Faculty Opinions recommendation of Serotonin signaling is a very early step in patterning of the left-right axis in chick and frog embryos.

2005 ◽  
Author(s):  
Judith S Eisen
Keyword(s):  
Early Step ◽  
Serotonin Signaling

scholarly journals Serotonin Signaling Is a Very Early Step in Patterning of the Left-Right Axis in Chick and Frog Embryos

2005 ◽  
Vol 15 (9) ◽  
pp. 794-803 ◽  
Author(s):  
Takahiro Fukumoto ◽  
Ido P. Kema ◽  
Michael Levin
Keyword(s):  
Early Step ◽  
Serotonin Signaling

Inhibition of ADP-Induced Responses in Human Platelets by Agents Elevating the Cyclic AMP Level: Comparison of Aggregation and Shape Change

1984 ◽  
Vol 52 (03) ◽  
pp. 333-335 ◽  
Author(s):  
Vider M Steen ◽  
Holm Holmsen
Keyword(s):  
Inhibitory Action ◽  
Human Platelet ◽  
Platelet Rich Plasma ◽  
Shape Change ◽  
Inhibitory Effect ◽  
Human Platelets ◽  
Inhibitory Effects ◽  
Early Step ◽  
Stimulus Response ◽  
Sequential Relationship

SummaryThe inhibitory effect of cAMP-elevating agents on shape change and aggregation in human platelets was studied to improve the understanding of the sequential relationship between these two responses.Human platelet-rich plasma was preincubated for 2 min at 37° C with prostaglandin E1 or adenosine, agents known to elevate the intracellular level of cAMP. Their inhibitory effects on ADP-induced shape change and aggregation were determined both separately and simultaneously. The dose-inhibition patterns for shape change and aggregation were similar for both PGE1 and adenosine. There was no distinct difference between the inhibitory action of these two inhibitors.These observations suggest that elevation of the intracellular concentration of cAMP interferes with an early step in the stimulus-response coupling that is common for aggregation and shape change.

Delivering Balinese Dance to the Digital Era: Multimedia-Enriched Dictionary

2020 ◽  
Vol 49 (2) ◽  
pp. 59-65
Author(s):  
I. Nengah Suandi ◽  
I. Made Bandem ◽  
I. Wayan Mudana ◽  
Ni Luh Partami ◽  
Kadek Yota Ernanda Aryanto
Keyword(s):  
Advanced Technology ◽  
Intangible Cultural Heritage ◽  
Current Development ◽  
User Survey ◽  
Early Step ◽  
Dance Movement ◽  
Cultural Wealth ◽  
Digital Era ◽  
Further Development ◽  
Multimedia Features

AbstractBalinese dance is the intangible cultural heritage which has become one of the main tourism draws in Indonesia, and worldwide that offers various cultural wealth with its unique qualities. It has strong characteristics, shown through the movements, music, and costumes. The richness of Balinese dance has attracted people, both scholars and tourists, to learn it. Unfortunately, it also presents a challenge for people who have just begun to learn it, due to their unfamiliarity with its terms taken from the local Balinese language. An Android-based application aimed at remedying this problem has been developed and has been evaluated for its main features and functionality. Several suggestions from initial users have been obtained and utilized for further development of the dictionary. By maintaining the multimedia features, the dictionary has become not only a reference for terms but also a practical reference for the dance movement itself. The results of the user survey suggested that further development using advanced technology could deliver more appealing experiences in learning Balinese dance. Furthermore, most of the respondents stated that the current development is appropriate as an early step in the efforts to preserve the record of Balinese dance.

scholarly journals Malignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Sau Yee Kok ◽  
Hiroko Oshima ◽  
Kei Takahashi ◽  
Mizuho Nakayama ◽  
Kazuhiro Murakami ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Primary Site ◽  
Cell Depletion ◽  
Driver Mutations ◽  
Effective Strategy ◽  
Malignant Cells ◽  
Early Step ◽  
Cell Clusters ◽  
Metastatic Cells

AbstractA concept of polyclonal metastasis has recently been proposed, wherein tumor cell clusters break off from the primary site and are disseminated. However, the involvement of driver mutations in such polyclonal mechanism is not fully understood. Here, we show that non-metastatic AP cells metastasize to the liver with metastatic AKTP cells after co-transplantation to the spleen. Furthermore, AKTP cell depletion after the development of metastases results in the continuous proliferation of the remaining AP cells, indicating a role of AKTP cells in the early step of polyclonal metastasis. Importantly, AKTP cells, but not AP cells, induce fibrotic niche generation when arrested in the sinusoid, and such fibrotic microenvironment promotes the colonization of AP cells. These results indicate that non-metastatic cells can metastasize via the polyclonal metastasis mechanism using the fibrotic niche induced by malignant cells. Thus, targeting the fibrotic niche is an effective strategy for halting polyclonal metastasis.

