Faculty Opinions recommendation of Folding of circular permutants with decreased contact order: general trend balanced by protein stability.

The correlations between the logarithm of the unfolding rate of 108 proteins and their structural parameters were calculated. We showed that there is a good correlation between the logarithm of folding rates (in native conditions) and unfolding rates (in denaturing conditions) (0.79) and protein stability and unfolding rate (0.79). Thus, the faster the protein folds, the faster it unfolds. Folding and unfolding rates are higher for the proteins with two-state kinetics, in comparison with the proteins with multi-state kinetics. At the same time, two-state bacterial proteins folds and unfolds two orders of magnitude faster than two-state eukaryotic proteins, and multi-state bacterial proteins folds and unfolds slower than multi-state eukaryotic proteins. Despite the fact that the folding rates of thermophilic and mesophilic proteins are close, the unfolding rates of thermophilic proteins is about two orders of magnitude lower than for mesophilic proteins. The correlation between unfolding rate and stability of thermophilic proteins is high (0.90). We also found that the unfolding rate correlates with such structural parameters as: size of the protein, radius of the cross-section, logarithm of absolute contact order, and radius of gyration. This information will be useful for engineering and designing new proteins with desired properties.

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The Impact of Anglicizing Former German-Language Psychology Journals on Authorship and Citation Frequencies

European Psychologist ◽

10.1027/1016-9040/a000074 ◽

2012 ◽

Vol 17 (3) ◽

pp. 190-198 ◽

Cited By ~ 2

Author(s):

Günter Krampen ◽

Thomas Huckert ◽

Gabriel Schui

Keyword(s):

Side Effects ◽

English Language ◽

General Trend ◽

Native Language ◽

Impact Factors ◽

German Language ◽

Journal Articles ◽

Number Of Citations ◽

The Impact ◽

Number Of Authors

Exemplary for other than English-language psychology journals, the impact of recent Anglicization of five former German-language psychology journals on (1) authorship (nationality, i.e., native language, and number of authors, i.e., single or multiple authorships), (2) formal characteristics of the journal (number of articles per volume and length of articles), and (3) number of citations of the articles in other journal articles, the language of the citing publications, and the impact factors (IF) is analyzed. Scientometric data on these variables are gathered for all articles published in the four years before anglicizing and in the four years after anglicizing the same journal. Results reveal rather quick changes: Citations per year since original articles’ publication increase significantly, and the IF of the journals go up markedly. Frequencies of citing in German-language journals decrease, citing in English-language journals increase significantly after the Anglicization of former German-language psychology journals, and there is a general trend of increasing citations in other languages as well. Side effects of anglicizing former German-language psychology journals include the publication of shorter papers, their availability to a more international authorship, and a slight, but significant increase in multiple authorships.

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Hydrogenolysis of glucose and fructose in glycol solutions over CuO-MgO-ZrO2 catalyst

Catalysis and petrochemistry ◽

10.15407/kataliz2020.30.048 ◽

2020 ◽

pp. 48-55

Author(s):

M.E. Sharanda ◽

◽

E.A. Bondarenko ◽

Keyword(s):

Ethylene Glycol ◽

Propylene Glycol ◽

Flow Reactor ◽

General Trend ◽

Raw Materials ◽

Reaction Products ◽

Renewable Raw Materials ◽

High Partial Pressure ◽

Zro2 Catalyst ◽

Phase Process

Ethylene glycol and propylene glycol are important representatives of polyols. On an industrial scale, they are obtained from petrochemical raw materials. Within a decade, significant efforts were made for the producing of polyols from biologically renewable raw materials - carbohydrates. The general trend for carbohydrate hydrogenolysis includes application of liquid-phase process with the use of modified metal-oxide catalysts, at 120-120 ° C and pressure of 3MPa or above. So high pressure is used for the reason to increase hydrogen solubility, and also due to the high partial pressure of low boiling solvents. We supposed that usage of high boiling solvents could allow hydrogenolysis to be performed at the lower pressure. Ethylene glycol and propylene glycol are of particular interest as such kind of solvent since they are both the main products of glucose hydrogenolysis. In this work, the process of hydrogenolysis of glucose and fructose over Cu / MgO-ZrO2 catalyst have been studied at temperature range of 160-200 °C and a pressure of 0.1-0.3 MPa in a flow reactor. The solvents were simultaneously the target products of the reaction - ethylene glycol and / or propylene glycol. Gas chromatography and 13C NMR were used for the reaction products identification. It was found that the solubility of glucose in propylene glycol is 21 % by weight, and in ethylene glycol 62% by weight. It was pointed out that the process of hydrogenolysis can take place at a pressure close to atmospheric. Under these conditions, the conversion of hexoses reaches 96-100 %. The reaction products are preferably propylene glycol and ethylene glycol. The total selectivity for C3-2 polyols is 90-94 %, that is higher than in the hydrogenolysis of glucose in aqueous solution.

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Pollen-Protein Interaction in Formulations: Effect of Pollens on Protein Stability

10.26226/morressier.57d6b2bfd462b8028d88cdec ◽

2016 ◽

Author(s):

Shashwati Atwe

Keyword(s):

Protein Stability ◽

Protein Interaction

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Human Neuraminidases Have Reduced Activity Towards Modified Sialic Acids on Glycoproteins

10.26434/chemrxiv.12510011 ◽

2020 ◽

Author(s):

Carmanah D. Hunter ◽

Elizabeth Porter ◽

Christopher Cairo

Keyword(s):

Substrate Specificity ◽

General Trend ◽

Sialic Acids ◽

Enzyme Specificity ◽

Naturally Occurring ◽

Bovine Submaxillary Mucin ◽

Reduced Activity

This work investigated the substrate specificity of hNEU enzymes for a glycoprotein substrate (bovine submaxillary mucin) containing 9-<i>O</i>-acetylated and Neu5Gc residues. Using this model substrate, we observe a general trend for hNEU tolerance of Neu5Ac>Neu5Gc>>>Neu5,9Ac<sub>2</sub>, consistent with our previous results with glycolipid substrates. These results expand our understanding of hNEU enzyme specificity and suggest that naturally occurring modifications of sialic acids can play a role in regulating hNEU activity.

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