Faculty Opinions recommendation of A genome-wide gene expression signature of environmental geography in leukocytes of Moroccan Amazighs.

2008 ◽  
Author(s):  
Yoav Gilad
Keyword(s):  
Gene Expression ◽  
Gene Expression Signature ◽  
Expression Signature ◽  
Environmental Geography ◽  
Genome Wide ◽  
A Genome ◽  
Genome Wide Gene Expression

Genome-Wide Gene Expression Signature Of Depression

2017 ◽  
Vol 27 ◽  
pp. S484
Author(s):  
Liliana Ciobanu ◽  
Perminder S. Sachdev ◽  
Julian N. Trollor ◽  
Simone Reppermund ◽  
Anbupalam Thalamuthu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Signature ◽  
Expression Signature ◽  
Genome Wide ◽  
Genome Wide Gene Expression

scholarly journals Genome-wide gene expression changes in postpartum depression point towards an altered immune landscape

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Divya Mehta ◽  
Karen Grewen ◽  
Brenda Pearson ◽  
Shivangi Wani ◽  
Leanne Wallace ◽  
...  
Keyword(s):  
Gene Expression ◽  
Depressive Symptoms ◽  
Postpartum Depression ◽  
Expression Profiles ◽  
Depression Scale ◽  
Well Being ◽  
Health Concern ◽  
Genome Wide ◽  
A Genome ◽  
Genome Wide Gene Expression

AbstractMaternal postpartum depression (PPD) is a significant public health concern due to the severe negative impact on maternal and child health and well-being. In this study, we aimed to identify genes associated with PPD. To do this, we investigated genome-wide gene expression profiles of pregnant women during their third trimester of pregnancy and tested the association of gene expression with perinatal depressive symptoms. A total of 137 women from a cohort from the University of North Carolina, USA were assessed. The main phenotypes analysed were Edinburgh Postnatal Depression Scale (EPDS) scores at 2 months postpartum and PPD (binary yes/no) based on an EPDS cutoff of 10. Illumina NextSeq500/550 transcriptomic sequencing from whole blood was analysed using the edgeR package. We identified 71 genes significantly associated with postpartum depression scores at 2 months, after correction for multiple testing at 5% FDR. These included several interesting candidates including TNFRSF17, previously reported to be significantly upregulated in women with PPD and MMP8, a matrix metalloproteinase gene, associated with depression in a genome-wide association study. Functional annotation of differentially expressed genes revealed an enrichment of immune response-related biological processes. Additional analysis of genes associated with changes in depressive symptoms from recruitment to 2 months postpartum identified 66 genes significant at an FDR of 5%. Of these genes, 33 genes were also associated with depressive symptoms at 2 months postpartum. Comparing the results with previous studies, we observed that 15.4% of genes associated with PPD in this study overlapped with 700 core maternal genes that showed significant gene expression changes across multiple brain regions (P = 7.9e-05) and 29–53% of the genes were also associated with estradiol changes in a pharmacological model of depression (P values range = 1.2e-4–2.1e-14). In conclusion, we identified novel genes and validated genes previously associated with oestrogen sensitivity in PPD. These results point towards the role of an altered immune transcriptomic landscape as a vulnerability factor for PPD.

Angiogenesis and Lymphangiogenesis in IBC: Insights from a Genome-Wide Gene Expression Profiling Study

2012 ◽  
pp. 225-242
Author(s):  
Peter B. Vermeulen ◽  
Gert Van den Eynden ◽  
Pascal Finetti ◽  
Daniel Birnbaum ◽  
Naoto T. Ueno ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Genome Wide ◽  
A Genome ◽  
Genome Wide Gene Expression

scholarly journals Fitness costs and benefits of gene expression plasticity in rice under drought

2021 ◽  
Author(s):  
Simon C Groen ◽  
Elena Hamann ◽  
Irina Calic ◽  
Colleen Cochran ◽  
Rachel Konshok ◽  
...  
Keyword(s):  
Gene Expression ◽  
Environmental Variability ◽  
Housekeeping Genes ◽  
Costs And Benefits ◽  
Compensatory Evolution ◽  
Architectural Features ◽  
Genome Wide ◽  
A Genome ◽  
Gene Modules ◽  
Genome Wide Gene Expression

Genome-wide gene expression changes in response to environmental variability have been widely documented, but we lack detailed and comprehensive understanding of the interplay between this form of phenotypic plasticity and natural selection. Selection on expression plasticity may be limited by environment-specific costs, and plasticity may in turn affect selection on baseline expression levels. Here, we address this fundamental issue by measuring selection on drought-induced plasticity of leaf transcripts in field-grown rice populations. Selection disfavored switching off housekeeping genes under drought. This stress-induced dysregulation did not constrain selection on baseline transcript levels, suggesting compensatory evolution may be possible. Selection rarely acted strongly on individual transcripts but worked polygenically on gradual (continuous) plasticity of co-expressed gene modules regulating photosynthesis via known drought-responsive transcription factors. Finally, selection was tied to inefficient gene architectural features and metabolic costs of expression. Our study provides a genome-wide view of costs and benefits of gene expression plasticity.

scholarly journals An RCOR1 loss–associated gene expression signature identifies a prognostically significant DLBCL subgroup

Blood ◽  
2015 ◽  
Vol 125 (6) ◽  
pp. 959-966 ◽  
Author(s):  
Fong Chun Chan ◽  
Adele Telenius ◽  
Shannon Healy ◽  
Susana Ben-Neriah ◽  
Anja Mottok ◽  
...  
Keyword(s):  
Gene Expression ◽  
Copy Number ◽  
Gene Expression Signature ◽  
Specific Gene ◽  
Transcriptome Data ◽  
Genomic Deletions ◽  
Expression Signature ◽  
Genome Wide ◽  
Key Points ◽  
Whole Transcriptome

Key Points Integration of genome-wide copy number and whole transcriptome data identifies key mutational events in the pathogenesis of DLBCL. Genomic deletions in RCOR1 are associated with a specific gene expression signature and with unfavorable clinical outcomes in DLBCL patients.

scholarly journals A Genome-wide Gene-Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau Pathology

Cell Reports ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. 633-644 ◽  
Author(s):  
Mar Matarin ◽  
Dervis A. Salih ◽  
Marina Yasvoina ◽  
Damian M. Cummings ◽  
Sebastian Guelfi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transgenic Mice ◽  
Expression Analysis ◽  
Gene Expression Analysis ◽  
Tau Pathology ◽  
Genome Wide ◽  
A Genome ◽  
Genome Wide Gene Expression
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