Faculty Opinions recommendation of Family poverty over the early life course and recurrent adolescent and young adult anxiety and depression: a longitudinal study.

2010 ◽  
Author(s):  
Sara Johnson
Keyword(s):  
Longitudinal Study ◽  
Young Adult ◽  
Life Course ◽  
Early Life ◽  
Adolescent And Young Adult ◽  
Anxiety And Depression

scholarly journals Family Poverty Over the Early Life Course and Recurrent Adolescent and Young Adult Anxiety and Depression: A Longitudinal Study

2010 ◽  
Vol 100 (9) ◽  
pp. 1719-1723 ◽  
Author(s):  
Jake M. Najman ◽  
Mohammad R. Hayatbakhsh ◽  
Alexandra Clavarino ◽  
William Bor ◽  
Michael J. O'Callaghan ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Young Adult ◽  
Life Course ◽  
Early Life ◽  
Adolescent And Young Adult ◽  
Anxiety And Depression

scholarly journals Welfare regimes modify the association of disadvantaged adult-life socioeconomic circumstances with self-rated health in old age

2019 ◽  
Vol 48 (4) ◽  
pp. 1352-1366 ◽  
Author(s):  
Stefan Sieber ◽  
Boris Cheval ◽  
Dan Orsholits ◽  
Bernadette W Van der Linden ◽  
Idris Guessous ◽  
...  
Keyword(s):  
Young Adult ◽  
Life Course ◽  
Old Age ◽  
Household Income ◽  
Early Life ◽  
Middle Age ◽  
Adult Life ◽  
Welfare Regimes ◽  
Logistic Regression Models ◽  
Self Rated Health

Abstract Background Welfare regimes in Europe modify individuals’ socioeconomic trajectories over their life-course, and, ultimately, the link between socioeconomic circumstances (SECs) and health. This paper aimed to assess whether the associations between life-course SECs (early-life, young adult-life, middle-age and old-age) and risk of poor self-rated health (SRH) trajectories in old age are modified by welfare regimes (Scandinavian [SC], Bismarckian [BM], Southern European [SE], Eastern European [EE]). Methods We used data from the longitudinal SHARE survey. Early-life SECs consisted of four indicators of living conditions at age 10. Young adult-life, middle-age, and old-age SECs indicators were education, main occupation and satisfaction with household income, respectively. The association of life-course SECs with poor SRH trajectories was analysed by confounder-adjusted multilevel logistic regression models stratified by welfare regime. We included 24 011 participants (3626 in SC, 10 256 in BM, 6891 in SE, 3238 in EE) aged 50 to 96 years from 13 European countries. Results The risk of poor SRH increased gradually with early-life SECs from most advantaged to most disadvantaged. The addition of adult-life SECs differentially attenuated the association of early-life SECs and SRH at older age across regimes: education attenuated the association only in SC and SE regimes and occupation only in SC and BM regimes; satisfaction with household income attenuated the association across regimes. Conclusions Early-life SECs have a long-lasting effect on SRH in all welfare regimes. Adult-life SECs attenuated this influence differently across welfare regimes.

scholarly journals Interleukin-17 induced by cumulative mild stress promoted depression-like behaviors in young adult mice

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Jinho Kim ◽  
Yoo-Hun Suh ◽  
Keun-A Chang
Keyword(s):  
Depressive Symptoms ◽  
Young Adult ◽  
Early Life ◽  
Maternal Separation ◽  
Common Mental Disorders ◽  
Later Life ◽  
Anxiety And Depression ◽  
Interleukin 17 ◽  
Mild Stress ◽  
Adult Depression

AbstractThe number of young adult patients with major depression, one of the most common mental disorders, is gradually increasing in modern society. Stressful experiences in early life are considered one of the risk factors for chronic depressive symptoms, along with an abnormal inflammatory response in later life. Although increased inflammatory activity has been identified in patients with depression, the cause of long-lasting depressive states is still unclear. To identify the effects of cumulative mild stress in brain development periods, we generated a young adult depression mouse model exposed to cumulative mild stress (CPMS; cumulative mild prenatal stress, mild maternal separation, and mild social defeat) to mimic early life adversities. CPMS mice exhibited more long-lasting anxiety and depression-like behaviors than groups exposed to single or double combinations of mild stress in young adult age. Using the molecular works, we found that inflammatory cytokines, especially interleukin (IL)-17, upregulated microglial activation in the hippocampus, amygdala, and prefrontal cortex of CPMS mice. In the brains of CPMS mice, we also identified changes in the T helper (Th)-17 cell population as well as differentiation. Finally, anti-IL-17 treatment rescued anxiety and depression-like behavior in CPMS mice. In conclusion, we found that cumulative mild stress promoted long-lasting depressive symptoms in CPMS mice through the upregulation of IL-17. We suggest that the CPMS model may be useful to study young adult depression and expect that IL-17 may be an important therapeutic target for depression in young adults.

scholarly journals Early life course processes leading to educational and economic attainment in young adulthood: Contributions of early socioeconomic adversity and education polygenic score

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0256967
Author(s):  
Kandauda A. S. Wickrama ◽  
Catherine Walker OˋNeal ◽  
Tae Kyoung Lee ◽  
Seonhwa Lee
Keyword(s):  
Young Adult ◽  
Life Course ◽  
Educational Outcomes ◽  
Early Life ◽  
Life Stage ◽  
Theoretical Perspective ◽  
Economic Outcomes ◽  
European Ancestry ◽  
Polygenic Score ◽  
Prospective Longitudinal

The present study investigated an integrated life course model, drawn from the life course theoretical perspective, to elucidate youth’s additive, cascading, and cumulative life course processes stemming from early socioeconomic adversity and education polygenic score (education PGS) as well as potential interactions between them (GxE), which contribute to subsequent young adult socioeconomic outcomes. Additionally, the independent, varying associations among social and genetic predictors, life-stage specific educational outcomes (educational achievement in adolescence and educational attainment, in later stages), and young adult economic outcomes were examined. The study used prospective, longitudinal data from the National Longitudinal Study of Adolescent and Adult Health (Add Health) with a sample of 5,728 youth of European ancestry. Early family socioeconomic adversity and individual education PGS were associated with life stage-specific educational outcomes through additive and cascading processes linked to young adults’ economic outcomes (personal earnings) through a cumulative process. A GxE moderation existed between individuals’ education PGS and early socioeconomic adversity at multiple life stages, explaining variation in adolescent educational outcomes. Both early socioeconomic adversity and education PGS were persistently associated with youth’s educational and economic outcomes throughout the early life course. In sum, the findings based on the integrated life course model showed how additive, cascading, and cumulative processes were related and conditioned one another, generating specific life course patterns and outcomes. The findings highlight the value of incorporating molecular genetic information into longitudinal developmental life course research and provide insight into malleable characteristics and appropriate timing for interventions addressing youth developmental characteristics.

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