A STUDY OF CLINICAL, SUBCLINICAL FEATURES AND THERAPEUTIC EFFICACY OF SECUKINUMAB IN PATIENTS WITH ACTIVE ANKYLOSING SPONDYLITIS

2020 ◽  
pp. 83-88
Author(s):  
Linh Nguyen Mai Ha ◽  
Van Nguyen Hoang Thanh
Keyword(s):  
New York ◽  
Ankylosing Spondylitis ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Therapeutic Efficacy ◽  
Clinical Symptoms ◽  
Age Of Onset ◽  
Spinal Pain ◽  
Erythrocyte Sedimentation ◽  
Ground Distance

Objectives: To study clinical, subclinical features and to evaluate therapeutic efficacy of Secukinumab in patients with active Ankylosing Spondylitis (AS). Patients and methods: Descriptive, comparative, retrospective and prospective study, combination with treatment intervention in patients diagnosis with AS, following to modified ACR-1984 criteria (New York criteria) who are inpatient or outpatient in the Department of General Internal Medicine - Endocrinology of Hue University of Medicine and Pharmacy and in the Department of Nephrology and Rheumatology of Hue Central Hospital from May 2018 to August 2019. Results: The study recruited of 38 patients, (76.3% males) with mean age of 29.76 ± 9.75 years old. The age of onset was about 23 years old and the percentage of patients who were diagnosed AS under 30 years old was 73.7%. The majority of patients were hospitalized with severe pain (92.1%), in which 86.8% of patients sufferred from spinal pain, 71.1% of patients showed peripheral joint pain, commonly seen in hip joints (44.7%). Other common symptoms were lumbar Schober (about 3 cm), hand to ground distance (about 20 cm), median BASDAI score: 4.15 ± 1.01, median ASDAS-CRP: 3.81 ± 0.94, increasing CRP (81.58%), increasing erythrocyte sedimentation rate (81.6%), the percentage of HLA-B27 (+): 81.25% (for patients who have received this test). For patients treated with Fraizeron, in general, there were changes in patient global assessment, noctural back pain, peripheral swelling, lumbar Schober, hand to ground distance, BASDAI, ASDAS-CRP, erythrocyte sedimentation rate, CRP. These changes were positive with p < 0.05. When we assessed the safety of Secukinumab, we did not record any clinical or subclinical undesirable effects. Conclusion: At week 16, Secukinumab has been effectively shown to improve clinical symptoms as well as subclinical symptoms in patients with AS. It is also considered safe for use in these patients. Key words: Ankylosing Spondylitis, Secukinumab

scholarly journals GAMBARAN NILAI HEMATOKRIT DAN LAJU ENDAP DARAH PADA ANAK DENGAN INFEKSI VIRUS DENGUE DI MANADO

2015 ◽  
Vol 3 (3) ◽  
Author(s):  
Sitti S. P. Kamuh ◽  
Arthur E. Mongan ◽  
Maya F. Memah
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Dengue Virus Infection ◽  
Erythrocyte Sedimentation

Abstract: Dengue is a major public health problem that can be found throughout the tropical and subtropical countries around the world. Spectrum of clinical manifestations of dengue virus infection varies greatly. In addition to clinical symptoms, the diagnosis of dengue virus infection need to be supported by blood tests such as hematocrit and erythrocyte sedimentation rate. This study aimed to determine the hematocrit value and erythrocyte sedimentation rate (ESR) in children with dengue virus infection in Manado. This study used a cross-sectional design and was conducted from Desember 2014 to January 2015 at GMIM Pancaran Kasih, Advent, and Robert Wolter Mongisidi hospitals in Manado. There were 37 patients that fulfilled the inclusion criteria, consisted of 17 males and 20 females. The results showed that of 37 patients, there were 36 with hematocrit within normal limits. Moreover, of 37 patients only 6 patients performed the ESR examination; only 1 child had a rapid ESR result (> 15mm/h). Conclusion: In this study, most of the pediatric patients with dengue virus infection in Manado had normal hematocrit. Of 6 patients who had performed ESR test, only 1 had rapid ESR.Keywords: dengue, hematocrit, erythrocyte sedimentation rateAbstrak: Dengue merupakan masalah kesehatan masyarakat yang utama dan dapat ditemui diseluruh daerah tropis dan subtropis di seluruh dunia. Spektrum manifestasi klinis infeksi virus dengue sangat bervariasi. Selain gejala klinis, diagnosis infeksi virus dengue perlu ditunjang hasil uji darah di laboratorium antara lain hematokrit dan laju endap darah (LED). Penelitian ini bertujuan untuk mengetahui nilai hematokrit dan LED pada anak dengan infeksi virus dengue di Manado. Penelitian ini menggunakan desain potong lintang, dilakukan pada bulan Desember 2014 sampai Januari 2015 di RSU GMIM Pancaran Kasih Manado, RS Advent Manado, dan RSAD Robert Wolter Mongisidi Teling17 anak laki-laki dan 20 anak perempuan. Hasil penelitian memperlihatkan 36 dari 37 pasien mempunyai hematokrit normal. Dasri 37 pasien, hanya 6 anak yang menjalani pemeriksaan LED; hanya 1 anak dengan LED cepat (> 15mm/jam). Simpulan: Pada studi ini, sebagian besar pasien anak dengan infeksi virus dengue di Manado mempunyai nilai hematokrit normal. Dari 6 pasien yang dilakukan pemeriksaan LED, 1 anak mempunyai hasil LED cepat.Kata kunci: dengue, hematrokrit, laju endap darah.

