The correction of epidermal barrier dysfunction in atopic dermatitis patients

Atopic dermatitis is chronic inflammatory multifactorial disease, which has genetic disorders, immune mechanisms of development and is under the ainfluence of a combination of exogenous and endogenous factors. Recently a leading role of the epidermal barrier dysfunction in the pathogenesis of atopic dermatitis was shown. The article presents data about emollient for skin care efficacy - Cetaphil® RESTORADERM, which consists of preceramides and filaggrin breakdown products in complex treatment of atopic dermatitis patients.

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Characteristics of immune response and role of cytokines in atopic dermatitis

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja469 ◽

2015 ◽

Vol 12 (1) ◽

pp. 3-14

Author(s):

O G Elisyutina ◽

E S Fedenko ◽

M N Boldyreva ◽

G O Gudima

Keyword(s):

Immune Response ◽

Atopic Dermatitis ◽

Genetic Disorders ◽

Multifactorial Disease ◽

Endogenous Factors ◽

Immune Mechanisms ◽

New Methods ◽

Methods Of Treatment

AD is a multifactorial disease, which is based on genetic disorders, immune mechanisms and influence of exogenous and endogenous factors. Study of immunopathogenesis of atopic dermatitis, it’s specific biomarkers, triggers is very important for understanding of causes and mechanisms of the disease as well as for developing of new methods of treatment. The review describes the current views on the immune response in AD.

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Experience of modern skin care series Atopic® using in atopic dermatitis children

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja327 ◽

2017 ◽

Vol 14 (2) ◽

pp. 76-81

Author(s):

O G Elisyutina ◽

A O Litovkina ◽

E S Fedenko

Keyword(s):

Immune Response ◽

Atopic Dermatitis ◽

Inflammatory Disease ◽

Skin Care ◽

Barrier Dysfunction ◽

Epidermal Barrier ◽

Endogenous Factors ◽

Complex Therapy ◽

Allergic Skin ◽

Disease Stages

Atopic dermatitis - chronic allergic skin inflammatory disease with genetic predisposition, dysbalance of immune response, dysfunction of an epidermal barrier and influence of various exogenous and endogenous factors. Epidermal barrier dysfunction leads to rising of permeability of a skin for allergens, microbs and nonspecific stimuli, as well as to sensitivity to various external influences. Clinically these implications are shown by skin xerosis symptoms therefore. According to modern clinical guidelines, the moisturizing agents, so called emollients, have to be used at all disease stages. Own data on use of modern skin care series Atopic® in complex therapy of atopic dermatitis patients are presented in the article.

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Current understanding of allergic march and the role of eczema in its development

Postępy Higieny i Medycyny Doświadczalnej ◽

10.5604/01.3001.0010.8706 ◽

2018 ◽

Vol 72 ◽

pp. 43-51

Author(s):

Karolina Gwoździewicz ◽

Ewa Cichocka-Jarosz

Keyword(s):

Atopic Dermatitis ◽

Subsequent Development ◽

Childhood And Adolescence ◽

Skin Microbiome ◽

Atopic Diseases ◽

Barrier Dysfunction ◽

Atopic March ◽

Leading Role ◽

Typical Sequence

An increasing morbidity of atopic diseases (atopic dermatitis, food allergy, asthma and allergic rhinitis) documented in large cohort epidemiological studies is at least partially determined by high hygienic standards of living. Over the last 40 years, the accepted concept of pathogenesis of atopic diseases, the so-called atopic march, was proposed by Fouchard in 1973. It referred to the natural history of atopy manifestation, with a typical sequence of symptoms presented as atopic dermatitis in early childhood for subsequent development of allergic respiratory symptoms in late childhood and adolescence. New data suggests that the leading role of atopic dermatitis in atopic march might be less pronounced than previously expected, indicating coexistence rather than succession of atopic symptoms. The objective of this paper is to present the currently discussed concepts of atopic dermatitis – its pathogenesis, etiology, course and role in the development of other allergic diseases. More widely, we will present: 1. The genetic factors involved in skin barrier disruption with the leading role of loss-of-function gene for filaggrin mutation, 2. Genetic defects and epigenetic regulation of the immune system 3. Epidermal changes with physical barrier dysfunction as well as 4. Skin microbiome disturbances with Staphylococcus aureus colonization leading to abnormalities of the epidermal protective barrier.

