 2 screening programmes, the Pilot Pomeranian Lung Cancer Screening Programme (pilot study) and the Moltest Bis programme, completed in a single centre. METHODS A total of 8649 healthy volunteers (aged 50–75 years, smoking history ≥20 pack-years) were enrolled in a pilot study between 2009 and 2011, and a total of 5534 healthy volunteers (aged 50–79, smoking history ≥30 pack-years) were enrolled in the Moltest Bis programme between 2016 and 2017. Each participant had a low-dose computed tomography scan of the chest. Participants with a nodule diameter of >10 mm or with suspected tumour morphology underwent a diagnostic work-up in the pilot study. In the Moltest Bis programme, the criteria were based on the volume of the detected nodule on the baseline low-dose computed tomography scan and the volume doubling time in the subsequent rounds. RESULTS Lung cancer was diagnosed in 107 (1.24%) and 105 (1.90%) participants of the pilot study and of the Moltest Bis programme, respectively (P = 0.002). A total of 300 (3.5%) and 199 (3.6%) patients, respectively, were referred for further invasive diagnostic work-ups (P = 0.69). A total of 125 (1.5%) and 80 (1.5%) patients, respectively, underwent surgical resection (P = 0.74). The number of resected benign lesions was similar: 44 (35.0%) and 20 (25.0%), respectively (P = 0.13), but with a downwards trend. Lobectomies and/or segmentectomies were performed in 84.0% and 90.0% of patients with lung cancer, respectively (P = 0.22). Notably, patients in the Moltest Bis programme underwent video-assisted thoracoscopic surgery more often than did those in the pilot study (72.5% vs 24.0%, P < 0.001). Surgical patients with stages I and II non-small-cell lung cancer (NSCLC) accounted for 83.4% of the Moltest patients and 86.4% of the pilot study patients (P = 0.44). CONCLUSIONS Modified inclusion criteria in the screening programme lead to a higher detection rate of NSCLC. Growing expertise in lung cancer screening leads to increased indications for minimally invasive surgery and an increased proportion of lung-sparing resections. A single-team experience in lung cancer screening does not lead to a major reduction in the rate of diagnostic procedures and operations for non-malignant lesions.