scholarly journals Effects of a 6-month exercise programme on disease activity, physical and functional parameters in patients with ankylosing spondylitis: Randomised controlled trial

2021 ◽  
Vol 77 (1) ◽  
Author(s):  
Kim Nolte ◽  
Dina C. Janse van Rensburg ◽  
Lizelle Fletcher
Keyword(s):  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Exercise Intervention ◽  
Exercise Programme ◽  
Physical Work ◽  
Post Intervention ◽  
Erythrocyte Sedimentation ◽  
Physical Variables

Background: Exercise forms an important component in the management of ankylosing spondylitis (AS). The objective of our study was to determine the effects of a 6-month swimming, land-based stretching, strengthening and breathing exercise intervention in AS patients.Methods/design: A total of 29 (14 females, 15 males) patients diagnosed with AS according to the Modified New York Criteria participated in our study. Participants were randomly assigned to an exercise group (ASE) (16 participants) and a control group (ASC) (13 participants). Erythrocyte sedimentation rate and C-reactive protein (CRP); anthropometric measurements; pulmonary function; aerobic capacity; balance; Bath AS Metrology Index; Bath AS Disease Activity Index and the Bath AS Functional Index were assessed.Discussion: Erythrocyte sedimentation rate and CRP did not change notably within or between the groups from pre- to post-intervention. The between group analyses of the physical assessments favoured the ASE with observable improvements in chest expansion (p = 0.002), forced expiration volume (p = 0.012), absolute (p = 0.017) and relative (p = 0.003) maximal oxygen consumption, absolute (p = 0.028) and relative (p = 0.001) physical work capacity. Within the ASE, there is statistical evidence of improvements in 11 of the 19 physical variables. Within the ASC, five of the physical variables deteriorated substantially (p between 0.004 and 0.037) and only balance overall stability on the right improved (p = 0.016). The three functional assessments in the ASE improved (p 0.007) compared with the ASC post-intervention. A 6-month combined exercise programme may improve physical and functional capacity of AS patients.Conclusion: A multimodal exercise intervention may be useful in the management of ankylosing spondylitis.Clinical implications: An unsupervised well -explained exercise programme combining swimming, land-based strengthening and stretching exercises and breathing exercises may be an option for patients with ankylosing spondylitis.Trial registration: Registration not undertaken at the time of writing.

scholarly journals The Association of Fecal Microbiota in Ankylosing Spondylitis Cases with C-Reactive Protein and Erythrocyte Sedimentation Rate

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Gang Liu ◽  
Yonghong Hao ◽  
Qiang Yang ◽  
Shucai Deng
Keyword(s):  
Ankylosing Spondylitis ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Gut Microbiome ◽  
Inverse Correlation ◽  
Positive Association ◽  
C Reactive Protein ◽  
Bacterial Populations ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation

The purpose of this work was to identify the features of the gut microbiome in cases of ankylosing spondylitis (AS) testing positive for human leukocyte antigen- (HLA-) B27 and healthy controls (HCs) as well as to determine how bacterial populations were correlated with C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Fecal DNA extracted from fecal samples from 10 AS cases and 12 HCs was subjected to 16S rRNA gene sequencing. The two research groups did not differ significantly regarding alpha diversity. By comparison to HCs, AS cases displayed a lower relative level of Bacteroidetes ( P < 0.05 ), but a higher level of Firmicutes and Verrucomicrobia ( P < 0.05 ). Furthermore, the correlation between the specific gut bacteria and ESR or CRP was investigated. At the phylum level, Firmicutes and Verrucomicrobia had a positive association with ESR and CRP, while Bacteroidetes exhibited an inverse correlation with ESR and CRP. Meanwhile, in terms of genus, Bacteroides had a positive association with ESR and CRP, whereas Ruminococcus and Parasutterella had an inverse correlation with ESR and CRP, and Helicobacter also displayed an inverse correlation with CRP. Such findings indicated dissimilarities between AS cases and HCs regarding the gut microbiome, as well as the existence of correlations between bacterial populations and both ESR and CRP.