Poverty and Prosperity: Political Economics in Eighteenth-Century Ireland

2020 ◽  
Vol 88 ◽  
pp. 73-96
Author(s):  
Marc A. Hight
Keyword(s):  
Political Economy ◽  
Eighteenth Century ◽  
Political Institutions ◽  
Full Employment ◽  
Well Being ◽  
Common Interest ◽  
Early Step ◽  
Political Situation ◽  
Irish People ◽  
Economic Thinking

AbstractI draw attention to a group of thinkers in Ireland in the first half of the eighteenth century that made significant contributions to the philosophy of political economy. Loosely organized around the Dublin Philosophical Society founded in 1731, these individuals employed a similar set of assumptions and shared a common interest in the well-being of the Irish people. I focus on Samuel Madden (1686-1765), Arthur Dobbs (1689-1765), and Thomas Prior (1680–1751) and argue for two main theses. First, these Irish thinkers shared a number of commonalities with the English mercantilist thinkers of the eighteenth century, and to the degree that they did, their proposals to aid Ireland and reduce poverty were largely doomed to failure. Second, these Irish thinkers also importantly diverged from typical eighteenth-century mercantilist thinking in several ways. These modifications to mercantilism resulted in large part from the unusual political situation of Ireland (as a nation politically dependent on England) and helped orient their economic thinking along more institutional lines. In particular, the emphasis of the Irish on full employment and on the modification of social as well as political institutions is an early step forward in making political economy more sophisticated.

scholarly journals Molecular Cloning and Functional Characterization of Three 5-HT Receptor Genes (HTR1B, HTR1E and HTR1F) in Chickens

Genes ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 891
Author(s):  
Caiyun Sun ◽  
Yang Qiu ◽  
Qin Ren ◽  
Xiao Zhang ◽  
Baolong Cao ◽  
...  
Keyword(s):  
Serotonin Receptor ◽  
Functional Characterization ◽  
Brain Regions ◽  
Luciferase Reporter ◽  
Molecular Characteristics ◽  
Intracellular Camp ◽  
Pituitary Cells ◽  
Dependent Manner ◽  
Serotonin Signaling ◽  
Reporter Assays

The serotonin (5-hydroxytryptamine, 5-HT) signaling system is involved in a variety of physiological functions, including the control of cognition, reward, learning, memory, and vasoconstriction in vertebrates. Contrary to the extensive studies in the mammalian system, little is known about the molecular characteristics of the avian serotonin signaling network. In this study, we cloned and characterized the full-length cDNA of three serotonin receptor genes (HTR1B, HTR1E and HTR1F) in chicken pituitaries. Synteny analyses indicated that HTR1B, HTR1E and HTR1F were highly conserved across vertebrates. Cell-based luciferase reporter assays showed that the three chicken HTRs were functional, capable of binding their natural ligands (5-HT) or selective agonists (CP94253, BRL54443, and LY344864) and inhibiting intracellular cAMP production in a dose-dependent manner. Moreover, activation of these receptors could stimulate the MAPK/ERK signaling cascade. Quantitative real-time PCR analyses revealed that HTR1B, HTR1E and HTR1F were primarily expressed in various brain regions and the pituitary. In cultured chicken pituitary cells, we found that LY344864 could significantly inhibit the secretion of PRL stimulated by vasoactive intestinal peptide (VIP) or forskolin, revealing that HTR1F might be involved in the release of prolactin in chicken. Our findings provide insights into the molecular mechanism and facilitate a better understanding of the serotonergic modulation via HTR1B, HTR1E and HTR1F in avian species.

Sign in / Sign up

Export Citation Format

Share Document