Faculty Opinions recommendation of Targets of small interfering RNA restriction during human immunodeficiency virus type 1 replication.

2008 ◽  
Author(s):  
Donald Burke
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Small Interfering Rna ◽  
Immunodeficiency Virus ◽  
Interfering Rna

scholarly journals RNA Interference Directed against Poly(ADP-Ribose) Polymerase 1 Efficiently Suppresses Human Immunodeficiency Virus Type 1 Replication in Human Cells

2004 ◽  
Vol 78 (16) ◽  
pp. 8931-8934 ◽  
Author(s):  
Masanori Kameoka ◽  
Souichi Nukuzuma ◽  
Asako Itaya ◽  
Yasuharu Tanaka ◽  
Katsuya Ota ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Rna Interference ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Human Cells ◽  
Immunodeficiency Virus ◽  
Interfering Rna ◽  
Parp 1 ◽  
Hiv 1

ABSTRACT We established small interfering RNA (siRNA) directed against poly(ADP-ribose) polymerase 1 (PARP-1) that effectively reduces the expression of PARP-1 in two human cell lines. Established siRNA against PARP-1 significantly suppressed human immunodeficiency virus type 1 (HIV-1) replication, as well as the activation of the integrated HIV-1 long terminal repeat promoter. These results indicate that PARP-1 is required for efficient HIV-1 replication in human cells. We propose that PARP-1 may serve as a cellular target for RNA interference-mediated gene silencing to inhibit HIV-1 replication.

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