scholarly journals Effects of balneotherapy on the reactants of acute inflammation phase in Ankylosing spondylitis

2009 ◽  
Vol 137 (5-6) ◽  
pp. 255-258 ◽  
Author(s):  
Bojana Stamenkovic ◽  
Aleksandra Stankovic ◽  
Jovan Nedovic ◽  
Sonja Stojanovic ◽  
Aleksandar Dimic ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Serum Concentrations ◽  
C Reactive Protein ◽  
Acid Glycoprotein ◽  
Reactive Protein ◽  
Medication Therapy ◽  
Erythrocyte Sedimentation ◽  
Before And After

Introduction. Ankylosing spondylitis (AS) is a chronic inflammatory disease that affects sacroiliac joints, spinal column and peripheral joints. Beside medication therapy, physical and balneotherapy play an important role in its complex treatment. Objective. The aim of the research was to establish serum concentrations of C-reactive protein (CRP), ? 1-acid glycoprotein (? 1-AGP), ceruloplasmine (CP) and erythrocyte sedimentation rate (SE) before and after the balneotherapy in ankylosing spondylitis. Methods. The research included 50 AS patients according to the revised New York criteria, of mean age 43 years, who were treated for 14 days on the average at the Clinic for Rheumatology of the Institute 'Niska Banja'. All the patients received medications and balneotherapy (radioactive oligomineral baths, peloid, massage, kinesitherapy); the serum concentrations of CRP, ?1-AGP, CP and SE were measured before and after balneotherapy. Serum proteins were determined using original Nor Partigen plates Boehringer. Erythrocyte sedimentation rate was measured by Westergreen method. Balneotherapy was applied individually, intensively or mildly, depending on the AS stage and activity phase. Results. After dosed balneotherapy, a significant decrease in the concentrations of CP (p<0.05), ?1-AGP (p<0.01) and CRP (p<0.05) was registered in the serums of AS patients. ESR was not significantly reduced. Conclusion. The research proved that ? 1-acid glycoprotein, ceruloplasmine and C-reactive protein represent more sensitive inflammation markers as compared to erythrocyte sedimentation rate. The identification of acute phase reactants is important in the evaluation of dosed balneotherapy efficiency in the treatment of ankylosing spondylitis.

scholarly journals Erythrocyte Sedimentation Rate in COVID-19 Infections

2020 ◽  
Author(s):  
Wei Zhang ◽  
Youshu Yuan ◽  
Shucheng Zhang ◽  
Can Jin ◽  
Linlin Wu ◽  
...  
Keyword(s):  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Clinical Symptoms ◽  
Guizhou Province ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
Age Gap ◽  
Number Of Patients ◽  
Critical Patients

AbstractObjectivesTo compare the clinical characteristics between the rapid cohort and the normal cohort of erythrocyte sedimentation rate (ESR) in COVID-19 infections, analyze the variables with significant differences, and explore the influencing factors of rapid ESR.MethodsSelected a total of 80 patients with ESR detection during hospitalization were measured in 146 patients who received medical observation in concentrated isolation hospital in Guizhou province in China, collected and compared demographic information, epidemiological data, clinical symptoms, laboratory test data and CT image data during the observation between rapid cohort and normal group of ESR.ResultsBy comparison, the proportion of male in the rapid cohort was higher than female. The average age was more than 35 years old, with a large age gap. The proportion of severe and critical patients was more than 26.53% (13/49). However, in the normal cohort the proportion of female was more than male, and the average age was about 8 years lower than the rapid cohort, and the age gap was smaller. The proportion of severe and critical patients was 12.90%, which was less than half of the rapid group. In the two groups, the proportion of clustered cases accounted for more than 50%, and the average number of patients in one family was more than 3. The most common clinical symptoms were cough, sputum, fever, sore throat and weakness of limbs. There were significant differences in ALT, γ-GT and C-reactive protein between the rapid and normal cohort (P<0.05), but no statistically significant in other indicators. Hemoglobin and C-reactive protein have a significant effect on erythrocyte sedimentation rate.ConclusionsIn this study, we found that ESR is related to Hemoglobin and C-reactive protein. (Funded by Science and Technology Department of Guizhou Province; Chinese ClinicalTrials.gov number, ChiCTR2000033346. opens in new tab.)

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