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Role of skin microbiome in epidermal barrier dysfunction and development of atopic dermatitis in high risk infants

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja26 ◽

2019 ◽

Vol 16 (1) ◽

pp. 59-64

Author(s):

N B Migacheva

Keyword(s):

At Risk ◽

Atopic Dermatitis ◽

Skin Barrier ◽

Transepidermal Water Loss ◽

Skin Microbiome ◽

Children At Risk ◽

Barrier Dysfunction ◽

Epidermal Barrier ◽

Microbiome Composition

Background. Colonization of skin with S. aureus in atopic dermatitis (AD) patients is a widespread phenomenon and a factor complicating the course of the disease. At present, it is not quite clear the role of S. aureus in the development of AD in children at risk. The aim of our study was to discribe the skin microbiome composition in young children at risk, as well as to investigate the role of S. aureus in skin barrier dysfunction and the development of AD. Material and methods. 12months follow-up study of 37 infants at risk has been performed. It included a general clinical examination, a microbiological investigation of skin microbiome (at 1 and 6 months), and investigation of epidermal barrier function by determining the transepidermal water loss (TEWL) at 1, 3, 6 and 12 months. Realization of AD during the observation period was considered as main outcome. Results. The prevalence of S. aureus colonization of infants aged 1 month was 45.9%, at the age of 6 months - 29.7%. Correlation analysis revealed an association between the skin colonization with S. aureus and a decrease of TEWL (p = 0.004), as well as the cumulative incidence of AD (p

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Faculty Opinions recommendation of Epicutaneous aeroallergen sensitization in atopic dermatitis infants - determining the role of epidermal barrier impairment.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1099233.556072 ◽

2008 ◽

Author(s):

Peter Schmid-Grendelmeier

Keyword(s):

Atopic Dermatitis ◽

Epidermal Barrier

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INFLUENCE OF BACTRIO-CARRY IN THE FAMILY ON THE COURSE OF ATOPIC DERMATITIS IN A CHILD

"Medical & pharmaceutical journal "Pulse" ◽

10.26787/nydha-2686-6838-2021-23-5-114-119 ◽

2021 ◽

pp. 114-119

Author(s):

Vasileva E.A. ◽

Kuyarov A.A. ◽

Kuyarov A.V.

Keyword(s):

Atopic Dermatitis ◽

Secondary Infection ◽

Family Members ◽

Upper Respiratory Tract ◽

Epidermal Barrier ◽

The Family ◽

Mucous Membranes ◽

High Degree ◽

Nose And Throat

The pathogenesis of atopic dermatitis (AD) is complex, and at present a unified concept of the development of the disease has not been formed. At the heart of pathogenesis, there is a complex interaction of numerous factors, such as genetic predisposition, dysfunction of the autonomic nervous system and the epidermal barrier. Previously, it has been proven that a high microbial contamination of the affected areas helps to maintain inflammation and aggravates skin dysfunction as a result of chronic inflammation, and favorable factors appear for the attachment of a secondary infection. However, little attention has been paid to dysfunctions of the epidermal barrier, the role of violations of the quantitative and qualitative composition of the microbiota in the development of AD, and this issue remains relevant at the present time. The aim of this study was to assess the effect of the carrier of bacteria on the mucous membranes of the upper respiratory tract in family members on the course of atopic dermatitis in a child. A bacteriological examination of the mucous membranes of the nose and throat was carried out in 34 children with AD and members of their families (74 people). When examining the mucous membranes of the nose and throat in family members of children with AD, it was found that the microflora isolated from family members in more than half of the cases has an increased potential for pathogenicity with a high degree of contamination (CFU lg 3), which forms an increased bacteriological load on the child. The tendency of bacterial carriage was revealed, contributing to the formation in the family of a permanent persistence of microflora with a high potential for pathogenicity. Asymptomatic carriage of bacteria forms an additional epidemiological load on the child, affects the severity of AD and is a risk factor in the development of secondary infection of the skin.

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Clinical Insights About Topical Treatment of Mild-to-Moderate Pediatric and Adult Atopic Dermatitis

Journal of Cutaneous Medicine and Surgery ◽

10.1177/1203475419843108 ◽

2019 ◽

Vol 23 (3_suppl) ◽

pp. 3S-13S ◽

Cited By ~ 1

Author(s):

Charles W. Lynde ◽

James Bergman ◽

Loretta Fiorillo ◽

Lyn Guenther ◽

Jill Keddy-Grant ◽

...

Keyword(s):

Atopic Dermatitis ◽

Calcineurin Inhibitors ◽

Skin Condition ◽

Future Research ◽

Barrier Dysfunction ◽

Psychosocial Burden ◽

Epidermal Barrier ◽

Topical Corticosteroids ◽

Topical Calcineurin Inhibitors ◽

Inflammatory Conditions

Atopic dermatitis (AD) is a chronic inflammatory skin condition, also referred to as atopic eczema, that is identified by itching and recurrent eczematous lesions. It often starts in infancy where it affects up to 20% of children but is also highly prevalent in adults. AD inflicts a significant psychosocial burden on patients and their families and increases the risk of other immune-mediated inflammatory conditions, such as asthma and allergic rhinitis, food allergy, and mental health disorders. It is a lifelong condition associated with epidermal barrier dysfunction and altered immune function. Through the use of emollients and anti-inflammatory agents, current prevention and treatment therapies attempt to restore epidermal barrier function. Acute flares are treated with topical corticosteroids. Topical calcineurin inhibitors (TCIs) and topical corticosteroids (TCSs) are used for proactive treatment to prevent remission. There remains a need and opportunity to improve AD care through future research directed toward an improved understanding of the heterogeneity of the disease and its subtypes, the role of autoimmunity in its pathogenesis, the mechanisms behind disease-associated itch and response to specific allergens, and the comparative effectiveness and safety of therapies.

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