Faculty Opinions recommendation of High prevalence of clarithromycin-resistant Helicobacter pylori strains and risk factors associated with resistance in Madrid, Spain.

Author(s):  
Yoshio Yamaoka ◽  
Seiji Shiota
2010 ◽  
Vol 138 (5) ◽  
pp. S-339
Author(s):  
Guillermo I. Perez Perez ◽  
Sonia Agudo Pena ◽  
Teresa Alarcon ◽  
Manuel Lopez Brea

2015 ◽  
Vol 143 (12) ◽  
pp. 2520-2531 ◽  
Author(s):  
W. S. KRUEGER ◽  
E. D. HILBORN ◽  
R. R. CONVERSE ◽  
T. J. WADE

SUMMARYHelicobacter pylori imparts a considerable burden to public health. Infections are mainly acquired in childhood and can lead to chronic diseases, including gastric ulcers and cancer. The bacterium subsists in water, but the environment's role in transmission remains poorly understood. The nationally representative National Health and Nutrition Examination Survey (NHANES) was examined for environmental risk factors associated with H. pylori seroprevalence. Data from 1999–2000 were examined and weighted to represent the US population. Multivariable logistic regression estimated adjusted odds ratios (aOR) and 95% confidence intervals (CI) for associations with seropositivity. Self-reported general health condition was inversely associated with seropositivity. Of participants aged <20 years, seropositivity was significantly associated with having a well as the source of home tap water (aOR 1·7, 95% CI 1·1–2·6) and living in a more crowded home (aOR 2·3, 95% CI 1·5–3·7). Of adults aged ⩾20 years, seropositivity was not associated with well water or crowded living conditions, but adults in soil-related occupations had significantly higher odds of seropositivity compared to those in non-soil-related occupations (aOR 1·9, 95% CI 1·2–2·9). Exposures to both well water and occupationally related soil increased the effect size of adults' odds of seropositivity compared to non-exposed adults (aOR 2·7, 95% CI 1·3-5·6). Environmental exposures (well-water usage and occupational contact with soil) play a role in H. pylori transmission. A disproportionate burden of infection is associated with poor health and crowded living conditions, but risks vary by age and race/ethnicity. These findings could help inform interventions to reduce the burden of infections in the United States.


2019 ◽  
Vol 29 (2) ◽  
pp. 166-173 ◽  
Author(s):  
Nabil Ahmed Badawy ◽  
Shokria Adely Labeeb ◽  
Mawaheb Falah Alsamdan ◽  
Badria Faleh Alazemi

Objectives: To estimate the prevalence of polypharmacy in community-dwelling, older Kuwaiti patients, describe the number and types of drugs used, and identify risk factors associated with polypharmacy. Subjects and Methods: This was a descriptive cross-sectional questionnaire-based survey in which we interviewed 500 community-dwelling Kuwaiti adults over 65 years of age. The data collection occurred during a 4-month period from March to July 2017. Results: Fifty-two percent (n = 260) of the patients were males, with a mean age of 71.73 ± 5.32 years. The prevalence of polypharmacy (5–8 drugs) and excessive polypharmacy (>8 drugs) was 58.4% (n = 292) and 10.2% (n = 51), respectively. The risk factors associated with an increased number of medicines used were: female gender (p = 0.019), a lower level of education (p = 0.003), a high number of hospital admissions (p = 0.000), clinics visited by the patient (p =0.000), and number of comorbidities (p = 0.000). The most commonly used medications (82.6% of the study population) were blood glucose-lowering agents, excluding insulin. Other commonly used medications were antihypertensive drugs and lipid-modifying agents. Conclusion: A significant sector of the older Kuwaiti patient population has a high prevalence of polypharmacy and is thus exposed to its potential hazards. The current study highlights the need to revise the drug-dispensing policy among community-dwelling, older Kuwaiti people, as well as to initiate educational programs among healthcare practitioners concerning prescribing issues in older individuals.


1989 ◽  
Vol 154 (4) ◽  
pp. 516-522 ◽  
Author(s):  
Margaret M. Ryan ◽  
Lorraine Dennerstein ◽  
Roger Pepperell

Sixty women aged between 30 and 55 years, having hysterectomy for benign conditions, were prospectively studied to investigate psychological adjustment to operation, and to explore social, psychological and physical factors associated with psychological outcome. A further 30 women were included for prospective research on psychological outcome. Investigations took place within two weeks of operation and after four months and 14 months. The findings indicated a high prevalence of pre-operative psychological morbidity (55%), which reduced to 31.7% afterwards. There was no evidence that hysterectomy led to a greater psychological distress. The principal risk factors of poor psychological outcome were the previous scores on the mental health measures and personality inventory. Involvement in the research process did not appear to affect psychological outcome.


2020 ◽  
Author(s):  
Rolande MABIKA MABIKA ◽  
Sandrine Lydie OYEGUE-LIABAGUI ◽  
Franck Mounioko ◽  
Serge Ely DIBAKOU ◽  
Arnaud MONGO DELIS ◽  
...  

Abstract Background Better knowledge of endogenous germs and their associated demographic and environmental risk factors in a locality are essential to treat childhood diarrheal diseases. The aim of the study was to identify and characterize bacterial and parasitic pathogens responsible for childhood diarrhea, and to identify environmental risk factors associated with diarrhea in children under 5 years old living in Koula-Moutou, East-Central Gabon. Methods A cross-sectional study was performed from May 2016 to February 2018. One-hundred and thirty-two (132) children under 5 years old were enrolled. The detection of pathogens in stool samples was performed using microscopic examination and MIF concentration for parasites, and conventional culture on selective media for enterobacteria. Results The prevalence of diarrheal pathogens was 46.1%, including bacterial enteropathogens (25.5%) and parasites (20.6%). A total of 228 pathogenic organisms were isolated, including 199 bacterial strains (87.3%) and 29 parasites (12.7%). The specific richness of the isolated enterobacteria was 24 species with a high prevalence of E. coli (39.8%), including 26.7% for the diarrheal cases and 13.1% for the controls. Twelve (12) parasite species were also isolated and the most common types of parasites were rhizopods (44.8%), which accounted for 37.9% of the diarrheal cases and 6.9% of the controls. Univariate analysis showed that the presence of watercourses (OR = 3.37) and domestic animals (OR = 1.65) were significant risk factors for diarrhea. Conclusion The findings show a high prevalence of bacterial enteropathogens but a low rate of parasites and bacteria-parasite co-infection in the study area. Risk factors associated with diarrhea among children under 5 years old were the presence of watercourses and domestic animals. These findings highlight the need to strengthen the routine examination of diarrheic stool samples for the diagnosis of pathogenic organisms. Further analyses are required to better understand the etiologies and risk factors associated with the transmission of bacteria and parasites in rural, semi-urban and urban regions of Gabon.


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